Lista de obras - Raimundo Freire - Dominio Público Uruguay

A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression

artículo científico publicado en 2018

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

artículo científico publicado en 2018

Bora and Aurora-A continue to activate Plk1 in mitosis

artículo científico publicado en 2013

Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress.

artículo científico publicado en 2009

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.

artículo científico publicado en 2018

Characterization of Pch2 localization determinants reveals a nucleolar-independent role in the meiotic recombination checkpoint

artículo científico publicado en 2019

Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation

scientific article published in Scientific Reports

Claspin - checkpoint adaptor and DNA replication factor

artículo científico publicado en 2018

Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome

artículo científico publicado en 2007

Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha

artículo científico publicado en 2001

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

artículo científico publicado en 2013

Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance

artículo científico publicado en 2013

Control of DNA Replication Initiation by Ubiquitin

artículo científico publicado en 2018

Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

scientific article published on 01 June 2019

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

scientific journal article

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

artículo científico publicado en 2017

Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.

artículo científico publicado en 2015

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1

artículo científico publicado en 2001

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor

artículo científico publicado en 2013

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.

artículo científico publicado en 2017

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.

artículo científico publicado en 2014

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.

artículo científico publicado en 2017

Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase.

artículo científico publicado en 2000

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

artículo científico publicado en 2013

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

artículo científico publicado en 2019

HCLK2 is required for activity of the DNA damage response kinase ATR.

artículo científico publicado en 2008

HUWE1 interacts with PCNA to alleviate replication stress

artículo científico publicado en 2016

Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

scientific article published on 16 August 2018

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis

artículo científico publicado en 1998

Human spindle checkpoint kinase Bub1 is cleaved during apoptosis.

artículo científico publicado en 2005

Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

scientific article published on 24 August 2020

Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling

artículo científico publicado en 2020

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

artículo científico publicado en 2015

Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis

artículo científico publicado en 2011

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

artículo científico publicado en 2016

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

artículo científico publicado en 2022

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

artículo científico publicado en 2014

New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress

artículo científico publicado en 2016

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

artículo científico publicado en 2015

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

scientific article published on 08 April 2020

Opposing roles for 53BP1 during homologous recombination.

artículo científico publicado en 2013

PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.

artículo científico publicado en 2016

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks

scientific article published on 30 March 2020

PHF6 promotes non-homologous end joining and G2 checkpoint recovery

artículo científico publicado en 2019

Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations

artículo científico publicado en 2014

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

artículo científico publicado en 2006

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

artículo científico publicado en 2008

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment

artículo científico publicado en 2016

Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition.

artículo científico publicado en 2012

SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage

artículo científico publicado en 2017

Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding

artículo científico publicado en 2009

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

artículo científico publicado en 2004

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

artículo científico publicado en 2020

TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.

artículo científico publicado en 2017

Telomere and Telomerase Modulation by the Mammalian Rad9/Rad1/Hus1 DNA-Damage-Checkpoint Complex

artículo científico publicado en 2006

The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells

artículo científico publicado en 2022

The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance.

artículo científico publicado en 2006

The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.

artículo científico publicado en 2011

The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response.

artículo científico publicado en 2011

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability

article

The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

scientific article published on 15 October 2019

TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint

scientific journal article

TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis

artículo científico publicado en 2004

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.

artículo científico publicado en 2014

USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication

scientific journal article

USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication

artículo científico publicado en 2016

Wip1 regulation: who controls a reset button?

artículo científico publicado en 2013

Lista de obras de Raimundo Freire

A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression

ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells

Bora and Aurora-A continue to activate Plk1 in mitosis

Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress.

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.

Characterization of Pch2 localization determinants reveals a nucleolar-independent role in the meiotic recombination checkpoint

Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation

Claspin - checkpoint adaptor and DNA replication factor

Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome

Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance

Control of DNA Replication Initiation by Ubiquitin

Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer

Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.

Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor

Drosophila Vps13 Is Required for Protein Homeostasis in the Brain.

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.

Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase.

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

HCLK2 is required for activity of the DNA damage response kinase ATR.

HUWE1 interacts with PCNA to alleviate replication stress

Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis

Human spindle checkpoint kinase Bub1 is cleaved during apoptosis.

Implications of CLSPN Variants in Cellular Function and Susceptibility to Cancer

Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage

Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis

Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features

New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

OZF is a Claspin-interacting protein essential to maintain the replication fork progression rate under replication stress

Opposing roles for 53BP1 during homologous recombination.

PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.

PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks

PHF6 promotes non-homologous end joining and G2 checkpoint recovery

Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations

Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment

Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition.

SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damage

Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts

TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9.

Telomere and Telomerase Modulation by the Mammalian Rad9/Rad1/Hus1 DNA-Damage-Checkpoint Complex

The CDK1-TOPBP1-PLK1 axis regulates the Bloom's syndrome helicase BLM to suppress crossover recombination in somatic cells

The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance.

The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates.

The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response.

The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability

The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint

TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.

USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication

USP7/HAUSP: A SUMO deubiquitinase at the heart of DNA replication

Wip1 regulation: who controls a reset button?