Lista de obras - H.Y.E. Chan - Dominio Público Uruguay

A Peptidylic Inhibitor for Neutralizing (GGGGCC)-Associated Neurodegeneration in C9ALS-FTD

artículo científico publicado en 2019

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.

artículo científico publicado en 2016

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.

artículo científico publicado en 2017

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

artículo científico publicado en 2021

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

artículo científico publicado en 2018

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

artículo científico publicado en 2018

Apple polyphenols extend the mean lifespan of Drosophila melanogaster.

artículo científico publicado en 2011

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

artículo científico publicado en 2016

Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing

scientific article published on 06 June 2008

BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells.

artículo científico publicado en 2009

Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.

artículo científico publicado en 2006

Black tea theaflavins extend the lifespan of fruit flies.

artículo científico publicado en 2009

Blueberry extract prolongs lifespan of Drosophila melanogaster.

artículo científico publicado en 2011

Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration

artículo científico publicado en 2018

CAG expansion induces nucleolar stress in polyglutamine diseases ⬇️

artículo científico publicado el 30 de julio de 2012

Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles

scientific article published on 08 February 2019

Conformational flexibility in the RNA stem-loop structures formed by CAG repeats

artículo científico publicado en 2017

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.

artículo científico publicado en 2012

Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress

artículo científico publicado en 2018

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases

scientific article published on 21 March 2017

Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration

artículo científico publicado en 2018

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations

scientific article published on 25 October 2019

Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor.

artículo científico publicado en 2017

Expression of expanded CAG transcripts triggers nucleolar stress in Huntington's disease.

artículo científico publicado en 2013

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

scientific journal article

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene

article

FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein

scientific article published on 28 February 2019

Fly-ing from genes to drugs.

artículo científico publicado en 2002

Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster.

artículo científico publicado en 2007

Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model.

artículo científico publicado en 2014

Identification and characterization of the gene for Drosophila L3 ribosomal protein.

artículo científico publicado en 1998

Identification and characterization of the gene for Drosophila S20 ribosomal protein.

artículo científico publicado en 1997

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

artículo científico publicado en 2016

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

artículo científico publicado en 2019

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

artículo científico publicado en 2012

Maternal oxytocin responsiveness improves specificity of positive social memory recall

artículo científico publicado en 2018

Mechanism for the Cellular Uptake of Targeted Gold Nanorods of Defined Aspect Ratios.

artículo científico publicado en 2016

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

artículo científico publicado en 2000

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

artículo científico publicado en 2015

Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats

artículo científico publicado en 2016

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

artículo científico publicado en 2015

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

scientific article published on 19 July 2018

Protective role of Engrailed in a Drosophila model of Huntington's disease.

artículo científico publicado en 2008

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis

artículo científico publicado en 2014

Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1.

artículo científico publicado en 2015

Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in Drosophila.

artículo científico publicado en 2002

Roles of the nucleolus in the CAG RNA-mediated toxicity

artículo científico publicado en 2014

Sesamin extends the mean lifespan of fruit flies ⬇️

artículo científico publicado el 6 de enero de 2013

Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery.

artículo científico publicado en 2018

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

artículo científico publicado en 1999

The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity.

artículo científico publicado en 2013

The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.

artículo científico publicado en 2014

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

artículo científico publicado en 2009

Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?

scientific article published on 01 July 2019

Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.

artículo científico publicado en 2007

Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11.

artículo científico publicado en 2016

Lista de obras de H.Y.E. Chan

A Peptidylic Inhibitor for Neutralizing (GGGGCC)-Associated Neurodegeneration in C9ALS-FTD

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

Apple polyphenols extend the mean lifespan of Drosophila melanogaster.

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing

BFA-induced compartments from the Golgi apparatus and trans-Golgi network/early endosome are distinct in plant cells.

Biophysical characterisation reveals structural disorder in the nucleolar protein, Dribble.

Black tea theaflavins extend the lifespan of fruit flies.

Blueberry extract prolongs lifespan of Drosophila melanogaster.

Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration

CAG expansion induces nucleolar stress in polyglutamine diseases ⬇️

Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles

Conformational flexibility in the RNA stem-loop structures formed by CAG repeats

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.

Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases

Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations

Expanded polyalanine tracts function as nuclear export signals and promote protein mislocalization via eEF1A1 factor.

Expression of expanded CAG transcripts triggers nucleolar stress in Huntington's disease.

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene

FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein

Fly-ing from genes to drugs.

Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster.

Hypnotic effects of a novel anti-insomnia formula on Drosophila insomnia model.

Identification and characterization of the gene for Drosophila L3 ribosomal protein.

Identification and characterization of the gene for Drosophila S20 ribosomal protein.

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

Maternal oxytocin responsiveness improves specificity of positive social memory recall

Mechanism for the Cellular Uptake of Targeted Gold Nanorods of Defined Aspect Ratios.

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

Protective role of Engrailed in a Drosophila model of Huntington's disease.

RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis

Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1.

Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in Drosophila.

Roles of the nucleolus in the CAG RNA-mediated toxicity

Sesamin extends the mean lifespan of fruit flies ⬇️

Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery.

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity.

The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?

Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.

Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11.