Lista de obras - Tony Velkov - Dominio Público Uruguay

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles

artículo científico publicado en 2017

A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection.

artículo científico publicado en 2016

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes

artículo científico publicado en 2016

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

artículo científico publicado en 2017

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography.

artículo científico publicado en 2008

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

artículo científico publicado en 2013

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

artículo científico publicado en 2022

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria

artículo científico publicado en 2017

Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa.

artículo científico publicado en 2018

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

artículo científico publicado en 2017

An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI.

artículo científico publicado en 2016

An improved purification procedure for cyclosporin synthetase

artículo científico publicado en 2005

An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

artículo científico publicado en 2019

Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1.

artículo científico publicado en 2012

Analysis of protein thiol changes occurring during rat sperm epididymal maturation

artículo científico publicado en 2014

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

artículo científico publicado en 2015

Antibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to Activity

artículo científico publicado en 2016

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

artículo científico publicado en 2017

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria

artículo científico publicado en 2015

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response

artículo científico publicado en 2017

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

artículo científico publicado en 2017

Can Cystic Fibrosis Patients Finally Catch a Breath With Lumacaftor/Ivacaftor?

artículo científico publicado en 2016

Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.

artículo científico publicado en 2016

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

artículo científico publicado en 2015

Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase

artículo científico publicado en 2011

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

artículo científico publicado en 2017

Characterization of the drug binding specificity of rat liver fatty acid binding protein.

artículo científico publicado en 2008

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis

artículo científico publicado en 2018

Cold adaptation generates mutations associated with the growth of influenza B vaccine viruses.

artículo científico publicado en 2015

Colistin and polymyxin B: peas in a pod, or chalk and cheese?

artículo científico publicado en 2014

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.

artículo científico publicado en 2015

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

artículo científico publicado en 2019

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across ten clinically relevant gram-negative bacteria

artículo científico publicado en 2017

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation

scientific article published on 03 July 2018

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice

artículo científico publicado en 2018

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

artículo científico publicado en 2016

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice

artículo científico publicado en 2020

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility.

artículo científico publicado en 2016

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

artículo científico publicado en 2015

Design and Evaluation of Novel Polymyxin Fluorescent Probes

artículo científico publicado en 2017

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

artículo científico publicado en 2010

Developing an anion host for lipid A binding and antibacterial activity

scientific article published on 18 March 2010

Development of HPLC and LC-MS/MS methods for the analysis of ivacaftor, its major metabolites and lumacaftor in plasma and sputum of cystic fibrosis patients treated with ORKAMBI or KALYDECO.

artículo científico publicado en 2016

Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations.

artículo científico publicado en 2012

Drug-drug plasma protein binding interactions of ivacaftor

artículo científico publicado en 2015

Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study.

artículo científico publicado en 2018

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

artículo científico publicado en 2007

Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers

scientific article published on 06 November 2018

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

artículo científico publicado en 2015

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae

scientific article published on 01 June 2018

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators.

artículo científico publicado en 2016

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

artículo científico publicado en 2017

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity

artículo científico publicado en 2017

Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF.

artículo científico publicado en 2007

Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant Acinetobacter baumannii in a Murine Bloodstream Infection Model

artículo científico publicado en 2020

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa.

artículo científico publicado en 2018

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

artículo científico publicado en 2016

Head and flagella subcompartmental proteomic analysis of human spermatozoa

artículo científico publicado en 2013

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

artículo científico publicado en 2017

Imaging the distribution of polymyxins in the kidney

artículo científico publicado en 2014

In situprobing the interior of single bacterial cells at nanometer scale

artículo científico publicado en 2014

Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead

artículo científico publicado en 2015

Interaction of phthalates and phenoxy acid herbicide environmental pollutants with intestinal intracellular lipid binding proteins.

artículo científico publicado en 2013

Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs ⬇️

artículo científico publicado el 18 de febrero de 2013

Intracellular localization of polymyxins in human alveolar epithelial cells

article

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

artículo científico publicado en 2017

Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain.

artículo científico publicado en 2009

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates

artículo científico publicado en 2018

Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.

artículo científico publicado en 2014

Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells

artículo científico publicado en 2015

Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase.

artículo científico publicado en 2002

Measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?

artículo científico publicado en 2014

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR

scholarly article by Maytham Hussein et al published 2018 in Computational and Structural Biotechnology Journal

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant

artículo científico publicado en 2018

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

artículo científico publicado en 2017

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

artículo científico publicado en 2015

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress.

artículo científico publicado en 2017

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus.

artículo científico publicado en 2015

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.

artículo científico publicado en 2012

Nanoscale focused ion beam tomography of single bacterial cells for assessment of antibiotic effects

artículo científico publicado en 2014

Near-Atomic Three-Dimensional Mapping for Site-Specific Chemistry of 'Superbugs'.

artículo científico publicado en 2016

Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity

artículo científico publicado en 2020

Ni2+-based immobilized metal ion affinity chromatography of lactose operon repressor protein from Escherichia coli.

artículo científico publicado en 2008

Non-ribosomal peptide synthetases as technological platforms for the synthesis of highly modified peptide bioeffectors--Cyclosporin synthetase as a complex example.

artículo científico publicado en 2003

Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens

artículo científico publicado en 2018

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients.

artículo científico publicado en 2017

PK/PD models in antibacterial development.

artículo científico publicado en 2013

Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs

artículo científico publicado en 2017

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats ⬇️

artículo científico publicado el 7 de junio de 2013

Pharmacokinetics of levobupivacaine following infant spinal anesthesia.

artículo científico publicado en 2016

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.

artículo científico publicado en 2017

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

artículo científico publicado en 2016

Phosphopeptide analysis of rodent epididymal spermatozoa.

artículo científico publicado en 2014

Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin.

artículo científico publicado en 2017

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells.

artículo científico publicado en 2013

Polymyxin B causes DNA damage in HK-2 cells and mice.

artículo científico publicado en 2018

Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensive Drug-resistant Pseudomonas aeruginosa.

artículo científico publicado en 2018

Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

artículo científico publicado en 2017

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

artículo científico publicado en 2013

Polymyxins for CNS infections: Pharmacology and neurotoxicity

artículo científico publicado en 2017

Polymyxins: a new hope in combating Gram-negative superbugs?

artículo científico publicado en 2016

Potential Toxicity of Polymyxins in Human Lung Epithelial Cells

artículo científico publicado en 2017

Probing the fibrate binding specificity of rat liver fatty acid binding protein.

artículo científico publicado en 2009

Probing the flexibility of the DsbA oxidoreductase from Vibrio cholerae--a 15N - 1H heteronuclear NMR relaxation analysis of oxidized and reduced forms of DsbA

artículo científico publicado en 2007

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

artículo científico publicado en 2014

Proteomics analysis of good and poor quality human sperm demonstrates several proteins are routinely aberrantly regulated

artículo científico publicado en 2017

Pulsed-voltage atom probe tomography of low conductivity and insulator materials by application of ultrathin metallic coating on nanoscale specimen geometry.

artículo científico publicado en 2017

Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe.

scientific article published on 09 January 2016

Rapamycin confers neuroprotection against colistin-induced oxidative stress, mitochondria dysfunction and apoptosis through the activation of autophagy and mTOR/Akt/CREB signaling pathways

artículo científico publicado en 2017

Rediscovering the octapeptins.

artículo científico publicado en 2017

Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies ⬇️

artículo científico publicado el 3 de noviembre de 2012

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

artículo científico publicado en 2015

Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules

artículo científico publicado en 2018

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

artículo científico publicado en 2008

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

artículo científico publicado en 2018

Structure--activity relationships of polymyxin antibiotics

artículo científico publicado en 2010

Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein

artículo científico publicado en 2012

Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.

artículo científico publicado en 2013

Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study

artículo científico publicado en 2018

Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol

artículo científico publicado en 2015

T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.

artículo científico publicado en 2018

Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.

artículo científico publicado en 2014

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

artículo científico publicado en 2022

The Plasma Protein Binding Proteome of Ertapenem: A Novel Compound-Centric Proteomic Approach for Elucidating Drug-Plasma Protein Binding Interactions.

artículo científico publicado en 2016

The RNA-dependent-RNA polymerase, an emerging antiviral drug target for the Hendra virus

artículo científico

The antigenic architecture of the hemagglutinin of influenza H5N1 viruses ⬇️

artículo científico publicado el 7 de agosto de 2013

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site.

artículo científico

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

artículo científico publicado en 2012

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

artículo científico publicado en 2017

The impact of backbone N-methylation on the structure-activity relationship of Leu10 -teixobactin

scientific article published on 06 August 2019

The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models

artículo científico publicado en 2018

The interaction of lipophilic drugs with intestinal fatty acid-binding protein.

artículo científico publicado en 2005

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

artículo científico publicado en 2018

The specificity of the influenza B virus hemagglutinin receptor binding pocket: what does it bind to?

artículo científico publicado en 2013

The thermodynamics of Pr55Gag-RNA interaction regulate the assembly of HIV.

artículo científico publicado en 2017

Thermodynamics of lipophilic drug binding to intestinal fatty acid binding protein and permeation across membranes.

artículo científico publicado en 2009

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

artículo científico publicado en 2016

Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling.

artículo científico publicado en 2015

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

scientific article published on 30 March 2017

Lista de obras de Tony Velkov

A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains

A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles

A Hydrogel-Based Localized Release of Colistin for Antimicrobial Treatment of Burn Wound Infection.

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes

A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography.

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria

Alterations of metabolic and lipid profiles in polymyxin-resistant Pseudomonas aeruginosa.

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

An "Unlikely" Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI.

An improved purification procedure for cyclosporin synthetase

An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1.

Analysis of protein thiol changes occurring during rat sperm epididymal maturation

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

Antibacterial Low Molecular Weight Cationic Polymers: Dissecting the Contribution of Hydrophobicity, Chain Length and Charge to Activity

Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response

Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens

Can Cystic Fibrosis Patients Finally Catch a Breath With Lumacaftor/Ivacaftor?

Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

Characterization of the N-Methyltransferase Activities of the Multifunctional Polypeptide Cyclosporin Synthetase

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

Characterization of the drug binding specificity of rat liver fatty acid binding protein.

Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis

Cold adaptation generates mutations associated with the growth of influenza B vaccine viruses.

Colistin and polymyxin B: peas in a pod, or chalk and cheese?

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.

Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa

Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across ten clinically relevant gram-negative bacteria

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation

Contemporary Anti-Ebola Drug Discovery Approaches and Platforms

Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice

Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility.

Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function

Design and Evaluation of Novel Polymyxin Fluorescent Probes

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

Developing an anion host for lipid A binding and antibacterial activity

Development of HPLC and LC-MS/MS methods for the analysis of ivacaftor, its major metabolites and lumacaftor in plasma and sputum of cystic fibrosis patients treated with ORKAMBI or KALYDECO.

Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations.

Drug-drug plasma protein binding interactions of ivacaftor

Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study.

Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.

Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae

From Breast Cancer to Antimicrobial: Combating Extremely Resistant Gram-Negative "Superbugs" Using Novel Combinations of Polymyxin B with Selective Estrogen Receptor Modulators.

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity

Generation of mutant leukaemia inhibitory factor (LIF)-IgG heavy chain fusion proteins as bivalent antagonists of LIF.

Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant Acinetobacter baumannii in a Murine Bloodstream Infection Model

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa.

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Head and flagella subcompartmental proteomic analysis of human spermatozoa

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

Imaging the distribution of polymyxins in the kidney

In situprobing the interior of single bacterial cells at nanometer scale

Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead

Interaction of phthalates and phenoxy acid herbicide environmental pollutants with intestinal intracellular lipid binding proteins.

Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs ⬇️

Intracellular localization of polymyxins in human alveolar epithelial cells

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes

Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain.

Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Clinical Isolates

Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.

Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells

Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase.

Measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress.