Lista de obras - Daniel Peeper - Dominio Público Uruguay

A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis

artículo científico publicado en 2009

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

artículo científico publicado en 2002

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

scientific article published on 10 October 2019

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

artículo científico publicado en 2013

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

artículo científico publicado en 2012

Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

artículo científico publicado en 2019

Antagonistic TSC22D1 variants control BRAFE600-induced senescence ⬇️

artículo científico publicado el 29 de marzo de 2011

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

artículo científico publicado en 2019

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

scientific article published on 01 January 2020

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

artículo científico publicado en 2022

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

artículo científico publicado en 2015

B cells and tertiary lymphoid structures promote immunotherapy response

artículo científico publicado en 2020

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

artículo científico publicado en 2016

BRAFE600-associated senescence-like cell cycle arrest of human naevi

scientific article (publication date: 4 August 2005)

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

artículo científico publicado en 2017

Cellular senescence in vivo: a barrier to tumorigenesis

scientific article published on 18 March 2008

Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux

scientific article published on 26 November 2019

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

scientific article published on 01 June 2020

Comment on “Absence of Senescence-Associated β-Galactosidase Activity in Human Melanocytic Nevi In Vivo”

artículo científico publicado en 2008

Comprehensive analysis of cutaneous and uveal melanoma liver metastases

artículo científico publicado en 2020

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

artículo científico publicado en 2015

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.

artículo científico publicado en 2018

CopywriteR: DNA copy number detection from off-target sequence data

artículo científico publicado en 2015

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis

artículo científico publicado en 2007

Cross-species oncogenomics in cancer gene identification

artículo científico publicado en 2006

Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

artículo científico publicado en 2015

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

artículo científico publicado en 2002

Erratum: Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

artículo científico publicado en 1997

Evidence of oncogene-induced senescence in thyroid carcinogenesis.

artículo científico publicado en 2011

FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice

scientific article published on 01 March 2020

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival

artículo científico publicado en 2015

Frequent clonal relations between metastases and non-index prostate cancer lesions

article

Functional Characterization of Human Cancer-Derived TRKB Mutations ⬇️

artículo científico publicado el 17 de febrero de 2011

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

artículo científico publicado en 2009

Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma

artículo científico publicado en 2013

High-Throughput Assessment of Kinome-wide Activation States

artículo científico publicado en 2019

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

artículo científico publicado en 2013

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

artículo científico publicado en 2019

If you can’t beat me, join me: collaborating oncogenes circumventing senescence and causing cancer ⬇️

artículo científico publicado el 1 de agosto de 2011

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

scientific article published on 22 June 2016

Interrogating open issues in cancer medicine with patient-derived xenografts

artículo científico publicado en 2017

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

artículo científico publicado en 2017

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts

artículo científico publicado en 2015

KLF4, p21 and context-dependent opposing forces in cancer

artículo científico publicado en 2006

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

artículo científico publicado en 2014

MITF: More Interesting Traits, Folks!

artículo científico publicado en 2016

Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities

scientific article published on 03 June 2019

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence

artículo científico publicado en 2017

Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma

artículo científico publicado en 2014

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

artículo científico publicado en 2021

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

scientific article published on 25 April 2016

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

artículo científico publicado en 2018

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

artículo científico publicado en 2008

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

artículo científico publicado en 2017

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

artículo científico publicado en 2014

Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy.

artículo científico publicado en 2014

Phenotypic diversity drives paracrine drug tolerance.

artículo científico publicado en 2017

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

artículo científico publicado en 2015

Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence

artículo científico publicado en 2014

Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4

scientific article published on 06 July 2021

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

artículo científico publicado en 2015

Proteomics and Phosphoproteomics Profiling of Drug-Addicted BRAFi-Resistant Melanoma Cells

artículo científico publicado en 2021

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma

artículo científico publicado en 2014

Rational Cancer Treatment Combinations: An Urgent Clinical Need

scientific article published on 01 June 2020

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance

scientific article published on 07 August 2020

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

artículo científico publicado en 2015

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes

artículo científico publicado en 2009

Senescence-messaging secretome: SMS-ing cellular stress

artículo científico publicado en 2009

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

artículo científico publicado en 2015

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

scientific journal article

Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer

artículo científico publicado en 2017

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

artículo científico publicado en 2018

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

scientific article published on 01 April 2018

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

artículo científico publicado en 2018

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

artículo científico publicado en 2005

The essence of senescence

artículo científico publicado en 2010

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

artículo científico publicado en 2020

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

artículo científico publicado en 2008

The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective

artículo científico publicado en 2005

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

artículo científico publicado en 2022

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

artículo científico publicado en 2022

Vemurafenib plus cobimetinib in unresectable stage IIIc or stage IV melanoma: response monitoring and resistance prediction with positron emission tomography and tumor characteristics (REPOSIT): study protocol of a phase II, open-label, multicenter s

scientific article published on 15 September 2017

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data

scholarly article by Roelof J C Kluin published in October 2018

Lista de obras de Daniel Peeper

A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

A screen for combination therapies in BRAF/NRAS wild type melanoma identifies nilotinib plus MEK inhibitor as a synergistic combination

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

Antagonistic TSC22D1 variants control BRAFE600-induced senescence ⬇️

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold

Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence

B cells and tertiary lymphoid structures promote immunotherapy response

BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch

Cellular senescence in vivo: a barrier to tumorigenesis

Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux

Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice

Comment on “Absence of Senescence-Associated β-Galactosidase Activity in Human Melanocytic Nevi In Vivo”

Comprehensive analysis of cutaneous and uveal melanoma liver metastases

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.

CopywriteR: DNA copy number detection from off-target sequence data

Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis

Cross-species oncogenomics in cancer gene identification

Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

Erratum: Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

Evidence of oncogene-induced senescence in thyroid carcinogenesis.

FGFR1 Oncogenic Activation Reveals an Alternative Cell of Origin of SCLC in Rb1/p53 Mice

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival

Frequent clonal relations between metastases and non-index prostate cancer lesions

Functional Characterization of Human Cancer-Derived TRKB Mutations ⬇️

Functional identification of LRF as an oncogene that bypasses RASV12-induced senescence via upregulation of CYCLIN E.

Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma

High-Throughput Assessment of Kinome-wide Activation States

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

If you can’t beat me, join me: collaborating oncogenes circumventing senescence and causing cancer ⬇️

Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer

Interrogating open issues in cancer medicine with patient-derived xenografts

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts

KLF4, p21 and context-dependent opposing forces in cancer

Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma

MITF: More Interesting Traits, Folks!

Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities

Massive reshaping of genome-nuclear lamina interactions during oncogene-induced senescence

Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Parallel in vivo and in vitro melanoma RNAi dropout screens reveal synthetic lethality between hypoxia and DNA damage response inhibition.

Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy.

Phenotypic diversity drives paracrine drug tolerance.

PhosphoPath: Visualization of Phosphosite-centric Dynamics in Temporal Molecular Networks.

Phosphoproteome dynamics in onset and maintenance of oncogene-induced senescence

Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

Proteomics and Phosphoproteomics Profiling of Drug-Addicted BRAFi-Resistant Melanoma Cells

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma

Rational Cancer Treatment Combinations: An Urgent Clinical Need

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

SUMOylation of DRIL1 directs its transcriptional activity towards leukocyte lineage-specific genes

Senescence-messaging secretome: SMS-ing cellular stress

Signal Transduction Reaction Monitoring Deciphers Site-Specific PI3K-mTOR/MAPK Pathway Dynamics in Oncogene-Induced Senescence.

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

The essence of senescence

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor