Lista de obras - J Kalervo Hiltunen - Dominio Público Uruguay

17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes

artículo científico publicado en 2018

17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS

artículo científico publicado en 2009

A hunt for OM45 synthetic petite interactions in Saccharomyces cerevisiae reveals a role for Miro GTPase Gem1p in cristae structure maintenance

artículo científico publicado en 2021

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells

artículo científico publicado en 2016

A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2.

artículo científico publicado en 2004

Adaptive changes in gluconeogenic enzymes in rat liver and kidney during long-term ethanol ingestion ⬇️

artículo científico publicado el 1 de octubre de 1978

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold

scientific journal article

An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.

artículo científico publicado en 2007

Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii

artículo científico publicado en 2011

Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE).

artículo científico publicado en 2009

Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution

artículo científico publicado en 2003

Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers

artículo científico publicado en 2003

Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei

artículo científico publicado en 2012

Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae.

artículo científico publicado en 2009

Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II

artículo científico publicado en 2003

Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH-binding motif.

artículo científico publicado en 2009

Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductased from developing cotton fibers

artículo científico publicado en 2005

Controllable Drug Release System in Living Cells Triggered by Enzyme-Substrate Recognition.

artículo científico publicado en 2015

Crystal Structure of Liganded Rat Peroxisomal Multifunctional Enzyme Type 1: A FLEXIBLE MOLECULE WITH TWO INTERCONNECTED ACTIVE SITES

artículo científico publicado en 2010

Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2

artículo científico publicado en 2005

Crystal structure of yeast peroxisomal multifunctional enzyme: structural basis for substrate specificity of (3R)-hydroxyacyl-CoA dehydrogenase units

artículo científico publicado en 2006

Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2.

artículo científico publicado en 2003

Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae.

artículo científico publicado en 2013

Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study

artículo científico publicado en 2013

Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation

artículo científico publicado en 2018

Dual targeted poplar ferredoxin NADP(+) oxidoreductase interacts with hemoglobin 1.

artículo científico publicado en 2016

Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart

artículo científico publicado en 1984

Effect of prolonged ethanol ingestion on hepatic lipogenesis and related enzyme activities ⬇️

artículo científico publicado el 15 de abril de 1977

Effects of pent-4-enoate on cellular redox state, glycolysis and fatty acid oxidation in isolated perfused rat heart ⬇️

artículo científico publicado el 15 de febrero de 1978

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

artículo científico publicado en 2007

Enzymatic assay for 3-hydroxyacyl-CoA and 2-trans-enoyl-CoA intermediates of beta-oxidation

artículo científico publicado en 1988

Ethanol-induced changes in gastric mucosal content of cyclic AMP and ATP in the rat.

artículo científico publicado en 1977

Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae

artículo científico publicado en 2021

Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae

scientific journal article

Function of human mitochondrial 2,4-dienoyl-CoA reductase and rat monofunctional Delta3-Delta2-enoyl-CoA isomerase in beta-oxidation of unsaturated fatty acids.

artículo científico publicado en 1999

Genetic and biochemical studies in yeast reveal that the cotton fibre-specific GhCER6 gene functions in fatty acid elongation.

artículo científico publicado en 2006

Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice

artículo científico publicado en 2017

Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ

scientific journal article

Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology

artículo científico publicado en 2004

Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana

artículo científico publicado en 2006

Identification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeast

scientific journal article

Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative

scientific journal article

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

artículo científico publicado en 2018

Importance of sequences adjacent to the terminal tripeptide in the import of a peroxisomal Candida tropicalis protein in plant peroxisomes

artículo científico publicado en 2000

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

artículo científico publicado en 2014

Intersection of RNA processing and the type II fatty acid synthesis pathway in yeast mitochondria

artículo científico publicado en 2008

Lipoic acid synthesis and attachment in yeast mitochondria.

artículo científico publicado en 2009

Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes

scientific journal article

MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder

scientific journal article

Measurements of intracellular ATP provide new insight into the regulation of glycolysis in the yeast Saccharomyces cerevisiae.

artículo científico publicado en 2011

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids

artículo científico publicado en 2013

Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue

scientific article published on 19 August 2019

Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis

artículo científico publicado en 2009

Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function

scientific article published on 29 August 2019

Mitochondrial fatty acid synthesis and respiration

artículo científico publicado en 2010

Mitochondrial fatty acid synthesis type II: more than just fatty acids

artículo científico publicado en 2008

Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology

artículo científico publicado en 2016

Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.

artículo científico publicado en 2009

Modification of the Monomer Composition of Polyhydroxyalkanoate Synthesized in Saccharomyces cerevisiae Expressing Variants of the β-Oxidation-Associated Multifunctional Enzyme ⬇️

artículo científico publicado el 1 de noviembre de 2003

Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases

artículo científico publicado en 1997

Mutagenic and enzymological studies of the hydratase and isomerase activities of 2-enoyl-CoA hydratase-1

scientific article published on 01 March 1999

Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis

artículo científico publicado en 2005

Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse

artículo científico publicado en 2009

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription.

artículo científico publicado en 2017

Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance

artículo científico publicado en 2017

On the molecular basis of D-bifunctional protein deficiency type III.

artículo científico publicado en 2013

Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity.

artículo científico publicado en 2002

Peroxisomal Delta(3),Delta(2)-enoyl CoA isomerases and evolution of cytosolic paralogues in embryophytes.

artículo científico publicado en 2008

Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids

artículo científico publicado en 1998

Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels.

artículo científico publicado en 2015

Peroxisomal beta-oxidation--a metabolic pathway with multiple functions

artículo científico publicado en 2006

Peroxisomal diseases.

artículo científico publicado en 1992

Peroxisomal membrane permeability and solute transfer.

artículo científico publicado en 2006

Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics

artículo científico publicado en 2011

Peroxisomes are oxidative organelles.

artículo científico publicado en 2010

Phytol is lethal for Amacr-deficient mice.

artículo científico publicado en 2015

Protein phosphorylation in mitochondria --a study on fermentative and respiratory growth of Saccharomyces cerevisiae.

artículo científico publicado en 2010

Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane

artículo científico publicado en 2009

Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.

artículo científico publicado en 2015

Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering.

artículo científico publicado en 2013

Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system

artículo científico publicado en 1975

Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice.

artículo científico publicado en 2014

Saturated very-long-chain fatty acids promote cotton fiber and Arabidopsis cell elongation by activating ethylene biosynthesis.

artículo científico publicado en 2007

Site-directed mutagenesis to enable and improve crystallizability of Candida tropicalis (3R)-hydroxyacyl-CoA dehydrogenase

artículo científico publicado en 2004

Structural biology of the thioester-dependent degradation and synthesis of fatty acids.

artículo científico publicado en 2005

Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties

artículo científico publicado en 2008

Structural studies of MFE-1: the 1.9 A crystal structure of the dehydrogenase part of rat peroxisomal MFE-1

artículo científico publicado en 2005

Structural studies on delta(3)-delta(2)-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily

artículo científico publicado en 2004

Structure-function analysis of enoyl thioester reductase involved in mitochondrial maintenance

artículo científico publicado en 2003

The 1.3 A crystal structure of human mitochondrial Delta3-Delta2-enoyl-CoA isomerase shows a novel mode of binding for the fatty acyl group

artículo científico publicado en 2004

The 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in Trypanosoma brucei.

artículo científico publicado en 2008

The Human Mitochondrial DNA Depletion Syndrome Gene MPV17 Encodes a Non-selective Channel That Modulates Membrane Potential.

artículo científico publicado en 2015

The Saccharomyces cerevisiae Peroxisomal 2,4-Dienoyl-CoA Reductase Is Encoded by the Oleate-inducible GeneSPS19 ⬇️

artículo científico publicado el 29 de agosto de 1997

The behavior of peroxisomes in vitro: mammalian peroxisomes are osmotically sensitive particles.

artículo científico publicado en 2004

The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae

artículo científico publicado en 2003

The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface

artículo científico publicado en 2007

The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations

artículo científico publicado en 2012

The yeast mitochondrial proteome, a study of fermentative and respiratory growth

artículo científico publicado en 2003

Transfer of metabolites across the peroxisomal membrane ⬇️

artículo científico publicado el 22 de diciembre de 2011

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

artículo científico publicado en 2016

UK114, a YjgF/Yer057p/UK114 family protein highly conserved from bacteria to mammals, is localized in rat liver peroxisomes

scientific journal article

Lista de obras de J Kalervo Hiltunen

17B-hydroxysteroid dehydrogenases as acyl thioester metabolizing enzymes

17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS

A hunt for OM45 synthetic petite interactions in Saccharomyces cerevisiae reveals a role for Miro GTPase Gem1p in cristae structure maintenance

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells

A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2.

Adaptive changes in gluconeogenic enzymes in rat liver and kidney during long-term ethanol ingestion ⬇️

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold

An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing.

Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii

Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE).

Binary structure of the two-domain (3R)-hydroxyacyl-CoA dehydrogenase from rat peroxisomal multifunctional enzyme type 2 at 2.38 A resolution

Candida tropicalis expresses two mitochondrial 2-enoyl thioester reductases that are able to form both homodimers and heterodimers

Channel-forming activities in the glycosomal fraction from the bloodstream form of Trypanosoma brucei

Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae.

Characterization of 2-enoyl thioester reductase from mammals. An ortholog of YBR026p/MRF1'p of the yeast mitochondrial fatty acid synthesis type II

Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH-binding motif.

Cloning and functional characterization of two cDNAs encoding NADPH-dependent 3-ketoacyl-CoA reductased from developing cotton fibers

Controllable Drug Release System in Living Cells Triggered by Enzyme-Substrate Recognition.

Crystal Structure of Liganded Rat Peroxisomal Multifunctional Enzyme Type 1: A FLEXIBLE MOLECULE WITH TWO INTERCONNECTED ACTIVE SITES

Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2

Crystal structure of yeast peroxisomal multifunctional enzyme: structural basis for substrate specificity of (3R)-hydroxyacyl-CoA dehydrogenase units

Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2.

Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae.

Dietary intake of n-3 long-chain polyunsaturated fatty acids and risk of myocardial infarction in coronary artery disease patients with or without diabetes mellitus: a prospective cohort study

Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation

Dual targeted poplar ferredoxin NADP(+) oxidoreductase interacts with hemoglobin 1.

Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart

Effect of prolonged ethanol ingestion on hepatic lipogenesis and related enzyme activities ⬇️

Effects of pent-4-enoate on cellular redox state, glycolysis and fatty acid oxidation in isolated perfused rat heart ⬇️

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Enzymatic assay for 3-hydroxyacyl-CoA and 2-trans-enoyl-CoA intermediates of beta-oxidation

Ethanol-induced changes in gastric mucosal content of cyclic AMP and ATP in the rat.

Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae

Function of heterologous Mycobacterium tuberculosis InhA, a type 2 fatty acid synthase enzyme involved in extending C20 fatty acids to C60-to-C90 mycolic acids, during de novo lipoic acid synthesis in Saccharomyces cerevisiae

Function of human mitochondrial 2,4-dienoyl-CoA reductase and rat monofunctional Delta3-Delta2-enoyl-CoA isomerase in beta-oxidation of unsaturated fatty acids.

Genetic and biochemical studies in yeast reveal that the cotton fibre-specific GhCER6 gene functions in fatty acid elongation.

Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice

Heterologous expression of mycobacterial proteins in Saccharomyces cerevisiae reveals two physiologically functional 3-hydroxyacyl-thioester dehydratases, HtdX and HtdY, in addition to HadABC and HtdZ

Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology

Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana

Identification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeast

Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative

Impaired mitochondrial fatty acid synthesis leads to neurodegeneration in mice

Importance of sequences adjacent to the terminal tripeptide in the import of a peroxisomal Candida tropicalis protein in plant peroxisomes

Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase

Intersection of RNA processing and the type II fatty acid synthesis pathway in yeast mitochondria

Lipoic acid synthesis and attachment in yeast mitochondria.

Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes

MECR Mutations Cause Childhood-Onset Dystonia and Optic Atrophy, a Mitochondrial Fatty Acid Synthesis Disorder

Measurements of intracellular ATP provide new insight into the regulation of glycolysis in the yeast Saccharomyces cerevisiae.

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids

Mitochondrial 2,4-dienoyl-CoA reductase (Decr) deficiency and impairment of thermogenesis in mouse brown adipose tissue

Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis

Mitochondrial acyl carrier protein (ACP) at the interface of metabolic state sensing and mitochondrial function

Mitochondrial fatty acid synthesis and respiration

Mitochondrial fatty acid synthesis type II: more than just fatty acids

Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology

Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.

Modification of the Monomer Composition of Polyhydroxyalkanoate Synthesized in Saccharomyces cerevisiae Expressing Variants of the β-Oxidation-Associated Multifunctional Enzyme ⬇️

Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases

Mutagenic and enzymological studies of the hydratase and isomerase activities of 2-enoyl-CoA hydratase-1

Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis

Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription.

Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance

On the molecular basis of D-bifunctional protein deficiency type III.

Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity.

Peroxisomal Delta(3),Delta(2)-enoyl CoA isomerases and evolution of cytosolic paralogues in embryophytes.

Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids

Peroxisomal Pex11 is a pore-forming protein homologous to TRPM channels.

Peroxisomal beta-oxidation--a metabolic pathway with multiple functions

Peroxisomal diseases.

Peroxisomal membrane permeability and solute transfer.

Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics

Peroxisomes are oxidative organelles.

Phytol is lethal for Amacr-deficient mice.

Protein phosphorylation in mitochondria --a study on fermentative and respiratory growth of Saccharomyces cerevisiae.

Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane

Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.