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Lista de obras de David A Jans

70-kDa heat shock cognate protein hsc70 mediates calmodulin-dependent nuclear import of the sex-determining factor SRY

artículo científico publicado en 2012

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.

artículo científico publicado en 2007

A monopartite sequence is essential for p45 NF‐E2 nuclear translocation, transcriptional activity and platelet production ⬇️

artículo científico publicado el 1 de noviembre de 2010

A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P protein

artículo científico publicado en 2012

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

artículo científico publicado en 2014

A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin.

artículo científico publicado en 2005

An AlphaScreen®-based assay for high-throughput screening for specific inhibitors of nuclear import.

artículo científico publicado en 2011

An efficient system for high-level expression and easy purification of authentic recombinant proteins

artículo científico publicado en 2004

An importin alpha/beta-recognized bipartite nuclear localization signal mediates targeting of the human herpes simplex virus type 1 DNA polymerase catalytic subunit pUL30 to the nucleus.

artículo científico publicado en 2007

Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.

artículo científico publicado en 2006

Arginine methylation increases the stability of human immunodeficiency virus type 1 Tat.

artículo científico publicado en 2009

Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein

artículo científico publicado en 2008

Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design

artículo científico publicado en 2018

Binding of p110 retinoblastoma protein inhibits nuclear import of simian virus SV40 large tumor antigen

artículo científico publicado en 2010

Bovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7.

artículo científico publicado en 2013

CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

artículo científico publicado en 2009

Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal.

artículo científico publicado en 2010

Central role of nuclear transport in signalling, viral infection and development.

artículo científico publicado en 2011

Central role of the respiratory syncytial virus matrix protein in infection.

artículo científico publicado en 2006

Changing subcellular localization of nuclear transport factors during human spermatogenesis.

artículo científico publicado en 2011

Comment onPhosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insightsby Rónaet al.(2013)

scientific article published on 30 September 2014

Compound effects of point mutations causing campomelic dysplasia/autosomal sex reversal upon SOX9 structure, nuclear transport, DNA binding, and transcriptional activation

artículo científico publicado en 2001

Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

artículo científico publicado en 2012

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

artículo científico publicado en 2018

Cytokine-induced slowing of STAT3 nuclear import; faster basal trafficking of the STAT3β isoform.

artículo científico publicado en 2014

Defective importin beta recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations.

artículo científico publicado en 2003

Dengue virus RNA polymerase NS5: a potential therapeutic target?

artículo científico publicado en 2006

Development of a pipeline for automated, high-throughput analysis of paraspeckle proteins reveals specific roles for importin α proteins.

artículo científico publicado en 2017

Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes.

artículo científico publicado en 2009

Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells.

artículo científico publicado en 2011

Drivers of germ cell maturation.

artículo científico publicado en 2005

Dual modes of rabies P-protein association with microtubules: a novel strategy to suppress the antiviral response.

artículo científico publicado en 2009

Dual nuclear import mechanisms of sex determining factor SRY: intracellular Ca 2+ as a switch ⬇️

artículo científico publicado el 4 de noviembre de 2010

Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH

artículo científico publicado en 2016

Dynamics of Leptomycin B‐Sensitive Nucleocytoplasmic Flux of Parathyroid Hormone‐Related Protein ⬇️

artículo científico publicado el 1 de noviembre de 2001

Enhanced tumour cell nuclear targeting in a tumour progression model

artículo científico publicado en 2015

Enhancement of protein transduction-mediated nuclear delivery by interaction with dynein/microtubules.

artículo científico publicado en 2009

Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity

artículo científico publicado en 2019

Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis.

artículo científico publicado en 2005

Fast track, dynein-dependent nuclear targeting of human immunodeficiency virus Vpr protein; impaired trafficking in a clinical isolate

artículo científico publicado en 2016

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

artículo científico publicado en 2015

Global enhancement of nuclear localization‐dependent nuclear transport in transformed cells ⬇️

artículo científico publicado el 12 de diciembre de 2011

HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism.

artículo científico publicado en 2006

High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses

artículo científico publicado en 2022

Human cytomegalovirus (HCMV) DNA polymerase processivity factor ppUL44 dimerizes in the cytosol before translocation to the nucleus.

artículo científico publicado en 2006

Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1.

artículo científico publicado en 2015

Hyperosmotic stress sustains cytokine-stimulated phosphorylation of STAT3, but slows its nuclear trafficking and impairs STAT3-dependent transcription.

artículo científico publicado en 2014

Identification of a role for nucleolin in rabies virus infection

artículo científico publicado en 2014

Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.

artículo científico publicado en 2005

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening

artículo científico publicado en 2018

Importin alpha mRNAs have distinct expression profiles during spermatogenesis.

artículo científico publicado en 2006

Importin alpha2-interacting proteins with nuclear roles during mammalian spermatogenesis.

artículo científico publicado en 2011

Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules.

artículo científico publicado en 2003

Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease.

artículo científico publicado en 2013

Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9.

artículo científico publicado en 2005

Interactome of the inhibitory isoform of the nuclear transporter Importin 13.

artículo científico publicado en 2016

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2

artículo científico publicado en 2015

Interleukin-15 mediates potent antiviral responses via an interferon-dependent mechanism.

artículo científico publicado en 2009

Intracellular calcium levels can regulate Importin-dependent nuclear import.

artículo científico publicado en 2014

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress

artículo científico publicado en 2013

Investigating dengue virus nonstructural protein 5 (NS5) nuclear import.

artículo científico publicado en 2014

Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?

scientific article published on 15 September 2020

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus ⬇️

artículo científico publicado el 1 de mayo de 2012

Kinetic properties of nuclear transport conferred by the retinoblastoma (Rb) NLS

artículo científico publicado en 2005

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

scientific journal article

Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates

artículo científico publicado en 2005

Mice Lacking Hbp1 Function Are Viable and Fertile

artículo científico publicado en 2017

Mitochondrial protein p32/HAPB1/gC1qR/C1qbp is required for efficient respiratory syncytial virus production.

artículo científico publicado en 2017

Modulation of host cell nucleocytoplasmic trafficking during picornavirus infection.

artículo científico

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein

scientific journal article

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

artículo científico publicado en 2019

Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2α phosphorylation in virus infected cells

artículo científico publicado en 2016

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.

artículo científico publicado en 2017

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain.

artículo científico publicado en 2016

Nuclear Transport of Respiratory Syncytial Virus Matrix Protein Is Regulated by Dual Phosphorylation Sites

artículo científico publicado en 2022

Nuclear drug delivery to target tumour cells.

scientific article published on 15 October 2009

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

artículo científico publicado en 2013

Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection.

artículo científico publicado en 2017

Nuclear import of the pre-integration complex (PIC): the Achilles heel of HIV?

artículo científico publicado en 2003

Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization

artículo científico publicado en 2014

Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha.

artículo científico publicado en 2002

Nuclear localization and secretion competence are conserved among henipavirus matrix proteins.

artículo científico publicado en 2017

Nuclear localization of dengue virus (DENV) 1-4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin.

artículo científico publicado en 2013

Nuclear localization of the dystrophin-associated protein α-dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity.

artículo científico publicado en 2015

Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?

artículo científico

Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules.

artículo científico publicado en 2002

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

artículo científico publicado en 2021

Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals.

artículo científico publicado en 2018

Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin α/β and CRM1 nuclear transporters and microtubule motor dynein.

artículo científico

Nucleocytoplasmic shuttling of the West Nile virus RNA-dependent RNA polymerase NS5 is critical to infection.

artículo científico publicado en 2018

Nucleocytoplasmic trafficking of Nipah virus W protein involves multiple discrete interactions with the nuclear import and export machinery.

artículo científico publicado en 2016

Nullbasic, a potent anti-HIV tat mutant, induces CRM1-dependent disruption of HIV rev trafficking

artículo científico publicado en 2012

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

artículo científico publicado en 2014

Oxidative stress impairs multiple regulatory events to drive persistent cytokine-stimulated STAT3 phosphorylation.

artículo científico publicado en 2014

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function

artículo científico publicado en 2018

Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-  Using Oriented Peptide Library Screening

artículo científico publicado en 2010

Proteases of human rhinovirus: role in infection.

artículo científico publicado en 2015

Protein transduction: cell penetrating peptides and their therapeutic applications

artículo científico publicado en 2006

Protein-protein interactions in RSV assembly: potential targets for attenuating RSV strains.

artículo científico

Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis

artículo científico publicado en 2015

Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness

artículo científico publicado en 2016

Quantitative Analysis of the Microtubule Interaction of Rabies Virus P3 Protein: Roles in Immune Evasion and Pathogenesis.

scientific article published on 21 September 2016

Quantitative analysis of DNA-protein interactions using double-labeled native gel electrophoresis and fluorescence-based imaging.

artículo científico publicado en 2006

Quantitative analysis of localization and nuclear aggregate formation induced by GFP-lamin A mutant proteins in living HeLa cells.

artículo científico publicado en 2006

Quantitative analysis of protein-protein interactions by native page/fluorimaging.

artículo científico publicado en 2005

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

scientific article published on 09 January 2020

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V.

artículo científico publicado en 2018

Recombinant modular transporters for cell-specific nuclear delivery of locally acting drugs enhance photosensitizer activity.

artículo científico publicado en 2003

Regulated nucleocytoplasmic transport in spermatogenesis: a driver of cellular differentiation?

artículo científico publicado en 2005

Regulating post-mitotic nuclear access: Cdk1-phosphorylation of NLSs.

artículo científico publicado en 2015

Regulation of nucleocytoplasmic trafficking of viral proteins: an integral role in pathogenesis?

artículo científico publicado en 2011

Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production

artículo científico publicado en 2019

Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

artículo científico publicado en 2015

Rhinovirus 16 2A Protease Affects Nuclear Localization of 3CD during Infection

artículo científico publicado en 2016

Rhinovirus 3C protease facilitates specific nucleoporin cleavage and mislocalisation of nuclear proteins in infected host cells.

artículo científico publicado en 2013

Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α

artículo científico publicado en 2003

Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-α.

artículo científico publicado en 2014

Secret life of importin-β; solenoid flexibility as the key to transport through the nuclear pore

artículo científico publicado en 2016

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

artículo científico publicado en 2016

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes ⬇️

artículo científico publicado el 1 de octubre de 2012

Smad3 Dosage Determines Androgen Responsiveness and Sets the Pace of Postnatal Testis Development ⬇️

artículo científico publicado el 8 de marzo de 2011

Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles

artículo científico publicado en 2015

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

artículo científico publicado en 2021

Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha

artículo científico publicado en 2003

Subversion of Host Cell Mitochondria by RSV to Favor Virus Production is Dependent on Inhibition of Mitochondrial Complex I and ROS Generation

artículo científico publicado en 2019

Tetraspanins in viral infections: a fundamental role in viral biology?

artículo científico publicado en 2005

The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal.

artículo científico publicado en 2009

The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production

artículo científico publicado en 2016

The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.

artículo científico

The Thr205 phosphorylation site within respiratory syncytial virus matrix (M) protein modulates M oligomerization and virus production

artículo científico publicado en 2014

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

artículo científico publicado en 2020

The biarsenical dye Lumio exhibits a reduced ability to specifically detect tetracysteine-containing proteins within live cells.

artículo científico publicado en 2007

The immune evasion function of J and Beilong virus V proteins is distinct from that of other paramyxoviruses, consistent with their inclusion in the proposed genus Jeilongvirus

artículo científico publicado en 2015

The nuclear import factor importin α4 can protect against oxidative stress

scientific journal article

The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain

scientific journal article

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention

artículo científico publicado en 2015

The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling

artículo científico publicado en 2013

The tumour specific pro-apoptotic factor apoptin (Vp3) from chicken anaemia virus.

artículo científico publicado en 2004

The type III effectors NleE and NleB from enteropathogenic E. coli and OspZ from Shigella block nuclear translocation of NF-kappaB p65.

artículo científico publicado en 2010

The α-importome of mammalian germ cell maturation provides novel insights for importin biology.

artículo científico publicado en 2014

Towards delineation of a developmental α-importome in the mammalian male germline ⬇️

artículo científico publicado el 13 de noviembre de 2012

Towards safe, non-viral therapeutic gene expression in humans.

artículo científico publicado en 2005

TrawlerWeb: an online de novo motif discovery tool for next-generation sequencing datasets.

artículo científico publicado en 2018

Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods.

artículo científico publicado en 2015

Tumour necrosis factor alpha (TNF- ) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF- to activate nuclear factor B and reduced sphingosine kinase-1 activity

artículo científico publicado en 2010

c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production

artículo científico publicado en 2017

p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival.

artículo científico publicado en 2013

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