Lista de obras - B Gabrielli - Dominio Público Uruguay

6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells.

artículo científico publicado en 2016

A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma.

artículo científico publicado en 2012

A distinct expression profile separates Turkish and Australian melanocytic naevi.

artículo científico publicado en 2015

A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K).

artículo científico publicado en 2016

A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma.

artículo científico publicado en 2016

A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress ⬇️

artículo científico publicado el 5 de marzo de 2012

Activation of p34cdc2 kinase by cyclin A ⬇️

artículo científico publicado el 1 de mayo de 1991

Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high-throughput screening.

artículo científico publicado en 2010

Analyzing checkpoint controls in human skin.

artículo científico publicado en 2004

Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.

artículo científico publicado en 2015

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers

artículo científico publicado en 2018

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci

artículo científico publicado en 2013

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

article

Cdc25B activity is regulated by 14-3-3.

artículo científico publicado en 2001

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.

artículo científico publicado en 2005

Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells.

artículo científico publicado en 2016

Cell cycle-tailored targeting of metastatic melanoma: Challenges and opportunities.

artículo científico publicado en 2017

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer.

artículo científico publicado en 2016

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

scientific article published on 14 June 2019

CtBPs promote cell survival through the maintenance of mitotic fidelity.

artículo científico publicado en 2009

Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle.

artículo científico publicado en 2014

Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events

artículo científico publicado en 2008

Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.

artículo científico publicado en 2009

DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability.

artículo científico publicado en 2014

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

artículo científico

Decatenation checkpoint-defective melanomas are dependent on PI3K for survival

artículo científico publicado en 2014

Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies ⬇️

artículo científico publicado el 2 de febrero de 2012

Defective decatenation checkpoint function is a common feature of melanoma.

artículo científico publicado en 2013

Discovery of Thalicthuberine as a Novel Antimitotic Agent from Nature that Disrupts Microtubule Dynamics and Induces Apoptosis in Prostate Cancer Cells.

artículo científico publicado en 2018

Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo

artículo científico publicado en 2018

Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma

article

Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer

scientific article published on 06 September 2019

Finally, how histone deacetylase inhibitors disrupt mitosis!

artículo científico publicado en 2011

Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of human ORFs and identification of human genes affecting viral titer

artículo científico publicado en 2012

Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma

scientific article published on 23 November 2016

Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer

artículo científico publicado en 2016

High-content imaging of neutral lipid droplets with 1,6-diphenylhexatriene.

artículo científico publicado en 2011

Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone Proteins

artículo científico publicado el 1 de enero de 2012

Histone deacetylase inhibitors induce mitotic slippage

artículo científico publicado en 2007

Hyperphosphorylation of the N-terminal Domain of Cdc25 Regulates Activity toward Cyclin B1/Cdc2 But Not Cyclin A/Cdk2 ⬇️

artículo científico publicado el 7 de noviembre de 1997

Identifying molecular targets mediating the anticancer activity of histone deacetylase inhibitors: a work in progress.

artículo científico publicado en 2002

In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.

artículo científico publicado en 2016

Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors.

artículo científico publicado en 2017

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

artículo científico publicado en 2015

Keeping replicative stress in Chk.

artículo científico publicado en 2012

Keratinocyte Sonic Hedgehog Up-regulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion

artículo científico publicado en 2017

Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo.

artículo científico publicado en 2018

Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site

artículo científico publicado en 2010

Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation.

artículo científico publicado en 2016

Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load

artículo científico publicado en 2019

Oxidative stress and cell senescence combine to cause maximal renal tubular epithelial cell dysfunction and loss in an in vitro model of kidney disease.

artículo científico publicado en 2012

Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomas

artículo científico publicado en 2018

Phosphorylation of Cdc25B3 Ser169 regulates 14-3-3 binding to Ser151 and Cdc25B activity.

artículo científico publicado en 2011

Production of a Soluble Cyclin B/cdc2 Substrate for cdc25 Phosphatase ⬇️

artículo científico publicado el 15 de diciembre de 1997

RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin.

artículo científico publicado en 2005

Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.

artículo científico publicado en 2014

Self-Renewal and High Proliferative Colony Forming Capacity of Late-Outgrowth Endothelial Progenitors Is Regulated by Cyclin-Dependent Kinase Inhibitors Driven by Notch Signaling.

artículo científico publicado en 2016

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

artículo científico publicado en 2014

The histone deacetylase inhibitor MGCD0103 has both deacetylase and microtubule inhibitory activity.

artículo científico publicado en 2010

Topoisomerase II Inhibitors and Poisons, and the Influence of Cell Cycle Checkpoints

artículo científico publicado en 2016

Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cells.

artículo científico publicado en 2013

Ultraviolet light-induced G2 phase cell cycle checkpoint blocks cdc25-dependent progression into mitosis ⬇️

artículo científico publicado el 14 de agosto de 1997

Lista de obras de B Gabrielli

6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells.

