Lista de obras - Ingo Drexler - Dominio Público Uruguay

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

artículo científico publicado en 2020

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

artículo científico publicado en 2007

A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).

artículo científico publicado en 2004

Active dissemination of cellular antigens by DCs facilitates CD8(+) T-cell priming in lymph nodes.

artículo científico publicado en 2017

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells

artículo científico publicado en 2016

Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines

artículo científico publicado en 2012

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

artículo científico publicado en 2016

Broad and potent antiviral activity of the NAE inhibitor MLN4924.

artículo científico publicado en 2016

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

artículo científico publicado en 2009

Construction and isolation of recombinant MVA.

artículo científico publicado en 2004

Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination

artículo científico publicado en 2007

Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines.

artículo científico publicado en 2007

Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function

artículo científico publicado en 2009

Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens

artículo científico publicado en 2009

Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens

artículo científico publicado en 2008

Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes

artículo científico publicado en 2014

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

artículo científico publicado en 2004

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.

artículo científico publicado en 2002

Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

artículo científico publicado en 2017

Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology.

artículo científico publicado en 2007

Impact of the TAP-like transporter in antigen presentation and phagosome maturation

artículo científico publicado en 2018

Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.

artículo científico publicado en 2003

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.

artículo científico publicado en 2011

Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity

artículo científico publicado en 2006

Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?

artículo científico publicado en 2018

Interplay between modified vaccinia virus Ankara and dendritic cells: phenotypic and functional maturation of bystander dendritic cells.

artículo científico publicado en 2011

Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling

artículo científico publicado en 2008

Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

artículo científico publicado en 2005

Melanoma-reactive class I-restricted cytotoxic T cell clones are stimulated by dendritic cells loaded with synthetic peptides, but fail to respond to dendritic cells pulsed with melanoma-derived heat shock proteins in vitro

artículo científico publicado en 2004

Modified vaccinia virus Ankara as antigen delivery system: how can we best use its potential?

artículo científico publicado en 2004

Modified vaccinia virus Ankara delivers a robust surrogate marker for immune monitoring to sarcoma cells even if cells are being exposed to chemotherapy and heat treatment

artículo científico publicado en 2012

Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model

artículo científico publicado en 2010

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

artículo científico publicado en 2014

Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways

artículo científico publicado en 2014

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol

artículo científico publicado en 2018

Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins

artículo científico publicado en 2002

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

artículo científico publicado en 2014

Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection ⬇️

artículo científico publicado el 7 de diciembre de 2011

Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction

artículo científico publicado en 2011

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines

artículo científico publicado en 2012

Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells

artículo científico publicado en 2014

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

artículo científico publicado en 2017

Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia

scientific article published on 17 October 2016

The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation.

artículo científico publicado en 2018

The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules

artículo científico publicado en 2005

The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays ⬇️

artículo científico publicado el 1 de enero de 2002

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

artículo científico publicado en 2010

Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design

artículo científico publicado en 2021

α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.

artículo científico publicado en 2014

Lista de obras de Ingo Drexler

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr).

Active dissemination of cellular antigens by DCs facilitates CD8(+) T-cell priming in lymph nodes.

Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells

Association of amphiregulin with the cetuximab sensitivity of gastric cancer cell lines

Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

Broad and potent antiviral activity of the NAE inhibitor MLN4924.

Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity

Construction and isolation of recombinant MVA.

Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination

Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines.

Cutting edge: memory CD8 T cell compartment grows in size with immunological experience but nevertheless can lose function

Cutting edge: mucosal application of a lyophilized viral vector vaccine confers systemic and protective immunity toward intracellular pathogens

Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens

Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes

HER-2/neu-mediated regulation of components of the MHC class I antigen-processing pathway.

Identification of vaccinia virus epitope-specific HLA-A*0201-restricted T cells and comparative analysis of smallpox vaccines.

Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology.

Impact of the TAP-like transporter in antigen presentation and phagosome maturation

Impaired transporter associated with antigen processing (TAP) function attributable to a single amino acid alteration in the peptide TAP subunit TAP1.

Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.

Infection of human dendritic cells with recombinant vaccinia virus MVA reveals general persistence of viral early transcription but distinct maturation-dependent cytopathogenicity

Interleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?

Interplay between modified vaccinia virus Ankara and dendritic cells: phenotypic and functional maturation of bystander dendritic cells.

Long-term immunity against actual poxviral HLA ligands as identified by differential stable isotope labeling

Melanoma patients respond to a new HLA-A*01-presented antigenic ligand derived from a multi-epitope region of melanoma antigen TRP-2.

Melanoma-reactive class I-restricted cytotoxic T cell clones are stimulated by dendritic cells loaded with synthetic peptides, but fail to respond to dendritic cells pulsed with melanoma-derived heat shock proteins in vitro

Modified vaccinia virus Ankara as antigen delivery system: how can we best use its potential?

Modified vaccinia virus Ankara delivers a robust surrogate marker for immune monitoring to sarcoma cells even if cells are being exposed to chemotherapy and heat treatment

Modified vaccinia virus Ankara exerts potent immune modulatory activities in a murine model

Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol

Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production

Rapid In Vivo Conversion of Effector T Cells into Th2 Cells during Helminth Infection ⬇️

Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction

Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines

Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia

The bone marrow is patrolled by NK cells that are primed and expand in response to systemic viral activation.

The poxviral scrapin MV-LAP requires a myxoma viral infection context to efficiently downregulate MHC-I molecules

The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays ⬇️

Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens.

Vaccinia Virus: From Crude Smallpox Vaccines to Elaborate Viral Vector Vaccine Design

α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.