Lista de obras - Coen Hemker - Dominio Público Uruguay

A coagulation reagent completely devoid of factor X; relation between clotting time and concentration of factor X

scientific article published on 01 January 1979

A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows

scientific article published on 01 February 1982

A new method for the preparation of artificial factor II reagents from normal human and bovine plasma

artículo científico publicado en 1977

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X.

artículo científico publicado en 2013

A quick method for the determination of decarboxyfactor X

artículo científico publicado el 1 de junio de 1978

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding.

artículo científico publicado en 2016

Acquired APC resistance and oral contraceptives: differences between two functional tests

scientific article published on 01 April 1999

Age-dependency of thrombin generation

artículo científico publicado en 2006

An inhibitor of clot formation in cord plasma

artículo científico publicado en 1979

Analysis of thrombin generation in plasma.

artículo científico publicado en 1994

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

artículo científico publicado en 1990

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

artículo científico publicado en 2016

Autoactivation of human blood coagulation factor XII on dextran derivatives of different molecular weight

artículo científico publicado el 15 de septiembre de 1992

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

artículo científico publicado en 1998

Automated determination of heparin with chromogenic substrates

scientific article published on 01 January 1984

Automated spectrophotometric heparin assays. Comparison of methods

artículo científico publicado en 1984

Calibrated automated thrombin generation measurement in clotting plasma

artículo científico publicado en 2003

Calibrated automated thrombinography (CAT)

scientific article published on 01 January 2005

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

artículo científico publicado en 2015

Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in Rats ⬇️

artículo científico publicado el 1 de enero de 1979

Clotting factors secreted by monocytes and macrophages: analytical considerations

scientific article published on 01 January 1985

Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation

artículo científico publicado en 2015

Comparison between the effect of pentosan polysulphate heparin and antithrombin III injections in antithrombin III deficient patients

artículo científico publicado en 1985

Computer evaluation of reference curves for the estimation of extrinsic coagulation factors

artículo científico publicado el 1 de enero de 1978

Contribution of the platelet factor V content to platelet factor 3 activity

scientific article published on 01 May 1980

Data management in thrombin generation.

artículo científico publicado en 2012

Design and synthesis of thrombin substrates with modified kinetic parameters

scientific article published on 01 September 1995

Development of a sensitive and rapid chromogenic factor IX assay for clinical use

artículo científico publicado en 1990

Differences in the mechanism of blood clot formation and nanostructure in infants and children compared with adults.

artículo científico publicado en 2015

Different properties of Factor VIII in von Willebrand's disease with Respectto Recovery in Cryoprecipitate.

artículo científico publicado en 1974

Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system

scientific article published on 01 June 2007

Differential interaction of clotting factors II, VII, IX and X with sephadex and dextran blue.

artículo científico publicado en 1972

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X.

artículo científico publicado en 1999

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.

artículo científico publicado en 2015

Elements from in vitro studies that help understand the action of heparins

scientific article published on 01 January 1991

Ellipsometry as a tool to study protein films at liquid-solid interfaces

artículo científico publicado el 1 de enero de 1978

Estimation of the rate constants in the michaelis-menten equations without restrictions as to time scale.

artículo científico publicado en 1972

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay.

artículo científico publicado en 2010

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

artículo científico publicado en 2005

Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.

artículo científico publicado en 2004

Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome

scientific article published on 01 January 2004

Fluorogenic Peptide‐Based Substrates for Monitoring Thrombin Activity ⬇️

artículo científico publicado el 31 de enero de 2012

Free factor Xa is on the main pathway of thrombin generation in clotting plasma

artículo científico publicado en 1989

Functional properties of factor Va subunits after proteolytic alterations by activated protein C

scientific article published on 01 May 1984

Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets

artículo científico publicado en 1982

Global/integral assays in hemostasis diagnostics: promises, successes, problems and prospects.

artículo científico publicado en 2015

Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection.

artículo científico publicado en 2005

Heparin neutralization during collection and processing of blood inhibited by pyridoxal 5'-phosphate

scientific article published on 01 January 1984

Heparin-like inhibitor of blood coagulation in normal newborn

artículo científico publicado en 1977

Heparin-like inhibitor, not vitamin-K deficiency, in the newborn

artículo científico publicado en 1977

Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets

artículo científico publicado en 1999

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways

artículo científico publicado en 1997

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

artículo científico publicado en 2007

Improvements of the method for the preparation of an artificial prothrombin reagent

artículo científico publicado en 1978

In vitro prothrombin synthesis from a purified precursor protein. I. Development of a bovine liver cell-free system

artículo científico publicado el 22 de octubre de 1976

In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase.

artículo científico publicado en 1978

In vitro prothrombin synthesis from a purified precursor protein. III. Preparation of an acid-soluble substrate for vitamin K-dependent carboxylase by limited proteolysis of bovine descarboxyprothrombin

artículo científico publicado en 1981

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

artículo científico publicado en 1981

Inhibition of blood coagulation factors by serine esterase inhibitors

artículo científico publicado en 1972

Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III

scientific article published on 01 January 1986

Inhibition of tissue factor-factor VIIa-catalyzed factor X activation by factor Xa-tissue factor pathway inhibitor. A rotating disc study on the effect of phospholipid membrane composition

artículo científico publicado en 1999

Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics

artículo científico publicado en 2004

Is there value in kinetic modeling of thrombin generation? No (unless…)

artículo científico publicado en 2012

Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord

artículo científico publicado en 1985

Kinetics of the formation of the factor X activating enzyme of the blood coagulation system

scientific article published on 01 March 1976

Kinetics of thrombin-induced release and activation of platelet factor V

artículo científico publicado en 1986

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

artículo científico publicado en 2012

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths.

artículo científico publicado en 2007

Lipid phase transitions and procoagulant activity

artículo científico publicado el 1 de abril de 1979

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion.

artículo científico publicado en 2016

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery.

artículo científico publicado en 2013

Monitoring new oral antithrombotics: what we should know before we can decide

artículo científico publicado en 2010

Monitoring of unbound protein in vesicle suspensions with off-null ellipsometry

artículo científico publicado en 1993

Monitoring platelet dependent thrombin generation in mice

artículo científico publicado en 2010

NATURE OF PROTHROMBIN BIOSYNTHESIS: PREPROTHROMBINAEMIA IN VITAMIN K-DEFICIENCY

scientific article published on 01 November 1963

New approaches for measuring coagulation.

artículo científico publicado en 2006

No effect of ethanol intake on thrombin generation parameters

artículo científico publicado en 2011

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

artículo científico publicado en 2013

On the clot-promoting activity of human platelets in a one-stage prothrombinase assay

artículo científico publicado en 1982

On the procoagulant activity of platelets stimulated by collagen and thrombin

scientific article published on 01 March 1984

Oral treatment of haemophilia A by gastrointestinal absorption of factor VIII entrapped in liposomes ⬇️

artículo científico publicado el 12 de enero de 1980

Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity

artículo científico publicado en 1977

Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor X

scientific article published on 01 January 1981

Partial purification of the protein moiety of porcine tissue thromboplastin

artículo científico publicado en 1977

Pharmacokinetic and pharmacodynamic characterization of a medium-molecular-weight heparin in comparison with UFH and LMWH.

artículo científico publicado en 2002

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk.

artículo científico publicado en 2004

Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density.

artículo científico publicado en 1998

Procoagulant activities in venoms from central Asian snakes ⬇️

artículo científico publicado el 1 de enero de 1991

Procoagulant effect of vitamin K antagonists?

scientific article published on 01 December 2011

Production of thrombin as a probe for mixing of phospholipids in membranes on solid supports

scientific article published on 01 July 1995

Prothrombin activation by prothrombinase in a tubular flow reactor.

artículo científico publicado en 1995

Prothrombin contributes to the assembly of the factor Va-factor Xa complex at phosphatidylserine-containing phospholipid membranes

artículo científico publicado en 1995

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin

artículo científico publicado en 2018

Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom.

artículo científico publicado en 1997

Quantitation of infarct size in man by means of plasma enzyme levels ⬇️

artículo científico publicado el 1 de agosto de 1975

Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis.

artículo científico publicado en 2007

Reaction Sequence of Blood Coagulation

artículo científico publicado en 1967

Recollections on thrombin generation.

artículo científico publicado en 2007

Reconstitution and lipid requirements of porcine tissue thromboplastin ⬇️

artículo científico publicado el 20 de julio de 1977

Reevaluation of some properties of fibrinogen, purified from cord blood of normal newborns

artículo científico publicado en 1983

Role of accessory components in the activation of vitamin K-dependent coagulation factors

artículo científico publicado en 1986

Simulation model for thrombin generation in plasma

artículo científico publicado en 1991

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions

scientific article published on 14 April 2016

Spectrophotometric method for the assay of human blood coagulation factor VIII

scientific article published on 01 January 1987

Surface exclusion and molecular mobility may explain Vroman effects in protein adsorption ⬇️

artículo científico publicado el 1 de enero de 1991

The action of Echis carinatus venom on the blood coagulation system. Demonstration of an activator of factor X

scientific article published on 01 July 1984

The activity state of factor VII in plasma: two pathways for the cold promoted activation of factor VII

artículo científico publicado en 1986

The application of thrombin generation in real life clinical situations

artículo científico publicado en 2015

The balance of pro- and anticoagulant processes underlying thrombin generation

artículo científico publicado en 2015

The contribution of alpha(2)-macroglobulin thrombin to the endogenous thrombin potential

artículo científico publicado en 2007

The determination of prothrombin using synthetic chromogenic substrates; choice of a suitable activator

scientific article published on 01 August 1978

The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady-state and time-resolved fluorescence depolarization of diphenylhexatriene

artículo científico publicado en 1987

The effect of fibrin(ogen) on thrombin generation and decay

artículo científico publicado en 2014

The effect of gamma-carboxyglutamate residues on the enzymatic properties of the activated blood clotting factor X. I. Activity towards synthetic substrates

artículo científico publicado en 1978

The influence of glycerol on the Ca flux in the isolated perfused rat heart

scientific article published on 01 May 1976

The inhibition of platelet prothrombinase activity by prostacyclin

scientific article published on 01 January 1984

The inhibition of vitamin K-dependent carboxylase by cyanide

artículo científico publicado en 1982

The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha-macroglobulin-thrombin.

artículo científico publicado en 2010

The placental transport of [3H]vitamin K1 in rats

artículo científico publicado en 1987

The prolongation of the thrombotest clotting time in newborns

scientific article published on 01 October 1988

The role of gamma-carboxyglutamyl residues in the positive cooperative binding of Ca2+ to blood coagulation factor X

artículo científico publicado en 1978

The technique of measuring thrombin generation with fluorescent substrates: 4. The H-transform, a mathematical procedure to obtain thrombin concentrations without external calibration.

artículo científico publicado en 2009

The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration

artículo científico publicado en 2008

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups

artículo científico publicado en 2015

Thrombin Generation in Zebrafish Blood

artículo científico publicado en 2016

Thrombin generation and plasma dilution

artículo científico publicado en 2010

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A ⬇️

artículo científico publicado el 1 de agosto de 2011

Thrombin generation assays: accruing clinical relevance.

artículo científico publicado en 2004

Thrombin generation for the control of heparin treatment, comparison with the activated partial thromboplastin time

artículo científico publicado en 2004

Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin.

artículo científico publicado en 2007

Thrombin generation in whole blood

artículo científico publicado en 2008

Thrombin generation is extremely sensitive to preheating conditions

scientific article published on 01 January 2011

Thrombin generation: What have we learned? ⬇️

artículo científico publicado el 2 de julio de 2012

Thrombin generation: biochemical possibilities and clinical reality

scientific article published on 01 July 2015

Thrombin-dependent Incorporation of von Willebrand Factor into a Fibrin Network.

artículo científico publicado en 2014

Thrombin-generating capacity in patients with von Willebrand's disease

artículo científico publicado en 2007

Use of chromogenic peptide substrates in the determination of clotting factors II, VII, IX and X in normal plasma and in plasma of patients treated with oral anticoagulants

scientific article published on 01 January 1982

Vitamin-K deficiency in the newborn

artículo científico publicado en 1977

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

artículo científico publicado en 2012

[Treatment of hemophilia B with PPSB]

scientific article published on 01 February 1968

von Willebrand factor stimulates thrombin-induced exposure of procoagulant phospholipids on the surface of fibrin-adherent platelets

artículo científico publicado en 2003

Lista de obras de Coen Hemker

A coagulation reagent completely devoid of factor X; relation between clotting time and concentration of factor X

A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows

A new method for the preparation of artificial factor II reagents from normal human and bovine plasma

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X.

A quick method for the determination of decarboxyfactor X

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding.

Acquired APC resistance and oral contraceptives: differences between two functional tests

Age-dependency of thrombin generation

An inhibitor of clot formation in cord plasma

Analysis of thrombin generation in plasma.

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Autoactivation of human blood coagulation factor XII on dextran derivatives of different molecular weight

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

Automated determination of heparin with chromogenic substrates

Automated spectrophotometric heparin assays. Comparison of methods

Calibrated automated thrombin generation measurement in clotting plasma

Calibrated automated thrombinography (CAT)

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in Rats ⬇️

Clotting factors secreted by monocytes and macrophages: analytical considerations

Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation

Comparison between the effect of pentosan polysulphate heparin and antithrombin III injections in antithrombin III deficient patients

Computer evaluation of reference curves for the estimation of extrinsic coagulation factors

Contribution of the platelet factor V content to platelet factor 3 activity

Data management in thrombin generation.

Design and synthesis of thrombin substrates with modified kinetic parameters

Development of a sensitive and rapid chromogenic factor IX assay for clinical use

Differences in the mechanism of blood clot formation and nanostructure in infants and children compared with adults.

Different properties of Factor VIII in von Willebrand's disease with Respectto Recovery in Cryoprecipitate.

Differential impact of conventional and low-dose oral hormone therapy (HT), tibolone and raloxifene on functionality of the activated protein C system

Differential interaction of clotting factors II, VII, IX and X with sephadex and dextran blue.

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X.

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation.

Elements from in vitro studies that help understand the action of heparins

Ellipsometry as a tool to study protein films at liquid-solid interfaces

Estimation of the rate constants in the michaelis-menten equations without restrictions as to time scale.

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay.

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B.

Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.

Fibrin polymerization is crucial for thrombin generation in platelet-rich plasma in a VWF-GPIb-dependent process, defective in Bernard-Soulier syndrome

Fluorogenic Peptide‐Based Substrates for Monitoring Thrombin Activity ⬇️

Free factor Xa is on the main pathway of thrombin generation in clotting plasma

Functional properties of factor Va subunits after proteolytic alterations by activated protein C

Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets

Global/integral assays in hemostasis diagnostics: promises, successes, problems and prospects.

Good mathematical practice: simulation of the hemostatic-thrombotic mechanism, a powerful tool but one that must be used with circumspection.

Heparin neutralization during collection and processing of blood inhibited by pyridoxal 5'-phosphate

Heparin-like inhibitor of blood coagulation in normal newborn

Heparin-like inhibitor, not vitamin-K deficiency, in the newborn

Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

Improvements of the method for the preparation of an artificial prothrombin reagent

In vitro prothrombin synthesis from a purified precursor protein. I. Development of a bovine liver cell-free system

In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase.

In vitro prothrombin synthesis from a purified precursor protein. III. Preparation of an acid-soluble substrate for vitamin K-dependent carboxylase by limited proteolysis of bovine descarboxyprothrombin

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue

Inhibition of blood coagulation factors by serine esterase inhibitors

Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III

Inhibition of tissue factor-factor VIIa-catalyzed factor X activation by factor Xa-tissue factor pathway inhibitor. A rotating disc study on the effect of phospholipid membrane composition

Initiating and potentiating role of platelets in tissue factor-induced thrombin generation in the presence of plasma: subject-dependent variation in thrombogram characteristics

Is there value in kinetic modeling of thrombin generation? No (unless…)

Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord

Kinetics of the formation of the factor X activating enzyme of the blood coagulation system

Kinetics of thrombin-induced release and activation of platelet factor V

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths.

Lipid phase transitions and procoagulant activity

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion.

Measurement of thrombin generation intra-operatively and its association with bleeding tendency after cardiac surgery.

Monitoring new oral antithrombotics: what we should know before we can decide

Monitoring of unbound protein in vesicle suspensions with off-null ellipsometry

Monitoring platelet dependent thrombin generation in mice

NATURE OF PROTHROMBIN BIOSYNTHESIS: PREPROTHROMBINAEMIA IN VITAMIN K-DEFICIENCY

New approaches for measuring coagulation.

No effect of ethanol intake on thrombin generation parameters

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

On the clot-promoting activity of human platelets in a one-stage prothrombinase assay