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Lista de obras de Kwang-Hyub Han

18F-fluorodeoxyglucose uptake on positron emission tomography as a prognostic predictor in locally advanced hepatocellular carcinoma.

artículo científico publicado en 2011

A 96-week randomized trial of switching to entecavir in chronic hepatitis B patients with a partial virological response to lamivudine.

artículo científico publicado en 2012

A case of embryonal sarcoma of the liver mimicking a hydatid cyst in an adult

artículo científico publicado en 2010

A case of hepaticoduodenal fistula development after transarterial chemoembolization in patient with hepatocellular carcinoma

artículo científico publicado el 25 de septiembre de 2011

A multicenter study of entecavir vs. tenofovir on prognosis of treatment-naïve chronic hepatitis B in South Korea

scientific article published on 06 April 2019

A novel liver stiffness measurement-based prediction model for cirrhosis in hepatitis B patients.

artículo científico publicado en 2010

A randomized comparative study of high-dose and low-dose hepatic arterial infusion chemotherapy for intractable, advanced hepatocellular carcinoma.

artículo científico publicado en 2009

Abnormal liver stiffness assessed using transient elastography (Fibroscan®) in HIV-infected patients without HBV/HCV coinfection receiving combined antiretroviral treatment

artículo científico publicado en 2013

Accuracy of transient elastography in assessing liver fibrosis in chronic viral hepatitis: A multicentre, retrospective study

artículo científico publicado en 2015

Acoustic radiation force impulse elastography: a better option for patients with extrahepatic cholestasis.

artículo científico publicado en 2012

Acute hepatitis A, B and C but not D is still prevalent in Mongolia: a time trend analysis.

artículo científico publicado en 2017

Addition of tumor multiplicity improves the prognostic performance of the hepatoma arterial-embolization prognostic score

artículo científico publicado en 2015

Adjuvant Hepatic Arterial Infusional Chemotherapy with 5-Fluorouracil and Cisplatin after Curative Resection of Hepatocellular Carcinoma

artículo científico publicado el 8 de noviembre de 2011

Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

artículo científico publicado en 2015

Alpha-Fetoprotein, Des-Gamma-Carboxy Prothrombin, and Modified RECIST Response as Predictors of Survival after Transarterial Radioembolization for Hepatocellular Carcinoma

artículo científico publicado en 2019

An Observational, Multicenter, Cohort Study Evaluating the Antiviral Efficacy and Safety in Korean Patients With Chronic Hepatitis B Receiving Pegylated Interferon-alpha 2a (Pegasys): TRACES Study

artículo científico publicado en 2016

An observational study on long-term renal outcome in patients with chronic hepatitis B treated with tenofovir disoproxil fumarate

artículo científico publicado en 2020

Analysis of miRNA expression patterns in human and mouse hepatocellular carcinoma cells.

artículo científico

Angled Cool-Tip Electrode for Radiofrequency Ablation of Small Superficial Subcapsular Tumors in the Liver: A Feasibility Study

artículo científico publicado en 2016

Anti-hepatitis A virus seroprevalence among patients with chronic viral liver disease in Korea.

artículo científico publicado en 2007

Antibody-secreting cells with a phenotype of Ki-67low, CD138high, CD31high, and CD38high secrete nonspecific IgM during primary hepatitis A virus infection.

artículo científico publicado en 2013

Antifibrotic effects of magnesium lithospermate B on hepatic stellate cells and thioacetamide-induced cirrhotic rats

artículo científico publicado el 30 de junio de 2011

Antiviral efficacy of lamivudine versus entecavir in patients with hepatitis B virus-related advanced hepatocellular carcinoma.

artículo científico publicado en 2012

Applicability of BCLC stage for prognostic stratification in comparison with other staging systems: single centre experience from long-term clinical outcomes of 1717 treatment-naïve patients with hepatocellular carcinoma.

artículo científico publicado en 2012

Ascites and spontaneous bacterial peritonitis: an Asian perspective.

scientific article published on September 2009

Ascitic fluid infection in patients with hepatitis B virus-related liver cirrhosis: culture-negative neutrocytic ascites versus spontaneous bacterial peritonitis

artículo científico publicado en 2009

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

artículo científico publicado en 2010

Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update

artículo científico publicado en 2012

Association Between Level of Fibrosis, Rather Than Antiviral Regimen, and Outcomes of Patients With Chronic Hepatitis B.

artículo científico publicado en 2016

Association between IL28B polymorphisms and spontaneous clearance of hepatitis B virus infection.

artículo científico publicado en 2013

Association between polymorphism of tumor necrosis factor-alpha promoter and response to lamivudine treatment in patients with chronic hepatitis B.

artículo científico publicado en 2009

Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea.

artículo científico publicado en 2006

Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S)

artículo científico publicado en 2014

Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats.

artículo científico publicado en 2009

Cell culture-adaptive mutations of NS5A affect replication of hepatitis C virus differentially depending on the viral genotypes.

artículo científico publicado en 2016

Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma

scientific article published on 26 August 2020

Characterization of focal liver masses using acoustic radiation force impulse elastography.

artículo científico publicado en 2013

Chemotherapy for advanced hepatocellular carcinoma

scientific article published on 01 May 2008

Chronic HBV infection with persistently normal ALT b. not to treat

Clinical Benefit of Hepatic Arterial Infusion Concurrent Chemoradiotherapy in Locally Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis

artículo científico publicado en 2015

Clinical Utility of a New Automated Hepatitis C Virus Core Antigen Assay for Prediction of Treatment Response in Patients with Chronic Hepatitis C.

artículo científico publicado en 2016

Clinical application of liver stiffness measurement using transient elastography: a surgical perspective

artículo científico publicado en 2013

Clinical application of transient elastography in patients with chronic viral hepatitis receiving antiviral treatment.

artículo científico

Clinical characteristics of acute hepatitis A complicated by acute kidney injury

artículo científico publicado el 8 de julio de 2011

Clinical factors related to recurrence after hepatic arterial concurrent chemoradiotherapy for advanced but liver-confined hepatocellular carcinoma.

scientific article published on 30 April 2013

Clinical features and prognosis of hepatocellular carcinoma in Mongolia: a multicentre study.

artículo científico publicado en 2011

Clinical features and prognosis of hepatocellular carcinoma with respect to pre‐S deletion and basal core promoter mutations of hepatitis B virus Genotype C2

artículo científico publicado el 1 de diciembre de 2011

Clinical features and prognosis of spontaneous bacterial peritonitis in korean patients with liver cirrhosis: a multicenter retrospective study.

artículo científico publicado en 2009

Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis.

artículo científico publicado en 2008

Clinical outcome of renal transplantation in patients with positive pre-transplant hepatitis B surface antigen.

artículo científico publicado en 2007

Clinical outcomes and predictors for relapse after cessation of oral antiviral treatment in chronic hepatitis B patients.

artículo científico publicado en 2015

Clinical outcomes and prognostic factors of patients with advanced hepatocellular carcinoma treated with sorafenib as first-line therapy: a Korean multicenter study

artículo científico publicado en 2014

Clinical predictors of silent but substantial liver fibrosis in primary Sjogren's syndrome.

artículo científico publicado en 2015

Clinical usefulness of double biomarkers AFP and PIVKA-II for subdividing prognostic groups in locally advanced hepatocellular carcinoma.

artículo científico publicado en 2013

Clinicopathological Characteristics in Combined Hepatocellular-Cholangiocarcinoma: A Single Center Study in Korea

artículo científico publicado el 1 de septiembre de 2011

Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy.

artículo científico publicado en 2015

Combination of Transient Elastography and an Enhanced Liver Fibrosis Test to Assess the Degree of Liver Fibrosis in Patients with Chronic Hepatitis B.

artículo científico publicado en 2018

Combination of preS deletions and A1762T/G1764A mutations in HBV subgenotype C2 increases the risk of developing HCC.

artículo científico publicado en 2011

Combination treatment of localized concurrent chemoradiation therapy and transarterial chemoembolization in locally advanced hepatocellular carcinoma with intrahepatic metastasis.

artículo científico publicado en 2012

Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats.

artículo científico publicado en 2013

Combined measurement of preoperative α-fetoprotein and des-γ-carboxy prothrombin predicts recurrence after curative resection in patients with hepatitis-B-related hepatocellular carcinoma.

artículo científico publicado en 2012

Combined use of AFP, PIVKA-II, and AFP-L3 as tumor markers enhances diagnostic accuracy for hepatocellular carcinoma in cirrhotic patients

artículo científico publicado en 2015

Comparison between chronic hepatitis B patients with untreated immune-tolerant phase vs. those with virological response by antivirals

artículo científico publicado en 2019

Comparison of the Effects of Telbivudine and Entecavir Treatment on Estimated Glomerular Filtration Rate in Patients with Chronic Hepatitis B.

artículo científico publicado en 2015

Complete response at first chemoembolization is still the most robust predictor for favorable outcome in hepatocellular carcinoma

artículo científico publicado en 2015

Concurrent chemoradiotherapy shows long-term survival after conversion from locally advanced to resectable hepatocellular carcinoma

artículo científico publicado en 2014

Conditional Survival Estimates Improve Over Time for Patients with Hepatocellular Carcinoma: An Analysis for Nationwide Korea Cancer Registry Database

artículo científico publicado en 2019

Conditional survival estimate in patients with Barcelona Clinic Liver Cancer stage B/C hepatocellular carcinoma treated with hepatic arterial infusion chemotherapy with/without concurrent radiotherapy.

artículo científico publicado en 2017

Consensus for Radiotherapy in Hepatocellular Carcinoma from The 5th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2014): Current Practice and Future Clinical Trials.

artículo científico publicado en 2016

Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma (EPOIHCC).

artículo científico

Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population.

artículo científico publicado en 2013

Conventional versus drug-eluting beads chemoembolization for hepatocellular carcinoma: Emphasis on the impact of tumor size.

artículo científico publicado en 2016

Cryoablation of Hepatocellular Carcinoma with High-Risk for Percutaneous Ablation: Safety and Efficacy.

artículo científico publicado en 2016

Daclatasvir Plus Asunaprevir for the Treatment of Patients with Hepatitis C Virus Genotype 1b Infection: Real-World Efficacy, Changes in Liver Stiffness and Fibrosis Markers, and Safety

artículo científico publicado en 2018

Development and validation of a prognostic model for patients with hepatocellular carcinoma undergoing radiofrequency ablation

scientific article published on 10 July 2019

Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization.

artículo científico publicado en 2019

Development of a transgenic mouse model of hepatocellular carcinoma with a liver fibrosis background.

artículo científico publicado en 2016

Dickkopf-1 induces angiogenesis via VEGF receptor 2 regulation independent of the Wnt signaling pathway.

artículo científico publicado en 2017

Diffusion and perfusion MRI prediction of progression-free survival in patients with hepatocellular carcinoma treated with concurrent chemoradiotherapy

artículo científico publicado en 2013

Discrimination of Nonalcoholic Steatohepatitis Using Transient Elastography in Patients with Nonalcoholic Fatty Liver Disease

artículo científico publicado en 2016

Dose escalation by intensity modulated radiotherapy in liver-directed concurrent chemoradiotherapy for locally advanced BCLC stage C hepatocellular carcinoma

scientific article published on 11 January 2019

Dose escalation in radiotherapy for incomplete transarterial chemoembolization of hepatocellular carcinoma

artículo científico publicado en 2019

Durability of the virological response after lamivudine discontinuation in lamivudine-resistant patients with a complete virological response after lamivudine and adefovir combination therapy.

artículo científico publicado en 2016

Early Predictor of Mortality due to Irreversible Posthepatectomy Liver Failure in Patients with Hepatocellular Carcinoma

artículo científico publicado en 2013

Early on-treatment change in liver stiffness predicts development of liver-related events in chronic hepatitis B patients receiving antiviral therapy.

artículo científico publicado en 2013

Early on-treatment predictions of clinical outcomes using alpha-fetoprotein and des-gamma-carboxy prothrombin responses in patients with advanced hepatocellular carcinoma.

artículo científico publicado en 2012

Early α-fetoprotein response as a predictor for clinical outcome after localized concurrent chemoradiotherapy for advanced hepatocellular carcinoma.

artículo científico publicado en 2010

Effect of yttrium-90 radioembolization on outcomes in Asian patients with early to advanced stage hepatocellular carcinoma.

artículo científico publicado en 2016

Effective biliary drainage and proper treatment improve outcomes of hepatocellular carcinoma with obstructive jaundice.

artículo científico publicado en 2014

Effects of Entecavir and Tenofovir on Renal Function in Patients with Hepatitis B Virus-Related Compensated and Decompensated Cirrhosis

artículo científico publicado en 2017

Effects of the knockdown of hypoxia inducible factor-1α expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines.

artículo científico publicado en 2010

Efficacy and Safety of Besifovir Dipivoxil Maleate Compared With Tenofovir Disoproxil Fumarate in Treatment of Chronic HBV Infection

artículo científico publicado en 2018

Efficacy and safety of transarterial chemoembolization in recurrent hepatocellular carcinoma after curative surgical resection.

artículo científico publicado en 2009

Efficacy of adefovir add-on lamivudine rescue therapy compared with switching to entecavir monotherapy in patients with lamivudine-resistant chronic hepatitis B.

artículo científico publicado en 2010

Efficacy of perifosine alone and in combination with sorafenib in an HrasG12V plus shp53 transgenic mouse model of hepatocellular carcinoma

scientific article published on 03 June 2015

Efficacy of switching from adefovir to tenofovir in chronic hepatitis B patients who exhibit suboptimal responses to adefovir-based combination rescue therapy due to resistance to nucleoside analogues (SATIS study).

artículo científico publicado en 2016

Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir

artículo científico publicado en 2013

Efficient long-term amplification of hepatitis B virus isolates after infection of slow proliferating HepG2-NTCP cells

scientific article published on 08 May 2019

Emerging therapies for hepatitis C

artículo científico publicado en 2014

Entecavir plus tenofovir combination therapy in patients with multidrug-resistant chronic hepatitis B: results of a multicentre, prospective study.

artículo científico publicado en 2016

Epidemiology of hepatocellular carcinoma in Japan and Korea. A review.

artículo científico publicado en 2008

Erratum to: Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update

artículo científico publicado en 2012

Estimating the Cost-Effectiveness of One-Time Screening and Treatment for Hepatitis C in Korea.

artículo científico publicado en 2017

Evaluation of the prognostic value of Okuda, Cancer of the Liver Italian Program, and Japan Integrated Staging systems for hepatocellular carcinoma patients undergoing radiotherapy

artículo científico publicado en 2007

Evolution from WHO to EASL and mRECIST for hepatocellular carcinoma: considerations for tumor response assessment.

artículo científico publicado en 2014

External validation of P2/MS and comparison with other simple non-invasive indices for predicting liver fibrosis in HBV-infected patients.

artículo científico publicado en 2009

Extremely low risk of hepatocellular carcinoma development in patients with chronic hepatitis B in immune-tolerant phase

scientific article published on 26 May 2020

Factors Influencing the Diagnostic Accuracy of Acoustic Radiation Force Impulse Elastography in Patients with Chronic Hepatitis B.

artículo científico publicado en 2015

Factors associated with significant liver fibrosis assessed using transient elastography in general population.

artículo científico publicado en 2015

Factors predictive of response to interferon-alpha therapy in hepatitis C virus type 1b infection.

artículo científico publicado en 2002

Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B

artículo científico publicado en 2010

Fatal spontaneous bacterial peritonitis by Leclercia adecarboxylata in a patient with hepatocellular carcinoma

artículo científico publicado en 2008

Feasibility of dynamic risk assessment for patients with repeated trans-arterial chemoembolization for hepatocellular carcinoma

artículo científico publicado en 2019

Feasibility of dynamic risk prediction for hepatocellular carcinoma development in patients with chronic hepatitis B.

artículo científico publicado en 2017

Feasibility of sorafenib combined with local radiotherapy in advanced hepatocellular carcinoma

artículo científico publicado en 2013

Fibrosis-matched outcomes between chronic hepatitis B patients with drug-induced virological response and inactive carriers

artículo científico publicado en 2018

Gallbladder wall thickening in patients with acute hepatitis.

artículo científico publicado en 2009

Gastroduodenal complications after concurrent chemoradiation therapy in patients with hepatocellular carcinoma: endoscopic findings and risk factors.

artículo científico publicado en 2010

Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean

artículo científico publicado en 2012

Graft function measured by transient elastography in living donor liver transplantation: preliminary.

artículo científico publicado en 2013

Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease

artículo científico publicado en 2015

HBsAg-negative and anti-HBc-positive in eosinophilic granulomatosis with polyangiitis: a retrospective pilot study.

artículo científico publicado en 2018

Hepatic Steatosis Index in the Detection of Fatty Liver in Patients with Chronic Hepatitis B Receiving Antiviral Therapy

scientific article published on 20 February 2020

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

artículo científico

Hepatic fibrosis assessed using transient elastography independently associated with coronary artery calcification.

artículo científico publicado en 2015

Hepatic splenosis preoperatively diagnosed as hepatocellular carcinoma in a patient with chronic hepatitis B: a case report.

artículo científico publicado en 2008

Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid

artículo científico

Hepatitis B e antigen-negative mutations in the precore and core promoter regions in Korean patients.

artículo científico publicado en 2009

Hepatitis B virus serology to predict antiviral response in chronic hepatitis B.

artículo científico

Hepatitis C Virus and Antiviral Drug Resistance

artículo científico publicado en 2016

Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions

artículo científico publicado en 2014

Hepatocellular carcinoma in Budd-Chiari syndrome: a single center experience with long-term follow-up in South Korea.

artículo científico publicado en 2012

Hepatocellular carcinoma presenting with bone metastasis: clinical characteristics and prognostic factors.

artículo científico publicado en 2008

Hepatocellular carcinoma specific graded prognostic assessment can predict outcomes for patients with brain metastases from hepatocellular carcinoma

artículo científico publicado en 2014

High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway

artículo científico

Histological subclassification of cirrhosis can predict recurrence after curative resection of hepatocellular carcinoma.

artículo científico publicado en 2014

How to improve treatment outcomes for hepatocellular carcinoma of intermediate and advanced stage.

artículo científico publicado en 2012

Identification of Proteins Indicating Radiation-induced Hepatic Toxicity in Cirrhotic Rats

artículo científico publicado el 1 de enero de 2010

Impact of Hepatitis B Virus (HBV) X Gene Mutations on Hepatocellular Carcinoma Development in Chronic HBV Infection

artículo científico publicado el 13 de abril de 2011

Impact of spontaneous hepatocellular carcinoma rupture on recurrence pattern and long-term surgical outcomes after partial hepatectomy.

artículo científico publicado en 2014

Improved oncologic outcomes with image-guided intensity-modulated radiation therapy using helical tomotherapy in locally advanced hepatocellular carcinoma

scientific article published on 09 May 2014

Improvement of Liver Fibrosis after Long-Term Antiviral Therapy Assessed by Fibroscan in Chronic Hepatitis B Patients With Advanced Fibrosis

artículo científico publicado en 2017

Incidence and risk factors of delayed postpolypectomy bleeding in patients with chronic liver disease.

artículo científico publicado en 2015

Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with transient elastography-defined subclinical cirrhosis

artículo científico publicado en 2015

Influence of Besifovir Dipivoxil Maleate Combined with L-Carnitine on Hepatic Steatosis in Patients with Chronic Hepatitis B

artículo científico publicado en 2020

Inhibition of tumour angiogenesis and growth by small hairpin HIF-1α and IL-8 in hepatocellular carcinoma

artículo científico publicado en 2013

Inter-observer variability of response evaluation criteria for hepatocellular carcinoma treated with chemoembolization

artículo científico publicado en 2015

Investigation of oncogenic cooperation in simple liver-specific transgenic mouse models using noninvasive in vivo imaging.

artículo científico publicado en 2013

Is local radiotherapy still valuable for patients with multiple intrahepatic hepatocellular carcinomas?

artículo científico publicado en 2009

Knockdown of HIF-1α and IL-8 induced apoptosis of hepatocellular carcinoma triggers apoptosis of vascular endothelial cells

artículo científico publicado en 2015

Lamivudine maintenance beyond one year after HBeAg seroconversion is a major factor for sustained virologic response in HBeAg-positive chronic hepatitis B.

artículo científico publicado en 2010

Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir

artículo científico publicado en 2012

Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection.

artículo científico publicado en 2017

Liver Cirrhosis, Not Antiviral Therapy, Predicts Clinical Outcome in Cohorts with Heterogeneous Hepatitis B Viral Status

artículo científico publicado en 2019

Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients

scientific article published on 14 February 2019

Liver cancer in Korea

artículo científico publicado en 2007

Liver cancer: Approaching a personalized care

artículo científico publicado en 2015

Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke

artículo científico publicado en 2017

Liver stiffness measurement in combination with noninvasive markers for the improved diagnosis of B-viral liver cirrhosis.

artículo científico publicado en 2009

Liver stiffness measurement using FibroScan is influenced by serum total bilirubin in acute hepatitis.

artículo científico publicado en 2008

Liver stiffness measurement using acoustic radiation force impulse (ARFI) elastography and effect of necroinflammation.

artículo científico publicado en 2012

Liver stiffness value-based risk estimation of late recurrence after curative resection of hepatocellular carcinoma: development and validation of a predictive model

artículo científico publicado en 2014

Liver stiffness-based model for prediction of hepatocellular carcinoma in chronic hepatitis B virus infection: comparison with histological fibrosis.

artículo científico publicado en 2014

Long-Term Follow-Up of Patients After Autologous Bone Marrow Cell Infusion for Decompensated Liver Cirrhosis.

artículo científico publicado en 2017

Long-term Outcomes of Antiviral Therapy in Patients With Advanced Chronic HBV Infection

scientific article published on 05 February 2019

Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B.

artículo científico publicado en 2010

Long-term changes of liver stiffness values assessed using transient elastography in patients with chronic hepatitis B receiving entecavir.

artículo científico publicado en 2013

Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance.

artículo científico

Long-term clinical outcome of large volume paracentesis with intravenous albumin in patients with spontaneous bacterial peritonitis: a randomized prospective study.

artículo científico

Long-term clinical outcome of phase IIb clinical trial of percutaneous injection with holmium-166/chitosan complex (Milican) for the treatment of small hepatocellular carcinoma

artículo científico

Long-term clinical outcomes of hepatic arterial infusion chemotherapy with cisplatin with or without 5-fluorouracil in locally advanced hepatocellular carcinoma.

artículo científico publicado en 2010

Long-term outcome of chronic hepatitis B based on histological grade and stage.

artículo científico

Long-term outcomes of chronic hepatitis B virus infection in the era of antiviral therapy in Korea.

artículo científico publicado en 2014

Lower incidence of hepatocellular carcinoma and cirrhosis in hepatitis C patients with sustained virological response by pegylated interferon and ribavirin

artículo científico

MRP2 haplotypes confer differential susceptibility to toxic liver injury

artículo científico publicado en 2007

Maintaining remission in lamivudine-resistant patients with a virological response to adefovir add-on lamivudine after stopping lamivudine therapy.

artículo científico publicado en 2014

Multicenter Retrospective Risk Assessment of Esophageal Variceal Bleeding in Patients with Cirrhosis: An Acoustic Radiation Force Impulse Elastography-Based Prediction Model

article

New automated hepatitis C virus (HCV) core antigen assay as an alternative to real-time PCR for HCV RNA quantification.

artículo científico publicado en 2010

New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia

artículo científico publicado en 2014

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations.

artículo científico publicado en 2012

Non-invasive assessment of changes in liver fibrosis via liver stiffness measurement in patients with chronic hepatitis B: impact of antiviral treatment on fibrosis regression

artículo científico publicado el 4 de agosto de 2010

Non-invasive prediction of development of hepatocellular carcinoma using transient elastography in patients with chronic liver disease.

artículo científico publicado en 2014

Noncontrast magnetic resonance imaging versus ultrasonography for hepatocellular carcinoma surveillance (MIRACLE-HCC): study protocol for a prospective randomized trial

scientific article published on 24 September 2018

Noninvasive Prediction of Erosive Esophagitis Using a Controlled Attenuation Parameter (CAP)-Based Risk Estimation Model

artículo científico publicado en 2015

Noninvasive models to predict liver cirrhosis in patients with chronic hepatitis B.

artículo científico

Non‐invasive assessment of liver fibrosis: The gap between ideal and real

artículo científico publicado el 1 de junio de 2011

Non‐invasive assessment of liver fibrosis: Time to move from cross‐sectional studies to longitudinal ones

artículo científico publicado el 1 de septiembre de 2010

Normal controlled attenuation parameter values: a prospective study of healthy subjects undergoing health checkups and liver donors in Korea.

artículo científico publicado en 2014

Number of target lesions for EASL and modified RECIST to predict survivals in hepatocellular carcinoma treated with chemoembolization.

artículo científico publicado en 2012

Optimal time for restoring the reliability of liver stiffness measurement in patients with chronic hepatitis B experiencing acute exacerbation

scientific article published on 01 August 2012

Outcome of adefovir add-on lamivudine rescue therapy of up to 5 years in patients with lamivudine-resistant chronic hepatitis B.

artículo científico publicado en 2015

Overall response of both intrahepatic tumor and portal vein tumor thrombosis is a good prognostic factor for hepatocellular carcinoma patients receiving concurrent chemoradiotherapy.

artículo científico publicado en 2013

PIVKA-II is a useful tumor marker for recurrent hepatocellular carcinoma after surgical resection.

artículo científico publicado en 2007

Partial virological response to adefovir add-on lamivudine rescue therapy in patients with lamivudine-resistant chronic hepatitis B.

artículo científico publicado en 2013

Partial virological response to entecavir in treatment-naive patients with chronic hepatitis B.

artículo científico publicado en 2011

Performance evaluation of the HepB Typer-Entecavir kit for detection of entecavir resistance mutations in chronic hepatitis B.

artículo científico publicado en 2013

Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis.

artículo científico publicado en 2012

Persistent hepatitis B viral replication affects recurrence of hepatocellular carcinoma after curative resection.

artículo científico publicado en 2007

Phase I dose escalation study of helical intensity-modulated radiotherapy-based stereotactic body radiotherapy for hepatocellular carcinoma

artículo científico publicado en 2016

Phase I/II trial of helical IMRT-based stereotactic body radiotherapy for hepatocellular carcinoma

artículo científico publicado en 2018

Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B.

artículo científico publicado en 2013

Predicting Liver-Related Events Using Transient Elastography in Chronic Hepatitis C Patients with Sustained Virological Response

artículo científico publicado en 2015

Prediction of development of liver-related events by transient elastography in hepatitis B patients with complete virological response on antiviral therapy.

artículo científico publicado en 2014

Prediction of esophageal variceal bleeding in B-viral liver cirrhosis using the P2/MS noninvasive index based on complete blood counts.

artículo científico publicado en 2012

Prediction of liver-related events using fibroscan in chronic hepatitis B patients showing advanced liver fibrosis.

artículo científico publicado en 2012

Prediction of microvascular invasion before curative resection of hepatocellular carcinoma.

artículo científico

Prediction of postoperative hepatic insufficiency by liver stiffness measurement (FibroScan((R))) before curative resection of hepatocellular carcinoma: a pilot study

artículo científico publicado en 2008

Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan®).

artículo científico publicado en 2012

Prediction of significant fibrosis in chronic hepatitis C patients with normal ALT

artículo científico publicado en 2011

Prediction of virologic response to tenofovir mono-rescue therapy for multidrug resistant chronic hepatitis B.

artículo científico publicado en 2015

Predictive Factors of Spontaneous Bacterial Peritonitis Caused by Gram-Positive Bacteria in Patients With Cirrhosis

artículo científico publicado en 2016

Predictive factors for long-term survival in patients with clinically significant portal hypertension following resection of hepatocellular carcinoma

artículo científico publicado el 15 de febrero de 2011

Predictive validation of qualitative fibrosis staging in patients with chronic hepatitis B on antiviral therapy

scientific article published on 30 October 2019

Predictive value of HBsAg quantification for determining the clinical course of genotype C HBeAg-negative carriers.

artículo científico publicado en 2011

Predictive value of liver cell dysplasia for development of hepatocellular carcinoma in patients with chronic hepatitis B.

artículo científico publicado en 2008

Predictors of Discordance in the Assessment of Skeletal Muscle Mass between Computed Tomography and Bioimpedance Analysis

artículo científico publicado en 2019

Predictors of failure to detect early hepatocellular carcinoma in patients with chronic hepatitis B who received regular surveillance.

artículo científico publicado en 2018

Predictors of refractory ascites development in patients with hepatitis B virus-related cirrhosis hospitalized to control ascitic decompensation

artículo científico publicado en 2013

Prevalence and Predictors of Significant Fibrosis Among Subjects with Transient Elastography-Defined Nonalcoholic Fatty Liver Disease.

artículo científico publicado en 2017

Prevention of hepatocellular carcinoma in patients with chronic hepatitis B virus infection.

artículo científico publicado en 2011

Prevention of hepatocellular carcinoma: beyond hepatitis B vaccination.

artículo científico

Pro-tumorigenic roles of TGF-β signaling during the early stages of liver tumorigenesis through upregulation of Snail.

artículo científico publicado en 2017

Prognosis of Untreated Minimally Active Chronic Hepatitis B Patients in Comparison With Virological Responders by Antivirals

artículo científico publicado en 2019

Prognosis of hepatocellular carcinoma patients with extrahepatic metastasis and the controllability of intrahepatic lesions.

artículo científico publicado en 2014

Prognostic Value of Alpha-Fetoprotein in Patients Who Achieve a Complete Response to Transarterial Chemoembolization for Hepatocellular Carcinoma

artículo científico publicado en 2021

Prognostic Value of FDG Uptake of Portal Vein Tumor Thrombosis in Patients With Locally Advanced Hepatocellular Carcinoma.

artículo científico publicado en 2017

Prognostic factors of sorafenib therapy in hepatocellular carcinoma patients with failure of transarterial chemoembolization

artículo científico publicado en 2017

Prognostic indicators for acute liver failure development and mortality in patients with hepatitis A: consecutive case analysis

artículo científico publicado en 2014

Prognostic role of magnetic resonance imaging vs. computed tomography for hepatocellular carcinoma undergoing chemoembolization.

artículo científico publicado en 2015

Prognostic value of 18F-FDG PET for hepatocellular carcinoma patients treated with sorafenib.

artículo científico publicado en 2011

Prognostic value of model for end-stage liver disease scores in patients with fulminant hepatic failure.

artículo científico publicado en 2013

Prognostic value of the 7th edition of the AJCC staging system as a clinical staging system in patients with hepatocellular carcinoma.

artículo científico publicado en 2011

Prognostic value of the combined use of transient elastography and fibrotest in patients with chronic hepatitis B.

artículo científico

Prognostic value of α-fetoprotein and des-γ-carboxy prothrombin responses in patients with hepatocellular carcinoma treated with transarterial chemoembolization.

artículo científico publicado en 2013

Progression of Untreated Minimally Active Chronic HBV Infection Compared to Inactive Infection

scientific article published on 11 January 2019

Proposal of a New Risk Score for Patients Treated with Transarterial Chemoembolization due to Recurrent Hepatocellular Carcinoma after Curative Resection: A Multicenter Study

artículo científico publicado en 2019

Prospective validation of ELF test in comparison with Fibroscan and FibroTest to predict liver fibrosis in Asian subjects with chronic hepatitis B.

artículo científico publicado en 2012

Quantitative hepatitis B surface antigen and hepatitis B e antigen titers in prediction of treatment response to entecavir.

artículo científico publicado en 2011

Quasispecies and pre-existing drug-resistant mutations of hepatitis B virus in patients with chronic hepatitis B

artículo científico publicado en 2013

Radiation-induced hepatic toxicity after radiotherapy combined with chemotherapy for hepatocellular carcinoma

scientific article published on 04 July 2007

Radioembolization With Yttrium-90 Resin Microspheres in Hepatocellular Carcinoma: A Multicenter Prospective Study.

artículo científico publicado en 2013

Radiological response predicts survival following transarterial chemoembolisation in patients with unresectable hepatocellular carcinoma.

artículo científico publicado en 2012

Radiological-pathological correlation study of hepatocellular carcinoma undergoing local chemoradiotherapy and surgery.

artículo científico publicado en 2016

Radiotherapeutic parameters predictive of liver complications induced by liver tumor radiotherapy.

artículo científico publicado en 2008

Re-evaluating transarterial chemoembolization for the treatment of hepatocellular carcinoma: Consensus recommendations and review by an International Expert Panel.

artículo científico publicado en 2013

Recent variceal bleeding: Doppler US hepatic vein waveform in assessment of severity of portal hypertension and vasoactive drug response.

artículo científico publicado en 2006

Red cell volume distribution width-to-platelet ratio in assessment of liver fibrosis in patients with chronic hepatitis B.

artículo científico publicado en 2015

Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus-related advanced fibrosis or cirrhosis.

artículo científico publicado en 2017

Reimbursement policies in the Asia-Pacific for chronic hepatitis B.

artículo científico publicado en 2014

Relationship between Cerebral Microbleeds and Liver Stiffness Determined by Transient Elastography

artículo científico publicado en 2015

Repetitive short-course hepatic arterial infusion chemotherapy with high-dose 5-fluorouracil and cisplatin in patients with advanced hepatocellular carcinoma.

artículo científico

Reproducibility of European Association for the Study of the Liver criteria and modified Response Evaluation Criteria in Solid Tumors in patients treated with sorafenib.

artículo científico publicado en 2018

Retrospective analysis of stereotactic body radiation therapy efficacy over radiofrequency ablation for hepatocellular carcinoma

scientific article published on 31 December 2018

Risk Assessment of Hepatitis B Virus–Related Hepatocellular Carcinoma Development Using Liver Stiffness Measurement (FibroScan) σ

artículo científico publicado el 11 de febrero de 2011

Risk Assessment of Hepatocellular Carcinoma Using Transient Elastography Vs. Liver Biopsy in Chronic Hepatitis B Patients Receiving Antiviral Therapy

artículo científico publicado en 2016

Risk assessment of clinical outcomes in Asian patients with chronic hepatitis B using enhanced liver fibrosis test.

artículo científico publicado en 2014

Risk assessment of esophageal variceal bleeding in B-viral liver cirrhosis by a liver stiffness measurement-based model.

artículo científico publicado en 2011

Risk assessment of hepatocellular carcinoma development for indeterminate hepatic nodules in patients with chronic hepatitis B

scientific article published on 31 May 2019

Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score.

artículo científico publicado en 2011

Risk prediction for patients with hepatocellular carcinoma undergoing chemoembolization: development of a prediction model

artículo científico publicado en 2015

Risk stratification for locally advanced hepatocellular carcinoma using pretreatment alpha-foetoprotein and 18 F-fluoro-2-deoxyglucose positron emission tomography.

artículo científico publicado en 2016

Role of 18F-fluorodeoxyglucose positron emission tomography in detecting extrahepatic metastasis in pretreatment staging of hepatocellular carcinoma.

artículo científico publicado en 2007

Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection.

artículo científico publicado en 2009

Sarcopaenia is associated with NAFLD independently of obesity and insulin resistance: Nationwide surveys (KNHANES 2008-2011)

artículo científico publicado en 2015

Sarcopenia Is Independently Associated with the Degree of Liver Fibrosis in Patients with Type 2 Diabetes Mellitus

artículo científico publicado en 2020

Sarcopenia assessed using bioimpedance analysis is associated independently with significant liver fibrosis in patients with chronic liver diseases

artículo científico publicado en 2020

Sarcopenia is associated with significant liver fibrosis independently of obesity and insulin resistance in nonalcoholic fatty liver disease: Nationwide surveys (KNHANES 2008-2011).

artículo científico publicado en 2015

Selection of the optimal radiotherapy technique for locally advanced hepatocellular carcinoma

artículo científico publicado en 2011

Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.

artículo científico publicado en 2017

Serotonin signals through a gut-liver axis to regulate hepatic steatosis

artículo científico publicado en 2018

Serum Dickkopf-1 as a Biomarker for the Diagnosis of Hepatocellular Carcinoma.

artículo científico publicado en 2015

Serum cytokine levels in chronic hepatitis B patients receiving peginterferon alpha-2a therapy.

artículo científico publicado en 2012

Serum cytokine levels in patients with chronic hepatitis B according to lamivudine therapy.

artículo científico publicado en 2011

Serum hyaluronic acid level: correlation with quantitative measurement of hepatic fibrosis in a cirrhotic rat model

artículo científico publicado en 2008

Silencing of hypoxia-inducible factor-1β induces anti-tumor effects in hepatoma cell lines under tumor hypoxia

artículo científico publicado en 2014

Sorafenib versus cytotoxic chemotherapy for patients with advanced hepatocellular carcinoma: a retrospective, single-institution study

artículo científico publicado el 20 de enero de 2011

Specific mutations in the enhancer II/core promoter/precore regions of hepatitis B virus subgenotype C2 in Korean patients with hepatocellular carcinoma.

artículo científico publicado en 2009

Spontaneous bacterial peritonitis in patients with hepatitis B virus-related liver cirrhosis: community-acquired versus nosocomial.

artículo científico publicado en 2012

Staged partial hepatectomy versus transarterial chemoembolization for the treatment of spontaneous hepatocellular carcinoma rupture: a multicenter analysis in Korea

scientific article published on 29 May 2019

Staging for hepatocellular carcinoma in light of tumor heterogeneity: Time to change or update?

artículo científico publicado en 2017

Subcirrhotic liver stiffness by FibroScan correlates with lower risk of hepatocellular carcinoma in patients with HBV-related cirrhosis.

artículo científico publicado en 2017

Subclassification of Barcelona Clinic Liver Cancer B and C hepatocellular carcinoma: A cohort study of the multicenter registry database.

artículo científico publicado en 2015

Subclinical but significant liver fibrosis in patients with ANCA-associated vasculitis

artículo científico publicado en 2018

Surgical resection after down-staging of locally advanced hepatocellular carcinoma by localized concurrent chemoradiotherapy.

artículo científico publicado en 2014

Surgical resection for pulmonary metastasis from hepatocellular carcinoma: analysis of prognosis in relation to primary control

artículo científico publicado en 2010

Survival Estimates after Stopping Sorafenib in Patients with Hepatocellular Carcinoma: NEXT Score Development and Validation.

artículo científico publicado en 2017

Survival of hepatocellular carcinoma patients may be improved in surveillance interval not more than 6 months compared with more than 6 months: a 15-year prospective study.

artículo científico publicado en 2013

Switching from tenofovir and nucleoside analogue therapy to tenofovir monotherapy in virologically suppressed chronic hepatitis B patients with antiviral resistance

artículo científico publicado en 2017

Systemic treatment in advanced/metastatic hepatocellular carcinoma in the era of targeted therapy.

artículo científico publicado en 2010

Tenofovir disoproxil fumarate monotherapy for nucleos(t)ide-naïve chronic hepatitis B patients in Korea: data from the clinical practice setting in a single-center cohort.

artículo científico publicado en 2014

Tenofovir versus tenofovir plus entecavir for chronic hepatitis B with lamivudine resistance and entecavir resistance

artículo científico publicado en 2016

The Effect of Interferon-Free Regimens on Health-Related Quality of Life in East Asian Patients with Chronic Hepatitis C.

artículo científico publicado en 2017

The Influence of Histologic Inflammation on the Improvement of Liver Stiffness Values Over 1 and 3 Years

artículo científico publicado en 2019

The Laennec staging system for histological sub-classification of cirrhosis is useful for stratification of prognosis in patients with liver cirrhosis

artículo científico publicado en 2012

The Modified Response Evaluation Criteria in Solid Tumors (RECIST) Yield a More Accurate Prognoses Than the RECIST 1.1 in Hepatocellular Carcinoma Treated with Transarterial Radioembolization

artículo científico publicado en 2020

The Relationship between Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease Measured by Controlled Attenuation Parameter.

artículo científico publicado en 2016

The accuracy of noninvasive methods in predicting the development of hepatocellular carcinoma and hepatic decompensation in patients with chronic hepatitis B

artículo científico publicado en 2012

The effect of radiotherapy in liver-confined but non-resectable Barcelona Clinic Liver Cancer stage C large hepatocellular carcinoma.

artículo científico publicado en 2016

The efficacy of endoscopic palliation of obstructive jaundice in hepatocellular carcinoma

artículo científico publicado en 2014

The efficacy of hepatic resection after neoadjuvant transarterial chemoembolization (TACE) and radiation therapy in hepatocellular carcinoma greater than 5 cm in size.

artículo científico publicado en 2009

The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B

artículo científico publicado el 1 de julio de 2010

The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma.

artículo científico publicado en 2012

The usefulness of liver stiffness measurement using FibroScan in chronic hepatitis C in South Korea: a multicenter, prospective study.

artículo científico publicado en 2011

Therapeutic benefit of radiotherapy in huge (≥10 cm) unresectable hepatocellular carcinoma

artículo científico publicado en 2014

Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients

artículo científico publicado el 1 de noviembre de 2010

Transarterial Chemoembolization in Treatment-Naïve and Recurrent Hepatocellular Carcinoma: A Propensity-Matched Outcome Analysis

scientific article published on 11 June 2019

Transarterial Radioembolization Versus Concurrent Chemoradiation Therapy for Locally Advanced Hepatocellular Carcinoma: A Propensity Score Matching Analysis

artículo científico publicado en 2017

Transarterial chemoembolization versus transarterial radioembolization in hepatocellular carcinoma: optimization of selecting treatment modality

artículo científico publicado en 2016

Transforming Growth Factor Beta Promotes Liver Tumorigenesis in Mice via Upregulation of Snail.

artículo científico

Transgenic mouse model expressing P53(R172H), luciferase, EGFP, and KRAS(G12D) in a single open reading frame for live imaging of tumor.

artículo científico publicado en 2015

Transgenic mouse models generated by hydrodynamic transfection for genetic studies of liver cancer and preclinical testing of anti-cancer therapy

artículo científico

Transient Elastography is Superior to FIB-4 in Assessing the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

artículo científico publicado en 2016

Transient elastography in chronic hepatitis B: an Asian perspective.

artículo científico publicado en 2010

Transient elastography-based risk estimation of hepatitis B virus-related occurrence of hepatocellular carcinoma: development and validation of a predictive model

artículo científico publicado en 2013

Transitional features of histologic type of non-alcoholic fatty liver disease in Korean young men.

artículo científico publicado en 2012

Treatment of recurrent hepatocellular carcinoma after liver transplantation

artículo científico publicado en 2011

Two-year treatment outcome of chronic hepatitis B infection treated with besifovir vs. entecavir: results from a multicentre study.

artículo científico publicado en 2014

Use of Wisteria Floribunda Agglutinin-Positive Human Mac-2 Binding Protein in Assessing Risk of Hepatocellular Carcinoma Due to Hepatitis B Virus

artículo científico publicado en 2016

Use of the delta neutrophil index as a prognostic factor of mortality in patients with spontaneous bacterial peritonitis: implications of a simple and useful marker.

artículo científico publicado en 2014

Use of transient elastography to predict de novo recurrence after radiofrequency ablation for hepatocellular carcinoma.

artículo científico publicado en 2015

Usefulness and safety of extracorporeal liver support therapy using MARSR for patients with liver failure: a preliminary report

artículo científico publicado en 2009

Usefulness of positron emission tomography with fluorine-18-fluorodeoxyglucose in predicting treatment response in unresectable hepatocellular carcinoma patients treated with external beam radiotherapy.

artículo científico publicado en 2011

Usefulness of urine strip test in the rapid diagnosis of spontaneous bacterial peritonitis.

artículo científico

Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation.

artículo científico publicado en 2017

Validation of PAGE-B model in Asian chronic hepatitis B patients receiving entecavir or tenofovir.

artículo científico publicado en 2017

Validation of hepatitis B virus-related hepatocellular carcinoma prediction models in the era of antiviral therapy.

artículo científico publicado en 2015

Validation of risk prediction models for the development of HBV-related HCC: a retrospective multi-center 10-year follow-up cohort study.

artículo científico publicado en 2017

Validation of the CAMD Score in Patients With Chronic Hepatitis B Virus Infection Receiving Antiviral Therapy

artículo científico publicado en 2019

Variability in liver stiffness values from different intercostal spaces.

artículo científico publicado en 2009

What is the role of diagnostic laparoscopy in a gastroenterology unit?

artículo científico publicado en 2007

Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts the risk of HBV-related liver cancer development.

artículo científico publicado en 2016

[Clinical outcomes of systemic chemotherapy in hepatocellular carcinoma patients with multiple lung metastases].

artículo científico publicado en 2008

[Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis]

artículo científico publicado en 2010

[Measurement of hepatic venous pressure gradient in liver cirrhosis: relationship with the status of cirrhosis, varices, and ascites in Korea]

artículo científico publicado en 2008

“Normal” range of alanine aminotransferase levels for Asian population

artículo científico publicado el 1 de febrero de 2011