Lista de obras - Klaus Groschner - Dominio Público Uruguay

15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis

artículo científico publicado en 2014

2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

artículo científico publicado en 2008

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

artículo científico publicado en 2009

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

artículo científico publicado en 2012

A TRPC3 blocker, Pyr3, prevents stent-induced arterial remodeling

A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide

artículo científico publicado en 2011

A novel STIM1-Orai1 gating interface essential for CRAC channel activation

artículo científico publicado en 2019

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

artículo científico publicado en 2013

A sequence in the carboxy-terminus of the alpha(1C) subunit important for targeting, conductance and open probability of L-type Ca(2+) channels.

artículo científico publicado en 2000

A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators

scientific article published on 16 February 2019

A type 2A phosphatase-sensitive phosphorylation site controls modal gating of L-type Ca2+ channels in human vascular smooth-muscle cells.

artículo científico publicado en 1996

Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells

scientific article published on 01 October 1992

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

artículo científico publicado en 2018

Basal dephosphorylation controls slow gating of L-type Ca2+ channels in human vascular smooth muscle.

artículo científico publicado en 1995

Bile acids induce arrhythmias in human atrial myocardium--implications for altered serum bile acid composition in patients with atrial fibrillation.

artículo científico publicado en 2013

Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.

artículo científico publicado en 2004

Ca2(+)-activated K+ channels in airway smooth muscle are inhibited by cytoplasmic adenosine triphosphate

artículo científico publicado en 1991

CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.

artículo científico publicado en 2004

Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.

artículo científico publicado en 2012

Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention.

artículo científico publicado en 2017

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction

artículo científico publicado en 2010

Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy.

artículo científico publicado en 2006

Characterization of muscarinic receptors mediating endothelium-dependent relaxation of bovine coronary artery

scientific article published on 01 July 1991

Cholesterol modulates Orai1 channel function

scientific article published on 26 January 2016

Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors

artículo científico publicado en 2014

Contribution of agonist-induced hyperpolarization to Ca2+ influx and formation of EDRF in vascular endothelial cells

artículo científico publicado en 1992

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

artículo científico publicado en 2011

Corrigendum: Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain

artículo científico publicado en 2017

Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity

artículo científico publicado en 1993

Crosstalk between voltage-independent Ca2+ channels and L-type Ca2+ channels in A7r5 vascular smooth muscle cells at elevated intracellular pH: evidence for functional coupling between L-type Ca2+ channels and a 2-APB-sensitive cation channel.

artículo científico publicado en 2003

Current modulation and membrane targeting of the calcium channel alpha1C subunit are independent functions of the beta subunit.

artículo científico publicado en 1999

Desensitization of endothelial nitric oxide synthase by receptor agonists

artículo científico publicado en 2002

Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.

artículo científico publicado en 2017

Divergent effects of extracellular and intracellular alkalosis on Ca2+ entry pathways in vascular endothelial cells.

artículo científico publicado en 1997

Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.

artículo científico publicado en 2006

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

artículo científico publicado en 2008

Enhanced Ca2+Entry and Tyrosine Phosphorylation Mediate Nanostructure-Induced Endothelial Proliferation.

artículo científico publicado en 2013

Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells

artículo científico publicado en 1999

Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels.

artículo científico publicado en 2001

Functional impairment of endothelial cells by the antimycotic amphotericin B.

artículo científico publicado en 2016

High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.

artículo científico publicado en 2009

IK.ACh activation by arachidonic acid occurs via a G-protein-independent pathway mediated by the GIRK1 subunit.

artículo científico

Identification of a rare subset of adipose tissue-resident progenitor cells, which express CD133 and TRPC3 as a VEGF-regulated Ca2+ entry channel.

artículo científico publicado en 2008

Identification of amino acid residues relevant for gating and permeation of the cation channel TRPC3

Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.

artículo científico publicado en 2013

Inhibitory effects of aclarubicin on nitric oxide production in aortic smooth muscle cells and macrophages

scientific article published on 01 March 2000

Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core

artículo científico publicado en 2017

Intracellular alkalinization augments alpha(1)-adrenoceptor-mediated vasoconstriction by promotion of Ca(2+) entry through the non-L-type Ca(2+) channels.

artículo científico publicado en 2001

Intracellular pH as a determinant of vascular smooth muscle function.

artículo científico publicado en 2006

Lipid-independent control of endothelial and neuronal TRPC3 channels by light

artículo científico publicado en 2019

Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca(2+)-entry

artículo científico publicado en 2016

Localization of VE-cadherin in plasmalemmal cholesterol rich microdomains and the effects of cholesterol depletion on VE-cadherin mediated cell-cell adhesion.

artículo científico publicado en 2014

Mechanisms of lipid regulation and lipid gating in TRPC channels

artículo científico publicado en 2016

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating ⬇️

artículo científico publicado el 9 de septiembre de 2011

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant

artículo científico publicado en 2009

Molecular engineering of the TRPC3 pore structure identifies Ca2+ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling.

