Lista de obras - Kathrin Maedler - Dominio Público Uruguay

Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4.

artículo científico publicado en 2018

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

scientific journal article

An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis

artículo científico publicado en 2018

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

artículo científico publicado en 2016

Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry

artículo científico publicado en 2015

Beta cells in type 2 diabetes - a crucial contribution to pathogenesis

artículo científico publicado en 2007

COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways

artículo científico publicado en 2012

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

artículo científico publicado en 2009

CXCL10- a path to β-cell death

artículo científico publicado en 2009

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

artículo científico publicado en 2020

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

artículo científico publicado en 2009

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass

artículo científico publicado en 2009

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

artículo científico publicado en 2017

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

artículo científico publicado en 2016

Efficient gene delivery and silencing of mouse and human pancreatic islets

artículo científico publicado en 2010

Enhanced cell adhesion on bioinert ceramics mediated by the osteogenic cell membrane enzyme alkaline phosphatase.

artículo científico publicado en 2016

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

artículo científico publicado en 2020

Erratum to: Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

artículo científico publicado en 2015

Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.

artículo científico publicado en 2016

Expression of Fas but not Fas ligand on fetal pig beta cells

artículo científico publicado en 2004

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways

artículo científico publicado en 2004

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

artículo científico publicado en 2002

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression

artículo científico publicado en 2013

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

artículo científico publicado en 2008

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

artículo científico publicado en 2004

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

artículo científico publicado en 2002

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

artículo científico publicado en 2018

Identification of ALOX5 as a gene regulating adiposity and pancreatic function

artículo científico publicado en 2008

Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.

artículo científico publicado en 2011

Imaging of the β-cells of the islets of Langerhans

Increased vulnerability of newly forming beta cells to cytokine-induced cell death

artículo científico publicado en 2005

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

artículo científico publicado en 2003

Interleukin-1 beta targeted therapy for type 2 diabetes

artículo científico publicado en 2009

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

artículo científico publicado en 2004

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

artículo científico publicado en 2018

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2

artículo científico publicado en 2016

Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance

artículo científico publicado en 2020

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

artículo científico publicado en 2006

Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study

artículo científico publicado en 2020

Lung Surfactant for Pulmonary Barrier Restoration in Patients With COVID-19 Pneumonia

artículo científico publicado en 2020

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

artículo científico publicado en 2014

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

artículo científico publicado en 2016

Macrophage-associated pro-inflammatory state in human islets from obese individuals

scientific article published on 02 December 2019

Manganese-mediated MRI signals correlate with functional β-cell mass during diabetes progression

artículo científico publicado en 2015

Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin

scientific article published on 22 October 2019

Mechanisms of beta-cell death in type 2 diabetes.

artículo científico publicado en 2005

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

artículo científico publicado en 2003

Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes

artículo científico publicado en 2019

Neratinib protects pancreatic beta cells in diabetes

scientific article published on 01 November 2019

Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization

artículo científico publicado en 2011

Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations

artículo científico publicado en 2009

Pancreatic β-cell rescue in diabetes by targeting Merlin

artículo científico publicado en 2017

Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies

artículo científico publicado en 2014

Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes

artículo científico publicado en 2013

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

artículo científico publicado en 2009

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

artículo científico publicado en 2008

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

artículo científico publicado en 2016

Rettet die Beta-Zelle: Neue Therapieansätze für Diabetes

STRIPAK Is a Regulatory Hub Initiating Hippo Signaling

artículo científico publicado en 2020

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

scientific article published on 05 April 2017

Sulfonylurea induced beta-cell apoptosis in cultured human islets

artículo científico publicado en 2004

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

artículo científico publicado en 2012

TCF7L2 splice variants have distinct effects on beta-cell turnover and function

artículo científico publicado en 2011

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

artículo científico publicado en 2014

TLR4 triggered complex inflammation in human pancreatic islets

scientific article published on 01 October 2018

TOSO promotes β-cell proliferation and protects from apoptosis

artículo científico publicado en 2012

The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization

artículo científico publicado en 2013

The Fas pathway is involved in pancreatic beta cell secretory function

artículo científico publicado en 2007

The Hippo signaling pathway in pancreatic β-cells: functions and regulations

artículo científico publicado en 2017

The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion

artículo científico publicado en 2013

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

artículo científico publicado en 2008

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

artículo científico publicado en 2007

UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells

artículo científico publicado en 2008

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

article

XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model

artículo científico publicado en 2010

mTORC in β cells: more Than Only Recognizing Comestibles

artículo científico publicado en 2017

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

artículo científico publicado en 2017

mTORC1 and IRS1: Another Deadly Kiss

artículo científico publicado en 2018

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function

artículo científico publicado en 2018

β-MSCs: successful fusion of MSCs with β-cells results in a β-cell like phenotype

artículo científico publicado en 2016

Lista de obras de Kathrin Maedler

Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through TLR4.

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

An SCFFBXO28 E3 Ligase Protects Pancreatic β-Cells from Apoptosis

Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes

Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry

Beta cells in type 2 diabetes - a crucial contribution to pathogenesis

COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways

CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.

CXCL10- a path to β-cell death

Commentary: A Human Pluripotent Stem Cell-Based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes

Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

Efficient gene delivery and silencing of mouse and human pancreatic islets

Enhanced cell adhesion on bioinert ceramics mediated by the osteogenic cell membrane enzyme alkaline phosphatase.

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

Erratum to: Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.

Expression of Fas but not Fas ligand on fetal pig beta cells

Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways

FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression

Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective po

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism

Identification of ALOX5 as a gene regulating adiposity and pancreatic function

Identification of an intracellular metabolic signature impairing beta cell function in the rat beta cell line INS-1E and human islets.

Imaging of the β-cells of the islets of Langerhans

Increased vulnerability of newly forming beta cells to cytokine-induced cell death

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

Interleukin-1 beta targeted therapy for type 2 diabetes

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage Response

Loss of Merlin/NF2 protects pancreatic β-cells from apoptosis by inhibiting LATS2

Loss of TAZ Boosts PPARγ to Cope with Insulin Resistance

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets

Lung Surfactant Accelerates Skin Wound Healing: A Translational Study with a Randomized Clinical Phase I Study

Lung Surfactant for Pulmonary Barrier Restoration in Patients With COVID-19 Pneumonia

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes

Macrophage-associated pro-inflammatory state in human islets from obese individuals

Manganese-mediated MRI signals correlate with functional β-cell mass during diabetes progression

Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin

Mechanisms of beta-cell death in type 2 diabetes.

Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes

Neratinib protects pancreatic beta cells in diabetes

Neutralizing interleukin-1beta (IL-1beta) induces beta-cell survival by maintaining PDX1 protein nuclear localization

Pancreatic beta cells and islets take up thiamin by a regulated carrier-mediated process: studies using mice and human pancreatic preparations

Pancreatic β-cell rescue in diabetes by targeting Merlin

Possible role of interleukin-1β in type 2 diabetes onset and implications for anti-inflammatory therapy strategies

Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes

Rettet die Beta-Zelle: Neue Therapieansätze für Diabetes

STRIPAK Is a Regulatory Hub Initiating Hippo Signaling

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Sulfonylurea induced beta-cell apoptosis in cultured human islets

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

TCF7L2 splice variants have distinct effects on beta-cell turnover and function

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

TLR4 triggered complex inflammation in human pancreatic islets

TOSO promotes β-cell proliferation and protects from apoptosis

The DPP-4 inhibitor linagliptin restores β-cell function and survival in human isolated islets through GLP-1 stabilization

The Fas pathway is involved in pancreatic beta cell secretory function

The Hippo signaling pathway in pancreatic β-cells: functions and regulations

The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

UCP-2 and UCP-3 proteins are differentially regulated in pancreatic beta-cells

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

XOMA 052, an anti-IL-1{beta} monoclonal antibody, improves glucose control and {beta}-cell function in the diet-induced obesity mouse model

mTORC in β cells: more Than Only Recognizing Comestibles

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

mTORC1 and IRS1: Another Deadly Kiss

mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function