Lista de obras - Junko Ohkanda - Dominio Público Uruguay

A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf

artículo científico publicado en 2019

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

artículo científico publicado en 2003

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface

artículo científico publicado en 2013

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase

artículo científico publicado en 2013

Bivalent inhibitors for disrupting protein surface-substrate interactions and for dual inhibition of protein prenyltransferases.

artículo científico publicado en 2011

Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.

artículo científico publicado en 2013

Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates

scientific article published on 03 February 2020

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

artículo científico publicado en 2004

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.

artículo científico publicado en 2002

Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine

scientific article published on 30 November 2018

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

scientific article published on 01 January 2000

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

artículo científico publicado en 2006

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

scientific article published on 01 September 2020

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.

artículo científico publicado en 2003

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.

artículo científico publicado en 2000

Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.

artículo científico publicado en 2015

Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions

artículo científico

Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces.

artículo científico publicado en 2008

Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.

artículo científico publicado en 2012

Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.

artículo científico publicado en 2011

Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c.

artículo científico publicado en 2011

Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity

scientific article published on 23 October 2018

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

scientific article published on June 2009

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.

artículo científico publicado en 2006

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents

artículo científico publicado el 1 de enero de 2003

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.

artículo científico publicado en 2003

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

artículo científico publicado en 2001

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

artículo científico publicado en 2002

Transannular proton transfer in the cyclization of geranylgeranyl diphosphate to fusicoccadiene, a biosynthetic intermediate of fusicoccins

artículo científico publicado en 2009

Lista de obras de Junko Ohkanda

A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase

Bivalent inhibitors for disrupting protein surface-substrate interactions and for dual inhibition of protein prenyltransferases.

Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein.

Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.

Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus.

Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta.

Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions.

Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions

Module assembly for protein-surface recognition: geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces.

Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.

Phosphopeptide-dependent labeling of 14-3-3 ζ proteins by fusicoccin-based fluorescent probes.

Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for α-chymotrypsin and cytochrome c.

Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity

Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase.

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells.

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

Transannular proton transfer in the cyclization of geranylgeranyl diphosphate to fusicoccadiene, a biosynthetic intermediate of fusicoccins