Filtros de búsqueda

Lista de obras de Inge Grundke-Iqbal

A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse).

artículo científico publicado en 2012

Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration ⬇️

artículo científico publicado el 1 de enero de 2013

Activation of Protein Phosphatase 2B and Hyperphosphorylation of Tau in Alzheimer's Disease ⬇️

artículo científico publicado el 1 de enero de 2011

Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease

artículo científico publicado en 2013

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial

artículo científico publicado en 2010

Alzheimer's disease, a multifactorial disorder seeking multitherapies ⬇️

artículo científico publicado el 1 de septiembre de 2010

An experimental rat model of sporadic Alzheimer’s disease and rescue of cognitive impairment with a neurotrophic peptide ⬇️

artículo científico publicado el 15 de noviembre de 2011

Anesthesia induces phosphorylation of tau

artículo científico publicado en 2009

Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains

artículo científico publicado en 2006

Beneficial Effect of a CNTF Tetrapeptide on Adult Hippocampal Neurogenesis, Neuronal Plasticity, and Spatial Memory in Mice ⬇️

artículo científico publicado el 1 de enero de 2010

Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat.

artículo científico publicado en 2005

Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease

artículo científico publicado en 2011

Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease

artículo científico publicado en 2012

Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease

artículo científico publicado en 2009

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

artículo científico publicado en 2013

Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease

artículo científico publicado en 2009

Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: a biomarker of blood-cerebrospinal fluid barrier permeability

artículo científico publicado en 2010

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

artículo científico publicado en 2005

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease

artículo científico publicado en 2011

Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.

artículo científico publicado en 2014

Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly

artículo científico publicado en 2008

Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome.

artículo científico publicado en 2008

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

artículo científico publicado en 2008

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes ⬇️

artículo científico publicado el 19 de mayo de 2011

Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5

scientific journal article

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease

artículo científico publicado en 2004

Developmental Regulation of Protein O-GlcNAcylation, O-GlcNAc Transferase, and O-GlcNAcase in Mammalian Brain ⬇️

artículo científico publicado el 22 de agosto de 2012

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases ⬇️

artículo científico publicado en 2009

Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation ⬇️

artículo científico publicado el 19 de abril de 2012

Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective

artículo científico publicado en 2006

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.

artículo científico

Diverse regulation of AKT and GSK‐3β by O‐GlcNAcylation in various types of cells ⬇️

artículo científico publicado el 8 de junio de 2012

Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain

artículo científico publicado en 2007

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion ⬇️

artículo científico publicado el 5 de julio de 2012

Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease

artículo científico publicado en 2009

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target

artículo científico publicado en 2006

Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage

artículo científico publicado en 2009

Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells

artículo científico publicado en 2008

Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients

artículo científico publicado en 2002

Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain

artículo científico publicado en 2004

Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide

artículo científico publicado en 2009

Failure of neuronal maturation in Alzheimer disease dentate gyrus

artículo científico publicado en 2008

I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A

scientific journal article

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

artículo científico publicado en 2006

In vitro analysis of tau phosphorylation sites and its biological activity.

artículo científico publicado en 2002

Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome

artículo científico publicado en 2008

Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats

artículo científico publicado en 2015

Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices

artículo científico publicado en 2003

Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

artículo científico publicado en 2005

Inhibitors of protein phosphatase-2A: topography and subcellular localization

artículo científico publicado en 2004

Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

artículo científico publicado en 2002

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

artículo científico publicado en 2007

Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay

artículo científico publicado en 2002

Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration.

artículo científico publicado en 2001

Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET

artículo científico publicado en 2011

Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies

artículo científico publicado en 2008

Mechanisms of tau-induced neurodegeneration

artículo científico publicado en 2009

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

article

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment

artículo científico publicado en 2015

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

artículo científico publicado en 2004

Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies

artículo científico publicado en 2005

NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain

artículo científico publicado en 2005

Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease

artículo científico publicado en 2002

Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures

artículo científico publicado en 2013

Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

artículo científico publicado en 2010

Novel therapeutic strategies for neurodegenerative disease

scientific article published on June 2009

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

artículo científico publicado en 2004

Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

artículo científico publicado en 2003

Opportunities and challenges in developing Alzheimer disease therapeutics ⬇️

artículo científico publicado el 30 de septiembre de 2011

Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome

artículo científico publicado en 2008

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

artículo científico publicado en 2006

PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta

artículo científico publicado en 2010

Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies

artículo científico publicado en 2014

Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

artículo científico publicado en 2010

Pharmacological approaches of neurofibrillary degeneration

artículo científico publicado en 2005

Phosphorylation of Tau at Thr212, Thr231, and Ser262 Combined Causes Neurodegeneration ⬇️

artículo científico publicado el 27 de julio de 2010

Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1.

artículo científico publicado en 2005

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

artículo científico publicado en 2006

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

artículo científico publicado en 2004

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

artículo científico publicado en 2009

Regional Comparison of the Neurogenic Effects of CNTF-Derived Peptides and Cerebrolysin in AβPP Transgenic Mice ⬇️

artículo científico publicado el 1 de enero de 2011

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease

artículo científico publicado en 2007

Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A

artículo científico publicado en 2011

Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells

artículo científico publicado en 2004

Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level

artículo científico publicado en 2006

Regulation of phosphorylation of tau by protein kinases in rat brain

artículo científico publicado en 2006

Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A ⬇️

artículo científico publicado el 5 de abril de 2011

Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome

artículo científico publicado en 2011

Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease

artículo científico publicado en 2002

Role of protein kinase B in Alzheimer's neurofibrillary pathology

artículo científico publicado en 2002

Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport

artículo científico publicado en 2004

Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats

artículo científico publicado en 2015

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

artículo científico publicado en 2002

Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation

artículo científico publicado en 2007

Splicing factor SC35 promotes tau expression through stabilization of its mRNA ⬇️

artículo científico publicado el 17 de febrero de 2011

Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers

artículo científico publicado en 2005

Targeting tau protein in Alzheimer's disease

artículo científico publicado en 2010

Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain

artículo científico publicado en 2004

Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification

artículo científico publicado en 2007

Tau pathology in Alzheimer disease and other tauopathies

artículo científico publicado en 2005

Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam

artículo científico publicado en 2014

The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment

artículo científico publicado en 2010

The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease

artículo científico publicado en 2002

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis

artículo científico publicado en 2006

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

artículo científico publicado en 2005

Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration

artículo científico publicado en 2002

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

artículo científico publicado en 2005

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease

artículo científico publicado en 2002

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda