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Lista de obras de Thomas H Bugge

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

artículo científico publicado en 2015

A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation

artículo científico publicado en 2013

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

artículo científico publicado en 2006

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

artículo científico publicado en 2004

Abstract 2059: Novel roles for GNA13 and RHOA as tumor suppressor genes

article

Accelerated wound healing by mTOR activation in genetically defined mouse models.

artículo científico publicado en 2010

Amalfi to Washington D. C.--twenty years of plasminogen activator research.

artículo científico publicado en 2005

An anthrax toxin variant with an improved activity in tumor targeting

artículo científico publicado en 2015

An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus

scientific article published on 01 January 1997

Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting

artículo científico publicado en 2016

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

artículo científico publicado en 2020

Anthrax target in macrophages unveiled

scientific article published on 01 February 2006

Anthrax toxin: structures, functions and tumour targeting

artículo científico publicado en 2003

Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation ⬇️

artículo científico publicado en 2017

Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice

artículo científico publicado en 2007

Bismaleimide cross‐linked anthrax toxin forms functional octamers with high specificity in tumor targeting

artículo científico publicado en 2019

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

artículo científico publicado en 2012

Cellular uptake of collagens and implications for immune cell regulation in disease

artículo científico publicado en 2020

Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.

artículo científico publicado en 2007

Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity

artículo científico publicado en 2002

Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities

artículo científico publicado en 2014

Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.

artículo científico publicado en 2007

Complex determinants in specific members of the mannose receptor family govern collagen endocytosis

artículo científico publicado en 2014

Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration

artículo científico publicado en 2009

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

artículo científico publicado en 2008

Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis

artículo científico publicado en 2006

Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin

artículo científico publicado en 2016

Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

artículo científico publicado en 2015

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

artículo científico publicado en 2005

Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter

artículo científico publicado en 2004

Detection of active matriptase using a biotinylated chloromethyl ketone peptide

artículo científico publicado en 2013

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography

artículo científico publicado en 2004

Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis

artículo científico publicado en 2013

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. ⬇️

artículo científico publicado en 2004

Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin

artículo científico publicado en 2009

Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin

artículo científico publicado en 2015

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin

artículo científico publicado en 2011

Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis

artículo científico publicado en 2012

Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes

scientific article published on 01 January 2003

Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway

artículo científico publicado en 2009

Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation

artículo científico publicado en 2006

Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT

artículo científico publicado en 2011

Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation.

artículo científico publicado en 2007

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

artículo científico publicado en 1996

Functional overlap between two classes of matrix-degrading proteases in wound healing

artículo científico publicado en 1999

Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice ⬇️

artículo científico publicado el 1 de diciembre de 1997

HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.

artículo científico publicado en 2017

Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary

artículo científico publicado en 2008

Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase

artículo científico publicado en 2013

Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironment

artículo científico publicado en 2007

Imaging collagen degradation in vivo highlights a key role for M2-polarized macrophages in extracellular matrix degradation

artículo científico publicado en 2013

Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry

artículo científico publicado en 2021

Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins

artículo científico publicado en 2009

Imaging specific cell-surface proteolytic activity in single living cells.

artículo científico publicado en 2006

Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

artículo científico publicado en 2018

Impaired wound healing in mice with a disrupted plasminogen gene

artículo científico publicado en 1996

Increased Expression of the Collagen Internalization Receptor uPARAP/Endo180 in the Stroma of Head and Neck Cancer

artículo científico publicado en 2006

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

artículo científico publicado en 2010

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas

artículo científico publicado en 2020

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

artículo científico publicado en 2020

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

artículo científico publicado en 2005

Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy

artículo científico publicado en 2005

Iterative, multiplexed CRISPR-mediated gene editing for functional analysis of complex protease gene clusters

scientific article published on 09 September 2019

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

artículo científico publicado en 2003

Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.

artículo científico publicado en 2002

Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.

artículo científico publicado en 2018

Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality

articulo cientifico

Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.

artículo científico publicado en 2003

M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway

artículo científico publicado en 2013

MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.

artículo científico publicado en 2007

MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells.

artículo científico publicado en 2005

Mannose receptor 2 attenuates renal fibrosis

artículo científico publicado en 2011

Mapping of two new human B-cell epitopes on HIV-1 gp120 ⬇️

artículo científico publicado el 1 de diciembre de 1992

Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling

artículo científico publicado en 2016

Matriptase deletion initiates a Sjögren's syndrome-like disease in mice

artículo científico publicado en 2014

Matriptase drives early-onset intestinal failure in a mouse model of congenital tufting enteropathy

artículo científico publicado en 2019

Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development

artículo científico publicado en 2006

Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome

artículo científico publicado en 2010

Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors

artículo científico publicado en 2014

Matriptase protects against experimental colitis and promotes intestinal barrier recovery

artículo científico publicado en 2011

Matriptase zymogen supports epithelial development, homeostasis and regeneration

artículo científico publicado en 2017

Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity

artículo científico publicado en 2005

Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota

artículo científico publicado en 2009

Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis

artículo científico publicado en 2007

Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis

artículo científico publicado en 2002

Matriptase: potent proteolysis on the cell surface

artículo científico publicado en 2006

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

artículo científico publicado en 2007

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

artículo científico publicado en 2009

Mechanism of FGF23 processing in fibrous dysplasia.

artículo científico publicado en 2012

Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

artículo científico publicado en 2003

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

artículo científico publicado en 2015

Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine

artículo científico publicado en 2010

Membrane-anchored serine proteases as regulators of epithelial function

scientific article published on 20 March 2020

Membrane-anchored serine proteases in health and disease.

artículo científico publicado en 2011

Membrane-anchored serine proteases in vertebrate cell and developmental biology

artículo científico publicado en 2011

Methods in molecular biology. Proteases and cancer. Methods and protocols. Preface

artículo científico publicado en 2009

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes

artículo científico publicado en 2004

Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes

scientific article published on 01 November 1999

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin ⬇️

artículo científico publicado el 2 de septiembre de 1997

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

artículo científico publicado en 2014

Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples

artículo científico publicado en 2005

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation

artículo científico publicado en 2013

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

artículo científico publicado en 2016

Peptide toxins directed at the matrix dissolution systems of cancer cells

artículo científico publicado en 2002

Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation

scientific article published on 17 May 2019

Plasminogen activator promotes recovery following spinal cord injury

artículo científico publicado en 2011

Plasminogen activators direct reorganization of the liver lobule after acute injury

artículo científico publicado en 2001

Plasminogen and wound healing

scientific article published on 01 July 1996

Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis ⬇️

artículo científico publicado el 16 de septiembre de 1997

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction

artículo científico publicado en 1995

Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver

artículo científico publicado en 1999

Plasminogen is a critical determinant of vascular remodeling in mice

artículo científico publicado en 2000

Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages

artículo científico publicado en 2002

Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice

artículo científico publicado en 2000

Plasminogen-receptor KT : plasminogen activation and beyond.

artículo científico publicado en 2016

Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II.

artículo científico publicado en 2014

Potent antitumor activity of a urokinase-activated engineered anthrax toxin

artículo científico publicado en 2003

Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity

artículo científico publicado en 2008

Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy

scientific article published on 18 January 2008

Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen.

artículo científico publicado en 2008

Proteolytic activation of the 1918 influenza virus hemagglutinin

artículo científico publicado en 2009

Prothrombin deficiency results in embryonic and neonatal lethality in mice

artículo científico publicado en 1998

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

artículo científico publicado en 2009

RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors

artículo científico publicado en 1992

Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.

artículo científico publicado en 2010

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation

artículo científico publicado en 2012

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice

artículo científico publicado en 2009

Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival

artículo científico publicado en 2014

Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent

scientific journal article

Role for the actomyosin complex in regulated exocytosis revealed by intravital microscopy

artículo científico publicado en 2011

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

artículo científico publicado en 2010

Solid tumor therapy by selectively targeting stromal endothelial cells

artículo científico publicado en 2016

Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis

artículo científico publicado en 2011

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

artículo científico publicado en 2007

TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition

scientific journal article

Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180

Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin

artículo científico publicado en 2001

The Low Density Lipoprotein Receptor-related Protein Modulates Protease Activity in the Brain by Mediating the Cellular Internalization of Both Neuroserpin and Neuroserpin-Tissue-type Plasminogen Activator Complexes ⬇️

artículo científico publicado el 30 de septiembre de 2003

The glycosylphosphatidylinositol-anchored serine protease PRSS21 (testisin) imparts murine epididymal sperm cell maturation and fertilizing ability.

artículo científico publicado en 2009

The membrane-anchored serine protease prostasin (CAP1/PRSS8) supports epidermal development and postnatal homeostasis independent of its enzymatic activity

artículo científico publicado en 2014

The non-phagocytic route of collagen uptake: a distinct degradation pathway

artículo científico publicado en 2011

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis

artículo científico publicado en 1999

The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin

artículo científico publicado en 2014

The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility

artículo científico publicado en 1995

The source of matrix-degrading enzymes in human cancer: Problems of research reproducibility and possible solutions

artículo científico publicado en 2015

The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate

artículo científico publicado en 2000

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

artículo científico publicado en 2003

Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase

artículo científico publicado en 2010

Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins

scientific article published on 06 April 2019

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

artículo científico publicado en 2017

Type II transmembrane serine proteases

artículo científico publicado en 2003

Type II transmembrane serine proteases

artículo científico publicado en 2009

Type II transmembrane serine proteases in development and disease

scientific article published on 04 December 2007

Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator

scientific article published on June 1996

Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin

artículo científico publicado en 2007

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

artículo científico publicado en 2011

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

artículo científico publicado en 2003

uPARAP/endo180 directs lysosomal delivery and degradation of collagen IV.

artículo científico publicado en 2004

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