Lista de obras - Adam Lesner - Dominio Público Uruguay

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

artículo científico publicado en 2018

A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome

artículo científico publicado en 2020

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

artículo científico publicado en 2013

A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.

artículo científico publicado en 2004

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer

artículo científico publicado en 2005

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

artículo científico publicado en 2010

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.

artículo científico publicado en 2015

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

artículo científico publicado en 2016

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015).

artículo científico publicado en 2016

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

artículo científico publicado en 2009

Biochemical and structural characterization of SplD protease from Staphylococcus aureus

artículo científico publicado en 2013

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia

artículo científico publicado en 2017

Bladder cancer detection using a peptide substrate of the 20S proteasome

artículo científico publicado en 2016

Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia

scientific article published on 14 April 2020

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

artículo científico publicado en 2014

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

artículo científico publicado en 2014

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme

scientific article published on 01 August 2001

Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis

artículo científico publicado en 2018

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

scientific article published in Journal of Biological Chemistry

Design and synthesis of new substrates of HtrA2 protease

artículo científico publicado en 2015

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

artículo científico publicado en 2008

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

artículo científico publicado en 2007

Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity

artículo científico publicado en 2018

Design, chemical synthesis and kinetic studies of trypsin chromogenic substrates based on the proteinase binding loop of Cucurbita maxima trypsin inhibitor (CMTI-III)

artículo científico publicado en 2000

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

artículo científico publicado en 2008

Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor

artículo científico publicado en 2014

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity ⬇️

artículo científico

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

artículo científico publicado en 2008

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples

artículo científico publicado en 2016

Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity

artículo científico publicado en 1997

Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis.

artículo científico publicado en 2018

Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.

artículo científico publicado en 2014

Future of Protease Activity Assays ⬇️

artículo científico publicado el 1 de enero de 2013

Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.

artículo científico publicado en 2010

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin

scientific article published on 29 January 2020

Hybrid analogues of SFTI-1 modified in P1position by β- and γ-amino acids andN-substituted β-alanines

artículo científico publicado en 2013

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity

artículo científico publicado en 2009

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

artículo científico publicado en 2010

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection

artículo científico publicado en 2002

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

artículo científico publicado en 2007

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1

artículo científico publicado en 2014

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

artículo científico publicado en 2016

Inhibitors of cathepsin G: a patent review (2005 to present).

artículo científico publicado en 2013

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

artículo científico publicado en 2010

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

artículo científico publicado en 2012

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

artículo científico publicado en 2015

Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

scientific article published on 01 November 2011

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

artículo científico publicado en 2009

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

artículo científico publicado en 2020

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis

artículo científico publicado en 2020

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.

artículo científico publicado en 2016

Low-molecular-weight aldehyde inhibitors of cathepsin G.

artículo científico publicado en 2009

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

artículo científico publicado en 2004

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

artículo científico publicado en 2004

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

artículo científico

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

artículo científico publicado en 2016

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

artículo científico publicado en 2007

New potent cathepsin G phosphonate inhibitors

artículo científico publicado en 2008

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

artículo científico publicado en 2014

Non‐Proteasomal Urine Activity in Bladder Cancer

artículo científico publicado en 2021

Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome

scientific article published on 24 August 2015

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

scholarly article by Natalia Gruba et al published 11 October 2018 in ACS Medicinal Chemistry Letters

PEGylated substrates of NSP4 protease: A tool to study protease specificity.

artículo científico publicado en 2016

Pegylated fluorescent peptides as substrates of proteolytic enzymes

artículo científico publicado en 2012

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

artículo científico publicado en 2008

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

artículo científico publicado en 2019

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

artículo científico publicado en 2017

Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions

artículo científico publicado en 2019

Proteinase 3 phosphonic inhibitors

artículo científico publicado en 2019

Proteolysis in health and disease

artículo científico publicado en 2013

Selection of Effective HTRA3 Activators Using Combinatorial Chemistry.

artículo científico publicado en 2017

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

artículo científico publicado en 2007

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach

artículo científico publicado en 2009

Simplified, serine-rich theta-defensin analogues as antitumour peptides.

artículo científico publicado en 2016

Structural Determinants of Substrate Specificity of SplF Protease from

artículo científico publicado en 2021

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

artículo científico publicado en 2015

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

scientific article published on 09 April 2019

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

artículo científico publicado en 2014

Substrate profiling of Zika virus NS2B-NS3 protease.

artículo científico publicado en 2016

Substrate specificity and inhibitory study of human airway trypsin-like protease.

artículo científico publicado en 2010

Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.

artículo científico publicado en 2011

Substrate specificity of human matriptase-2.

artículo científico publicado en 2013

Sunflower Trypsin Inhibitor 1 as a Molecular Scaffold for Drug Discovery ⬇️

artículo científico publicado el 1 de diciembre de 2011

Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications

artículo científico

Synthesis and Evaluation of Biological Activity of Antimicrobial--Pro-Proliferative Peptide Conjugates

artículo científico publicado en 2015

Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms

artículo científico publicado en 2014

Temperature-induced changes of HtrA2(Omi) protease activity and structure

artículo científico publicado en 2012

The Bactericidal Activity of Temporin Analogues Against Methicillin Resistant Staphylococcus aureus

scientific article published on 25 September 2019

The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies.

artículo científico publicado en 2014

The LD loop as an important structural element required for transmission of the allosteric signal in the HtrA (DegP) protease from Escherichia coli

artículo científico publicado en 2016

The influence of substrate peptide length on human beta-tryptase specificity

artículo científico publicado en 2008

The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region.

artículo científico publicado en 2010

The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.

artículo científico publicado en 2017

Three Wavelength Substrate System of Neutrophil Serine Proteinases

scientific article published on 08 August 2012

Trypsin inhibitors from the garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis

scientific article published on 03 May 2007

Ultrasensitive internally quenched substrates of human cathepsin L.

artículo científico publicado en 2014

Visualization of kallikreins in thyroid epithelial and carcinoma cells

scholarly article by Eileen Kroll et al published 13 May 2016 in Endocrine Abstracts

Lista de obras de Adam Lesner

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome

A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.

A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.

A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer

Analogues of Trypsin Inhibitor SFTI-1 with Disulfide Bridge Substituted by Various Length of Carbonyl Bridges

Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.

Analysis of urinary cathepsin C for diagnosing Papillon-Lefèvre syndrome

Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015).

Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells.

Biochemical and structural characterization of SplD protease from Staphylococcus aureus

Biochemical properties of the HtrA homolog from bacterium Stenotrophomonas maltophilia

Bladder cancer detection using a peptide substrate of the 20S proteasome

Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia

Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme

Conjugate of Enkephalin and Temporin Peptides as a Novel Therapeutic Agent for Sepsis

Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis

Design and synthesis of new substrates of HtrA2 protease

Design of selective substrates of proteinase 3 using combinatorial chemistry methods

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

Design, Synthesis, and Enzymatic Evaluation of Novel ZnO Quantum Dot-Based Assay for Detection of Proteinase 3 Activity

Design, chemical synthesis and kinetic studies of trypsin chromogenic substrates based on the proteinase binding loop of Cucurbita maxima trypsin inhibitor (CMTI-III)

Designing of substrates and inhibitors of bovine alpha-chymotrypsin with synthetic phenylalanine analogues in position P(1).

Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity ⬇️

Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.

Development of the first internally-quenched fluorescent substrates of human cathepsin C: The application in the enzyme detection in biological samples

Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity

Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis.

Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.

Future of Protease Activity Assays ⬇️

Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.

Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin

Hybrid analogues of SFTI-1 modified in P1position by β- and γ-amino acids andN-substituted β-alanines

Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity

Implication of the disulfide bridge in trypsin inhibitor SFTI-1 in its interaction with serine proteinases.

Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection

Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells.

Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1

Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease

Inhibitors of cathepsin G: a patent review (2005 to present).

Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing

Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin

Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.

Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

Introduction of non-natural amino acid residues into the substrate-specific P1 position of trypsin inhibitor SFTI-1 yields potent chymotrypsin and cathepsin G inhibitors.

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis

Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.

Low-molecular-weight aldehyde inhibitors of cathepsin G.

Microarray analysis of differentially expressed genes in cells resistant to HIV-1.

Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1.

Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

New potent cathepsin G phosphonate inhibitors

New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases

Non‐Proteasomal Urine Activity in Bladder Cancer

Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome

One Step Beyond: Design of Substrates Spanning Primed Positions of Zika Virus NS2B-NS3 Protease

PEGylated substrates of NSP4 protease: A tool to study protease specificity.

Pegylated fluorescent peptides as substrates of proteolytic enzymes

Peptomeric analogues of trypsin inhibitor SFTI-1 isolated from sunflower seeds

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions

Proteinase 3 phosphonic inhibitors

Proteolysis in health and disease

Selection of Effective HTRA3 Activators Using Combinatorial Chemistry.

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach

Simplified, serine-rich theta-defensin analogues as antitumour peptides.

Structural Determinants of Substrate Specificity of SplF Protease from

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains

Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C

Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

Substrate profiling of Zika virus NS2B-NS3 protease.