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Lista de obras de Elaine Sanij

A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes

artículo científico publicado en 2014

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

artículo científico publicado en 2016

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

scientific article published on 26 May 2020

CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer

scientific article published on 31 August 2020

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

artículo científico publicado en 2016

Chromatin organization and expression

artículo científico publicado en 2008

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

artículo científico publicado en 2015

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence

artículo científico publicado en 2015

Genome wide mapping of UBF binding-sites in mouse and human cell lines

artículo científico publicado en 2015

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53

scientific journal article

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

artículo científico publicado en 2016

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

artículo científico publicado en 2017

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

artículo científico publicado en 2014

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

scientific article published on 18 September 2020

Signaling to the ribosome in cancer--It is more than just mTORC1.

artículo científico publicado en 2011

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

artículo científico publicado en 2010

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

artículo científico publicado en 2017

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

The nucleolus: an emerging target for cancer therapy

artículo científico publicado en 2013

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

artículo científico publicado en 2009

UBF levels determine the number of active ribosomal RNA genes in mammals

scientific journal article

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

artículo científico publicado en 2010

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