Lista de obras - Matthias Geyer - Dominio Público Uruguay

1H, 15N, and 13C assignments of the N-terminal activation domain of Dictyostelium discoideum Formin C

scientific article published on 07 October 2010

A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.

artículo científico publicado en 2010

A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells.

artículo científico publicado en 2002

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

artículo científico publicado en 2001

AURELIA, a program for computer-aided analysis of multidimensional NMR spectra.

artículo científico publicado en 1995

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

artículo científico publicado en 2021

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells

artículo científico publicado en 2013

Alternative splicing regulates stochastic NLRP3 activity

scientific article published on 19 July 2019

Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome

artículo científico publicado en 2001

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1

artículo científico publicado en 2006

Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef.

artículo científico publicado en 2006

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

artículo científico publicado en 2008

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

artículo científico publicado en 2014

C-terminal structure and mobility of rabbit skeletal muscle light meromyosin as studied by one- and two-dimensional 1H NMR spectroscopy and X-ray small-angle scattering

artículo científico publicado en 1991

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

artículo científico publicado en 2016

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

article

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

artículo científico publicado en 2020

Chemotactic activity of HIV-1 Nef for human monocytes.

artículo científico publicado en 2006

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux

artículo científico publicado en 2010

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

artículo científico publicado en 2008

Complex formation and light activation in membrane-embedded sensory rhodopsin II as seen by solid-state NMR spectroscopy.

artículo científico publicado en 2010

Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1

artículo científico publicado en 1999

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

artículo científico publicado en 1996

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

scientific article published on 29 August 2016

Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly

artículo científico publicado en 2020

D186/D190 is an allele-dependent determinant of HIV-1 Nef function

artículo científico publicado en 2016

DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain

artículo científico publicado en 2009

Deficiency in coatomer complex I causes aberrant activation of STING signalling

artículo científico publicado en 2022

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

artículo científico publicado en 2019

Discovery and resistance mechanism of a selective CDK12 degrader

artículo científico

Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres

artículo científico publicado en 2014

Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.

artículo científico publicado en 2001

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.

artículo científico publicado en 2008

Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection

artículo científico publicado en 2012

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

artículo científico publicado en 2017

Extracellular HIV-1 Nef increases migration of monocytes.

artículo científico publicado en 2006

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers

scientific article published on 26 February 2013

FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers.

artículo científico publicado en 2014

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

artículo científico publicado en 2012

Fifteen formins for an actin filament: a molecular view on the regulation of human formins.

artículo científico publicado en 2010

Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses

artículo científico publicado en 2010

Formins as effector proteins of Rho GTPases

artículo científico publicado en 2014

Functional characterization of the human Cdk10/Cyclin Q complex

artículo científico publicado en 2022

HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis

artículo científico publicado en 2014

HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity

artículo científico publicado en 2015

HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

artículo científico publicado en 2011

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.

artículo científico publicado en 2009

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

artículo científico publicado en 2007

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

artículo científico publicado en 2012

In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the r

scientific article published on 20 December 2006

Insights into the activation of transcription elongation by lentiviruses: structure of the Cyclin T1-Tat-TAR RNA complex.

artículo científico publicado en 2009

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

artículo científico publicado en 2021

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

artículo científico publicado en 1996

Link between primate lentiviral coreceptor usage and Nef function

artículo científico publicado en 2013

MIR sequences recruit zinc finger protein ZNF768 to expressed genes.

artículo científico publicado en 2019

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

artículo científico publicado en 2019

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice.

artículo científico publicado en 2017

Mechanistic insights into the translocation of full length HIV-1 Tat across lipid membranes

artículo científico publicado en 2011

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

artículo científico publicado en 2017

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

artículo científico publicado en 2011

Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome

artículo científico publicado en 2002

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

artículo científico publicado en 2017

NMR assignment of the Cyclin T-binding domain of human Hexim1

artículo científico publicado en 2006

NMR spectroscopic investigation of early events in IAPP amyloid fibril formation

artículo científico publicado en 2009

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

artículo científico publicado en 2014

Nef surfaces: where to interfere with function

artículo científico publicado en 2011

Observation of slow dynamic exchange processes in Ras protein crystals by 31P solid state NMR spectroscopy.

artículo científico publicado en 2002

Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression

artículo científico publicado en 2002

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

artículo científico publicado en 2015

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

artículo científico publicado en 2019

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

artículo científico publicado en 2016

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides

artículo científico publicado en 2011

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

artículo científico publicado en 2007

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

artículo científico publicado en 2012

Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs

article

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.

artículo científico publicado en 2018

Sensitizing HR-proficient cancers to PARP inhibitors

artículo científico publicado en 2017

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

artículo científico publicado en 2012

Sequence-specific resonance assignment of the Ras-binding domain of AF6

artículo científico publicado en 2000

Sequential NMR assignment of the RAS-binding domain of Byr2

artículo científico publicado en 2000

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

scientific article published in Nature Communications

Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations

artículo científico publicado en 2019

Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

artículo científico publicado en 2006

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

artículo científico publicado en 2016

Structural and biochemical analysis of Ras-effector signaling via RalGDS

artículo científico publicado en 1999

Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter

scientific article published in 2022

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody

artículo científico publicado en 2014

Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1

artículo científico publicado en 2011

Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb

artículo científico publicado en 2007

Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

artículo científico publicado el 1 de septiembre de 1997

Structure, Dynamics, Lipid Binding, and Physiological Relevance of the Putative GTPase-binding Domain of Dictyostelium Formin C

artículo científico publicado en 2011

Structure--function relationships in HIV-1 Nef.

artículo científico publicado en 2001

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

artículo científico publicado en 2009

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

artículo científico publicado en 1995

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

artículo científico publicado en 2002

Synergistic activation of Toll-like receptor 8 by two RNA degradation products.

artículo científico publicado en 2015

Synthesis, characterization and application of two nucleoside triphosphate analogues, GTPgammaNH(2) and GTPgammaF.

artículo científico publicado en 2002

Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.

artículo científico publicado en 2007

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

artículo científico publicado en 2008

The RNA polymerase II carboxy-terminal domain (CTD) code

artículo científico publicado en 2013

The Rev/Rex homolog HERV-K cORF multimerizes via a C-terminal domain

artículo científico publicado en 2001

The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo

artículo científico publicado en 2016

The control of HIV transcription: keeping RNA polymerase II on track

artículo científico publicado en 2011

The formin Drosophila homologue of Diaphanous2 (Diaph2) controls microtubule dynamics in colorectal cancer cells independent of its FH2-domain

artículo científico publicado en 2019

The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21

scientific article published on 01 December 2019

The structure and substrate specificity of human Cdk12/Cyclin K

artículo científico publicado en 2014

The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation.

artículo científico publicado en 2015

Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily

artículo científico publicado en 1999

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

artículo científico publicado en 1993

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation.

artículo científico publicado en 2015

When the Lymphocyte Loses Its Clothes ⬇️

artículo científico publicado el 1 de abril de 2003

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

artículo científico publicado en 2000

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

scientific article published on 01 March 2020

Lista de obras de Matthias Geyer

1H, 15N, and 13C assignments of the N-terminal activation domain of Dictyostelium discoideum Formin C

A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.

A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells.

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

AURELIA, a program for computer-aided analysis of multidimensional NMR spectra.

Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation

Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells

Alternative splicing regulates stochastic NLRP3 activity

Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1

Biochemical indication for myristoylation-dependent conformational changes in HIV-1 Nef.

Biophysical Analysis of the Interaction of Rab6a GTPase with Its Effector Domains

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation

C-terminal structure and mobility of rabbit skeletal muscle light meromyosin as studied by one- and two-dimensional 1H NMR spectroscopy and X-ray small-angle scattering

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Chemotactic activity of HIV-1 Nef for human monocytes.

Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

Complex formation and light activation in membrane-embedded sensory rhodopsin II as seen by solid-state NMR spectroscopy.

Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1

Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly

D186/D190 is an allele-dependent determinant of HIV-1 Nef function

DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain

Deficiency in coatomer complex I causes aberrant activation of STING signalling

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

Discovery and resistance mechanism of a selective CDK12 degrader

Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres

Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.

Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection

Efficient Vpu-Mediated Tetherin Antagonism by an HIV-1 Group O Strain

Extracellular HIV-1 Nef increases migration of monocytes.

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers

FHOD1 regulates stress fiber organization by controlling the dynamics of transverse arcs and dorsal fibers.

FMNL2 drives actin-based protrusion and migration downstream of Cdc42.

Fifteen formins for an actin filament: a molecular view on the regulation of human formins.

Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses

Formins as effector proteins of Rho GTPases

Functional characterization of the human Cdk10/Cyclin Q complex

HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis

HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity

HIV-1 Nef induces proinflammatory state in macrophages through its acidic cluster domain: involvement of TNF alpha receptor associated factor 2.

HIV-1 Nef membrane association depends on charge, curvature, composition and sequence.

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the r

Insights into the activation of transcription elongation by lentiviruses: structure of the Cyclin T1-Tat-TAR RNA complex.

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding

Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

Link between primate lentiviral coreceptor usage and Nef function

MIR sequences recruit zinc finger protein ZNF768 to expressed genes.

MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation

Mechanisms of NLRP1-Mediated Autoinflammatory Disease in Humans and Mice.

Mechanistic insights into the translocation of full length HIV-1 Tat across lipid membranes

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

NMR assignment of the Cyclin T-binding domain of human Hexim1

NMR spectroscopic investigation of early events in IAPP amyloid fibril formation

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

Nef surfaces: where to interfere with function

Observation of slow dynamic exchange processes in Ras protein crystals by 31P solid state NMR spectroscopy.

Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

Reduced Susceptibility to VIRIP-Based HIV-1 Entry Inhibitors Has a High Genetic Barrier and Severe Fitness Costs

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells.

Sensitizing HR-proficient cancers to PARP inhibitors

Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

Sequence-specific resonance assignment of the Ras-binding domain of AF6