Lista de obras - Rekha G Panchal - Dominio Público Uruguay

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

artículo científico publicado en 2011

A high content imaging assay for identification of Botulinum neurotoxin inhibitors

artículo científico publicado en 2014

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

artículo científico publicado en 2014

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

artículo científico publicado en 2012

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease

artículo científico publicado en 2007

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection

artículo científico publicado en 2015

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns

artículo científico publicado en 2014

Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer

artículo científico publicado en 1992

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

artículo científico publicado en 2005

Analysis of Ebola virus and VLP release using an immunocapture assay.

artículo científico publicado en 2005

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

artículo científico publicado en 2005

Anti-Ebola Activity of Diazachrysene Small Molecules.

artículo científico publicado en 2015

Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogens

artículo científico publicado en 2015

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

artículo científico publicado en 2016

Bacterial genome engineering and synthetic biology: combating pathogens

artículo científico publicado en 2016

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

artículo científico publicado en 2016

Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics

scientific article published in Scientific Reports

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

artículo científico publicado en 2012

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

artículo científico publicado en 2015

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

scientific article published on 07 February 2019

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

artículo científico publicado en 2005

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

artículo científico publicado en 2005

Development of high-content imaging assays for lethal viral pathogens.

artículo científico publicado en 2010

Differential phosphorylation of neuronal substrates by catalytic subunits of Aplysia cAMP-dependent protein kinase with alternative N termini.

artículo científico publicado en 1994

Evaluation of Ebola Virus Inhibitors for Drug Repurposing.

artículo científico publicado en 2015

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

artículo científico publicado en 2002

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

artículo científico publicado en 2014

Functional reconstitution of protein ion channels into planar polymerizable phospholipid membranes.

artículo científico publicado en 2005

Gene transfer: manipulating and monitoring function in cells and tissues.

artículo científico publicado en 2001

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging

artículo científico publicado en 2015

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

artículo científico publicado en 2012

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

artículo científico publicado en 2015

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

artículo científico publicado en 2011

Identification of small molecule inhibitors of anthrax lethal factor

artículo científico publicado en 2004

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

artículo científico publicado en 2003

Induced IL-10 splice altering approach to antiviral drug discovery.

artículo científico publicado en 2014

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection

artículo científico publicado en 2013

L1000CDS2: LINCS L1000 characteristic direction signatures search engine

artículo científico publicado en 2016

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.

artículo científico publicado en 2018

Molecular mechanisms of filovirus cellular trafficking.

artículo científico publicado en 2003

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

artículo científico publicado en 2003

Novel therapeutic strategies to selectively kill cancer cells.

artículo científico publicado en 1998

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization

artículo científico publicado en 2006

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

artículo científico publicado en 2012

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

artículo científico publicado en 2015

Pore formation is not associated with macroscopic redistribution of P2X7 receptors.

artículo científico publicado en 2002

Pore-forming proteins and their application in biotechnology.

artículo científico publicado en 2002

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

artículo científico publicado en 2013

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

artículo científico publicado en 2007

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

artículo científico publicado en 2014

Rational design of small molecules as vaccine adjuvants.

artículo científico publicado en 2014

Restriction fragment length polymorphisms of the human N-myc gene in normal healthy individuals and oral cancer patients in India.

artículo científico publicado en 1994

Robust biofilm assay for quantification and high throughput screening applications

scientific article published on 28 February 2019

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

artículo científico publicado en 2015

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

artículo científico publicado en 2018

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols)

artículo científico publicado en 2008

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

artículo científico publicado en 2014

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide

scientific article published on 18 January 2019

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

artículo científico publicado en 2003

Tumor protease-activated, pore-forming toxins from a combinatorial library.

artículo científico publicado en 1996

Lista de obras de Rekha G Panchal

A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

A high content imaging assay for identification of Botulinum neurotoxin inhibitors

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection

Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns

Amplification and overexpression of epidermal growth factor receptor gene in human oropharyngeal cancer

An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.

Analysis of Ebola virus and VLP release using an immunocapture assay.

Anthrax biosensor, protective antigen ion channel asymmetric blockade.

Anti-Ebola Activity of Diazachrysene Small Molecules.

Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogens

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease

Bacterial genome engineering and synthetic biology: combating pathogens

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison

Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.

Dendritic cells endocytose Bacillus anthracis spores: implications for anthrax pathogenesis.

Development of high-content imaging assays for lethal viral pathogens.

Differential phosphorylation of neuronal substrates by catalytic subunits of Aplysia cAMP-dependent protein kinase with alternative N termini.

Evaluation of Ebola Virus Inhibitors for Drug Repurposing.

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

Functional reconstitution of protein ion channels into planar polymerizable phospholipid membranes.

Gene transfer: manipulating and monitoring function in cells and tissues.

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging

High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.

Identification of small molecule inhibitors of anthrax lethal factor

In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.

Induced IL-10 splice altering approach to antiviral drug discovery.

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection

L1000CDS2: LINCS L1000 characteristic direction signatures search engine

Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges.

Molecular mechanisms of filovirus cellular trafficking.

Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity.

Novel therapeutic strategies to selectively kill cancer cells.

Passive immunotherapy of Bacillus anthracis pulmonary infection in mice with antisera produced by DNA immunization

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Pore formation is not associated with macroscopic redistribution of P2X7 receptors.

Pore-forming proteins and their application in biotechnology.

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Rational design of small molecules as vaccine adjuvants.

Restriction fragment length polymorphisms of the human N-myc gene in normal healthy individuals and oral cancer patients in India.

Robust biofilm assay for quantification and high throughput screening applications

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons

Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action

Sizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols)

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

Tumor protease-activated, pore-forming toxins from a combinatorial library.