Lista de obras - Mirjam H.M. Heemskerk - Dominio Público Uruguay

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.

artículo científico publicado en 2016

A Good Manufacturing Practice procedure to engineer donor virus-specific T cells into potent anti-leukemic effector cells

artículo científico

A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies.

artículo científico publicado en 2018

Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes

artículo científico publicado en 2014

Adoptive immunotherapy using PRAME-specific T cells in medulloblastoma

artículo científico publicado en 2018

Adult and cord blood T cells can acquire HA-1 specificity through HA-1 T-cell receptor gene transfer

artículo científico publicado en 2005

Allo-HLA reactivity of virus-specific memory T cells is common

artículo científico publicado en 2010

Allo-HLA-reactive T cells inducing graft-versus-host disease are single peptide specific

artículo científico publicado en 2011

Allogeneic HLA-A*02-restricted WT1-specific T cells from mismatched donors are highly reactive but show off-target promiscuity

artículo científico publicado en 2011

Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients

artículo científico publicado en 2009

Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo

artículo científico publicado en 2009

Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity

artículo científico publicado en 2006

CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses.

artículo científico publicado en 2016

Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile.

artículo científico publicado en 2019

Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals.

artículo científico publicado en 2013

Clinically applicable CD34<sup>+</sup>-derived blood dendritic cell subsets exhibit key subset-specific features and potently boost anti-tumor T and NK cell responses

artículo científico publicado en 2021

Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7

artículo científico publicado en 2008

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

artículo científico publicado en 2015

Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma.

artículo científico publicado en 2008

Design and validation of conditional ligands for HLA-B08:01, HLA-B15:01, HLA-B35:01, and HLA-B44:05

artículo científico publicado en 2015

Designer T cells by T cell receptor replacement.

artículo científico publicado en 2006

Differential activation of the death receptor pathway in human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing

scientific article published on 01 December 2007

Discovery of T cell epitopes implementing HLA-peptidomics into a reverse immunology approach.

artículo científico publicado en 2013

Early cytomegalovirus reactivation leaves a specific and dynamic imprint on the reconstituting T cell compartment long-term after hematopoietic stem cell transplantation

artículo científico publicado en 2014

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

artículo científico publicado en 2006

Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA

scientific article published on 01 January 2002

Extracellular domains of CD8α and CD8ß subunits are sufficient for HLA class I restricted helper functions of TCR-engineered CD4(+) T cells

artículo científico publicado en 2013

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

scientific article published on 01 October 2019

Functional analysis of killer Ig-like receptor-expressing cytomegalovirus-specific CD8+ T cells.

artículo científico publicado en 2009

Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors

artículo científico publicado en 2007

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells

artículo científico publicado en 2002

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer.

artículo científico publicado en 2011

Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies.

artículo científico publicado en 2016

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

artículo científico publicado en 2008

HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

scientific article published on 20 August 2020

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

artículo científico publicado en 2018

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

artículo científico publicado en 2003

High-throughput identification of antigen-specific TCRs by TCR gene capture

artículo científico publicado en 2013

High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations

artículo científico publicado en 2011

Identification of Biological Relevant Minor Histocompatibility Antigens within the B-lymphocyte-Derived HLA-Ligandome Using a Reverse Immunology Approach.

artículo científico publicado en 2015

Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease ⬇️

artículo científico publicado el 19 de octubre de 2011

Identification of non-mutated neoantigens presented by TAP-deficient tumors.

artículo científico publicado en 2018

Identification of varicella-zoster virus-specific CD8 T cells in patients after T-cell-depleted allogeneic stem cell transplantation

artículo científico publicado en 2009

Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies

artículo científico publicado en 2020

Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies

artículo científico publicado en 2005

Induction of A. fumigatus-specific CD4-positive T cells in patients recovering from invasive aspergillosis

artículo científico publicado en 2014

Kinetic preservation of dual specificity of coprogrammed minor histocompatibility antigen-reactive virus-specific T cells

artículo científico publicado en 2009

MB-64ADOPTIVE CELL IMMUNOTHERAPY IN MEDULLOBLASTOMA BASED ON T CELLS REDIRECTED TOWARD TUMOR CELLS BY PRAME SPECIFIC αβTCR GENE MODIFICATION.

artículo científico publicado en 2016

Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice

artículo científico publicado en 2002

Mixed T cell receptor dimers harbor potentially harmful neoreactivity

artículo científico publicado en 2010

Mixed functional characteristics correlating with TCR-ligand koff -rate of MHC-tetramer reactive T cells within the naive T-cell repertoire.

artículo científico publicado en 2013

Monitoring of indirect allorecognition: wishful thinking or solid data?

artículo científico publicado en 2008

Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells ⬇️

artículo científico publicado el 31 de enero de 2013

Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene

article

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

artículo científico publicado en 2015

Naturally processed non-canonical HLA-A*02:01 presented peptides

artículo científico publicado en 2014

Optimization of the HA-1-specific T-cell receptor for gene therapy of hematologic malignancies ⬇️

artículo científico publicado el 25 de noviembre de 2010

Optimizing TCR gene transfer

artículo científico publicado en 2006

PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma.

artículo científico publicado en 2017

PRAME-Specific Allo-HLA-Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer

article

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

artículo científico publicado en 2020

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow

artículo científico publicado en 2019

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs.

artículo científico publicado en 2018

Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications

artículo científico publicado en 2006

Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells.

artículo científico publicado en 2016

Rapid Re-expression of Retrovirally Introduced VersusEndogenous TCRs in Engineered T cells AfterAntigen-specific Stimulation ⬇️

artículo científico publicado el 1 de marzo de 2011

Rapid assessment of the antigenic integrity of tetrameric HLA complexes by human monoclonal HLA antibodies.

artículo científico publicado en 2006

Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region

scientific article published on 17 July 2003

Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer

artículo científico publicado en 2004

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

artículo científico publicado en 2009

Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

artículo científico publicado en 2017

Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic

scientific article published on 04 October 2019

Specific T-cell Responses Against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

artículo científico publicado en 2017

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.

artículo científico publicado en 2006

T-cell receptor gene transfer for the treatment of leukemia and other tumors

artículo científico publicado en 2010

T-cell receptor gene transfer for treatment of leukemia.

artículo científico publicado en 2008

TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1.

artículo científico publicado en 2017

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

artículo científico publicado en 2012

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

artículo científico publicado en 2016

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses

artículo científico publicado en 2020

The human leukocyte antigen-presented ligandome of B lymphocytes

artículo científico publicado en 2013

The molecular bases of δ/αβ T cell-mediated antigen recognition.

artículo científico publicado en 2014

The single antigen expressing lines (SALs) concept: an excellent tool for screening for HLA-specific antibodies

artículo científico publicado en 2005

Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b

artículo científico publicado en 2014

Transcriptional silencing of RFXAP in MHC class II-deficiency

artículo científico publicado en 2008

Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity.

artículo científico publicado en 2010

Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition.

artículo científico publicado en 2016

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

artículo científico publicado en 2008

microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients

artículo científico publicado en 2018

Lista de obras de Mirjam H.M. Heemskerk

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer.

A Good Manufacturing Practice procedure to engineer donor virus-specific T cells into potent anti-leukemic effector cells

A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies.

Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes

Adoptive immunotherapy using PRAME-specific T cells in medulloblastoma

Adult and cord blood T cells can acquire HA-1 specificity through HA-1 T-cell receptor gene transfer

Allo-HLA reactivity of virus-specific memory T cells is common

Allo-HLA-reactive T cells inducing graft-versus-host disease are single peptide specific

Allogeneic HLA-A*02-restricted WT1-specific T cells from mismatched donors are highly reactive but show off-target promiscuity

Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients

Alpha beta T cell receptor transfer to gamma delta T cells generates functional effector cells without mixed TCR dimers in vivo

Alphabeta T-cell receptor engineered gammadelta T cells mediate effective antileukemic reactivity

CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses.

Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile.

Characterization of the T-cell-mediated immune response against the Aspergillus fumigatus proteins Crf1 and catalase 1 in healthy individuals.

Clinically applicable CD34<sup>+</sup>-derived blood dendritic cell subsets exhibit key subset-specific features and potently boost anti-tumor T and NK cell responses

Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

Defective synthesis or association of T-cell receptor chains underlies loss of surface T-cell receptor-CD3 expression in enteropathy-associated T-cell lymphoma.

Design and validation of conditional ligands for HLA-B*08:01, HLA-B*15:01, HLA-B*35:01, and HLA-B*44:05

Designer T cells by T cell receptor replacement.

Differential activation of the death receptor pathway in human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing

Discovery of T cell epitopes implementing HLA-peptidomics into a reverse immunology approach.

Early cytomegalovirus reactivation leaves a specific and dynamic imprint on the reconstituting T cell compartment long-term after hematopoietic stem cell transplantation

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex

Efficient induction of minor histocompatibility antigen HA-1-specific cytotoxic T-cells using dendritic cells retrovirally transduced with HA-1-coding cDNA

Extracellular domains of CD8α and CD8ß subunits are sufficient for HLA class I restricted helper functions of TCR-engineered CD4(+) T cells

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Functional analysis of killer Ig-like receptor-expressing cytomegalovirus-specific CD8+ T cells.

Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer.

Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies.

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia

High-throughput identification of antigen-specific TCRs by TCR gene capture

High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations

Identification of Biological Relevant Minor Histocompatibility Antigens within the B-lymphocyte-Derived HLA-Ligandome Using a Reverse Immunology Approach.

Identification of a Coordinated CD8 and CD4 T Cell Response Directed Against Mismatched HLA Class I Causing Severe Acute Graft-versus-Host Disease ⬇️

Identification of non-mutated neoantigens presented by TAP-deficient tumors.

Identification of varicella-zoster virus-specific CD8 T cells in patients after T-cell-depleted allogeneic stem cell transplantation

Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies

Impact of peptides on the recognition of HLA class I molecules by human HLA antibodies

Induction of A. fumigatus-specific CD4-positive T cells in patients recovering from invasive aspergillosis

Kinetic preservation of dual specificity of coprogrammed minor histocompatibility antigen-reactive virus-specific T cells

MB-64ADOPTIVE CELL IMMUNOTHERAPY IN MEDULLOBLASTOMA BASED ON T CELLS REDIRECTED TOWARD TUMOR CELLS BY PRAME SPECIFIC αβTCR GENE MODIFICATION.

Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice

Mixed T cell receptor dimers harbor potentially harmful neoreactivity

Mixed functional characteristics correlating with TCR-ligand koff -rate of MHC-tetramer reactive T cells within the naive T-cell repertoire.

Monitoring of indirect allorecognition: wishful thinking or solid data?

Multi-cistronic vector encoding optimized safety switch for adoptive therapy with T-cell receptor-modified T cells ⬇️

Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene

Natural killer cells facilitate PRAME-specific T-cell reactivity against neuroblastoma

Naturally processed non-canonical HLA-A*02:01 presented peptides

Optimization of the HA-1-specific T-cell receptor for gene therapy of hematologic malignancies ⬇️

Optimizing TCR gene transfer

PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma.

PRAME-Specific Allo-HLA-Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs.

Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications

Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells.

Rapid Re-expression of Retrovirally Introduced VersusEndogenous TCRs in Engineered T cells AfterAntigen-specific Stimulation ⬇️

Rapid assessment of the antigenic integrity of tetrameric HLA complexes by human monoclonal HLA antibodies.

Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region

Reprogramming of virus-specific T cells into leukemia-reactive T cells using T cell receptor gene transfer

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic

Specific T-cell Responses Against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.

T-cell receptor gene transfer for the treatment of leukemia and other tumors

T-cell receptor gene transfer for treatment of leukemia.

TCR-based therapy for multiple myeloma and other B-cell malignancies targeting intracellular transcription factor BOB1.

TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo.

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

Design and validation of conditional ligands for HLA-B08:01, HLA-B15:01, HLA-B35:01, and HLA-B44:05