Lista de obras - Ian J Majewski - Dominio Público Uruguay

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

artículo científico publicado en 2020

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

artículo científico publicado en 2006

A non-canonical function of Ezh2 preserves immune homeostasis.

artículo científico publicado en 2017

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

scientific article published on 04 December 2018

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.

artículo científico publicado en 2013

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

artículo científico publicado en 2018

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

artículo científico publicado en 2015

ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity

artículo científico publicado en 2011

Clinker: visualizing fusion genes detected in RNA-seq data

article

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1

artículo científico publicado en 2007

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

artículo científico publicado en 2013

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

artículo científico publicado en 2021

Epigenetic regulator Smchd1 functions as a tumor suppressor

artículo científico publicado en 2012

Finding a suitable library size to call variants in RNA-Seq

artículo científico publicado en 2020

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

artículo científico publicado en 2008

Hls5 regulated erythroid differentiation by modulating GATA-1 activity

artículo científico

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing

artículo científico publicado en 2013

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

artículo científico publicado en 2016

Integrative modeling identifies key determinants of inhibitor sensitivity in breast cancer cell lines.

artículo científico publicado en 2018

JAFFA: High sensitivity transcriptome-focused fusion gene detection

artículo científico publicado en 2015

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

artículo científico publicado en 2015

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

artículo científico publicado en 2018

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data

artículo científico publicado en 2021

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

artículo científico publicado en 2016

On fitness: how do mutations shape the biology of cancer?

scientific article published on 08 March 2019

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

artículo científico publicado en 2010

PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

artículo científico publicado en 2015

PIK3CA mutations are associated with reduced pathological complete response rates in primary HER2-positive breast cancer: pooled analysis of 967 patients from five prospective trials investigating lapatinib and trastuzumab.

artículo científico publicado en 2016

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity

artículo científico publicado en 2008

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

artículo científico publicado en 2013

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

artículo científico publicado en 2015

SuperFreq: Integrated mutation detection and clonal tracking in cancer

artículo científico publicado en 2020

Taming the dragon: genomic biomarkers to individualize the treatment of cancer.

artículo científico publicado en 2011

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

artículo científico publicado en 2016

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

artículo científico publicado en 2017

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

artículo científico publicado en 2013

Lista de obras de Ian J Majewski

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia

A non-canonical function of Ezh2 preserves immune homeostasis.

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia

An α-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer.

BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity

Clinker: visualizing fusion genes detected in RNA-seq data

Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing

Epigenetic regulator Smchd1 functions as a tumor suppressor

Finding a suitable library size to call variants in RNA-Seq

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

Hls5 regulated erythroid differentiation by modulating GATA-1 activity

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer

Integrative modeling identifies key determinants of inhibitor sensitivity in breast cancer cell lines.

JAFFA: High sensitivity transcriptome-focused fusion gene detection

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data

Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer

On fitness: how do mutations shape the biology of cancer?

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells

PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

PIK3CA mutations are associated with reduced pathological complete response rates in primary HER2-positive breast cancer: pooled analysis of 967 patients from five prospective trials investigating lapatinib and trastuzumab.

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

SuperFreq: Integrated mutation detection and clonal tracking in cancer

Taming the dragon: genomic biomarkers to individualize the treatment of cancer.

The BCL2 selective inhibitor venetoclax induces rapid onset apoptosis of CLL cells in patients via a TP53-independent mechanism.

The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism