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Lista de obras de Shunichi Takeda

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

artículo científico publicado en 2016

A chemical neurotoxin, MPTP induces Parkinson's disease like phenotype, movement disorders and persistent loss of dopamine neurons in medaka fish

artículo científico publicado en 2009

A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

artículo científico publicado en 2007

A mutated EGFR is sufficient to induce malignant melanoma with genetic background-dependent histopathologies.

artículo científico publicado en 2010

A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage

artículo científico publicado en 2006

A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin

artículo científico publicado en 2006

A novel approach using DNA-repair-deficient chicken DT40 cell lines for screening and characterizing the genotoxicity of environmental contaminants

artículo científico publicado en 2009

A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes

artículo científico publicado en 2013

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

artículo científico publicado en 2017

ATF6α/β-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

artículo científico publicado en 2013

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

artículo científico publicado en 2015

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

scientific journal article

Accumulation of true single strand breaks and AP sites in base excision repair deficient cells

artículo científico publicado en 2010

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells

artículo científico publicado en 2001

Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model

artículo científico publicado en 2008

Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish

artículo científico publicado en 2010

An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.

artículo científico publicado en 2009

An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

artículo científico publicado en 2007

Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.

artículo científico publicado en 2002

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

artículo científico publicado en 2011

BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

artículo científico publicado en 2015

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes

article published in the Proceedings of the National Academy of Sciences of the United States of America

Berberine induces double-strand DNA breaks in Rev3 deficient cells

artículo científico publicado en 2014

Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences

artículo científico publicado en 2009

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.

artículo científico publicado en 2001

Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS.

artículo científico publicado en 2009

Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM.

artículo científico publicado en 2004

Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction

artículo científico publicado en 2013

Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression

artículo científico publicado en 2018

Cohesin associates with spindle poles in a mitosis-specific manner and functions in spindle assembly in vertebrate cells

scientific article published on 30 December 2008

Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair

artículo científico publicado en 2006

Connecting the dots between septins and the DNA damage checkpoint

artículo científico publicado en 2007

Conserved domains in the chicken homologue of BRCA2

artículo científico publicado en 2002

Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action

artículo científico publicado en 2011

Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse

artículo científico publicado en 2007

Corrigendum to “DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion” [Biochem. Biophys. Res. Commun. 371 (2008) 225–229]

article

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.

artículo científico publicado en 2010

Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

artículo científico publicado en 2007

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

artículo científico publicado en 2008

Cytotoxicity of Tirapazamine (3-Amino-1,2,4-benzotriazine-1,4-dioxide)-Induced DNA Damage in Chicken DT40 Cells

artículo científico publicado en 2016

DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells

artículo científico publicado en 2007

DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation

artículo científico publicado en 2004

DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.

artículo científico publicado en 2009

DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion

artículo científico publicado en 2008

DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair

artículo científico publicado en 2001

DNA-dependent protein kinase inhibits AID-induced antibody gene conversion

artículo científico publicado en 2007

Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage

artículo científico publicado en 2005

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms

Differential usage of non-homologous end-joining and homologous recombination in double strand break repair

artículo científico publicado en 2006

Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype

artículo científico publicado en 2004

Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance.

artículo científico publicado en 1998

Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells

artículo científico publicado en 2015

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis

artículo científico publicado en 2010

Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2

artículo científico publicado en 2003

EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

artículo científico publicado en 2014

Early expression of Ig μ chain from a transgene significantly reduces the duration of the pro-B stage but does not affect the small pre-B stage

scientific article published on 01 August 1996

Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group.

artículo científico publicado en 2001

Escherichia coli extract-catalyzed recombination in switch regions of mouse immunoglobulin genes.

artículo científico publicado en 1983

Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers

artículo científico publicado en 2014

Exploring the pathogenetic mechanisms underlying Parkinson's disease in medaka fish

artículo científico publicado en 2014

Extensive chromosomal breaks are induced by tamoxifen and estrogen in DNA repair-deficient cells

artículo científico publicado en 2004

FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells

artículo científico publicado en 2010

Fen-1 facilitates homologous recombination by removing divergent sequences at DNA break ends

artículo científico publicado en 2005

Fibroblast-dependent growth of mouse mast cells in vitro: duplication of mast cell depletion in mutant mice of W/Wv genotype.

artículo científico publicado en 1988

Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

artículo científico publicado en 2015

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination

artículo científico publicado en 2010

Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines

artículo científico publicado en 2002

Generation and phenotypic analysis of conditionally inactivated mutant cells

Generation of medaka gene knockout models by target-selected mutagenesis

artículo científico publicado en 2006

Genetic Evidence for Genotoxic Effect of Entecavir, an Anti-Hepatitis B Virus Nucleotide Analog

artículo científico publicado en 2016

Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination

artículo científico publicado en 2020

Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair

artículo científico publicado en 2001

Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks

artículo científico publicado en 2006

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes

artículo científico publicado en 2009

Genetic evidence that the non-homologous end-joining repair pathway is involved in LINE retrotransposition

artículo científico publicado en 2009

Genistein‐induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells

Genotoxic potentials and related mechanisms of bisphenol A and other bisphenol compounds: a comparison study employing chicken DT40 cells

artículo científico publicado en 2013

Genotoxicity of several polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs, and their mechanisms of toxicity

artículo científico publicado en 2011

Histone H1 null vertebrate cells exhibit altered nucleosome architecture

artículo científico publicado en 2010

Histone H1 variant, H1R is involved in DNA damage response

scientific article published on 05 July 2007

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity

artículo científico publicado en 2014

Homologous DNA recombination in vertebrate cells

artículo científico publicado en 2001

Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium

artículo científico publicado en 2016

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells ⬇️

artículo científico publicado el 15 de septiembre de 1998

Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52.

artículo científico publicado en 1998

Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C

artículo científico publicado en 2001

Human replicative DNA polymerase δ can bypass T-T (6-4) ultraviolet photoproducts on template strands

artículo científico publicado en 2010

Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

artículo científico publicado en 2014

In vitro effects of recombinant interleukin 7 on growth and differentiation of bone marrow pro-B- and pro-T-lymphocyte clones and fetal thymocyte clones.

artículo científico publicado en 1989

In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

artículo científico publicado en 2016

Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells

artículo científico publicado en 2015

Increased ratio of targeted to random integration after transfection of chicken B cell lines.

artículo científico publicado en 1991

Induction of the 2B9 antigen/dipeptidyl peptidase IV/CD26 on human natural killer cells by IL-2, IL-12 or IL-15.

artículo científico publicado en 1997

Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells

artículo científico publicado en 2007

Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks

artículo científico publicado en 2013

Introduction and Expression of the Interleukin 2 Receptor (Tac) Gene in Hematopoietic Stem Cells with Retrovirus Vectors

article

Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

artículo científico publicado en 2011

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage

artículo científico publicado en 2005

Involvement of vertebrate polkappa in Rad18-independent postreplication repair of UV damage

artículo científico publicado en 2002

KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

artículo científico publicado en 2010

Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line

artículo científico publicado en 2008

Leptin receptor-deficient (knockout) medaka, Oryzias latipes, show chronical up-regulated levels of orexigenic neuropeptides, elevated food intake and stage specific effects on growth and fat allocation.

artículo científico publicado en 2013

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

artículo científico publicado en 1996

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

artículo científico publicado en 2016

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.

artículo científico publicado en 2016

Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage

artículo científico publicado en 2017

Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells

artículo científico publicado en 2005

Multiple roles of vertebrate REV genes in DNA repair and recombination

artículo científico publicado en 2005

Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity

artículo científico publicado en 2010

Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development

artículo científico

Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence.

artículo científico publicado en 1985

Oxidative stress at low levels can induce clustered DNA lesions leading to NHEJ mediated mutations

artículo científico publicado en 2016

PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.

artículo científico publicado en 2008

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates

artículo científico publicado en 2013

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

artículo científico publicado en 2006

Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase

artículo científico publicado en 2007

Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells

artículo científico publicado en 2016

Post-replication repair in DT40 cells: translesion polymerases versus recombinases

artículo científico publicado en 2004

Potentials and mechanisms of genotoxicity of six pharmaceuticals frequently detected in freshwater environment

artículo científico publicado en 2012

Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers

artículo científico publicado en 1989

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

artículo científico publicado en 2015

Proteasome inhibition in medaka brain induces the features of Parkinson's disease

artículo científico publicado en 2010

Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes

artículo científico publicado en 2016

Purification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions

artículo científico publicado en 2011

RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells

artículo científico publicado en 2002

RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors

artículo científico publicado en 2007

RAP80 acts independently of BRCA1 in repair of topoisomerase II poison-induced DNA damage

artículo científico publicado en 2010

Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

artículo científico publicado en 1998

Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

artículo científico publicado en 2001

Rapid assessment of two major repair activities against DNA double-strand breaks in vertebrate cells

artículo científico publicado en 2005

Rapid generation of specific antibodies by enhanced homologous recombination

artículo científico publicado en 2005

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition

artículo científico publicado en 2014

Re-evaluation of the probabilities for productive rearrangements on the κ andλloci

artículo científico publicado en 1996

Regulation of the Fanconi anemia pathway by a SUMO-like delivery network

artículo científico publicado en 2011

Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines

artículo científico publicado en 2015

Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

artículo científico publicado en 2016

Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.

artículo científico publicado en 2004

SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells

SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss

artículo científico publicado en 2014

Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells

artículo científico publicado en 2017

Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination

artículo científico publicado en 2005

Simultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesions

artículo científico publicado en 2010

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

artículo científico publicado en 1999

Split Dose Recovery Studies using Homologous Recombination Deficient Gene Knockout Chicken B Lymphocyte Cells

article

Stereospecific PARP trapping by BMN 673 and comparison with olaparib and rucaparib

artículo científico publicado en 2013

TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors

artículo científico publicado en 2017

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

artículo científico publicado en 2012

Targeted disruption of an H3-IV/H3-V gene pair causes increased expression of the remaining H3 genes in the chicken DT40 cell line.

artículo científico publicado en 1995

The 9-1-1 DNA clamp is required for immunoglobulin gene conversion

artículo científico publicado en 2008

The BRCT domain of PARP-1 is required for immunoglobulin gene conversion ⬇️

artículo científico publicado en 2010

The POLD3 subunit of DNA polymerase δ can promote translesion synthesis independently of DNA polymerase ζ.

artículo científico publicado en 2015

The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment

artículo científico publicado en 2012

The USP1/UAF1 complex promotes double-strand break repair through homologous recombination

artículo científico publicado en 2011

The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination

artículo científico publicado en 2011

The essential functions of human Rad51 are independent of ATP hydrolysis

artículo científico publicado en 1999

The histone chaperone facilitates chromatin transcription (FACT) protein maintains normal replication fork rates

artículo científico

The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line

artículo científico publicado en 2016

The unfolded protein response transducer ATF6 represents a novel transmembrane-type endoplasmic reticulum-associated degradation substrate requiring both mannose trimming and SEL1L protein

artículo científico publicado en 2013

The vital link between the ubiquitin-proteasome pathway and DNA repair: impact on cancer therapy

scientific article published on 06 February 2009

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

artículo científico publicado en 2002

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

artículo científico publicado en 2012

Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents

artículo científico publicado en 2014

Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

artículo científico publicado en 2012

Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage

artículo científico publicado en 2006

Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage

artículo científico publicado en 2006

Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish

artículo científico publicado en 2011

Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein

artículo científico publicado en 2015

Werner and Bloom helicases are involved in DNA repair in a complementary fashion

artículo científico publicado en 2002

XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes

artículo científico publicado en 2003

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