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Lista de obras de Yusuke Moritoh

A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure.

artículo científico publicado en 2009

Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells

artículo científico publicado en 2003

Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice

artículo científico publicado en 2008

Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice

artículo científico publicado en 2009

Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice

artículo científico publicado en 2010

Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice

artículo científico publicado en 2009

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

scientific article published on 25 November 2010

Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792

artículo científico publicado en 2019

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor

artículo científico publicado en 2011

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.

artículo científico publicado en 2011

Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease

artículo científico publicado en 2020

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis

artículo científico publicado en 2010

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca channels

artículo científico publicado en 2018

Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice

scientific article published on 31 August 2016

Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells ⬇️

artículo científico publicado en 2010

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity

scientific article published on 10 June 2019

SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice

artículo científico publicado en 2019

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

artículo científico publicado en 2009

The GPR40 full agonist SCO-267 improves liver parameters in a mouse model of nonalcoholic fatty liver disease without affecting glucose or body weight

artículo científico publicado en 2020

The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice

artículo científico publicado en 2008

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