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Lista de obras de Matti Jauhiainen

17β-Estradiol and estradiol fatty acyl esters and estrogen-converting enzyme expression in adipose tissue in obese men and women

artículo científico publicado en 2013

A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate

artículo científico publicado en 2017

A metabolic view on menopause and ageing

artículo científico publicado en 2014

ANGPTL3 serum concentration and rare genetic variants in Finnish population

artículo científico publicado en 2017

Accumulation of genistein and lipophilic genistein derivatives in lipoproteins during incubation with human plasma in vitro

artículo científico publicado en 2003

Acidic extracellular environments strongly impair ABCA1-mediated cholesterol efflux from human macrophage foam cells

artículo científico publicado en 2010

Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample

artículo científico publicado en 2004

Acute Psychological Stress Accelerates Reverse Cholesterol Transport via Corticosterone-Dependent Inhibition of Intestinal Cholesterol Absorption ⬇️

artículo científico publicado el 28 de agosto de 2012

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

artículo científico publicado en 2012

Aggregatibacter actinomycetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice

artículo científico publicado en 2007

Aggregation of lipoprotein and inflammatory parameters in families with a history of premature myocardial infarction: the Tallinn myocardial infarction study

artículo científico publicado en 2008

Altered HDL Remodeling and Functionality in Familial Hypercholesterolemia

artículo científico publicado en 2018

Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein

artículo científico publicado en 2006

Amerindian-specific regions under positive selection harbour new lipid variants in Latinos

artículo científico publicado en 2014

Analysis of lipid transfer activity between model nascent HDL particles and plasma lipoproteins: implications for current concepts of nascent HDL maturation and genesis

artículo científico publicado en 2009

Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes

artículo científico publicado en 2012

Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids

artículo científico publicado en 2013

Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for pandemrix-associated narcolepsy risk.

artículo científico publicado en 2014

ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.

artículo científico publicado en 2016

Apolipoprotein A-I Exerts Bactericidal Activity against Yersinia enterocolitica Serotype O:3 ⬇️

artículo científico publicado el 6 de septiembre de 2011

Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease

artículo científico publicado en 2007

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase

artículo científico publicado en 2007

Atherogenic, enlarged, and dysfunctional HDL in human PLTP/apoA-I double transgenic mice

artículo científico publicado en 2007

Atomistic MD simulation reveals the mechanism by which CETP penetrates into HDL enabling lipid transfer from HDL to CETP

artículo científico publicado en 2014

Avian phospholipid transfer protein causes HDL conversion without affecting cholesterol efflux from macrophages

artículo científico publicado en 2009

Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties

artículo científico publicado en 2015

Ceramides in the pathophysiology of the anterior segment of the eye.

artículo científico

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice

artículo científico publicado en 2009

Chlamydial lipopolysaccharide is present in serum during acute coronary syndrome and correlates with CRP levels

artículo científico publicado en 2006

Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles

artículo científico publicado en 2007

Chymase released from hypoxia-activated cardiac mast cells cleaves human apolipoproteinA-I at Tyr192 and compromises its cardioprotective activity

artículo científico publicado en 2018

Cln5-deficiency in mice leads to microglial activation, defective myelination and changes in lipid metabolism

artículo científico publicado en 2011

Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL.

artículo científico publicado en 2007

Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol

artículo científico publicado en 2010

Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk

artículo científico publicado en 2012

Consumption of polyunsaturated fat improves the saturated fatty acid-mediated impairment of HDL antioxidant potential

artículo científico publicado en 2015

Decreased high-density lipoprotein (HDL) particle size, prebeta-, and large HDL subspecies concentration in Finnish low-HDL families: relationship with intima-media thickness

artículo científico publicado en 2006

Deficiency of the INCL protein Ppt1 results in changes in ectopic F1-ATP synthase and altered cholesterol metabolism

artículo científico publicado en 2008

Degradation of phospholipid transfer protein (PLTP) and PLTP-generated pre-beta-high density lipoprotein by mast cell chymase impairs high affinity efflux of cholesterol from macrophage foam cells

artículo científico publicado en 2003

Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants

artículo científico publicado en 2018

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

artículo científico publicado en 2013

Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

artículo científico publicado en 2011

Determinants of low HDL levels in familial combined hyperlipidemia

artículo científico publicado en 2003

Determination of human plasma phospholipid transfer protein mass and activity

artículo científico publicado en 2005

Dietary determinants of serum paraoxonase activity in healthy humans

artículo científico publicado en 2002

Dietary fatty acids and cholesterol differentially modulate HDL cholesterol metabolism in Golden-Syrian hamsters

artículo científico publicado en 2005

Differential effects of gemfibrozil and fenofibrate on reverse cholesterol transport from macrophages to feces in vivo.

artículo científico publicado en 2010

Dry eye symptoms are increased in mice deficient in phospholipid transfer protein (PLTP).

artículo científico publicado en 2011

Effect of HDL composition and particle size on the resistance of HDL to the oxidation

artículo científico publicado en 2010

Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice

artículo científico publicado en 2008

Effect of different forms of dietary hydrogenated fats on LDL particle size

artículo científico publicado en 2003

Effect of pravastatin treatment on Chlamydia pneumoniae infection, inflammation and serum lipids in NIH/S mice

artículo científico publicado en 2007

Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice

artículo científico publicado en 2005

Effect of treatment with human apolipoprotein A-I on atherosclerosis in uremic apolipoprotein-E deficient mice

artículo científico publicado en 2008

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [ 18 F]FDG uptake in Ldlr −/− Apob 100/100 mice

Effects of medium-chain fatty acids and oleic acid on blood lipids, lipoproteins, glucose, insulin, and lipid transfer protein activities

artículo científico publicado en 2004

Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet).

artículo científico publicado en 2014

Efficacy of a Therapeutic Lifestyle Change/Step 2 diet in moderately hypercholesterolemic middle-aged and elderly female and male subjects.

artículo científico publicado en 2002

Enhanced vascular permeability facilitates entry of plasma HDL and promotes macrophage-reverse cholesterol transport from skin in mice.

artículo científico publicado en 2014

Estimation of VLDL, IDL, LDL, HDL2, apoA-I, and apoB from the Friedewald inputs--apoB and IDL, but not LDL, are associated with mortality in type 1 diabetes

artículo científico publicado en 2009

Estradiol fatty acid esterification is increased in high density lipoprotein subclass 3 isolated from hypertriglyceridemic subjects

artículo científico publicado en 2005

European Lipoprotein Club: Report of the 24th ELC Annual Conference, Tutzing, 10-13 September 2001.

artículo científico publicado en 2002

European Lipoprotein Club: Report of the 27th ELC Annual Conference, Tutzing, 6–9 September 2004

European lipoprotein club: report of the 25th ELC annual conference. Tutzing, 9-12 September 2002.

artículo científico publicado en 2003

Exacerbated neuronal ceroid lipofuscinosis phenotype in Cln1/5 double-knockout mice

artículo científico publicado en 2012

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

artículo científico publicado en 2017

Fatty acyl esterification and deesterification of 17β-estradiol in human breast subcutaneous adipose tissue

artículo científico publicado en 2012

Genomic, Transcriptomic, and Lipidomic Profiling Highlights the Role of Inflammation in Individuals With Low High-density Lipoprotein Cholesterol

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1)--distinct characteristics in neurons

artículo científico publicado en 2007

HDL subspecies in young adult twins: heritability and impact of overweight.

artículo científico publicado en 2009

HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL 2b particles

artículo científico publicado en 2008

Haptoglobin 2 allele associates with unstable carotid plaque and major cardiovascular events

artículo científico publicado en 2013

Haptoglobin Hp2 Variant Promotes Premature Cardiovascular Death in Stroke Survivors

artículo científico publicado en 2017

Hemostatic factors as predictors of coronary events and total mortality: The FINRISK '92 Hemostasis Study

artículo científico publicado en 2002

Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis

artículo científico

Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-feces RCT and HDL antioxidant properties.

artículo científico publicado en 2013

High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level

artículo científico publicado en 2008

High-density lipoprotein-associated 17beta-estradiol fatty acyl ester uptake by Fu5AH hepatoma cells: implications of the roles of scavenger receptor class B, type I and the low-density lipoprotein receptor

artículo científico publicado en 2007

High-density lipoproteins (HDL) are present in stenotic aortic valves and may interfere with the mechanisms of valvular calcification.

