Lista de obras - Harel Weinstein - Dominio Público Uruguay

A Flexible Docking Procedure for the Exploration of Peptide Binding Selectivity to Known Structures and Homology Models of PDZ Domains

scientific article published on 01 October 2005

A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling.

artículo científico publicado en 2016

A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites

scientific article published in Journal of Biological Chemistry

A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs

scientific article published on 02 June 2019

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.

scientific article published on 06 January 2017

A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited

artículo científico publicado en 2019

A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice

scientific article published on 01 January 1998

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

scientific article published on 31 July 2006

A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding

scientific article published on 01 November 2000

A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits.

artículo científico publicado en 2011

A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2

artículo científico publicado en 2014

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

artículo científico publicado en 2008

A knowledge-based scale for the analysis and prediction of buried and exposed faces of transmembrane domain proteins.

artículo científico publicado en 2004

A lightweight method for evaluating in situ workflow efficiency

artículo científico publicado en 2021

A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain

artículo científico publicado en 2015

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport.

artículo científico publicado en 2018

A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding.

artículo científico publicado en 2005

A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif

artículo científico publicado en 1998

A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P.

artículo científico publicado en 2003

A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases

artículo científico publicado en 1997

A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system

artículo científico publicado el 21 de enero de 1977

AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems.

artículo científico publicado en 2015

Accurate In Silico Modeling of Asymmetric Bilayers Based on Biophysical Principles

artículo científico publicado en 2018

Acetylcholine-Like Molecular Arrangement in Psychomimetic Anticholinergic Drugs ⬇️

artículo científico publicado el 1 de noviembre de 1973

Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters.

artículo científico publicado en 2016

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

artículo científico publicado en 2009

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

artículo científico publicado en 2018

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

artículo científico publicado en 2008

Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide ⬇️

artículo científico publicado el 1 de diciembre de 1977

Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy

artículo científico publicado en 2016

Batch mode generation of residue-based diagrams of proteins.

artículo científico

Binding mechanisms of TATA box-binding proteins: DNA kinking is stabilized by specific hydrogen bonds

artículo científico publicado en 2000

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

artículo científico publicado en 2009

Building protein diagrams on the web with the residue-based diagram editor RbDe.

artículo científico publicado en 2003

Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain

scientific journal article

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

artículo científico publicado en 1999

Chloride binding site of neurotransmitter sodium symporters

artículo científico publicado en 2013

Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors

artículo científico publicado en 2010

Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB.

artículo científico publicado en 2016

Comparative modeling and molecular dynamics studies of the delta, kappa and mu opioid receptors ⬇️

artículo científico publicado el 1 de septiembre de 1997

Computational approaches to detect allosteric pathways in transmembrane molecular machines

artículo científico publicado en 2016

Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.

artículo científico publicado en 2015

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290

artículo científico publicado en 2016

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

artículo científico publicado en 2014

Conformational dynamics of ligand-dependent alternating access in LeuT.

artículo científico publicado en 2014

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

artículo científico publicado en 2002

Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.

artículo científico publicado en 2001

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

artículo científico publicado en 2005

Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TATA box-binding protein

artículo científico publicado en 1997

Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer.

artículo científico publicado en 2006

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

scientific article published on 31 October 2019

ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling

artículo científico publicado en 2014

Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia.

artículo científico publicado en 2008

Electrostatic analysis of DNA binding properties in lysine to leucine mutants of TATA-box binding proteins

artículo científico publicado en 1995

Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex.

artículo científico publicado en 2003

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

artículo científico publicado en 2017

Experimental conditions can obscure the second high-affinity site in LeuT.

artículo científico publicado en 2012

Functional Microdomains in G-protein-coupled Receptors

artículo científico publicado en 1998

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

artículo científico publicado en 2006

Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops

artículo científico publicado en 2015

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

artículo científico publicado en 2001

Functional role of arginine-11 in the N-terminal helix of skeletal troponin C: combined mutagenesis and molecular dynamics investigation

artículo científico publicado en 1995

Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor

artículo científico publicado en 1999

GPCRmd uncovers the dynamics of the 3D-GPCRome

scientific article published on 13 July 2020

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

scientific article published in Nature Communications

Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles

scientific article published on 25 January 2019

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

artículo científico publicado en 2000

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties.

artículo científico publicado en 2018

Identification of GATC- and CCGG-recognizing Type II REases and their putative specificity-determining positions using Scan2S--a novel motif scan algorithm with optional secondary structure constraints

artículo científico publicado en 2008

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

artículo científico publicado en 2009

In support of the BMRB.

artículo científico publicado en 2012

Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT ⬇️

artículo científico publicado el 5 de septiembre de 2012

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

artículo científico publicado en 2010

Key issues in the computational simulation of GPCR function: representation of loop domains.

artículo científico publicado en 2002

Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding.

artículo científico publicado en 2008

Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties

artículo científico publicado en 2012

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

artículo científico publicado en 2015

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin

artículo científico publicado en 2017

Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3.

artículo científico publicado en 2004

Membrane driven spatial organization of GPCRs

artículo científico publicado en 2013

Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins

scientific article published on 21 November 2019

Membrane localization is critical for activation of the PICK1 BAR domain

artículo científico publicado en 2008

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.

artículo científico publicado en 2014

Modeling activated states of GPCRs: the rhodopsin template

artículo científico publicado en 2006

Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption.

artículo científico publicado en 2009

Modeling membrane proteins based on low-resolution electron microscopy maps: a template for the TM domains of the oxalate transporter OxlT.

artículo científico publicado en 2005

Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy.

artículo científico publicado en 2003

Molecular determinants for the complex binding specificity of the PDZ domain in PICK1

scientific journal article

Molecular dynamics simulations of peptides and proteins with a continuum electrostatic model based on screened Coulomb potentials.

artículo científico publicado en 2003

Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange.

artículo científico publicado en 2004

Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers

artículo científico publicado en 2000

Multiple Interactions of the Asp2.61(98)Side Chain of the Gonadotropin-Releasing Hormone Receptor Contribute Differentially to Ligand Interaction†

artículo científico publicado en 2000

Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework

artículo científico publicado en 2008

NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT.

artículo científico publicado en 2014

Neurofilament (NF) Assembly; Divergent Characteristics of Human and Rodent NF-L Subunits ⬇️

artículo científico publicado el 27 de febrero de 1998

Not just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins.

artículo científico publicado en 2014

On the use of the transmembrane domain of bacteriorhodopsin as a template for modeling the three-dimensional structure of guanine nucleotide-binding regulatory protein-coupled receptors ⬇️

artículo científico publicado el 1 de mayo de 1992

PDZBase: a protein-protein interaction database for PDZ-domains

artículo científico publicado en 2004

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.

artículo científico publicado en 2014

Phosphatidylinositol 4,5-Biphosphate (PIP2) Lipids Regulate the Phosphorylation of Syntaxin N-Terminus by Modulating Both Its Position and Local Structure ⬇️

artículo científico publicado el 18 de septiembre de 2012

Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method

artículo científico publicado en 2002

Probing the structural determinants for the function of intracellular loop 2 in structurally cognate G-protein-coupled receptors

artículo científico publicado en 2010

Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond.

artículo científico publicado en 1998

Protein and lipid interactions driving molecular mechanisms of in meso crystallization

scientific article published on 14 February 2014

Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization.

artículo científico publicado en 2007

Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome

scientific article published on 23 July 2020

Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to G-Protein Coupled Receptors ⬇️

artículo científico publicado el 2 de noviembre de 2011

Related contribution of specific helix 2 and 7 residues to conformational activation of the serotonin 5-HT2A receptor

artículo científico publicado en 1995

Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.

artículo científico publicado en 1996

Schematic representation of residue-based protein context-dependent data: an application to transmembrane proteins

artículo científico publicado en 1999

Selective binding of the TATA box-binding protein to the TATA box-containing promoter: analysis of structural and energetic factors

artículo científico publicado en 1998

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

artículo científico publicado en 2017

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

artículo científico publicado en 2010

Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus

artículo científico publicado en 2015

State-dependent conformations of the translocation pathway in the tyrosine transporter Tyt1, a novel neurotransmitter:sodium symporter from Fusobacterium nucleatum.

artículo científico publicado en 2006

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter ⬇️

artículo científico publicado el 24 de septiembre de 2012

Structural change mechanisms in regulatory proteins

artículo científico publicado en 1996

Structural intermediates in a model of the substrate translocation path of the bacterial glutamate transporter homologue GltPh.

artículo científico publicado en 2012

Structural mimicry of proline kinks: tertiary packing interactions support local structural distortions.

artículo científico publicado en 2002

Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers.

artículo científico publicado en 2002

Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites

scientific article published on 01 December 2000

Structure and dynamics of calmodulin in solution.

artículo científico publicado en 1998

Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1

artículo científico publicado en 2010

Studies on histamine H2 receptors coupled to cardiac adenylate cyclase. Effects of guanylnucleotides and structural requirements for agonist activity

artículo científico publicado el 4 de octubre de 1979

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

artículo científico publicado en 2009

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

artículo científico publicado en 2015

TIT for TAT: the properties of inosine and adenosine in TATA box DNA.

artículo científico publicado en 1999

The Allostery Landscape: Quantifying Thermodynamic Couplings in Biomolecular Systems

scientific article published on 21 October 2016

The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor

scientific article published in Journal of Biological Chemistry

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites.

artículo científico publicado en 2018

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor

scientific article published on 19 July 2019

The behavioral effects of phencyclidines may be due to their blockade of potassium channels ⬇️

artículo científico publicado el 1 de diciembre de 1981

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

artículo científico publicado en 2010

The correlation between multidomain enzymes and multiple activation mechanisms— The case of phospholipase Cβ and its membrane interactions ⬇️

artículo científico publicado el 30 de agosto de 2011

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT.

