Lista de obras -

2011 Update: antigen-specific therapy in type 1 diabetes

artículo científico publicado en 2011

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

artículo científico publicado en 2015

A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy

artículo científico publicado en 2010

Animal models of human type 1 diabetes.

artículo científico publicado en 2009

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

artículo científico publicado en 2006

Antibody cross-reactivity and the viral aetiology of type 1 diabetes.

artículo científico publicado en 2013

Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy

artículo científico publicado en 2017

Antigen-based immune modulation: DNA vectors and beyond

artículo científico publicado en 2002

Antigen-driven effector CD8 T cell function regulated by T-bet

artículo científico publicado en 2003

Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential

artículo científico publicado en 2010

Antigen-specific induction of regulatory T cells for type 1 diabetes therapy

artículo científico publicado en 2005

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

artículo científico publicado en 2011

At long last: clinically significant immunomodulatory therapies

scientific article published on 01 September 2007

BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells

artículo científico publicado en 2014

CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes

artículo científico publicado en 2009

CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor

artículo científico publicado en 2019

CD40L expression by CD4+ but not CD8+ T cells regulates antiviral immune responses in acute LCMV infection in mice.

artículo científico publicado en 2016

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes

artículo científico publicado en 2013

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

artículo científico publicado en 2014

Can an immune-regulatory vaccine prevent HIV infection?

artículo científico publicado en 2012

Can we learn from viruses how to prevent type 1 diabetes?: the role of viral infections in the pathogenesis of type 1 diabetes and the development of novel combination therapies

scientific article published on January 2009

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes

artículo científico publicado en 2019

Combination therapies for type 1 diabetes: why not now?

artículo científico publicado en 2010

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease

artículo científico publicado en 2015

Defining optimal immunotherapies for type 1 diabetes. Introduction

artículo científico publicado en 2008

Diabetes: A virus-gene collaboration

artículo científico publicado en 2009

Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics.

artículo científico publicado en 2005

Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells

artículo científico publicado en 2014

Distinct housing conditions reveal a major impact of adaptive immunity on the course of obesity-induced type 2 diabetes

E1-INT (Transition Therapeutics/Novo Nordisk).

artículo científico publicado en 2005

Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety

artículo científico publicado en 2002

Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine

artículo científico publicado en 2014

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.

scientific article published on 07 October 2013

First-Trimester Human Fetal Pancreas Transplantation for Type 1 Diabetes Treatment

artículo científico publicado en 2008

Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice

artículo científico publicado en 2012

Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes

artículo científico publicado en 2009

Higher proinflammatory cytokine production and spontaneous activation in some type 1 and type 2 diabetic subjects

scientific article published on 27 August 2014

How can we improve the translational landscape for a faster cure of type 1 diabetes?

artículo científico publicado en 2009

How viral infections affect the autoimmune process leading to type 1 diabetes

artículo científico publicado en 2005

Humanizing Animal Models: A Key to Autoimmune Diabetes Treatment ⬇️

artículo científico publicado el 2 de febrero de 2011

IL-4R is expressed on alpha and beta cells of human pancreata

scientific article published on 26 March 2020

IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes

scientific article published on 03 December 2019

IL-7 receptor α blockade, an off-switch for autoreactive T cells

artículo científico publicado en 2012

Immune intervention with anti-CD3 in diabetes

artículo científico publicado en 2005

Immunoinformatics: an overview of computational tools and techniques for understanding immune function

artículo científico publicado en 2007

Immunology: insulin trigger for diabetes.

artículo científico publicado en 2005

Immunosuppression in islet transplantation

artículo científico publicado en 2008

Immunotherapy after recent-onset type 1 diabetes: combinatorial treatment for achieving long-term remission in humans?

artículo científico publicado en 2004

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

artículo científico publicado en 2016

Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside

artículo científico publicado en 2009

Immunotherapy of type 1 diabetes--how to rationally prioritize combination therapies in T1D.

artículo científico publicado en 2010

Increased memory conversion of naïve CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure

artículo científico publicado en 2011

Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes

artículo científico publicado en 2014

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis

scientific article published on 11 December 2019

Interleukin-21 is required for the development of type 1 diabetes in NOD mice

artículo científico publicado en 2009

Intravital imaging of CTLs killing islet cells in diabetic mice

artículo científico publicado en 2011

Introducing baselines for therapeutic use of regulatory T cells and cytokines in autoimmunity.

artículo científico publicado en 2003

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes

artículo científico publicado en 2008

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

artículo científico publicado en 2016

Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes

artículo científico publicado en 2004

Juvenile autoimmune diabetes: a pathogenic role for maternal antibodies?

artículo científico publicado en 2002

Keeping the patient perspective: Where are we in the world of type 1 diabetes?

artículo científico publicado en 2013

Limitations in immunotherapy with CD3 antibodies: comment on the article by Drs. Chatenoud and Bach

artículo científico publicado en 2005

Long-term viability through selective permeability

artículo científico publicado en 2020

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.

artículo científico publicado en 2018

Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.

artículo científico publicado en 2017

Molecular and cellular control of T1/T2 immunity at the interface between antimicrobial defense and immune pathology

artículo científico publicado en 2004

Mucosal exposure to antigen: cause or cure of type 1 diabetes?

artículo científico publicado en 2007

NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner.

artículo científico publicado en 2009

Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)

artículo científico publicado en 2013

New trends in immunosuppression--sixth international congress. New drug candidates. 5-8 February 2004, Salzburg, Austria

artículo científico publicado en 2004

One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI<sub>15-24</sub>

artículo científico publicado en 2021

Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

artículo científico publicado en 2004

Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse

artículo científico publicado en 2016

Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes

artículo científico publicado en 2015

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes

artículo científico publicado en 2013

Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3.

artículo científico publicado en 2012

Progress in the development of immune-based therapies for type 1 diabetes mellitus

artículo científico publicado en 2006

Protection against or triggering of Type 1 diabetes? Different roles for viral infections ⬇️

artículo científico publicado el 1 de enero de 2011

Rational development of antigen-specific therapies for type 1 diabetes

artículo científico publicado en 2007

Recent advances in understanding Type 1 Diabetes

artículo científico publicado en 2016

Regulation of viral and autoimmune responses.

artículo científico publicado en 2003

Regulatory Immune Mechanisms beyond Regulatory T Cells

scientific article published on 14 May 2019

Regulatory T cells and type 1 diabetes

artículo científico publicado en 2004

Regulatory T cells control diabetes without compromising acute anti-viral defense

artículo científico publicado en 2014

Remodeling rodent models to mimic human type 1 diabetes

article

Resuscitating adaptive Tregs with combination therapies?

artículo científico publicado en 2008

Stopping diabetes in its tracks: autologous non-myeloablative stem cell transplantation

artículo científico publicado en 2007

Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study

artículo científico publicado en 2019

TGF-β blockade does not improve control of an established persistent viral infection

artículo científico publicado en 2012

Temporal intra-individual variation of immunological biomarkers in type 1 diabetes patients: implications for future use in cross-sectional assessment

artículo científico publicado en 2013

The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes

article

The Hsp60 peptide p277 enhances anti-CD3 mediated diabetes remission in non-obese diabetic mice

artículo científico publicado en 2015

The clinical and immunological significance of GAD-specific autoantibody and T-cell responses in type 1 diabetes

artículo científico publicado en 2013

The effect of Toll-like receptor stimulation on the motility of regulatory T cells

artículo científico publicado en 2020

The microbiology of human hygiene and its impact on type 1 diabetes

artículo científico publicado en 2012

Tolerance tag team.

artículo científico publicado en 2004

Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass

artículo científico publicado en 2008

Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice

artículo científico publicado en 2013

Type 1 diabetes as a relapsing-remitting disease?

artículo científico publicado en 2007

Type 1 diabetes vaccine development: Animal models vs. humans ⬇️

artículo científico publicado el 1 de enero de 2011

Unraveling the autoimmune translational research process layer by layer

artículo científico publicado en 2012

Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay.

artículo científico publicado en 2011

Virtual optimization of nasal insulin therapy predicts immunization frequency to be crucial for diabetes protection ⬇️

artículo científico publicado en 2010

β-Cell mass versus function in type 1 diabetes mellitus: truth or dare?

artículo científico publicado en 2017

Lista de obras de

2011 Update: antigen-specific therapy in type 1 diabetes

A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.

A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy

Animal models of human type 1 diabetes.

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

Antibody cross-reactivity and the viral aetiology of type 1 diabetes.

Antigen-Specific Peptide Immunotherapy for Type 1 Diabetes: Proof of Safety, Hope for Efficacy

Antigen-based immune modulation: DNA vectors and beyond

Antigen-driven effector CD8 T cell function regulated by T-bet

Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential

Antigen-specific induction of regulatory T cells for type 1 diabetes therapy

Antigen-specific prevention of type 1 diabetes in NOD mice is ameliorated by OX40 agonist treatment

At long last: clinically significant immunomodulatory therapies

BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells

CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes

CD40-targeted peptide proposed for type 1 diabetes therapy lacks relevant binding affinity to its cognate receptor

CD40L expression by CD4+ but not CD8+ T cells regulates antiviral immune responses in acute LCMV infection in mice.

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes

CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

Can an immune-regulatory vaccine prevent HIV infection?

Can we learn from viruses how to prevent type 1 diabetes?: the role of viral infections in the pathogenesis of type 1 diabetes and the development of novel combination therapies

Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes

Combination therapies for type 1 diabetes: why not now?

Current concepts on the pathogenesis of type 1 diabetes--considerations for attempts to prevent and reverse the disease

Defining optimal immunotherapies for type 1 diabetes. Introduction

Diabetes: A virus-gene collaboration

Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic activity, or homing characteristics.

Direct infection of dendritic cells during chronic viral infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells

Distinct housing conditions reveal a major impact of adaptive immunity on the course of obesity-induced type 2 diabetes

E1-INT (Transition Therapeutics/Novo Nordisk).

Endogenous expression levels of autoantigens influence success or failure of DNA immunizations to prevent type 1 diabetes: addition of IL-4 increases safety

Enteroviruses, hygiene and type 1 diabetes: toward a preventive vaccine

Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1.

First-Trimester Human Fetal Pancreas Transplantation for Type 1 Diabetes Treatment

Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice

Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes

Higher proinflammatory cytokine production and spontaneous activation in some type 1 and type 2 diabetic subjects

How can we improve the translational landscape for a faster cure of type 1 diabetes?

How viral infections affect the autoimmune process leading to type 1 diabetes

Humanizing Animal Models: A Key to Autoimmune Diabetes Treatment ⬇️

IL-4R is expressed on alpha and beta cells of human pancreata

IL-6 is present in beta and alpha cells in human pancreatic islets: Expression is reduced in subjects with type 1 diabetes

IL-7 receptor α blockade, an off-switch for autoreactive T cells

Immune intervention with anti-CD3 in diabetes

Immunoinformatics: an overview of computational tools and techniques for understanding immune function

Immunology: insulin trigger for diabetes.

Immunosuppression in islet transplantation

Immunotherapy after recent-onset type 1 diabetes: combinatorial treatment for achieving long-term remission in humans?

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside

Immunotherapy of type 1 diabetes--how to rationally prioritize combination therapies in T1D.

Increased memory conversion of naïve CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure

Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis

Interleukin-21 is required for the development of type 1 diabetes in NOD mice

Intravital imaging of CTLs killing islet cells in diabetic mice

Introducing baselines for therapeutic use of regulatory T cells and cytokines in autoimmunity.

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes

Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes

Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes

Juvenile autoimmune diabetes: a pathogenic role for maternal antibodies?

Keeping the patient perspective: Where are we in the world of type 1 diabetes?

Limitations in immunotherapy with CD3 antibodies: comment on the article by Drs. Chatenoud and Bach

Long-term viability through selective permeability

Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.

Metabolically inactive insulin analogue does not prevent autoimmune diabetes in NOD mice.

Molecular and cellular control of T1/T2 immunity at the interface between antimicrobial defense and immune pathology

Mucosal exposure to antigen: cause or cure of type 1 diabetes?

NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner.

Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)

New trends in immunosuppression--sixth international congress. New drug candidates. 5-8 February 2004, Salzburg, Austria

One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI<sub>15-24</sub>

Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

Oral insulin (human, murine, or porcine) does not prevent diabetes in the non-obese diabetic mouse

Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes

Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetes

Preexisting autoantibodies predict efficacy of oral insulin to cure autoimmune diabetes in combination with anti-CD3.

Progress in the development of immune-based therapies for type 1 diabetes mellitus

Protection against or triggering of Type 1 diabetes? Different roles for viral infections ⬇️