artículo científico publicado en 2011

High-fat meals induce systemic cytokine release without evidence of endotoxemia-mediated cytokine production from circulating monocytes or myeloid dendritic cells

artículo científico publicado en 2014

Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice ⬇️

artículo científico

Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass

artículo científico publicado en 2010

Human macrophage cholesterol efflux potential is enhanced by HDL-associated 17beta-estradiol fatty acyl esters.

artículo científico publicado en 2009

Human tear fluid lipidome: from composition to function

artículo científico publicado en 2011

Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2.

artículo científico publicado en 2012

Hypertriglyceridemia is associated with prebeta-HDL concentrations in subjects with familial low HDL.

artículo científico publicado en 2005

Identification and analysis of anti-HDL scFv-antibodies obtained from phage display based synthetic antibody library

artículo científico publicado en 2015

Identification of alpha-1 acid glycoprotein as a lysophospholipid binding protein: a complementary role to albumin in the scavenging of lysophosphatidylcholine

artículo científico publicado en 2006

Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level

artículo científico publicado en 2017

Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice

artículo científico publicado en 2007

Increased apolipoprotein E level and reduced high-density lipoprotein mean particle size associate with low high-density lipoprotein cholesterol and features of metabolic syndrome.

artículo científico publicado en 2010

Influence of Isoforms and Carboxyl-Terminal Truncations on the Capacity of Apolipoprotein E To Associate with and Activate Phospholipid Transfer Protein

artículo científico publicado en 2015

Instability of LDL particles predicts future cardiovascular deaths

artículo científico publicado en 2017

Interaction of phospholipid transfer protein with human tear fluid mucins ⬇️

artículo científico publicado el 19 de agosto de 2010

Interaction of purified tear lipocalin with lipid membranes

artículo científico publicado en 2005

Interfacial and lipid transfer properties of human phospholipid transfer protein

Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP).

artículo científico publicado en 2002

Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation

artículo científico publicado en 2017

LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfraction.

artículo científico publicado en 2002

LXR-dependent regulation of macrophage-specific reverse cholesterol transport is impaired in a model of genetic diabesity.

artículo científico publicado en 2017

Lecithin/cholesterol acyltransferase induces estradiol esterification in high-density lipoprotein, increasing its antioxidant potential

artículo científico publicado en 2004

Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques

artículo científico publicado en 2016

Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies

artículo científico publicado en 2008

Lipid transfer protein activities in subjects with impaired glucose tolerance

artículo científico publicado en 2007

Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response.

artículo científico publicado en 2014

Lipoprotein-associated estrogens

artículo científico publicado en 2002

Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis

artículo científico publicado en 2008

Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy

scientific article published on February 2017

Low-expression variant of fatty acid-binding protein 4 favors reduced manifestations of atherosclerotic disease and increased plaque stability

artículo científico publicado en 2014

Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development

artículo científico publicado en 2006

Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse

artículo científico publicado en 2011

Mast cell-dependent proteolytic modification of HDL particles during anaphylactic shock in the mouse reduces their ability to induce cholesterol efflux from macrophage foam cells ex vivo

artículo científico publicado en 2009

Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation

artículo científico publicado en 2010

Matrix metalloproteinase 8 degrades apolipoprotein A-I and reduces its cholesterol efflux capacity

artículo científico publicado en 2014

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids

artículo científico publicado en 2013

Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophage-specific reverse cholesterol transport.

artículo científico publicado en 2013

Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

artículo científico publicado en 2009

Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization

artículo científico publicado en 2012

Nerve growth factor (NGF) and pro-NGF increase low-density lipoprotein (LDL) receptors in neuronal cells partly by different mechanisms: role of LDL in neurite outgrowth

artículo científico publicado en 2015

New medications targeting triglyceride-rich lipoproteins: Can inhibition of ANGPTL3 or apoC-III reduce the residual cardiovascular risk?

Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels

artículo científico publicado en 2010

Novel enzyme immunoassay utilizing lipopolysaccharide-binding protein as a capture molecule for the measurement of chlamydial lipopolysaccharide in serum

artículo científico publicado en 2005

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

article

Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism

artículo científico publicado en 2013

Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.

artículo científico publicado en 2007

PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma

artículo científico publicado en 2003

PPAR-β/δ activation promotes phospholipid transfer protein expression.

artículo científico publicado en 2015

Partial filling affinity capillary electrophoresis with cationic poly(vinylpyrrolidone)-based copolymer coatings for studies on human lipoprotein-steroid interactions

artículo científico publicado en 2009

Partial sleep restriction activates immune response-related gene expression pathways: experimental and epidemiological studies in humans

artículo científico publicado en 2013

Patients with type 1 diabetes show signs of vascular dysfunction in response to multiple high-fat meals

artículo científico publicado en 2014

Periodontitis decreases the antiatherogenic potency of high density lipoprotein

artículo científico publicado en 2003

Phenol-Enriched Virgin Olive Oil Promotes Macrophage-Specific Reverse Cholesterol Transport In Vivo

artículo científico publicado en 2020

Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells ⬇️

artículo científico publicado el 1 de mayo de 2003

Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study

artículo científico publicado en 2008

Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity

artículo científico publicado en 2006

Plasma phospholipid transfer protein-mediated reactions are impaired by hypochlorite-modification of high density lipoprotein

artículo científico publicado en 2003

Positron emission tomography tracer [68GA]NODAGA-EXENDIN-4 detects glucagon-like peptide-1 receptor expression in mouse atherosclerotic vascular lesions

Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans

artículo científico publicado en 2006

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

artículo científico publicado en 2016

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

artículo científico publicado en 2009

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

artículo científico publicado en 2015

Salivary biomarkers in association with periodontal parameters and the periodontitis risk haplotype

scientific article published on 03 September 2018

Secretion of sterols and the NPC2 protein from primary astrocytes

artículo científico publicado en 2004

Sequential estrogen-progestin replacement therapy in healthy postmenopausal women: effects on cholesterol efflux capacity and key proteins regulating high-density lipoprotein levels

artículo científico publicado en 2002

Serum angiopoietin-like 4 protein levels and expression in adipose tissue are inversely correlated with obesity in monozygotic twins

artículo científico publicado en 2011

Serum chlamydial lipopolysaccharide as a prognostic factor for a new cardiovascular event

artículo científico publicado en 2008

Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity

artículo científico publicado en 2008

Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide

artículo científico publicado en 2004

Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes

artículo científico publicado en 2019

Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

artículo científico publicado en 2014

Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition

artículo científico publicado en 2014

Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans

artículo científico publicado en 2005

Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells

artículo científico publicado en 2012

Steroid hormone-fatty acid esters and bone

artículo científico publicado en 2008

Steroid sulfatase activity in subcutaneous and visceral adipose tissue: a comparison between pre- and postmenopausal women

artículo científico publicado en 2015

Subantimicrobial-dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages

artículo científico publicado en 2013

Sugar treatment of human lipoprotein particles and their separation by capillary electrophoresis

artículo científico publicado en 2010

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

The Cholesterol Content of Western Diets Plays a Major Role in the Paradoxical Increase in High-Density Lipoprotein Cholesterol and Upregulates the Macrophage Reverse Cholesterol Transport Pathway

scientific article published on 01 November 2011

The absence of macrophage Nrf2 promotes early atherogenesis

artículo científico publicado en 2013

The effect of proatherogenic microbes on macrophage cholesterol homeostasis in apoE-deficient mice

artículo científico publicado en 2011

The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice

artículo científico publicado en 2013

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models

artículo científico publicado en 2013

The impact of gender and serum estradiol levels on HDL‐mediated reverse cholesterol transport ⬇️

artículo científico publicado el 9 de febrero de 2013

The interplay between lipoprotein phenotypes, adiponectin, and alcohol consumption

artículo científico publicado en 2011

The orientation and dynamics of estradiol and estradiol oleate in lipid membranes and HDL disc models

artículo científico publicado en 2014

The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk

artículo científico publicado en 2010

The role of ANGPTL3 in controlling lipoprotein metabolism

artículo científico publicado en 2016

Thermodynamic and kinetic approaches for evaluation of monoclonal antibody - Lipoprotein interactions

artículo científico publicado en 2016

Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism

artículo científico publicado en 2016

Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸F-fluoromethylcholine

artículo científico publicado en 2016

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

artículo científico publicado en 2016

Unraveling the disease pathogenesis behind lethal hydrolethalus syndrome revealed multiple changes in molecular and cellular level

artículo científico publicado en 2009

Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function.

artículo científico publicado en 2012

What have we learnt about high-density lipoprotein cholesterol measurements during 32years? Experiences in Finland 1980–2012 ⬇️

artículo científico publicado el 18 de octubre de 2012

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