Lista de obras - F Becq - Dominio Público Uruguay

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

artículo científico publicado en 2008

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells

scientific journal article

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

artículo científico publicado en 2015

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

artículo científico publicado en 2014

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts

artículo científico publicado en 2014

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

artículo científico publicado en 2008

Acute effects of adenosine triphosphates, cyclic 3',5'-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Ssertoli cells

artículo científico publicado en 1999

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

artículo científico publicado en 2010

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

artículo científico publicado en 2011

Anion channels in a human pancreatic cancer cell line (Capan-1) of ductal origin

artículo científico publicado el 1 de enero de 1992

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

artículo científico publicado en 2008

Benzo(c)quinolizinium drugs inhibit degradation of Delta F508-CFTR cytoplasmic domain.

artículo científico publicado en 2003

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

artículo científico publicado en 2010

CFTR and Ca Signaling in Cystic Fibrosis.

artículo científico publicado en 2011

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

artículo científico publicado en 2010

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

artículo científico publicado en 2007

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

artículo científico publicado en 2012

CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.

artículo científico publicado en 2013

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

artículo científico publicado en 2007

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

artículo científico publicado en 2017

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

artículo científico publicado en 2007

Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells

scientific article published on 01 April 1993

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

artículo científico publicado en 2003

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

artículo científico publicado en 2002

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

artículo científico publicado en 2014

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.

artículo científico publicado en 1999

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

artículo científico publicado en 2010

Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis

artículo científico publicado en 2012

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

artículo científico publicado en 2004

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

artículo científico publicado en 2017

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

artículo científico publicado en 1999

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

artículo científico publicado en 2007

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

artículo científico publicado en 2006

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

artículo científico publicado en 2005

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

artículo científico publicado en 2013

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

artículo científico publicado en 2011

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

artículo científico publicado en 2006

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

scientific journal article

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.

artículo científico publicado en 2010

Function, pharmacological correction and maturation of new Indian CFTR gene mutations.

artículo científico publicado en 2014

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

artículo científico publicado en 2004

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

artículo científico publicado en 2002

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

artículo científico publicado en 2008

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

artículo científico publicado en 2010

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells

artículo científico publicado en 2014

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

artículo científico publicado en 2017

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators.

artículo científico publicado en 2003

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells

artículo científico publicado en 2015

MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

artículo científico publicado en 2006

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

artículo científico publicado en 2006

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

artículo científico publicado en 2013

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

artículo científico publicado en 2016

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

artículo científico publicado en 2018

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

artículo científico publicado en 2016

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

artículo científico publicado en 2014

NHE-RF1 protein rescues DeltaF508-CFTR function.

artículo científico publicado en 2007

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype ⬇️

artículo científico publicado el 25 de junio de 2011

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

artículo científico publicado en 2008

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

scientific article published on 30 May 2006

Phosphatase inhibitors activate normal and defective CFTR chloride channels ⬇️

artículo científico publicado el 13 de septiembre de 1994

Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells

scientific article published on 01 August 1993

Predicting CFTR activity with front-runner cystic fibrosis drugs.

artículo científico publicado en 2015

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

artículo científico publicado en 2008

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes

scientific article published on 01 March 2016

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

artículo científico publicado en 2020

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

artículo científico publicado en 2006

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

artículo científico publicado en 2013

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

artículo científico publicado en 2006

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

artículo científico publicado en 2014

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

artículo científico publicado en 2015

Saturated fatty acids alter the late secretory pathway by modulating membrane properties

scientific article published on 02 October 2013

Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.

artículo científico publicado en 2014

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

artículo científico publicado el 21 de abril de 2011

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

artículo científico publicado en 2005

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

artículo científico publicado en 2007

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

artículo científico publicado en 1998

Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

artículo científico publicado en 2007

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

artículo científico publicado en 2004

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.

artículo científico publicado en 2004

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

artículo científico publicado en 2015

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

artículo científico publicado en 2016

Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling

artículo científico publicado en 2001

The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection

artículo científico publicado en 2016

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein.

artículo científico publicado en 2004

The cystic fibrosis mutation G551D alters the non-Michaelis-Menten behavior of the cystic fibrosis transmembrane conductance regulator (CFTR) channel and abolishes the inhibitory Genistein binding site.

artículo científico publicado en 2002

The glycine residues G551 and G1349 within the ATP-binding cassette signature motifs play critical roles in the activation and inhibition of cystic fibrosis transmembrane conductance regulator channels by phloxine B.

artículo científico publicado en 2005

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy

artículo científico publicado en 2013

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

artículo científico publicado en 2014

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

artículo científico publicado en 2014

The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential role during sperm capacitation

artículo científico publicado en 2012

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

artículo científico publicado en 2010

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel

scientific journal article

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

artículo científico publicado en 2010

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

artículo científico publicado en 2018

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells.

artículo científico publicado en 2015

Lista de obras de F Becq

9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels.

A Novel voltage-dependent chloride current activated by extracellular acidic pH in cultured rat Sertoli cells

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells.

A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo.

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts

Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells.

Acute effects of adenosine triphosphates, cyclic 3',5'-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Ssertoli cells

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Anion channels in a human pancreatic cancer cell line (Capan-1) of ductal origin

Anti-inflammatory effect of miglustat in bronchial epithelial cells.

Benzo(c)quinolizinium drugs inhibit degradation of Delta F508-CFTR cytoplasmic domain.

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

CFTR and Ca Signaling in Cystic Fibrosis.

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes.

CFTR: effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel.

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR.

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

Characterization of cAMP dependent CFTR-chloride channels in human tracheal gland cells

Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004.

Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensitivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells.

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis

Determination of CFTR chloride channel activity and pharmacology using radiotracer flux methods.

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

Development of substituted Benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel.

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high-affinity inhibitors of cystic fibrosis transmembrane conductance regulator chloride channels.

Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels

Disruption of CFTR chloride channel alters mechanical properties and cAMP-dependent Cl- transport of mouse aortic smooth muscle cells.

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells.

Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine.

Function, pharmacological correction and maturation of new Indian CFTR gene mutations.

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels

Genistein modifies the activation kinetics and magnitude of phosphorylated wild-type and G551D-CFTR chloride currents.

Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a

Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity.

Inhibition of ATP-sensitive K+ channels by substituted benzo[c]quinolizinium CFTR activators.

Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells

MPB-07 Reduces the Inflammatory Response toPseudomonas aeruginosain Cystic Fibrosis Bronchial Cells

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells.

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors.

NHE-RF1 protein rescues DeltaF508-CFTR function.

Orphan missense mutations in the cystic fibrosis transmembrane conductance regulator: A three-step biological approach to establishing a correlation between genotype and phenotype ⬇️

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Phosphatase inhibitors activate normal and defective CFTR chloride channels ⬇️

Possible regulation of CFTR-chloride channels by membrane-bound phosphatases in pancreatic duct cells

Predicting CFTR activity with front-runner cystic fibrosis drugs.

Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622.

Pushing the limits of catalytic C-H amination in polyoxygenated cyclobutanes

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors

Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the alpha-glucosidase inhibitor miglustat

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells.

Saturated fatty acids alter the late secretory pathway by modulating membrane properties

Searching for combinations of small-molecule correctors to restore f508del-cystic fibrosis transmembrane conductance regulator function and processing.

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain ⬇️

Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius.

Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity.

Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels.