Lista de obras - Gérard Lambeau - Dominio Público Uruguay

1,3,5-Triazepan-2,6-diones as conformationally constrained dipeptide mimetics. In silico guided identification of sPLA2 inhibitors.

artículo científico publicado en 2009

12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages

scientific article published on 04 December 2019

A novel bacterial resistance mechanism against human group IIA-secreted phospholipase A2: role of Streptococcus pyogenes sortase A.

artículo científico publicado en 2011

A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor.

artículo científico publicado en 2001

Absence of inflammatory conditions in human varicose saphenous veins.

artículo científico publicado en 2012

Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor

artículo científico publicado en 2005

An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade.

artículo científico publicado en 2007

Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels.

artículo científico publicado en 2006

Anti-PLA2R1 Antibodies as Prognostic Biomarker in Membranous Nephropathy

artículo científico publicado en 2021

Anti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy.

artículo científico publicado en 2017

Antimalarial Activity of Human Group IIA Secreted Phospholipase A2 in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins

scientific article published on 18 October 2019

Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function.

artículo científico publicado en 2006

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy

artículo científico publicado en 2016

Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).

artículo científico publicado en 2001

Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2

scientific article published on 01 August 2000

Biochemistry and physiology of mammalian secreted phospholipases A2.

artículo científico publicado en 2008

Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2.

artículo científico publicado en 2002

Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).

artículo científico publicado en 2003

Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin.

artículo científico publicado en 2005

Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA.

artículo científico publicado en 2001

Cloning and expression of a membrane receptor for secretory phospholipases A2.

artículo científico publicado en 1994

Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2

scientific journal article

Cross-reactivity of anti-PLA2R1 autoantibodies to rabbit and mouse PLA2R1 antigens and development of two novel ELISAs with different diagnostic performances in idiopathic membranous nephropathy

scientific article published on 19 August 2015

Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy

artículo científico publicado en 2013

Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis.

artículo científico publicado en 2003

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

scientific article published on 01 April 2019

Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms

scientific journal article

Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.

artículo científico publicado en 2008

Effects of the propeptide of group X secreted phospholipase A(2) on substrate specificity and interfacial activity on phospholipid monolayers

artículo científico publicado en 2012

Emerging roles of secreted phospholipase A(2) enzymes: an update.

artículo científico publicado en 2012

Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

artículo científico publicado en 2010

Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos

scientific article published on 01 April 2019

Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy.

artículo científico publicado en 2015

Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells

scientific article published on 01 February 2000

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

artículo científico publicado en 2010

Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method

artículo científico publicado en 2007

Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis

artículo científico publicado en 2008

Group IIA-Secreted Phospholipase A2 in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates

artículo científico publicado en 2018

Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils.

artículo científico publicado en 2017

Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.

artículo científico publicado en 2011

Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice

artículo científico publicado en 2010

Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.

artículo científico publicado en 2013

Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.

artículo científico publicado en 2013

Group X secreted phospholipase A2 specifically decreases sperm motility in mice

artículo científico publicado en 2011

Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis

artículo científico publicado en 2002

High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy

artículo científico publicado en 2019

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms

artículo científico publicado en 2012

Hydrolysis of minor glycerophospholipids of plasma lipoproteins by human group IIA, V and X secretory phospholipases A2

artículo científico publicado en 2006

Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma

artículo científico publicado en 2016

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.

artículo científico publicado en 2015

In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.

artículo científico publicado en 2015

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities

artículo científico publicado en 2007

Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2.

artículo científico publicado en 2003

Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.

artículo científico publicado en 2002

Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.

artículo científico publicado en 2014

Les phospholipases, enzymes clés de la physiologie spermatique

artículo científico publicado en 2012

M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy

artículo científico publicado en 2009

Membranous nephropathy: Pathophysiology and natural history

artículo científico publicado en 2017

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease

artículo científico publicado en 2009

Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy

artículo científico publicado en 2020

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

artículo científico publicado en 2006

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy

scientific article published on 01 March 2019

Novel Mammalian Group XII Secreted Phospholipase A2Lacking Enzymatic Activity, ⬇️

artículo científico publicado el 7 de octubre de 2003

PLA2R1 kills cancer cells by inducing mitochondrial stress.

artículo científico publicado en 2013

PLA2R1 mediates tumor suppression by activating JAK2.

artículo científico publicado en 2013

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy.

artículo científico publicado en 2017

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling

scientific article published on 29 April 2010

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

artículo científico publicado en 2015

Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.

artículo científico publicado en 2003

Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients

artículo científico publicado en 2014

Preparation of the Full Set of Recombinant Mouse- and Human-Secreted Phospholipases A2.

artículo científico publicado en 2016

Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2

artículo científico publicado en 2010

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2β (iPLA2β) and Group X Secreted Phospholipase A2 (sPLA2)

artículo científico publicado en 2015

Properties of receptors for neurotoxic phospholipases A2 in different tissues ⬇️

artículo científico publicado el 1 de junio de 1991

Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.

artículo científico publicado en 2014

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

artículo científico publicado en 2007

Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells

scientific article published on 01 October 2000

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

artículo científico publicado en 2014

Role of the phospholipase A2 receptor in liposome drug delivery in prostate cancer cells

artículo científico publicado en 2014

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

artículo científico publicado en 2016

Secreted Phospholipases A2 in Hereditary Angioedema With C1-Inhibitor Deficiency

scientific article published on 23 July 2018

Secreted group IIA phospholipase A2 protects humans against the group B streptococcus: experimental and clinical evidence.

artículo científico publicado en 2013

Secreted phospholipase A(2) group IIA is a neurotoxin released by stimulated human glial cells.

artículo científico publicado en 2012

Secreted phospholipase A(2) induces vascular endothelial cell migration

artículo científico publicado en 2000

Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor

artículo científico publicado en 2006

Secreted phospholipase A2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures.

artículo científico publicado en 2002

Secreted phospholipases A2 in cancer: diverse mechanisms of action.

artículo científico

Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells

artículo científico publicado en 2014

Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo

artículo científico publicado en 1999

Snake venoms as a source of compounds modulating sperm physiology: Secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice

artículo científico publicado en 2010

Special issue: from membranes to pathologies

artículo científico publicado en 2014

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human Group IIA secreted phospholipase A2 to exert its bactericidal effects

scientific article published on 15 October 2018

Streptococcal Lancefield polysaccharides are critical cell wall determinants for human group IIA secreted phospholipase A2 to exert its bactericidal effects

Structural elements of secretory phospholipases A2 involved in the binding to M-type receptors

artículo científico publicado en 1995

Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes.

artículo científico publicado en 2005

T-cell and antibody responses to phospholipase A2 from different species show distinct cross-reactivity patterns.

artículo científico publicado en 2011

The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2

artículo científico publicado en 2006

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

artículo científico publicado en 2006

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia

artículo científico publicado en 2015

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy

artículo científico publicado en 2014

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy

artículo científico publicado en 2015

Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum

artículo científico publicado en 2005

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.

artículo científico publicado en 2000

[New physiopathological roles for the PLA2R1 receptor in cancer and membranous nephropathy]

artículo científico publicado en 2014

Lista de obras de Gérard Lambeau

1,3,5-Triazepan-2,6-diones as conformationally constrained dipeptide mimetics. In silico guided identification of sPLA2 inhibitors.

12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages

A novel bacterial resistance mechanism against human group IIA-secreted phospholipase A2: role of Streptococcus pyogenes sortase A.

A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor.

Absence of inflammatory conditions in human varicose saphenous veins.

Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor

An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade.

Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels.

Anti-PLA2R1 Antibodies as Prognostic Biomarker in Membranous Nephropathy

Anti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy.

Antimalarial Activity of Human Group IIA Secreted Phospholipase A2 in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins

Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function.

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy

Bactericidal properties of human and murine groups I, II, V, X, and XII secreted phospholipases A(2).

Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2

Biochemistry and physiology of mammalian secreted phospholipases A2.

Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2.

Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).

Characterization and differentiation-dependent regulation of secreted phospholipases A in human keratinocytes and in healthy and psoriatic human skin.

Characterization of group X phospholipase A(2) as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA.

Cloning and expression of a membrane receptor for secretory phospholipases A2.

Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2

Cross-reactivity of anti-PLA2R1 autoantibodies to rabbit and mouse PLA2R1 antigens and development of two novel ELISAs with different diagnostic performances in idiopathic membranous nephropathy

Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primary membranous nephropathy

Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis.

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

Distinct arachidonate-releasing functions of mammalian secreted phospholipase A2s in human embryonic kidney 293 and rat mastocytoma RBL-2H3 cells through heparan sulfate shuttling and external plasma membrane mechanisms

Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate.

Effects of the propeptide of group X secreted phospholipase A(2) on substrate specificity and interfacial activity on phospholipid monolayers

Emerging roles of secreted phospholipase A(2) enzymes: an update.

Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice.

Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos

Epitope Spreading of Autoantibody Response to PLA2R Associates with Poor Prognosis in Membranous Nephropathy.

Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.

Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex method

Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis

Group IIA-Secreted Phospholipase A2 in Human Serum Kills Commensal but Not Clinical Enterococcus faecium Isolates

Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils.

Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.

Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice

Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.

Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice.

Group X secreted phospholipase A2 specifically decreases sperm motility in mice

Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis

High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms

Hydrolysis of minor glycerophospholipids of plasma lipoproteins by human group IIA, V and X secretory phospholipases A2

Identification of Epithelial Phospholipase A2 Receptor 1 as a Potential Target in Asthma

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.

In vitro anti-Plasmodium falciparum properties of the full set of human secreted phospholipases A2.

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities

Inhibitory effects of surfactant protein A on surfactant phospholipid hydrolysis by secreted phospholipases A2.

Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.

Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.

Les phospholipases, enzymes clés de la physiologie spermatique

M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy

Membranous nephropathy: Pathophysiology and natural history

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease

Multi-Autoantibody Signature and Clinical Outcome in Membranous Nephropathy

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy

Novel Mammalian Group XII Secreted Phospholipase A2Lacking Enzymatic Activity, ⬇️

PLA2R1 kills cancer cells by inducing mitochondrial stress.

PLA2R1 mediates tumor suppression by activating JAK2.

Phospholipase A2 Receptor 1 Epitope Spreading at Baseline Predicts Reduced Likelihood of Remission of Membranous Nephropathy.

Phospholipolyzed LDL induces an inflammatory response in endothelial cells through endoplasmic reticulum stress signaling

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.

Prediction of membranous nephropathy recurrence after transplantation by monitoring of anti-PLA2R1 (M-type phospholipase A2 receptor) autoantibodies: a case series of 15 patients

Preparation of the Full Set of Recombinant Mouse- and Human-Secreted Phospholipases A2.

Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A2β (iPLA2β) and Group X Secreted Phospholipase A2 (sPLA2)

Properties of receptors for neurotoxic phospholipases A2 in different tissues ⬇️

Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells

Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth

Role of the phospholipase A2 receptor in liposome drug delivery in prostate cancer cells