artículo científico publicado en 2010

NH4Cl-induced contraction of porcine coronary artery involves activation of dihydropyridine-sensitive Ca2+ entry

scientific article published on 01 March 1996

NO and cholinergic signalling in the heart: divergent routes to regulatory phosphorylation of the cardiac L-type Ca2+ channel ⬇️

artículo científico publicado el 1 de noviembre de 2003

Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells

artículo científico publicado en 2017

Na+/Ca2+Exchange Facilitates Ca2+-dependent Activation of Endothelial Nitric-oxide Synthase

artículo científico publicado en 1999

Non-Orai Partners of STIM Proteins: Role in ER-PM Communication and Ca2+ Signaling

artículo científico publicado en 2018

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

artículo científico publicado en 2017

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways

artículo científico publicado en 2012

Novel pyrazole inhibitors for discrimination between receptor-operated and store-operated Ca2+ entry

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect

artículo científico publicado en 2016

Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain

scientific article published on 12 December 2016

Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex.

artículo científico publicado en 2006

Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions

scientific article published on 08 April 2019

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line.

artículo científico publicado en 2015

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

artículo científico publicado en 2009

Polymodal TRPC signaling: Emerging role in phenotype switching and tissue remodeling

artículo científico publicado en 2010

Protein kinase-C mediates dual modulation of L-type Ca2+ channels in human vascular smooth muscle

artículo científico publicado en 1994

Protein–Protein Interactions in TRPC Channel Complexes

Reprint of "Mechanisms of lipid regulation and lipid gating in TRPC channels".

artículo científico publicado en 2016

Revelation of an enigmatic signaling machinery-First insights into the mammalian TRPC architecture.

artículo científico publicado en 2018

S-nitrosation controls gating and conductance of the alpha 1 subunit of class C L-type Ca(2+) channels.

artículo científico publicado en 2001

SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells

artículo científico publicado en 1992

STIM1 and Orai1 regulate Ca microdomains for activation of transcription

scientific article published on 06 November 2018

Store-operated calcium entry into rat basophil leukaemia cells: contribution of TRPC3 and Orai1

artículo científico publicado en 2009

Studying Subunit Interaction and Complex Assembly of TRP Channels

artículo científico publicado en 2012

Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes.

artículo científico publicado en 2012

TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes

scientific article published on 24 April 2020

TRPC-mediated Ca2+ signaling and control of cellular functions

scientific article published on 02 March 2019

TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.

artículo científico publicado en 2006

TRPC3 as a Target of Novel Therapeutic Interventions.

artículo científico publicado en 2018

TRPC3 as a key player in electrical remodelling of atrial myocardium

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.

artículo científico publicado en 2015

TRPC3 overexpression promotes angiotensin II-induced cardiac dysfunction

TRPC3/6/7: Topical aspects of biophysics and pathophysiology.

scientific article published on 29 March 2008

TRPC3: a multifunctional signaling molecule.

artículo científico

TRPC3: a multifunctional, pore-forming signalling molecule.

artículo científico publicado en 2007

TRPC4 expression determines sensitivity of the platelet-type capacitative Ca2+ entry channel to intracellular alkalosis.

artículo científico publicado en 2006

The effects of the stereoisomers of propafenone and diprafenone in guinea-pig heart ⬇️

artículo científico publicado el 1 de marzo de 1991

The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.

artículo científico publicado en 2007

The role of myoendothelial cell contact in non-nitric oxide-, non-prostanoid-mediated endothelium-dependent relaxation of porcine coronary artery.

artículo científico publicado en 1994

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.

artículo científico publicado en 2017

Trp proteins form store-operated cation channels in human vascular endothelial cells

artículo científico publicado en 1998

Two ways to feel the pressure: an endothelial Ca(2+) entry channel with dual mechanosensitivity

artículo científico publicado en 2002

Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177.

artículo científico publicado en 2014

Voltage-sensitive chloride channels of large conductance in the membrane of pig aortic endothelial cells

artículo científico publicado en 1992

[Cetirizine]

artículo científico publicado en 1998

Lista de obras de Klaus Groschner

15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis

2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

A TRPC3 blocker, Pyr3, prevents stent-induced arterial remodeling

A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide

A novel STIM1-Orai1 gating interface essential for CRAC channel activation

A novel homology model of TRPC3 reveals allosteric coupling between gate and selectivity filter.

A sequence in the carboxy-terminus of the alpha(1C) subunit important for targeting, conductance and open probability of L-type Ca(2+) channels.

A single point mutation in the TRPC3 lipid-recognition window generates supersensitivity to benzimidazole channel activators

A type 2A phosphatase-sensitive phosphorylation site controls modal gating of L-type Ca2+ channels in human vascular smooth-muscle cells.

Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells

An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.

Basal dephosphorylation controls slow gating of L-type Ca2+ channels in human vascular smooth muscle.

Bile acids induce arrhythmias in human atrial myocardium--implications for altered serum bile acid composition in patients with atrial fibrillation.

Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.

Ca2(+)-activated K+ channels in airway smooth muscle are inhibited by cytoplasmic adenosine triphosphate

CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.

Canonical transient receptor potential (TRPC) 1 acts as a negative regulator for vanilloid TRPV6-mediated Ca2+ influx.

Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention.

Cell-cell contact formation governs Ca2+ signaling by TRPC4 in the vascular endothelium: evidence for a regulatory TRPC4-beta-catenin interaction

Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy.

Characterization of muscarinic receptors mediating endothelium-dependent relaxation of bovine coronary artery

Cholesterol modulates Orai1 channel function

Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors

Contribution of agonist-induced hyperpolarization to Ca2+ influx and formation of EDRF in vascular endothelial cells

Cooperativeness of Orai cytosolic domains tunes subtype-specific gating.

Corrigendum: Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain

Cromakalim inhibits multiple mechanisms of smooth muscle activation with similar stereoselectivity

Crosstalk between voltage-independent Ca2+ channels and L-type Ca2+ channels in A7r5 vascular smooth muscle cells at elevated intracellular pH: evidence for functional coupling between L-type Ca2+ channels and a 2-APB-sensitive cation channel.

Current modulation and membrane targeting of the calcium channel alpha1C subunit are independent functions of the beta subunit.

Desensitization of endothelial nitric oxide synthase by receptor agonists

Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure.

Divergent effects of extracellular and intracellular alkalosis on Ca2+ entry pathways in vascular endothelial cells.

Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

Enhanced Ca2+Entry and Tyrosine Phosphorylation Mediate Nanostructure-Induced Endothelial Proliferation.

Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells

Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels.

Functional impairment of endothelial cells by the antimycotic amphotericin B.

High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.

IK.ACh activation by arachidonic acid occurs via a G-protein-independent pathway mediated by the GIRK1 subunit.

Identification of a rare subset of adipose tissue-resident progenitor cells, which express CD133 and TRPC3 as a VEGF-regulated Ca2+ entry channel.

Identification of amino acid residues relevant for gating and permeation of the cation channel TRPC3

Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.

Inhibitory effects of aclarubicin on nitric oxide production in aortic smooth muscle cells and macrophages

Intensified Microwave-Assisted N-Acylation Procedure - Synthesis and Activity Evaluation of TRPC3 Channel Agonists with a 1,3-Dihydro-2H-benzo[d]imidazol-2-one Core

Intracellular alkalinization augments alpha(1)-adrenoceptor-mediated vasoconstriction by promotion of Ca(2+) entry through the non-L-type Ca(2+) channels.

Intracellular pH as a determinant of vascular smooth muscle function.

Lipid-independent control of endothelial and neuronal TRPC3 channels by light

Live-cell imaging of ER-PM contact architecture by a novel TIRFM approach reveals extension of junctions in response to store-operated Ca(2+)-entry

Localization of VE-cadherin in plasmalemmal cholesterol rich microdomains and the effects of cholesterol depletion on VE-cadherin mediated cell-cell adhesion.

Mechanisms of lipid regulation and lipid gating in TRPC channels

Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating ⬇️

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant

Molecular engineering of the TRPC3 pore structure identifies Ca2+ permeation through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling.

NH4Cl-induced contraction of porcine coronary artery involves activation of dihydropyridine-sensitive Ca2+ entry

NO and cholinergic signalling in the heart: divergent routes to regulatory phosphorylation of the cardiac L-type Ca2+ channel ⬇️

Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells

Na+/Ca2+Exchange Facilitates Ca2+-dependent Activation of Endothelial Nitric-oxide Synthase

Non-Orai Partners of STIM Proteins: Role in ER-PM Communication and Ca2+ Signaling

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways

Novel pyrazole inhibitors for discrimination between receptor-operated and store-operated Ca2+ entry

Optopharmacological control of TRPC channels by coumarin-caged lipids is associated with a phototoxic membrane effect

Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain

Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex.

Photopharmacology and opto-chemogenetics of TRPC channels-some therapeutic visions

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line.

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.

Polymodal TRPC signaling: Emerging role in phenotype switching and tissue remodeling

Protein kinase-C mediates dual modulation of L-type Ca2+ channels in human vascular smooth muscle

Protein–Protein Interactions in TRPC Channel Complexes

Reprint of "Mechanisms of lipid regulation and lipid gating in TRPC channels".

Revelation of an enigmatic signaling machinery-First insights into the mammalian TRPC architecture.

S-nitrosation controls gating and conductance of the alpha 1 subunit of class C L-type Ca(2+) channels.

SK&F 96365 inhibits histamine-induced formation of endothelium-derived relaxing factor in human endothelial cells

STIM1 and Orai1 regulate Ca microdomains for activation of transcription

Store-operated calcium entry into rat basophil leukaemia cells: contribution of TRPC3 and Orai1