Lista de obras - Irmela Jeremias - Dominio Público Uruguay

A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia

scientific article published on 24 September 2018

Activation of DNA damage response by antitumor therapy counteracts the activity of vinca alkaloids

artículo científico publicado en 2013

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

artículo científico publicado en 2015

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.

artículo científico publicado en 2015

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations

artículo científico publicado en 2017

Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells

artículo científico publicado en 1999

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.

artículo científico publicado en 2015

CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.

artículo científico publicado en 2005

CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.

artículo científico publicado en 2017

Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.

artículo científico publicado en 2013

Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia

artículo científico publicado en 2018

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL

artículo científico publicado en 2018

Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells

artículo científico publicado en 2004

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

artículo científico publicado en 2014

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.

artículo científico publicado en 2014

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics.

artículo científico publicado en 2018

Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo

scientific article published on 24 June 2015

Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice.

artículo científico publicado en 2012

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice

scientific article published on 20 September 2018

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

scientific article published on 10 May 2019

Important role of caspase-8 for chemosensitivity of ALL cells.

artículo científico publicado en 2011

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

artículo científico publicado en 2021

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

artículo científico publicado en 2020

Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation

scientific article published on 01 October 1998

Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

artículo científico publicado en 2000

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

artículo científico publicado en 2019

Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.

artículo científico publicado en 2012

Loss of KDM6A confers drug resistance in acute myeloid leukemia

scientific article published on 14 June 2019

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

artículo científico publicado en 2016

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

artículo científico publicado en 2015

Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

artículo científico publicado en 2011

MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

artículo científico publicado en 1998

NOXA as critical mediator for drug combinations in polychemotherapy

artículo científico publicado en 2012

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

scientific article published on 18 November 2019

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

artículo científico publicado en 2012

Requirement for LIM kinases in acute myeloid leukemia

artículo científico publicado en 2020

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

artículo científico publicado en 2018

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

artículo científico publicado en 2011

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

scientific article published on 25 November 2008

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

artículo científico publicado en 2010

Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

artículo científico publicado en 2021

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

artículo científico publicado en 2020

Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

artículo científico publicado en 2018

Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP

scientific article published on 12 June 2008

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

artículo científico publicado en 2012

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

artículo científico publicado en 2003

TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation

artículo científico publicado en 2014

Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics

scientific article published on 11 October 2018

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

artículo científico publicado en 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

artículo científico publicado en 2016

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.

artículo científico publicado en 2012

The target landscape of clinical kinase drugs

artículo científico publicado en 2017

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

artículo científico publicado en 2021

Tumor Cell Dormancy-Triggered by the Niche

scientific article published on 01 May 2019

Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects

artículo científico publicado en 2005

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

artículo científico publicado en 2017

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells

artículo científico publicado en 2020

Lista de obras de Irmela Jeremias

A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia

Activation of DNA damage response by antitumor therapy counteracts the activity of vinca alkaloids

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.

Azacitidine combined with the selective FLT3 kinase inhibitor crenolanib disrupts stromal protection and inhibits expansion of residual leukemia-initiating cells in FLT3-ITD AML with concurrent epigenetic mutations

Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.

CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.

CRISPR/Cas9-edited NSG mice as PDX models of human leukemia to address the role of niche-derived SPARC.

Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.

Characteristics and Therapeutic Targeting of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL

Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells

Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.

Dual PI3K/mTOR inhibition shows antileukemic activity in MLL-rearranged acute myeloid leukemia.

Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics.

Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo

Efficient RNA interference in patients' acute lymphoblastic leukemia cells amplified as xenografts in mice.

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML

Important role of caspase-8 for chemosensitivity of ALL cells.

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL

Interleukin-1 receptor antagonist and interleukin-6 for early diagnosis of neonatal sepsis 2 days before clinical manifestation

Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

Leukemia-initiating cells of patient-derived acute lymphoblastic leukemia xenografts are sensitive toward TRAIL.

Loss of KDM6A confers drug resistance in acute myeloid leukemia

Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199.

Mitochondrial Thioredoxin Reductase Is Essential for Early Postischemic Myocardial Protection

MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

NOXA as critical mediator for drug combinations in polychemotherapy

RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

Requirement for LIM kinases in acute myeloid leukemia

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy

Spatiotemporal patterning of EpCAM is important for murine embryonic endo- and mesodermal differentiation

Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation

Targeting the ER-mitochondria interface sensitizes leukemia cells towards cytostatics

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.

The target landscape of clinical kinase drugs

The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors

Tumor Cell Dormancy-Triggered by the Niche

Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects

Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia.

ZBTB7A prevents RUNX1-RUNX1T1-dependent clonal expansion of human hematopoietic stem and progenitor cells