Lista de obras - Hanna-Kirsti S Leiros - Dominio Público Uruguay

A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.

artículo científico publicado en 2017

A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement

artículo científico publicado en 2014

Atomic resolution structures of trypsin provide insight into structural radiation damage

artículo científico publicado en 2001

Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp

artículo científico publicado en 2016

Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans

artículo científico publicado en 2010

Cold adapted enzymes.

artículo científico publicado en 2000

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

artículo científico publicado en 2012

Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo- -Lactamases

artículo científico publicado en 2013

Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5

artículo científico publicado en 2007

DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases.

artículo científico publicado en 2018

Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening

artículo científico publicado en 2015

Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila

article

Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1.

artículo científico publicado en 2016

Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark

artículo científico publicado en 2017

Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface.

artículo científico publicado en 2014

Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase

artículo científico publicado en 2018

Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2.

artículo científico publicado en 2016

Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library

artículo científico publicado en 2013

High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans

artículo científico publicado en 2008

His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo- -Lactamase VIM-7

artículo científico publicado en 2014

Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?

artículo científico publicado en 2006

Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.

artículo científico publicado en 2017

MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability.

artículo científico publicado en 2015

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

artículo científico publicado en 2019

Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1.

artículo científico publicado en 2015

Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening

artículo científico publicado en 2016

Specific radiation damage can be used to solve macromolecular crystal structures

artículo científico publicado en 2003

Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.

artículo científico publicado en 2017

Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases

artículo científico publicado en 2015

Structural and biophysical analysis of interactions between cod and human uracil-DNAN-glycosylase (UNG) and UNG inhibitor (Ugi)

artículo científico publicado en 2014

Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability

artículo científico publicado en 2007

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophila

artículo científico publicado en 2013

Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.

artículo científico publicado en 2004

Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10

artículo científico publicado en 2020

Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation

scientific article published on 01 August 2019

Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis

artículo científico publicado en 2017

Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies

artículo científico publicado en 2005

Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

artículo científico publicado en 2014

The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida

artículo científico publicado en 2015

The biological assembly of OXA-48 reveals a dimer interface with high charge complementarity and very high affinity

scientific article published on 07 September 2018

The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 A resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domains

artículo científico publicado en 2007

The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor.

artículo científico publicado en 2016

ZN148 - a modular synthetic metallo-β-lactamase inhibitor reverses carbapenem-resistance in Gram-negative pathogens in vivo

artículo científico publicado en 2020

Lista de obras de Hanna-Kirsti S Leiros

A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.

A high-throughput, restriction-free cloning and screening strategy based on ccdB-gene replacement

Atomic resolution structures of trypsin provide insight into structural radiation damage

Biochemical characterization and structural analysis of a new cold-active and salt-tolerant esterase from the marine bacterium Thalassospira sp

Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans

Cold adapted enzymes.

Crystal Structure of the Mobile Metallo- -Lactamase AIM-1 from Pseudomonas aeruginosa: Insights into Antibiotic Binding and the Role of Gln157

Crystal Structures of Pseudomonas aeruginosa GIM-1: Active-Site Plasticity in Metallo- -Lactamases

Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5

DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases.

Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening

Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila

Discovery of a novel covalent non-β-lactam inhibitor of the metallo-β-lactamase NDM-1.

Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436 from Four Patients Involving Six Different Hospitals in Denmark

Enzyme-adenylate structure of a bacterial ATP-dependent DNA ligase with a minimized DNA-binding surface.

Exploring the role of L209 residue in the active site of NDM-1 a metallo-β-lactamase

Fragment-based discovery of inhibitor scaffolds targeting the metallo-β-lactamases NDM-1 and VIM-2.

Functional and structural studies of a novel cold-adapted esterase from an Arctic intertidal metagenomic library

High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans

His224 Alters the R2 Drug Binding Site and Phe218 Influences the Catalytic Efficiency of the Metallo- -Lactamase VIM-7

Is radiation damage dependent on the dose rate used during macromolecular crystallography data collection?

Metallo-β-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.

MutT from the fish pathogen Aliivibrio salmonicida is a cold-active nucleotide-pool sanitization enzyme with unexpectedly high thermostability.

OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs

Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1.

Screening and Design of Inhibitor Scaffolds for the Antibiotic Resistance Oxacillinase-48 (OXA-48) through Surface Plasmon Resonance Screening

Specific radiation damage can be used to solve macromolecular crystal structures

Structural Insights into TMB-1 and the Role of Residues 119 and 228 in Substrate and Inhibitor Binding.

Structural and biochemical characterization of VIM-26 shows that Leu224 has implications for the substrate specificity of VIM metallo-β-lactamases

Structural and biophysical analysis of interactions between cod and human uracil-DNAN-glycosylase (UNG) and UNG inhibitor (Ugi)

Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability

Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophila

Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.

Structural insights into the enhanced carbapenemase efficiency of OXA-655 compared to OXA-10

Structural intermediates of a DNA-ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation

Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis

Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled X-ray radiation damage studies

Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin

The autoinducer synthases LuxI and AinS are responsible for temperature-dependent AHL production in the fish pathogen Aliivibrio salmonicida

The biological assembly of OXA-48 reveals a dimer interface with high charge complementarity and very high affinity

The crystal structure of DR2241 from Deinococcus radiodurans at 1.9 A resolution reveals a multi-domain protein with structural similarity to chelatases but also with two additional novel domains

The structure of the metallo-β-lactamase VIM-2 in complex with a triazolylthioacetamide inhibitor.

ZN148 - a modular synthetic metallo-β-lactamase inhibitor reverses carbapenem-resistance in Gram-negative pathogens in vivo