A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma.

A distinct expression profile separates Turkish and Australian melanocytic naevi.

A mutation in the Cdon gene potentiates congenital nevus development mediated by NRAS(Q61K).

A novel ATM-dependent checkpoint defect distinct from loss of function mutation promotes genomic instability in melanoma.

A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress ⬇️

Activation of p34cdc2 kinase by cyclin A ⬇️

Adaptation and validation of DNA synthesis detection by fluorescent dye derivatization for high-throughput screening.

Analyzing checkpoint controls in human skin.

Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer.

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers

CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

Cdc25B activity is regulated by 14-3-3.

Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis.

Cell Cycle Phase-Specific Drug Resistance as an Escape Mechanism of Melanoma Cells.

Cell cycle-tailored targeting of metastatic melanoma: Challenges and opportunities.

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer.

Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

CtBPs promote cell survival through the maintenance of mitotic fidelity.

Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle.

Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events

Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.

DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability.

DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

Decatenation checkpoint-defective melanomas are dependent on PI3K for survival

Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies ⬇️

Defective decatenation checkpoint function is a common feature of melanoma.

Discovery of Thalicthuberine as a Novel Antimitotic Agent from Nature that Disrupts Microtubule Dynamics and Induces Apoptosis in Prostate Cancer Cells.

Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo

Erratum: A stress-induced early innate response causes multidrug tolerance in melanoma

Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer

Finally, how histone deacetylase inhibitors disrupt mitosis!

Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of human ORFs and identification of human genes affecting viral titer

Genome-Wide Overexpression Screen Identifies Genes Able to Bypass p16-Mediated Senescence in Melanoma

Genome-wide gain-of-function screen for genes that induce epithelial-to-mesenchymal transition in breast cancer

High-content imaging of neutral lipid droplets with 1,6-diphenylhexatriene.

Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone Proteins

Histone deacetylase inhibitors induce mitotic slippage

Hyperphosphorylation of the N-terminal Domain of Cdc25 Regulates Activity toward Cyclin B1/Cdc2 But Not Cyclin A/Cdk2 ⬇️

Identifying molecular targets mediating the anticancer activity of histone deacetylase inhibitors: a work in progress.

In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.

Inhibition of Aurora A and Aurora B Is Required for the Sensitivity of HPV-Driven Cervical Cancers to Aurora Kinase Inhibitors.

JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.

Keeping replicative stress in Chk.

Keratinocyte Sonic Hedgehog Up-regulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion

Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo.

Mitotic phosphorylation of Cdc25B Ser321 disrupts 14-3-3 binding to the high affinity Ser323 site

Multiparameter analysis of naevi and primary melanomas identifies a subset of naevi with elevated markers of transformation.

Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load

Oxidative stress and cell senescence combine to cause maximal renal tubular epithelial cell dysfunction and loss in an in vitro model of kidney disease.

Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomas

Phosphorylation of Cdc25B3 Ser169 regulates 14-3-3 binding to Ser151 and Cdc25B activity.

Production of a Soluble Cyclin B/cdc2 Substrate for cdc25 Phosphatase ⬇️

RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin.

Rapid mapping of interactions between Human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy.

Self-Renewal and High Proliferative Colony Forming Capacity of Late-Outgrowth Endothelial Progenitors Is Regulated by Cyclin-Dependent Kinase Inhibitors Driven by Notch Signaling.

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

The histone deacetylase inhibitor MGCD0103 has both deacetylase and microtubule inhibitory activity.

Topoisomerase II Inhibitors and Poisons, and the Influence of Cell Cycle Checkpoints

Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cells.

Ultraviolet light-induced G2 phase cell cycle checkpoint blocks cdc25-dependent progression into mitosis ⬇️