Lista de obras - Amira Klip - Dominio Público Uruguay

A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

artículo científico publicado en 2015

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

artículo científico publicado en 2002

A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle

artículo científico publicado en 2008

Activation of the glucose transporter GLUT4 by insulin

artículo científico publicado en 2002

Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors

artículo científico publicado en 2003

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

artículo científico publicado en 2014

Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation

artículo científico publicado en 2008

Arp2/3- and Cofilin-coordinated Actin Dynamics Is Required for Insulin-mediated GLUT4 Translocation to the Surface of Muscle Cells ⬇️

artículo científico publicado el 25 de agosto de 2010

Bone marrow adipose cells - cellular interactions and changes with obesity

scientific article published on 06 March 2020

Cellular location of insulin-triggered signals and implications for glucose uptake

artículo científico publicado en 2005

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

artículo científico publicado en 2007

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

artículo científico publicado en 2017

Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling

scientific journal article

Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant

artículo científico publicado en 2011

Contracting C2C12 myotubes release CCL2 in an NF-κB-dependent manner to induce monocyte chemoattraction

artículo científico publicado en 2015

Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells

artículo científico publicado en 2010

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

artículo científico

Deconstructing metabolic inflammation using cellular systems

artículo científico publicado en 2017

Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation

artículo científico publicado en 2019

Desperately seeking sugar: glial cells as hypoglycemia sensors

artículo científico publicado en 2005

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

artículo científico publicado en 2005

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

scientific article published on October 2009

Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays

artículo científico publicado en 2008

Dissecting signalling by individual Akt/PKB isoforms, three steps at once

artículo científico publicado en 2015

Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers

artículo científico publicado en 2010

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

artículo científico publicado en 2014

Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells ⬇️

artículo científico publicado el 28 de diciembre de 2012

Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14.

artículo científico publicado en 2017

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4 ⬇️

artículo científico publicado el 25 de marzo de 2011

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

artículo científico publicado en 2016

Exercise- and insulin-stimulated muscle glucose transport: distinct mechanisms of regulation.

artículo científico publicado en 2002

Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells

artículo científico publicado en 2007

GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity

artículo científico publicado en 2009

GLUT4 Translocation in Single Muscle Cells in Culture: Epitope Detection by Immunofluorescence

artículo científico publicado en 2018

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells

artículo científico publicado en 2008

GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice

artículo científico publicado en 2021

Glucose transporter 4: cycling, compartments and controversies

artículo científico publicado en 2005

Health care crisis in Gaza

artículo científico publicado en 2009

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis

artículo científico publicado en 2018

Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.

artículo científico publicado en 2004

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

artículo científico publicado en 2004

Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides

artículo científico publicado en 2005

Insulin uptake and action in microvascular endothelial cells of lymphatic and blood origin

artículo científico publicado en 2018

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)

artículo científico publicado en 2006

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

artículo científico publicado en 2017

Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

scientific article published on 04 May 2020

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake

artículo científico publicado en 2004

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells

artículo científico publicado en 2003

Intracellular traffic and activation of the muscle glucose transporter.

artículo científico publicado en 2004

Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award

artículo científico publicado en 2007

Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia

artículo científico publicado en 2018

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis

artículo científico publicado en 2003

Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners

artículo científico publicado en 2005

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

artículo científico publicado en 2006

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

artículo científico publicado en 2012

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

scientific journal article

Muscle insulin resistance: assault by lipids, cytokines and local macrophages

artículo científico publicado en 2010

Muscle-specific Pten deletion protects against insulin resistance and diabetes

artículo científico publicado en 2005

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

scientific journal article

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

scientific journal article

NOD1 Activators Link Innate Immunity to Insulin Resistance ⬇️

artículo científico publicado el 29 de junio de 2011

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance ⬇️

artículo científico publicado el 6 de octubre de 2010

NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells

artículo científico publicado en 2015

Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice

artículo científico publicado en 2002

Nucleotides released from palmitate-activated murine macrophages attract neutrophils

artículo científico publicado en 2020

Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance

scientific journal article

PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells

artículo científico publicado en 2011

Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells

artículo científico publicado en 2008

Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε

artículo científico publicado en 2011

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

scientific article published on 24 October 2019

Putting Rac1 on the path to glucose uptake

artículo científico publicado en 2013

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells ⬇️

artículo científico publicado el 16 de noviembre de 2010

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells

artículo científico publicado en 2006

Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance ⬇️

artículo científico publicado el 2 de mayo de 2013

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

artículo científico publicado en 2016

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

artículo científico publicado en 2013

Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis

artículo científico publicado en 2009

Reciprocal regulation of endocytosis and metabolism

artículo científico publicado en 2014

Rho GTPases-Emerging Regulators of Glucose Homeostasis and Metabolic Health.

