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Lista de obras de Angela Santoni

"Immuno-Transient Receptor Potential Ion Channels": The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses.

artículo científico publicado en 2018

15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors

artículo científico publicado en 2007

Activation of Lymphocyte Cytolytic Machinery: Where are We?

artículo científico publicado en 2013

Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells.

artículo científico publicado en 2002

Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms

artículo científico publicado en 2019

Activin A as a mediator of NK-dendritic cell functional interactions

artículo científico publicado en 2014

An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development

artículo científico publicado en 2010

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

artículo científico publicado en 2019

Analysis of the role of chemokines in angiogenesis.

artículo científico publicado en 2003

Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells

artículo científico publicado en 2015

Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis

scientific article published on 03 April 2007

Antigen-specific CD8 T cells in cell cycle circulate in the blood after vaccination

artículo científico publicado en 2019

Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies

artículo científico publicado en 2010

Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells

artículo científico publicado en 2015

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner

artículo científico publicado en 2016

Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization

artículo científico publicado en 2019

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor

scientific article published on 13 February 2020

Bone marrow CD8 T cells are in a different activation state than those in lymphoid periphery

scientific article published on 01 July 2002

Bone marrow CD8 cells down-modulate membrane IL-7R expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment

artículo científico publicado en 2007

CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets

artículo científico publicado en 2008

CD155: A Multi-Functional Molecule in Tumor Progression

scientific article published on 30 January 2020

CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axis

scientific article published on 16 January 2020

CD8 cell division maintaining cytotoxic memory occurs predominantly in the bone marrow

artículo científico publicado en 2005

CIN85 regulates the ligand-dependent endocytosis of the IgE receptor: a new molecular mechanism to dampen mast cell function

artículo científico publicado en 2005

CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.

artículo científico publicado en 2011

CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation

artículo científico publicado en 2013

CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-β1.

artículo científico publicado en 2010

CXCR3/CXCL10 Axis Regulates Neutrophil-NK Cell Cross-Talk Determining the Severity of Experimental Osteoarthritis.

artículo científico publicado en 2017

Ca-activated K channels modulate microglia affecting motor neuron survival in hSOD1 mice

artículo científico publicado en 2018

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response ⬇️

artículo científico

Cancer extracellular vesicles as novel regulators of NK cell response

scientific article published on 30 November 2019

Cancer-associated CD43 glycoforms as target of immunotherapy.

artículo científico publicado en 2013

Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91.

artículo científico publicado en 2014

Cbl family proteins: balancing FcεRI-mediated mast cell and basophil activation

artículo científico publicado en 2011

Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy

artículo científico publicado en 2012

Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling

artículo científico publicado en 2005

Chemokine regulation of innate lymphoid cell tissue distribution and function

artículo científico publicado en 2018

Chemokines and NK cells: regulators of development, trafficking and functions.

artículo científico publicado en 2012

Chemotherapy-elicited upregulation of NKG2D and DNAM-1 ligands as a therapeutic target in multiple myeloma.

artículo científico publicado en 2013

Correction: Kinetics of In Vivo Proliferation and Death of Memory and Naive CD8 Cells: Parameter Estimation Based on 5-Bromo-2′-Deoxyuridine Incorporation in Spleen, Lymph Nodes, and Bone Marrow

Counter-regulation of regulatory T cells by autoreactive CD8+ T cells in rheumatoid arthritis

scientific article published on 16 February 2019

DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction

artículo científico publicado en 2011

Dendritic cells modulate c-kit expression on the edge between activation and death

scientific article published on 25 February 2019

Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability.

artículo científico publicado en 2011

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells

scientific article published on 05 January 2009

Differential chemotactic receptor requirements for NK cell subset trafficking into bone marrow.

artículo científico

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.

artículo científico publicado en 2016

Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells.

artículo científico publicado en 2017

Drug-induced senescent Multiple Myeloma cells elicit NK cell proliferation by direct or exosome-mediated IL-15 trans-presentation.

artículo científico publicado en 2018

Dysregulation of Chemokine/Chemokine Receptor Axes and NK Cell Tissue Localization during Diseases

artículo científico publicado en 2016

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies

artículo científico publicado en 2015

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice

artículo científico publicado en 2015

Environmental stimuli shape microglial plasticity in glioma.

artículo científico publicado en 2017

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

artículo científico publicado en 2016

Evaluation of Rho family small G-protein activity induced by integrin ligation on human leukocytes.

artículo científico publicado en 2004

Ex vivo acidic preconditioning enhances bone marrow ckit+ cell therapeutic potential via increased CXCR4 expression

artículo científico publicado en 2011

Expression of interleukin 15 (IL-15) in human rhabdomyosarcoma, osteosarcoma and Ewing's sarcoma

artículo científico publicado en 1997

FcεRI Signaling in the Modulation of Allergic Response: Role of Mast Cell-Derived Exosomes

artículo científico publicado en 2020

GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells

artículo científico publicado en 2017

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.

artículo científico publicado en 2015

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis.

artículo científico publicado en 2017

Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion.

artículo científico publicado en 2010

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice

artículo científico publicado en 2020

Heat shock protein-90 inhibitors increase MHC class I-related chain A and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation

artículo científico publicado en 2009

High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma.

artículo científico publicado en 2017

High-efficient lentiviral vector-mediated gene transfer into primary human NK cells

artículo científico publicado en 2006

Hitting More Birds with a Stone: Impact of TGF-β on ILC Activity in Cancer

artículo científico publicado en 2020

How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.

artículo científico publicado en 2017

Hyperthermia enhances CD95-ligand gene expression in T lymphocytes

artículo científico publicado en 2005

IL-15 inhibits IL-7Rα expression by memory-phenotype CD8⁺ T cells in the bone marrow.

artículo científico publicado en 2012

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.

artículo científico publicado en 2017

Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation

artículo científico publicado en 2019

Immunoregulatory and Effector Activities of Nitric Oxide and Reactive Nitrogen Species in Cancer

artículo científico publicado en 2016

Impact of bone marrow-derived signals on NK cell development and functional maturation

artículo científico publicado en 2018

Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state

artículo científico publicado en 2010

In Vitro and In Vivo Models to Study Chemokine Regulation of Angiogenesis

artículo científico publicado el 1 de enero de 2004

In Vivo Imaging of Natural Killer Cell Trafficking in Tumors

artículo científico publicado en 2015

Increased frequency of human leukocyte antigen-E inhibitory receptor CD94/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis.

artículo científico publicado en 2007

Induction of human NK cell-mediated cytotoxicity by CD40 triggering on antigen presenting cells

artículo científico publicado en 2003

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

artículo científico publicado en 2016

Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.

artículo científico publicado en 2013

Inhibition of trail gene expression by cyclopentenonic prostaglandin 15-deoxy-delta12,14-prostaglandin J2 in T lymphocytes.

artículo científico publicado en 2007

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.

artículo científico publicado en 2017

Interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship.

artículo científico publicado en 2012

Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses

scientific article published on 29 April 2020

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians

artículo científico publicado en 2018

Key Role of the CD56CD16 Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells

Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis.

artículo científico publicado en 2004

Kinetics of in vivo proliferation and death of memory and naive CD8 T cells: parameter estimation based on 5-bromo-2'-deoxyuridine incorporation in spleen, lymph nodes, and bone marrow

artículo científico publicado en 2008

Lipid raft-dependent FcepsilonRI ubiquitination regulates receptor endocytosis through the action of ubiquitin binding adaptors

artículo científico publicado en 2009

Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer

scientific article published on 03 November 2020

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma.

artículo científico publicado en 2018

Mandatory vaccination in Italy: Time for engagement of immunologists

artículo científico publicado en 2018

Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy

artículo científico publicado en 2008

Memory NK Cell Features Exploitable in Anticancer Immunotherapy

artículo científico publicado en 2019

Memory T-cell competition for bone marrow seeding

article

Multicolor flow cytometric analysis of TLR2 and TLR9 expression and function in NK cells from patients with ANCA-associated vasculitis.

artículo científico publicado en 2017

Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment.

artículo científico publicado en 2015

Multiple levels of chemokine receptor regulation in the control of mouse natural killer cell development

artículo científico publicado en 2014

NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice

artículo científico publicado en 2018

NK Cell Reconstitution in Paediatric Leukemic Patients after T-Cell-Depleted HLA-Haploidentical Haematopoietic Stem Cell Transplantation Followed by the Reinfusion of iCasp9-Modified Donor T Cells

scientific article published on 07 November 2019

NK cells and interferons.

artículo científico publicado en 2014

NKG2A inhibits NKG2C effector functions of γδ T cells: implications in health and disease.

artículo científico publicado en 2010

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10

scientific article published on 25 March 2020

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

artículo científico publicado en 2015

NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses ⬇️

artículo científico publicado el 9 de enero de 2013

NKG2D and Its Ligands: "One for All, All for One".

artículo científico publicado en 2018

NKG2D/Ligand dysregulation and functional alteration of innate immunity cell populations in pediatric IBD

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance.

artículo científico publicado en 2017

Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions.

artículo científico

Natural killer (NK) cells from killers to regulators: distinct features between peripheral blood and decidual NK cells

artículo científico publicado en 2007

Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells

artículo científico publicado en 2016

Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

scientific article published on 14 April 2020

Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes

artículo científico publicado en 2002

Negative regulation of innate lymphoid cell responses in inflammation and cancer

scientific article published on 31 January 2019

Negative signals from FcepsilonRI engagement attenuate mast cell functions.

artículo científico publicado en 2007

Neutrophil diversity and plasticity in tumour progression and therapy

artículo científico publicado en 2020

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer

artículo científico publicado en 2015

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.

artículo científico publicado en 2015

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

scholarly article

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production

artículo científico publicado en 2017

Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression.

artículo científico publicado en 2016

Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway.

artículo científico publicado en 2006

PI5KI-dependent signals are critical regulators of the cytolytic secretory pathway.

artículo científico publicado en 2007

PIP2-dependent regulation of Munc13-4 endocytic recycling: impact on the cytolytic secretory pathway

artículo científico publicado en 2012

Peripheral and intestinal CD4+ T cells with a regulatory phenotype in pediatric patients with inflammatory bowel disease.

artículo científico publicado en 2010

Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy

artículo científico publicado en 2017

Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 (TRPV-1) channels: role in the survival of glioma patients

artículo científico publicado en 2016

Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention

artículo científico publicado en 2019

Proline-rich tyrosine kinase 2 and Rac activation by chemokine and integrin receptors controls NK cell transendothelial migration

artículo científico publicado en 2003

Re: Gut Microbiome Influences Efficacy of PD-1-based Immunotherapy Against Epithelial Tumors

artículo científico publicado en 2018

Reactive oxygen species- and DNA damage response-dependent NK cell activating ligand upregulation occurs at transcriptional levels and requires the transcriptional factor E2F1.

artículo científico publicado en 2014

Reconstitution of multifunctional CD56lowCD16low natural killer cell subset in children with acute leukemia given α/β T cell-depleted HLA-haploidentical haematopoietic stem cell transplantation.

artículo científico publicado en 2017

Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy

artículo científico publicado en 2008

Regulation and trafficking of the HLA-E molecules during monocyte-macrophage differentiation

artículo científico publicado en 2015

Regulation of NKG2D Expression and Signaling by Endocytosis

artículo científico publicado en 2016

Regulation of NKG2D-Dependent NK Cell Functions: The Yin and the Yang of Receptor Endocytosis

artículo científico publicado en 2017

Regulation of PD-L1 Expression by NF-κB in Cancer

scientific article published on 25 November 2020

Regulation of fc receptor endocytic trafficking by ubiquitination.

artículo científico

Role of Distinct Natural Killer Cell Subsets in Anticancer Response

artículo científico publicado en 2017

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

scientific article published on 28 September 2020

SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells

artículo científico publicado en 2002

Senescent cells: Living or dying is a matter of NK cells

scientific article published on 27 February 2019

Syk-dependent regulation of Hrs phosphorylation and ubiquitination upon FcεRI engagement: impact on Hrs membrane/cytosol localization

scientific journal article

Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

scientific article published on 04 December 2020

Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy

artículo científico publicado en 2016

Targeting of CXCR3 improves anti-myeloma efficacy of adoptively transferred activated natural killer cells

artículo científico publicado en 2019

The Cyclopentenone-Type Prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits CD95 Ligand Gene Expression in T Lymphocytes: Interference with Promoter Activation Via Peroxisome Proliferator-Activated Receptor-γ-Independent Mechanisms ⬇️

artículo científico publicado el 1 de mayo de 2003

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.

artículo científico publicado en 2014

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

artículo científico publicado en 2015

The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress

scientific article published on 11 June 2019

The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases

artículo científico publicado en 2020

The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing

scientific article published on 27 March 2019

The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway

scientific journal article

The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway

artículo científico publicado en 2003

The global response to the COVID-19 pandemic: how have immunology societies contributed?

scientific article published on 10 September 2020

The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors

artículo científico publicado en 2019

The human antibody fragment DIATHIS1 specific for CEACAM1 enhances natural killer cell cytotoxicity against melanoma cell lines in vitro

artículo científico publicado en 2015

The multifaceted role of PIP2 in leukocyte biology.

artículo científico

The use of filamentous bacteriophage fd to deliver MAGE-A10 or MAGE-A3 HLA-A2-restricted peptides and to induce strong antitumor CTL responses

artículo científico publicado en 2008

The yin-yang of the interaction between myelomonocytic cells and NK cells

artículo científico publicado en 2018

Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors

artículo científico publicado en 2012

Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells

scientific article published on 17 October 2019

Translating the anti-myeloma activity of Natural Killer cells into clinical application

artículo científico publicado en 2018

Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer

artículo científico publicado en 2020

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming.

artículo científico publicado en 2018

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients

artículo científico publicado en 2015

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells.

artículo científico publicado en 2015

Ubiquitination and endocytosis of the high affinity receptor for IgE.

artículo científico publicado en 2010

Uterine NK cell development, migration and function

artículo científico publicado en 2008

Vaccines: An achievement of civilization, a human right, our health insurance for the future

article

c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.

artículo científico publicado en 2014

p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells.

artículo científico publicado en 2004

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.

artículo científico publicado en 2016

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