Lista de obras - Marc Ostermeier - Dominio Público Uruguay

A Comprehensive, High-Resolution Map of a Gene's Fitness Landscape.

artículo científico publicado en 2016

A Positive Selection for Nucleoside Kinases in E. coli

artículo científico publicado en 2016

A comprehensive, high-resolution map of a gene's fitness landscape

artículo científico publicado en 2014

A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand.

artículo científico publicado en 2012

A molecular switch created by in vitro recombination of nonhomologous genes.

artículo científico publicado en 2004

A protein therapeutic modality founded on molecular regulation.

artículo científico publicado en 2011

A xylose-stimulated xylanase-xylose binding protein chimera created by random nonhomologous recombination

artículo científico publicado en 2016

Advancements in the development of HIF-1α-activated protein switches for use in enzyme prodrug therapy

artículo científico publicado en 2014

An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity.

artículo científico publicado en 2008

An externally tunable bacterial band-pass filter.

scholarly article

Beyond cataloging the Library of Babel.

artículo científico publicado en 2007

Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics.

artículo científico publicado en 2015

Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity

artículo científico publicado en 2012

Collateral fitness effects of mutations

artículo científico publicado en 2020

Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation

artículo científico publicado en 2019

Construction of Protein Switches by Domain Insertion and Directed Evolution.

artículo científico publicado en 2017

Creation of an allosteric enzyme by domain insertion.

artículo científico publicado en 2004

Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug.

artículo científico publicado en 2008

Design of protein switches based on an ensemble model of allostery

artículo científico publicado en 2015

Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase

artículo científico publicado en 2016

Directed evolution of improved zinc finger methyltransferases

artículo científico publicado en 2014

Directed evolution of protein switches and their application to the creation of ligand-binding proteins.

artículo científico publicado en 2005

Electrochemical activation of engineered protein switches

artículo científico publicado en 2015

Environmental changes bridge evolutionary valleys

artículo científico publicado en 2016

Enzymatic protein switches built from paralogous input domains

artículo científico publicado en 2015

Fitness Effects of Single Amino Acid Insertions and Deletions in TEM-1 β-Lactamase

scientific article published on 26 April 2019

Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells.

artículo científico publicado en 2009

Hybrid enzymes: manipulating enzyme design ⬇️

artículo científico publicado el 1 de junio de 1998

In vitro recombination of non-homologous genes can result in gene fusions that confer a switching phenotype to cells

artículo científico publicado en 2011

Insertion of a xylanase in xylose binding protein results in a xylose-stimulated xylanase

artículo científico publicado en 2015

Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression

artículo científico publicado en 2016

Mathematical expressions useful in the construction, description and evaluation of protein libraries.

artículo científico publicado en 2005

Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 beta-lactamase switch.

artículo científico publicado en 2005

NMR characterization of an engineered domain fusion between maltose binding protein and TEM1 beta-lactamase provides insight into its structure and allosteric mechanism.

artículo científico publicado en 2010

Non‐allosteric enzyme switches possess larger effector‐induced changes in thermodynamic stability than their non‐switch analogs ⬇️

artículo científico publicado el 8 de marzo de 2013

PFunkel: efficient, expansive, user-defined mutagenesis.

artículo científico publicado en 2012

Pervasive Pairwise Intragenic Epistasis among Sequential Mutations in TEM-1 β-Lactamase

scientific article published on 25 March 2019

Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria

artículo científico publicado en 2018

Protein switch engineering by domain insertion.

artículo científico publicado en 2013

Protein switches identified from diverse insertion libraries created using S1 nuclease digestion of supercoiled‐form plasmid DNA ⬇️

artículo científico publicado el 15 de junio de 2011

Protein-Programmed Accumulation of Yeast Cytosine Deaminase in Cancer Cells in Response to Mock-Hypoxia

scientific article published on 23 April 2019

Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides.

artículo científico publicado en 2001

Rational design of a fusion protein to exhibit disulfide-mediated logic gate behavior.

artículo científico publicado en 2014

Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway

artículo científico publicado en 2016

Sites in the AAV5 capsid tolerant to deletions and tandem duplications

artículo científico publicado en 2010

Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation ⬇️

artículo científico publicado el 14 de junio de 2012

Structure prediction of domain insertion proteins from structures of individual domains.

artículo científico publicado en 2008

Surface-tethered protein switches

artículo científico publicado en 2011

Synthetic gene libraries: in search of the optimal diversity.

artículo científico publicado en 2003

Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.

artículo científico publicado en 2017

The high-affinity maltose switch MBP317-347 has low affinity for glucose: implications for targeting tumors with metabolically directed enzyme prodrug therapy

artículo científico publicado en 2013

The interplay between effector binding and allostery in an engineered protein switch.

artículo científico publicado en 2016

The thymidylate kinase genes from Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus confer 3'-azido-3'-deoxythymidine resistance to Escherichia coli.

artículo científico publicado en 2014

Theoretical distribution of truncation lengths in incremental truncation libraries.

artículo científico publicado en 2003

Thermostability Enhancement of GH 62 α- l -Arabinofuranosidase by Directed Evolution and Rational Design

artículo científico publicado en 2024

Lista de obras de Marc Ostermeier

A Comprehensive, High-Resolution Map of a Gene's Fitness Landscape.

A Positive Selection for Nucleoside Kinases in E. coli

A comprehensive, high-resolution map of a gene's fitness landscape

A hot-spot motif characterizes the interface between a designed ankyrin-repeat protein and its target ligand.

A molecular switch created by in vitro recombination of nonhomologous genes.

A protein therapeutic modality founded on molecular regulation.

A xylose-stimulated xylanase-xylose binding protein chimera created by random nonhomologous recombination

Advancements in the development of HIF-1α-activated protein switches for use in enzyme prodrug therapy

An engineered split M.HhaI-zinc finger fusion lacks the intended methyltransferase specificity.

An externally tunable bacterial band-pass filter.

Beyond cataloging the Library of Babel.

Characterization of monobody scaffold interactions with ligand via force spectroscopy and steered molecular dynamics.

Circular permutation in the Ω-loop of TEM-1 β-lactamase results in improved activity and altered substrate specificity

Collateral fitness effects of mutations

Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation

Construction of Protein Switches by Domain Insertion and Directed Evolution.

Creation of an allosteric enzyme by domain insertion.

Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug.

Design of protein switches based on an ensemble model of allostery

Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase

Directed evolution of improved zinc finger methyltransferases

Directed evolution of protein switches and their application to the creation of ligand-binding proteins.

Electrochemical activation of engineered protein switches

Environmental changes bridge evolutionary valleys

Enzymatic protein switches built from paralogous input domains

Fitness Effects of Single Amino Acid Insertions and Deletions in TEM-1 β-Lactamase

Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells.

Hybrid enzymes: manipulating enzyme design ⬇️

In vitro recombination of non-homologous genes can result in gene fusions that confer a switching phenotype to cells

Insertion of a xylanase in xylose binding protein results in a xylose-stimulated xylanase

Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression

Mathematical expressions useful in the construction, description and evaluation of protein libraries.

Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 beta-lactamase switch.

NMR characterization of an engineered domain fusion between maltose binding protein and TEM1 beta-lactamase provides insight into its structure and allosteric mechanism.

Non‐allosteric enzyme switches possess larger effector‐induced changes in thermodynamic stability than their non‐switch analogs ⬇️

PFunkel: efficient, expansive, user-defined mutagenesis.

Pervasive Pairwise Intragenic Epistasis among Sequential Mutations in TEM-1 β-Lactamase

Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria

Protein switch engineering by domain insertion.

Protein switches identified from diverse insertion libraries created using S1 nuclease digestion of supercoiled‐form plasmid DNA ⬇️

Protein-Programmed Accumulation of Yeast Cytosine Deaminase in Cancer Cells in Response to Mock-Hypoxia

Rapid generation of incremental truncation libraries for protein engineering using alpha-phosphothioate nucleotides.

Rational design of a fusion protein to exhibit disulfide-mediated logic gate behavior.

Shifting Fitness and Epistatic Landscapes Reflect Trade-offs along an Evolutionary Pathway

Sites in the AAV5 capsid tolerant to deletions and tandem duplications

Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation ⬇️

Structure prediction of domain insertion proteins from structures of individual domains.

Surface-tethered protein switches

Synthetic gene libraries: in search of the optimal diversity.

Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.

The high-affinity maltose switch MBP317-347 has low affinity for glucose: implications for targeting tumors with metabolically directed enzyme prodrug therapy

The interplay between effector binding and allostery in an engineered protein switch.

The thymidylate kinase genes from Mycobacterium tuberculosis and methicillin-resistant Staphylococcus aureus confer 3'-azido-3'-deoxythymidine resistance to Escherichia coli.

Theoretical distribution of truncation lengths in incremental truncation libraries.

Thermostability Enhancement of GH 62 α- l -Arabinofuranosidase by Directed Evolution and Rational Design