artículo científico publicado en 2019

Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release

artículo científico publicado en 2016

Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells

artículo científico publicado en 2008

Shuttling glucose across brain microvessels, with a little help from GLUT1 and AMP kinase. Focus on “AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress” ⬇️

artículo científico publicado el 18 de julio de 2012

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

artículo científico publicado en 2014

Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells

artículo científico publicado en 2014

Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling

artículo científico publicado en 2003

Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose

artículo científico

Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity

artículo científico publicado en 2002

TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells

artículo científico publicado en 2012

The AMP-activated protein kinase activator AICAR does not induce GLUT4 translocation to transverse tubules but stimulates glucose uptake and p38 mitogen-activated protein kinases alpha and beta in skeletal muscle

artículo científico publicado en 2003

The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2

scientific journal article

The Rab GTPase-activating protein AS160 integrates Akt, protein kinase C, and AMP-activated protein kinase signals regulating GLUT4 traffic

artículo científico publicado en 2007

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

artículo científico publicado en 2015

The cell biology of systemic insulin function.

artículo científico publicado en 2018

The many ways to regulate glucose transporter 4.

artículo científico publicado en 2009

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation

artículo científico publicado en 2002

The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6.

artículo científico publicado en 2007

Thirty sweet years of GLUT4

artículo científico publicado en 2019

Tissue-specific roles of IRS proteins in insulin signaling and glucose transport

artículo científico publicado en 2006

Triiodothyronine acutely stimulates glucose transport into L6 muscle cells without increasing surface GLUT4, GLUT1, or GLUT3.

artículo científico publicado en 2012

Turning signals on and off: GLUT4 traffic in the insulin-signaling highway

artículo científico publicado en 2005

Type 2 diabetes mellitus and inflammation: Prospects for biomarkers of risk and nutritional intervention ⬇️

artículo científico publicado el 26 de mayo de 2010

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

artículo científico publicado en 2017

Insulin action on glucose transporters through molecular switches, tracks and tethers

artículo científico publicado en 2008

Lista de obras de Amira Klip

A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis

A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation

A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle

Activation of the glucose transporter GLUT4 by insulin

Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors

Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance

Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation

Arp2/3- and Cofilin-coordinated Actin Dynamics Is Required for Insulin-mediated GLUT4 Translocation to the Surface of Muscle Cells ⬇️

Bone marrow adipose cells - cellular interactions and changes with obesity

Cellular location of insulin-triggered signals and implications for glucose uptake

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance

Clathrin-dependent and independent endocytosis of glucose transporter 4 (GLUT4) in myoblasts: regulation by mitochondrial uncoupling

Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant

Contracting C2C12 myotubes release CCL2 in an NF-κB-dependent manner to induce monocyte chemoattraction

Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Deconstructing metabolic inflammation using cellular systems

Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation

Desperately seeking sugar: glial cells as hypoglycemia sensors

Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells

Dissecting GLUT4 traffic components in L6 myocytes by fluorescence-based, single-cell assays

Dissecting signalling by individual Akt/PKB isoforms, three steps at once

Documenting GLUT4 exocytosis and endocytosis in muscle cell monolayers

Dynamic GLUT4 sorting through a syntaxin-6 compartment in muscle cells is derailed by insulin resistance-causing ceramide

Electrical Stimuli Release ATP to Increase GLUT4 Translocation and Glucose Uptake via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells ⬇️

Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14.

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4 ⬇️

Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

Exercise- and insulin-stimulated muscle glucose transport: distinct mechanisms of regulation.

Fish glucose transporter (GLUT)-4 differs from rat GLUT4 in its traffic characteristics but can translocate to the cell surface in response to insulin in skeletal muscle cells

GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity

GLUT4 Translocation in Single Muscle Cells in Culture: Epitope Detection by Immunofluorescence

GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells

GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize glycemia in diabetic mice

Glucose transporter 4: cycling, compartments and controversies

Health care crisis in Gaza

Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis

Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive factor-dependent SNARE mechanisms but different v-SNAREs: role of TI-VAMP.

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides

Insulin uptake and action in microvascular endothelial cells of lymphatic and blood origin

Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake

Intracellular segregation of phosphatidylinositol-3,4,5-trisphosphate by insulin-dependent actin remodeling in L6 skeletal muscle cells

Intracellular traffic and activation of the muscle glucose transporter.

Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award

Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia

Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis

Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation

Muscle insulin resistance: assault by lipids, cytokines and local macrophages

Muscle-specific Pten deletion protects against insulin resistance and diabetes

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells

NOD1 Activators Link Innate Immunity to Insulin Resistance ⬇️

NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance ⬇️

NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells

Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice

Nucleotides released from palmitate-activated murine macrophages attract neutrophils

Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance

PKCε regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells

Palmitate- and lipopolysaccharide-activated macrophages evoke contrasting insulin responses in muscle cells

Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

Putting Rac1 on the path to glucose uptake

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells ⬇️

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells

Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance ⬇️

Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice

Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle

Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis

Reciprocal regulation of endocytosis and metabolism

Rho GTPases-Emerging Regulators of Glucose Homeostasis and Metabolic Health.