artículo científico publicado en 2013

The fourth transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle

scientific journal article

The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivate

artículo científico publicado en 2002

The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions

artículo científico publicado en 1999

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state.

artículo científico publicado en 2017

The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride

artículo científico publicado en 2014

The study of G-protein coupled receptor oligomerization with computational modeling and bioinformatics.

artículo científico publicado en 2005

Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter.

artículo científico publicado en 2017

Three-dimensional representations of G protein-coupled receptor structures and mechanisms

scientific article published on 01 January 2002

Topology of Type II REases revisited; structural classes and the common conserved core

artículo científico publicado en 2007

Toward realistic modeling of dynamic processes in cell signaling: quantification of macromolecular crowding effects

artículo científico publicado en 2007

Transport domain unlocking sets the uptake rate of an aspartate transporter.

artículo científico publicado en 2015

Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways

scientific article published on 01 May 2006

Turkey must end violent response to protests

artículo científico publicado en 2013

Why GPCRs behave differently in cubic and lamellar lipidic mesophases

artículo científico publicado en 2012

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

scientific article published on 21 February 2020

Lista de obras de Harel Weinstein

A Flexible Docking Procedure for the Exploration of Peptide Binding Selectivity to Known Structures and Homology Models of PDZ Domains

A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling.

A Locus of the Gonadotropin-releasing Hormone Receptor That Differentiates Agonist and Antagonist Binding Sites

A Machine Learning Approach for the Discovery of Ligand-Specific Functional Mechanisms of GPCRs

A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.

A New Computational Method for Membrane Compressibility: Bilayer Mechanical Thickness Revisited

A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na+ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding

A dynamic model of membrane-bound phospholipase Cβ2 activation by Gβγ subunits.

A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2

A juxtamembrane mutation in the N terminus of the dopamine transporter induces preference for an inward-facing conformation.

A knowledge-based scale for the analysis and prediction of buried and exposed faces of transmembrane domain proteins.

A lightweight method for evaluating in situ workflow efficiency

A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport.

A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding.

A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif

A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P.

A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases

A theoretical model study of the comparative effectiveness of atropine and scopolamine action in the central nervous system

AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems.

Accurate In Silico Modeling of Asymmetric Bilayers Based on Biophysical Principles

Acetylcholine-Like Molecular Arrangement in Psychomimetic Anticholinergic Drugs ⬇️

Allosteric Mechanisms of Molecular Machines at the Membrane: Transport by Sodium-Coupled Symporters.

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation.

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1

An intracellular interaction network regulates conformational transitions in the dopamine transporter.

Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide ⬇️

Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy

Batch mode generation of residue-based diagrams of proteins.

Binding mechanisms of TATA box-binding proteins: DNA kinking is stabilized by specific hydrogen bonds

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

Building protein diagrams on the web with the residue-based diagram editor RbDe.

Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain

Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

Chloride binding site of neurotransmitter sodium symporters

Cholesterol modulates the membrane effects and spatial organization of membrane-penetrating ligands for G-protein coupled receptors

Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances - The case of the benzofuran 5-MAPB.

Comparative modeling and molecular dynamics studies of the delta, kappa and mu opioid receptors ⬇️

Computational approaches to detect allosteric pathways in transmembrane molecular machines

Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290

Conformational changes in dopamine transporter intracellular regions upon cocaine binding and dopamine translocation

Conformational dynamics of ligand-dependent alternating access in LeuT.

Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.

Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression.

Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.

Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TATA box-binding protein

Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer.

Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling

Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia.

Electrostatic analysis of DNA binding properties in lysine to leucine mutants of TATA-box binding proteins

Energetic and structural considerations for the mechanism of protein sliding along DNA in the nonspecific BamHI-DNA complex.

Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins

Experimental conditions can obscure the second high-affinity site in LeuT.

Functional Microdomains in G-protein-coupled Receptors

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Functional mechanisms of neurotransmitter transporters regulated by lipid-protein interactions of their terminal loops

Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp.

Functional role of arginine-11 in the N-terminal helix of skeletal troponin C: combined mutagenesis and molecular dynamics investigation

Functional role of the spatial proximity of Asp114(2.50) in TMH 2 and Asn332(7.49) in TMH 7 of the mu opioid receptor

GPCRmd uncovers the dynamics of the 3D-GPCRome

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties.

Identification of GATC- and CCGG-recognizing Type II REases and their putative specificity-determining positions using Scan2S--a novel motif scan algorithm with optional secondary structure constraints

Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.

In support of the BMRB.

Ion-Controlled Conformational Dynamics in the Outward-Open Transition from an Occluded State of LeuT ⬇️

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

Key issues in the computational simulation of GPCR function: representation of loop domains.

Ligand selectivity of D2 dopamine receptors is modulated by changes in local dynamics produced by sodium binding.

Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

Mechanisms of Lipid Scrambling by the G Protein-Coupled Receptor Opsin

Mechanistic insights from a refined three-dimensional model of integrin alphaIIbbeta3.