Lista de obras - ZEEV RONAI - Dominio Público Uruguay

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

artículo científico publicado en 2016

A darker side to p53.

artículo científico publicado en 2007

A new function for p53 ubiquitination

artículo científico publicado en 2006

ATF2 alters melanocyte response and macrophage recruitment in UV-irradiated neonatal mouse skin

artículo científico publicado en 2015

ATF2 – at the crossroad of nuclear and cytosolic functions ⬇️

artículo científico publicado el 8 de junio de 2012

Adaptive Stress Responses During Tumor Metastasis and Dormancy

artículo científico publicado en 2016

Aldolase-DNA interactions in a SEWA cell system

artículo científico publicado el 28 de febrero de 1992

Analysis of JNK, Mdm2 and p14(ARF) contribution to the regulation of mutant p53 stability

scientific article published on 01 January 2000

Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

artículo científico publicado el 16 de mayo de 1992

Anti-red blood cell autoantibodies induced in rat by Plasmodium berghei infection bind to a cross-reacting determinant present also in other cell types.

artículo científico publicado en 1983

BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.

artículo científico publicado en 2009

Balancing Mdm2 - a Daxx-HAUSP matter

scientific article published on 01 August 2006

CREB and its associated proteins act as survival factors for human melanoma cells

artículo científico publicado en 1998

Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene.

artículo científico publicado en 1998

Control of p53 multimerization by Ubc13 is JNK-regulated

scholarly article

Cooperation between STAT3 and c-jun suppresses Fas transcription.

artículo científico publicado en 2001

Distinct pattern of p53 phosphorylation in human tumors

scientific article published on 01 June 2001

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

artículo científico publicado en 2015

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

artículo científico publicado en 2003

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways

artículo científico publicado en 2011

Effects of 8-methoxypsoralen and ultraviolet light A on EGF receptor (HER-1) expression

scientific article published on 01 December 1988

Elevated binding to URE/PEBP2 during the late stages of NNK and benzo[a]pyrene-induced carcinogenesis in A/J mice

scientific article published on 01 April 1996

Evidence that oocyte maturation induced by an oncogenic ras-p21 protein and insulin is mediated by overlapping yet distinct mechanisms

artículo científico publicado el 1 de diciembre de 1992

Expression and transcriptional activity of AP-1, CRE, and URE binding proteins in B16 mouse melanoma subclones.

artículo científico publicado en 1994

Expression of a 32 kDa protein in rat mammary tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide

artículo científico publicado en 1996

Fbx8 makes Arf6 refractory to function via ubiquitination.

artículo científico publicado en 2007

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

artículo científico publicado en 2014

Gene mutation as a target for early detection in cancer diagnosis.

artículo científico publicado en 2001

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

artículo científico publicado en 2015

Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma

artículo científico publicado en 2013

Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus

artículo científico publicado en 2001

Glycolytic enzymes as DNA binding proteins.

artículo científico publicado en 1993

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 mice

artículo científico publicado en 2019

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

scientific article published on 14 February 2019

Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

artículo científico publicado en 2001

Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway.

artículo científico publicado en 2000

Inhibition of Siah ubiquitin ligase function.

artículo científico publicado en 2008

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

artículo científico publicado en 2009

Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.

artículo científico publicado en 2012

Inhibition of melanoma growth and metastasis by ATF2-derived peptides.

artículo científico publicado en 2004

Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2

artículo científico publicado en 2013

JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.

artículo científico publicado en 2010

JNKing Revealed

scientific article published on 01 September 2004

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

artículo científico publicado en 2001

MEKK1/JNK signaling stabilizes and activates p53.

artículo científico publicado en 1998

Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation.

artículo científico publicado en 2006

Melanoma initiating cells - easy as ABC?

artículo científico publicado en 2008

Melanoma-initiating cells: a compass needed.

artículo científico publicado en 2009

Muscle-epidermis interactions affect exoskeleton patterning in Caenorhabditis elegans.

artículo científico publicado en 2007

Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis

artículo científico publicado en 2005

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

artículo científico publicado en 2012

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

scientific article published on 01 July 2020

Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2.

artículo científico publicado en 2005

Precision Oncology: The Road Ahead.

artículo científico publicado en 2017

Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.

artículo científico publicado en 2007

Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation

scientific article published on 01 January 1997

RACK1 Function in Cell Motility and Protein Synthesis.

scientific article published on September 2013

RAF-isotype switching: from B to C through PDE ⬇️

artículo científico publicado el 1 de mayo de 2011

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

artículo científico publicado en 2009

Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase.

artículo científico publicado en 2004

Reciprocal relationships between the resistance to stresses and cellular aging.

artículo científico publicado en 1998

Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling.

artículo científico publicado en 2001

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

artículo científico publicado en 2018

Regulation of c-jun by lung carcinogens in Clara cells of hamsters

artículo científico publicado en 1994

Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.

artículo científico publicado en 2002

Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies

artículo científico publicado en 2015

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

artículo científico publicado en 2007

Regulators and effectors of Siah ubiquitin ligases.

artículo científico

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells ⬇️

artículo científico publicado el 27 de marzo de 2012

Rewired Notch/p53 by Numb'ing Mdm2.

artículo científico publicado en 2018

Roadmap for New Opportunities in Melanoma Research

artículo científico publicado en 2007

SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation

scientific article published on 18 June 2019

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53

scientific article published on 01 August 2002

Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents.

artículo científico publicado en 1997

Serial circulating immune complex values and development of metastatic disease in breast cancer and malignant melanoma patients

artículo científico publicado en 1986

Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.

artículo científico publicado en 2011

Siah2 control of T-regulatory cells limits anti-tumor immunity

scientific article published on 07 January 2020

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.

artículo científico publicado en 2013

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

artículo científico publicado en 2010

Structure-Based Design of Covalent Siah Inhibitors ⬇️

artículo científico publicado el 25 de julio de 2013

Suppressor role of activating transcription factor 2 (ATF2) in skin cancer

artículo científico publicado en 2008

TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage

artículo científico publicado en 2001

Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival

artículo científico publicado en 2018

The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis

artículo científico publicado en 2008

The Mdm-2 amino terminus is required for Mdm2 binding and SUMO-1 conjugation by the E2 SUMO-1 conjugating enzyme Ubc9

scientific article published in 2001

The SCF(HOS/beta-TRCP)-ROC1 E3 ubiquitin ligase utilizes two distinct domains within CUL1 for substrate targeting and ubiquitin ligation

artículo científico publicado en 2000

The UPs and DOWNs of MITF in melanoma resistance.

artículo científico publicado en 2014

The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress.

artículo científico publicado en 2012

The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.

artículo científico publicado en 2003

The gut microbiome: an unexpected player in cancer immunity

artículo científico publicado en 2019

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class Switching in B Lymphocytes

scientific article published on 10 December 2018

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

artículo científico publicado en 2021

Transcriptional repression of IFNβ1 by ATF2 confers melanoma resistance to therapy.

artículo científico publicado en 2015

Translational reprogramming marks adaptation to asparagine restriction in cancer

scientific article published on 18 November 2019

Tricking melanoma to self-digest: a deal of a meal!

scientific article published on 01 August 2009

UPR, autophagy, and mitochondria crosstalk underlies the ER stress response

artículo científico publicado en 2015

USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains

artículo científico publicado en 2011

UV irradiation and heat shock mediate JNK activation via alternate pathways.

artículo científico publicado en 1995

Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity

artículo científico publicado en 2019

Ubiquitin ligases in oncogenic transformation and cancer therapy

artículo científico publicado en 2017

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses

artículo científico publicado en 2007

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

artículo científico publicado en 2011

Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.

artículo científico publicado en 2004

Ultraviolet irradiation and c-jun over-expression regulates replication of polyoma sequences in WOP cells through a PEBP2 binding site

artículo científico publicado en 1995

Vascular Normalization by Loss of Siah2 Results in Increased Chemotherapeutic Efficacy

artículo científico publicado en 2012

Wnt/beta-catenin signaling induces the expression and activity of betaTrCP ubiquitin ligase receptor

artículo científico publicado en 2000

c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

artículo científico publicado en 1997

c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis

artículo científico publicado en 2009

c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability.

artículo científico publicado en 2003

Lista de obras de ZEEV RONAI

A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

A darker side to p53.

A new function for p53 ubiquitination

ATF2 alters melanocyte response and macrophage recruitment in UV-irradiated neonatal mouse skin

ATF2 – at the crossroad of nuclear and cytosolic functions ⬇️

Adaptive Stress Responses During Tumor Metastasis and Dormancy

Aldolase-DNA interactions in a SEWA cell system

Analysis of JNK, Mdm2 and p14(ARF) contribution to the regulation of mutant p53 stability

Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Anti-red blood cell autoantibodies induced in rat by Plasmodium berghei infection bind to a cross-reacting determinant present also in other cell types.

BI-69A11-mediated inhibition of AKT leads to effective regression of xenograft melanoma.

Balancing Mdm2 - a Daxx-HAUSP matter

CREB and its associated proteins act as survival factors for human melanoma cells

Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene.

Control of p53 multimerization by Ubc13 is JNK-regulated

Cooperation between STAT3 and c-jun suppresses Fas transcription.

Distinct pattern of p53 phosphorylation in human tumors

Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways

Effects of 8-methoxypsoralen and ultraviolet light A on EGF receptor (HER-1) expression

Elevated binding to URE/PEBP2 during the late stages of NNK and benzo[a]pyrene-induced carcinogenesis in A/J mice

Evidence that oocyte maturation induced by an oncogenic ras-p21 protein and insulin is mediated by overlapping yet distinct mechanisms

Expression and transcriptional activity of AP-1, CRE, and URE binding proteins in B16 mouse melanoma subclones.

Expression of a 32 kDa protein in rat mammary tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide

Fbx8 makes Arf6 refractory to function via ubiquitination.

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

Gene mutation as a target for early detection in cancer diagnosis.

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.

Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma

Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus

Glycolytic enzymes as DNA binding proteins.

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5 mice

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells

Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.

Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway.

Inhibition of Siah ubiquitin ligase function.

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11.

Inhibition of melanoma growth and metastasis by ATF2-derived peptides.

Inhibition of melanoma growth by small molecules that promote the mitochondrial localization of ATF2

JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.

JNKing Revealed

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

MEKK1/JNK signaling stabilizes and activates p53.

Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation.

Melanoma initiating cells - easy as ABC?

Melanoma-initiating cells: a compass needed.

Muscle-epidermis interactions affect exoskeleton patterning in Caenorhabditis elegans.

Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis

PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria

PRMT5 control of cGAS/STING and NLRC5 pathways defines melanoma response to antitumor immunity

Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2.

Precision Oncology: The Road Ahead.

Preclinical studies of celastrol and acetyl isogambogic acid in melanoma.

Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation

RACK1 Function in Cell Motility and Protein Synthesis.

RAF-isotype switching: from B to C through PDE ⬇️

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase

Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase.

Reciprocal relationships between the resistance to stresses and cellular aging.

Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling.

Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

Regulation of c-jun by lung carcinogens in Clara cells of hamsters

Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.

Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

Regulators and effectors of Siah ubiquitin ligases.

Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells ⬇️

Rewired Notch/p53 by Numb'ing Mdm2.

Roadmap for New Opportunities in Melanoma Research

SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53

Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents.

Serial circulating immune complex values and development of metastatic disease in breast cancer and malignant melanoma patients

Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.

Siah2 control of T-regulatory cells limits anti-tumor immunity

Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors