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Lista de obras de P Nigel Leigh

A clinical tool for predicting survival in ALS.

scientific article published on 04 July 2016

A common haplotype within the PON1 promoter region is associated with sporadic ALS.

artículo científico publicado en 2008

A new MRI rating scale for progressive supranuclear palsy and multiple system atrophy: validity and reliability

artículo científico publicado en 2011

A novel central motor conduction abnormality in D90A-homozygous patients with amyotrophic lateral sclerosis

artículo científico publicado en 2004

A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group

scientific article published on 01 August 1998

A positron emission tomography study of frontal lobe function (verbal fluency) in amyotrophic lateral sclerosis

artículo científico publicado en 1995

A proposed staging system for amyotrophic lateral sclerosis

artículo científico publicado en 2012

A virtual user involvement forum for people living with motor neuron disease

ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth

artículo científico publicado en 2005

Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS

artículo científico publicado en 2005

Absence of cognitive, behavioral, or emotional dysfunction in progressive muscular atrophy

artículo científico publicado en 2006

Accepting or declining non-invasive ventilation or gastrostomy in amyotrophic lateral sclerosis: patients' perspectives

artículo científico publicado en 2015

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

artículo científico publicado en 2012

Altered cortical activation during a motor task in ALS. Evidence for involvement of central pathways

artículo científico publicado en 2007

Altered patterns of cortical activation in ALS patients during attention and cognitive response inhibition tasks

artículo científico publicado en 2011

Amino acids for amyotrophic lateral sclerosis / motor neuron disease

artículo científico publicado en 2008

Amino acids for amyotrophic lateral sclerosis / motor neuron disease

artículo científico publicado en 2003

Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis in South-East England: a population-based study. The South-East England register for amyotrophic lateral sclerosis (SEALS Registry).

artículo científico publicado en 2007

Amyotrophic lateral sclerosis in an urban setting

article by Clare A. Johnston et al published December 2006 in Journal of Neurology

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

artículo científico publicado en 2007

Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trial

artículo científico publicado en 2004

An Overview of MicroRNAs as Biomarkers of ALS

An estimate of amyotrophic lateral sclerosis heritability using twin data.

artículo científico publicado en 2010

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

artículo científico publicado en 2014

Analysis of terms used for the diagnosis and classification of amyotrophic lateral sclerosis and motor neuron disease

Androgen-controlled specific gene expression in neuroblastoma cells

artículo científico publicado en 1995

Androgen-induced up-regulation of tubulin isoforms in neuroblastoma cells.

artículo científico publicado en 2001

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

artículo científico publicado en 2016

Association of apolipoprotein E ∈4 allele with bulbar-onset motor neuron disease

artículo científico publicado en 1996

Automated, high accuracy classification of Parkinsonian disorders: a pattern recognition approach

artículo científico publicado en 2013

Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders

artículo científico publicado en 2013

Biomarkers in amyotrophic lateral sclerosis

artículo científico publicado en 2009

Building user involvement in motor neurone disease: key lessons

artículo científico publicado en 2004

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis

artículo científico publicado en 2014

Chapter 21 Disease-Modifying Therapies in Motor Neuron Disorders: The Present Position and Potential Future Developments

Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport

artículo científico publicado en 2002

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study

artículo científico publicado en 2010

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis

article

Clinical care of patients with amyotrophic lateral sclerosis

artículo científico publicado en 2007

Commentary on ‘A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS’

Comparison of the King's and MiToS staging systems for ALS.

artículo científico publicado en 2017

Comparison of two percutaneous radiological gastrostomy tubes in the nutritional management of ALS patients

artículo científico publicado en 2005

Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation.

artículo científico publicado en 1997

Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS.

artículo científico publicado en 2007

Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis

Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.

artículo científico publicado en 2007

Cortical thickness, surface area and volume measures in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy

artículo científico publicado en 2014

Cuznsod‐associated amyotrophic lateral sclerosis ⬇️

artículo científico publicado el 1 de agosto de 1997

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS

artículo científico publicado en 1999

Cytoskeletal abnormalities in motor neuron disease. An immunocytochemical study

artículo científico publicado en 1989

D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype

artículo científico publicado en 2002

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

artículo científico publicado el 6 de junio de 1992

Debrisoquine hydroxylase gene polymorphism in Parkinson's disease and amyotrophic lateral sclerosis.

artículo científico publicado en 1995

Decision Making About Gastrostomy and Noninvasive Ventilation in Amyotrophic Lateral Sclerosis

Defining survival as an outcome measure in amyotrophic lateral sclerosis.

artículo científico publicado en 2009

Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells

artículo científico publicado en 2004

Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis

artículo científico publicado en 1999

Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport

artículo científico publicado en 2008

Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS.

artículo científico publicado en 2011

Diffusion Tensor Imaging in Sporadic and Familial (D90A SOD1) Forms of Amyotrophic Lateral Sclerosis

Diffusion tensor imaging of Parkinson's disease, multiple system atrophy and progressive supranuclear palsy: a tract-based spatial statistics study

artículo científico publicado en 2014

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.

artículo científico publicado en 2005

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

scientific article published on 01 May 1996

EFNS task force on management of amyotrophic lateral sclerosis: guidelines for diagnosing and clinical care of patients and relatives

artículo científico publicado en 2005

Eating-derived pleasure in amyotrophic lateral sclerosis as a predictor of non-oral feeding

artículo científico publicado en 2012

Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials

artículo científico publicado en 2004

Electrical injury and amyotrophic lateral sclerosis: a systematic review of the literature

artículo científico publicado en 2006

Entristar skin-level gastrostomy tube: primary placement with radiologic guidance in patients with amyotrophic lateral sclerosis

artículo científico publicado en 2004

Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale

artículo científico publicado en 2014

Evidence of an environmental effect on survival in ALS.

artículo científico publicado en 2014

Expression of the human groEL stress-protein homologue in the brain and spinal cord

scientific article published on 01 September 1993

Extramotor involvement in ALS: PET studies with the GABAA ligand [11C]flumazenil

artículo científico publicado en 2000

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

artículo científico publicado en 2007

Frontotemporal white matter changes in amyotrophic lateral sclerosis

artículo científico publicado en 2005

Functional magnetic resonance imaging of verbal fluency and confrontation naming using compressed image acquisition to permit overt responses

artículo científico publicado en 2003

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy

artículo científico publicado en 2009

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

artículo científico publicado en 2016

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

artículo científico publicado en 2009

Geographical clustering of amyotrophic lateral sclerosis in South-East England: a population study

artículo científico publicado en 2008

Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: a double- blind, randomized, multicentre, placebo-controlled trial

artículo científico publicado en 2009

Glutamate slows axonal transport of neurofilaments in transfected neurons

artículo científico publicado en 2000

Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis

artículo científico publicado en 2014

Histochemical and immunocytochemical study of ubiquitinated neuronal inclusions in amyotrophic lateral sclerosis

scientific article published on 01 April 1993

Homozygosity analysis in amyotrophic lateral sclerosis

artículo científico publicado en 2013

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase

artículo científico publicado en 2003

Imaging the brain during sniffing: A pilot fMRI study

Imaging: MRS/MRI/PET/SPECT: summary.

artículo científico publicado en 2002

Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis

artículo científico publicado en 2001

Intron 7 retention and exon 9 skipping EAAT2 mRNA variants are not associated with amyotrophic lateral sclerosis

article

Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?

artículo científico publicado en 2012

Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

scholarly article by Jason A Chen published in August 2018

Late-onset Tay-Sachs disease

artículo científico publicado en 2017

Latent cluster analysis of ALS phenotypes identifies prognostically differing groups

artículo científico publicado en 2009

Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells

artículo científico publicado en 2002

Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial

artículo científico publicado en 2013

Living with motor neurone disease: lives, experiences of services and suggestions for change

article by Rhidian A. Hughes et al published January 2005 in Health & Social Care in the Community

Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability

artículo científico publicado en 2011

Magnetic resonance spectroscopic study of parkinsonism related to boxing

artículo científico publicado en 1995

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.

artículo científico publicado en 2012

Marital relationships in amyotrophic lateral sclerosis

artículo científico publicado en 2010

Mechanical ventilation for amyotrophic lateral sclerosis/motor neuron disease

artículo científico publicado en 2003

Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials

artículo científico publicado en 2017

Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype

artículo científico publicado en 2008

Motor neuron disease and its management

artículo científico publicado en 1999

Mushroom-cage gastrostomy tube placement in patients with amyotrophic lateral sclerosis: a 5-year experience in 104 patients in a single institution

artículo científico publicado en 2009

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

artículo científico publicado en 2016

Natural history and clinical features of the flail arm and flail leg ALS variants

artículo científico publicado en 2009

Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

artículo científico publicado en 2003

Neuronal damage induced by beta-N-oxalylamino-L-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline

artículo científico publicado en 1993

Neuronal loss associated with cognitive performance in amyotrophic lateral sclerosis: an (11C)-flumazenil PET study

artículo científico publicado en 2008

Neuroprotective effect of free radical scavengers on beta-N-oxalylamino-L-alanine (BOAA)-induced neuronal damage in rat hippocampus

artículo científico publicado en 1994

New VAPB deletion variant and exclusion of VAPB mutations in familial ALS.

artículo científico publicado en 2008

New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies

artículo científico publicado en 1989

No association of the SOD1 locus and disease susceptibility or phenotype in sporadic ALS.

artículo científico publicado en 2004

No evidence for a large difference in ALS frequency in populations of African and European origin: a population based study in inner city London

artículo científico publicado en 2012

Nutritional factors associated with survival following enteral tube feeding in patients with motor neurone disease

artículo científico publicado en 2010

Nutritional management in MND/ALS patients: an evidence based review

artículo científico publicado en 2004

P12 Predictors of mood in amyotrophic lateral sclerosis: physical and psychological factors

P20 Frontal white matter connections and cognitive change in amyotrophic lateral sclerosis: a DTI-tractography study

Palliative care in motor neurone disease

artículo científico publicado en 1995

Patients' health-related quality of life and utilities associated with different stages of amyotrophic lateral sclerosis

article

Patients' health-related quality-of-life and health state values for motor neurone disease/amyotrophic lateral sclerosis.

artículo científico publicado en 2003

Pentoxifylline in ALS: a double-blind, randomized, multicenter, placebo-controlled trial

artículo científico publicado en 2006

Polymorphisms in the glutamate transporter gene EAAT2 in European ALS patients

artículo científico publicado en 1999

Positron emission tomography (PET) – its potential to provide surrogate markers in ALS

Prevalence of depression in a 12-month consecutive sample of patients with ALS.

artículo científico publicado en 2007

Prevalence of depression in amyotrophic lateral sclerosis and other motor disorders

artículo científico publicado en 2010

Processing and memory for emotional and neutral material in amyotrophic lateral sclerosis

artículo científico publicado en 2012

Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002

artículo científico publicado en 2003

Protective effects of estrogens on polyglutamine-expanded androgen receptor aggregation in mice

artículo científico publicado en 2003

Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31].

artículo científico publicado en 2011

Psychological as well as illness factors influence acceptance of non-invasive ventilation (NIV) and gastrostomy in amyotrophic lateral sclerosis (ALS): a prospective population study

artículo científico publicado en 2014

Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

artículo científico publicado en 2016

Recent advances in amyotrophic lateral sclerosis

artículo científico publicado en 2000

Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor

artículo científico publicado en 1998

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis

scientific journal article

Regionality of disease progression predicts prognosis in amyotrophic lateral sclerosis

artículo científico publicado en 2015

Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat

artículo científico publicado en 2013

Respiratory Muscle Strength as a Predictive Biomarker for Survival in Amyotrophic Lateral Sclerosis

scientific article published on 05 August 2016

Riluzole treatment, survival and diagnostic criteria in Parkinson plus disorders: the NNIPPS study

artículo científico publicado en 2009

SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis

artículo científico publicado en 2009

Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial

artículo científico publicado en 2017

Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial

artículo científico publicado en 2014

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study.

artículo científico publicado en 2018

Symptom prevalence among people affected by advanced and progressive neurological conditions--a systematic review

artículo científico publicado en 2007

Symptom prevalence, severity and palliative care needs assessment using the Palliative Outcome Scale: a cross-sectional study of patients with Parkinson's disease and related neurological conditions

artículo científico publicado en 2012

Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis

artículo científico publicado en 2015

TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations

artículo científico publicado en 2009

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

artículo científico publicado en 2008

The anatomy of cognitive impairment in amyotrophic lateral sclerosis: more than frontal lobe dysfunction

artículo científico publicado en 2011

The association between ALS and population density: A population based study

artículo científico publicado en 2010

The benefit of evolving multidisciplinary care in ALS: a diagnostic cohort survival comparison

artículo científico publicado en 2017

The economic costs of progressive supranuclear palsy and multiple system atrophy in France, Germany and the United Kingdom

artículo científico publicado en 2011

The effect of polyglutamine expansion in the human androgen receptor on its ability to suppress beta-catenin-Tcf/Lef dependent transcription.

artículo científico publicado en 2004

The emotional lability questionnaire: a new measure of emotional lability in amyotrophic lateral sclerosis

scientific article published on 01 October 1999

The management of motor neurone disease.

artículo científico publicado en 2003

The psychological impact of motor neurone disease.

artículo científico publicado en 1994

The risk to relatives of patients with sporadic amyotrophic lateral sclerosis

artículo científico publicado en 2011

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci ⬇️

artículo científico publicado en 2009

The sex ratio in amyotrophic lateral sclerosis: A population based study

artículo científico publicado en 2010

The validation of El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis: A clinicopathological study ⬇️

artículo científico publicado el 1 de mayo de 1995

Trouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis?

artículo científico publicado en 2005

Truncated forms of the androgen receptor are associated with polyglutamine expansion in X-linked spinal and bulbar muscular atrophy

scientific article published on 01 January 1998

Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q.

artículo científico publicado en 2003

Ubiquitin and heat shock protein expression in amyotrophic lateral sclerosis

scientific article published on 01 February 1991

Use of clinical staging in amyotrophic lateral sclerosis for phase 3 clinical trials

artículo científico publicado en 2014

Use of human intravenous immunoglobulin in lower motor neuron syndromes

artículo científico publicado en 1999

Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis

article

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

artículo científico publicado en 2008

Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis

Word retrieval in amyotrophic lateral sclerosis: a functional magnetic resonance imaging study.

artículo científico publicado en 2004

[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

artículo científico publicado en 2005

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

artículo científico publicado en 2001

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

article

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