Lista de obras -

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

artículo científico publicado en 2008

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

artículo científico publicado en 2017

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.

artículo científico publicado en 2015

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

scientific article published on 05 June 2019

Engineering enhanced protein disaggregases for neurodegenerative disease

artículo científico publicado en 2015

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

artículo científico publicado en 2017

Functional analysis of proposed substrate-binding residues of Hsp104

artículo científico publicado en 2020

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

scientific article published on 05 April 2019

Isolating potentiated Hsp104 variants using yeast proteinopathy models

artículo científico publicado en 2014

Mechanistic Insights into Hsp104 Potentiation

artículo científico publicado en 2016

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

scientific article published on 01 August 2019

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

artículo científico publicado en 2018

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

artículo científico publicado en 2012

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

artículo científico publicado en 2014

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

artículo científico publicado en 2014

Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain

artículo científico publicado en 2018

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.

artículo científico publicado en 2017

Quality Control in the ER: Misfolded Prohormones Get a Checkup

scientific article published on 01 August 2019

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

artículo científico publicado en 2017

Redesign of a protein - peptide interaction: Characterization and applications

artículo científico publicado en 2009

Reversing deleterious protein aggregation with re-engineered protein disaggregases.

artículo científico publicado en 2014

Shock and awe: unleashing the heat shock response to treat Huntington disease.

artículo científico publicado en 2011

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

artículo científico publicado en 2016

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

artículo científico publicado en 2018

The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation

artículo científico publicado en 2015

Therapeutic genetic variation revealed in diverse Hsp104 homologs

artículo científico publicado en 2020

Lista de obras de

A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.

Avidity for Polypeptide Binding by Nucleotide-Bound Hsp104 Structures.

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.

Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

Engineering enhanced protein disaggregases for neurodegenerative disease

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

Functional analysis of proposed substrate-binding residues of Hsp104

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

Isolating potentiated Hsp104 variants using yeast proteinopathy models

Mechanistic Insights into Hsp104 Potentiation

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins

Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain

Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.

Quality Control in the ER: Misfolded Prohormones Get a Checkup

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104.

Redesign of a protein - peptide interaction: Characterization and applications

Reversing deleterious protein aggregation with re-engineered protein disaggregases.

Shock and awe: unleashing the heat shock response to treat Huntington disease.

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation

Therapeutic genetic variation revealed in diverse Hsp104 homologs