Lista de obras - Piotr Kosson - Dominio Público Uruguay

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.

artículo científico publicado en 2005

A new structural motif for mu-opioid antagonists.

artículo científico publicado en 2005

Affinity of fentanyl and its derivatives for the σ1-receptor

scientific article published on 13 June 2019

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

artículo científico publicado en 2020

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents.

artículo científico publicado en 2016

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

artículo científico publicado en 2016

Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth.

artículo científico publicado en 2004

Biological properties of a new fluorescent biphalin fragment analogue

artículo científico publicado en 2002

Biphalin analogs containing β(3)-homo-amino acids at the 4,4' positions: Synthesis and opioid activity profiles

artículo científico publicado en 2015

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

artículo científico publicado en 2008

Blood-brain barrier permeability differentiates Sadowski mouse lines of high and low stress-induced analgesia: electron microscopy analysis.

artículo científico publicado en 2011

Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures?

scientific article published on 03 April 2020

Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

artículo científico publicado en 2005

Codon optimization of antigen coding sequences improves the immune potential of DNA vaccines against avian influenza virus H5N1 in mice and chickens

artículo científico publicado en 2016

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

artículo científico publicado en 2015

Endomorphins interact with tachykinin receptors

artículo científico publicado en 2005

Enzymatic degradation studies of endomorphin-2 and its analogs containing N-methylated amino acids.

artículo científico publicado en 2005

Expression, purification and characterization of glycosylated influenza H5N1 hemagglutinin produced in Pichia pastoris.

artículo científico publicado en 2014

Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis

artículo científico publicado en 2019

High-Titre Neutralizing Antibodies to H1N1 Influenza Virus after Mouse Immunization with Yeast Expressed H1 Antigen: A Promising Influenza Vaccine Candidate

artículo científico publicado en 2019

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

artículo científico publicado en 2016

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20.

artículo científico publicado en 2013

Immunogenicity of DNA Vaccine against H5N1 Containing Extended Kappa B Site: In Vivo Study in Mice and Chickens.

artículo científico publicado en 2017

In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

artículo científico publicado en 2020

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera

artículo científico publicado en 2012

Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin

artículo científico publicado en 2008

Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

artículo científico publicado en 2005

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis

scientific article published on 01 September 2018

Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models.

artículo científico publicado en 2017

Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs

artículo científico publicado en 2004

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects

artículo científico publicado en 2010

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R.

artículo científico publicado en 2017

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.

artículo científico publicado en 2018

Role of the blood-brain barrier in differential response to opioid peptides and morphine in mouse lines divergently bred for high and low swim stress-induced analgesia

artículo científico publicado en 2014

Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties.

artículo científico publicado en 2011

Synthesis and biological activity of N-methylated analogs of endomorphin-2

scientific article published on 06 September 2005

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.

artículo científico publicado en 2005

Synthesis and pharmacological properties of a new fluorescent opioid peptide analog.

artículo científico publicado en 2009

Synthesis and receptor binding of opioid peptide analogues containing beta3-homo-amino acids

artículo científico publicado en 2009

Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids

artículo científico publicado en 2016

TAPP analogs containing β3 -homo-amino acids: synthesis and receptor binding

scientific article published on 12 July 2012

The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

artículo científico publicado en 2017

The analgesic hybrid of dermorphin/substance P and analog of enkephalin improve wound healing in streptozotocin-induced diabetic rats

scientific article published on 19 November 2019

The impact of β-azido(or 1-piperidinyl)methylamino acids in position 2 or 3 on biological activity and conformation of dermorphin analogues

artículo científico publicado en 2016

The role of allogenic keratin-derived dressing in wound healing in a mouse model.

artículo científico publicado en 2016

[(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs

artículo científico publicado en 2006

β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP

artículo científico publicado en 2020

Lista de obras de Piotr Kosson

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.

A new structural motif for mu-opioid antagonists.

Affinity of fentanyl and its derivatives for the σ1-receptor

Antinociceptive and Cytotoxic Activity of Opioid Peptides with Hydrazone and Hydrazide Moieties at the C-Terminus

Antinociceptive effect induced by a combination of opioid and neurotensin moieties vs. their hybrid peptide [Ile(9)]PK20 in an acute pain treatment in rodents.

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Binding of the new morphiceptin analogs to human MCF-7 breast cancer cells and their effect on growth.

Biological properties of a new fluorescent biphalin fragment analogue

Biphalin analogs containing β(3)-homo-amino acids at the 4,4' positions: Synthesis and opioid activity profiles

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

Blood-brain barrier permeability differentiates Sadowski mouse lines of high and low stress-induced analgesia: electron microscopy analysis.

Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures?

Characterization of antinociceptive activity of novel endomorphin-2 and morphiceptin analogs modified in the third position.

Codon optimization of antigen coding sequences improves the immune potential of DNA vaccines against avian influenza virus H5N1 in mice and chickens

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

Endomorphins interact with tachykinin receptors

Enzymatic degradation studies of endomorphin-2 and its analogs containing N-methylated amino acids.

Expression, purification and characterization of glycosylated influenza H5N1 hemagglutinin produced in Pichia pastoris.

Fentanyl Family at the Mu-Opioid Receptor: Uniform Assessment of Binding and Computational Analysis

High-Titre Neutralizing Antibodies to H1N1 Influenza Virus after Mouse Immunization with Yeast Expressed H1 Antigen: A Promising Influenza Vaccine Candidate

Hydrazone Linker as a Useful Tool for Preparing Chimeric Peptide/Nonpeptide Bifunctional Compounds.

Identification of Dmt-D-Lys-Phe-Phe-OH as a highly antinociceptive tetrapeptide metabolite of the opioid-neurotensin hybrid peptide PK20.

Immunogenicity of DNA Vaccine against H5N1 Containing Extended Kappa B Site: In Vivo Study in Mice and Chickens.

In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera

Intrathecal antinociceptive interaction between the NMDA antagonist ketamine and the opioids, morphine and biphalin

Novel endomorphin-2 analogs with mu-opioid receptor antagonist activity.

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis

Opioid Tripeptides Hybridized with trans-1-Cinnamylpiperazine as Proliferation Inhibitors of Pancreatic Cancer Cells in Two- and Three-Dimensional in vitro Models.

Opioid receptor binding and in vivo antinociceptive activity of position 3-substituted morphiceptin analogs

PK20, a new opioid-neurotensin hybrid peptide that exhibits central and peripheral antinociceptive effects

Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R.

Pramipexole and Fingolimod exert neuroprotection in a mouse model of Parkinson's disease by activation of sphingosine kinase 1 and Akt kinase.

Role of the blood-brain barrier in differential response to opioid peptides and morphine in mouse lines divergently bred for high and low swim stress-induced analgesia

Superpotent [Dmt¹] dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties.

Synthesis and biological activity of N-methylated analogs of endomorphin-2

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.

Synthesis and pharmacological properties of a new fluorescent opioid peptide analog.

Synthesis and receptor binding of opioid peptide analogues containing beta3-homo-amino acids

Synthesis, binding affinities and metabolic stability of dimeric dermorphin analogs modified with β3-homo-amino acids

TAPP analogs containing β3 -homo-amino acids: synthesis and receptor binding

The Length of N-Glycans of Recombinant H5N1 Hemagglutinin Influences the Oligomerization and Immunogenicity of Vaccine Antigen

The analgesic hybrid of dermorphin/substance P and analog of enkephalin improve wound healing in streptozotocin-induced diabetic rats

The impact of β-azido(or 1-piperidinyl)methylamino acids in position 2 or 3 on biological activity and conformation of dermorphin analogues

The role of allogenic keratin-derived dressing in wound healing in a mouse model.

[(35)S]GTPgammaS binding stimulated by endomorphin-2 and morphiceptin analogs

β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP