Lista de obras - Mark Wheatley - Dominio Público Uruguay

A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists.

artículo científico publicado en 2005

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

artículo científico publicado en 2005

A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

artículo científico publicado en 2009

A selective biotinylated probe for V1a vasopressin receptors

artículo científico publicado en 1991

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor ⬇️

artículo científico publicado el 3 de diciembre de 2010

An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.

artículo científico publicado en 2018

An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist

artículo científico publicado en 2003

Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate

scientific article published on 01 September 1989

Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs.

artículo científico publicado en 1998

Calcium-mobilizing actions of chimeric hormone-mastoparan peptides.

artículo científico publicado en 1997

Characterisation of brain D2 dopamine receptors solubilised by lysophosphatidylcholine

artículo científico publicado en 1983

Characterization of G protein-coupled receptors expressed by ECV304 human endothelial cells.

artículo científico publicado en 1998

Characterization of an epitope-tagged vasopressin V1a receptor: a probe for receptor structure and function

scientific article published on 01 August 1997

Characterization of the human oxytocin receptor ligand binding site

scientific article published on 01 August 1997

Characterization of the structure of RAMP1 by mutagenesis and molecular modeling

artículo científico publicado en 2006

Chimeric analogues of vasopressin and bradykinin

scientific article published on 01 August 1997

Chimeric hormones and neuropeptides

artículo científico publicado en 1997

Chimeric strategies for the rational design of bioactive analogs of small peptide hormones ⬇️

artículo científico publicado el 1 de junio de 1997

Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus.

artículo científico publicado en 2000

Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor.

artículo científico publicado en 2002

Defining the ligand-binding site for vasopressin receptors: a peptide mimetic approach.

artículo científico publicado en 1995

Design and synthesis of heterofunctional V1a-selective vasopressin receptor ligands with lysine at position 9

artículo científico publicado en 1992

Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†

artículo científico publicado en 2006

Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity

artículo científico publicado en 1999

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

artículo científico publicado en 2007

Family resemblances? Ligand binding and activation of family A and B G-protein-coupled receptors

artículo científico publicado en 2007

Fluorescent and biotinylated linear peptides as selective bifunctional ligands for the V1a vasopressin receptor.

artículo científico publicado en 1993

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

artículo científico publicado en 2008

G Protein-Coupled Receptors

artículo científico publicado en 2010

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

artículo científico publicado en 2015

G-protein-coupled receptor phosphorylation and palmitoylation.

artículo científico publicado en 2004

G-protein-coupled receptors: from structural insights to functional mechanisms

artículo científico publicado en 2013

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.

artículo científico publicado en 2016

Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role.

artículo científico publicado en 1999

Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity--absence of VPRs in sheep liver

artículo científico publicado en 1993

Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin

artículo científico publicado en 2004

Homology between neurohypophyseal hormone receptors.

artículo científico publicado en 1993

Human liver vasopressin receptors

artículo científico publicado en 1991

Identification of an extracellular segment of the oxytocin receptor providing agonist-specific binding epitopes.

artículo científico publicado en 2001

Interaction of calcitonin-gene-related peptide with its receptors

artículo científico publicado en 2002

Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context

artículo científico publicado en 2019

Intramedullary blood vessels of the spinal cord express V1a vasopressin receptors: visualization by a biotinylated ligand

artículo científico publicado en 1995

Lifting the lid on GPCRs: the role of extracellular loops

artículo científico publicado en 2012

Ligand Binding and Activation of the CGRP Receptor

artículo científico publicado en 2009

Ligand binding and activation of the CGRP receptor.

artículo científico publicado en 2007

Ligand-induced conformational changes in a SMALP-encapsulated GPCR

scientific article published on 29 February 2020

Localisation of arginine vasopressin V1a receptors on sympatho-adrenal preganglionic neurones.

artículo científico publicado en 1998

Molecular pharmacology of V1a vasopressin receptors.

artículo científico publicado en 1995

Muscarinic receptor subtypes and the selectivity of agonists and antagonists

artículo científico publicado en 1988

Novel strategies for the design of receptor-selective vasopressin analogues: Aib-substitution and retro-inverso transformation.

artículo científico publicado en 1999

Novel vasopressin receptor ligands ⬇️

artículo científico publicado el 1 de abril de 1991

Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration.

artículo científico

Pharmacological characterization of linear analogues of vasopressin generated by the systematic substitution of positions 1 and 6 by L-amino acids

artículo científico publicado en 1994

Preparation of a membrane fraction for receptor studies and solubilization of receptor proteins with retention of biological activity

artículo científico publicado en 1997

Probing the V1a vasopressin receptor binding site with pyroglutamate-substituted linear antagonists

artículo científico publicado en 1996

Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor

artículo científico publicado en 1989

Reconstitution of solubilised brain D2 dopamine receptors into phospholipid vesicles

artículo científico publicado en 1984

Renal bradykinin and vasopressin receptors: ligand selectivity and classification

artículo científico publicado en 1996

Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles

scientific article published on 19 May 2020

Soluble and membrane-bound muscarinic acetylcholine receptors

scientific article published on 01 January 1986

Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins

artículo científico publicado en 2014

Structure and function of neurohypophysial hormone receptors.

artículo científico publicado en 1997

Structure-function analysis of RAMP1 by alanine mutagenesis

artículo científico publicado en 2009

Structure-function analysis of RAMP1-RAMP3 chimeras.

artículo científico publicado en 2010

Structure/function studies on receptors for vasopressin and oxytocin

scientific article published on 01 January 1998

Surfactant-free purification of membrane proteins with intact native membrane environment

artículo científico publicado en 2011

Synthesis and characterization of tagged human oxytocin receptors (hOTRs) ⬇️

artículo científico publicado el 1 de mayo de 1998

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

artículo científico publicado en 2007

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.

scientific article published on January 2009

The Effect on CGRP-Binding of Mutations to the Hydrophilic Residues within the First Transmembrane Region of Human Calcitonin Receptor-Like Receptor (CRLR)

The activation of the CGRP receptor

artículo científico publicado en 2013

The expression, activity and localisation of the secretory pathway Ca2+ -ATPase (SPCA1) in different mammalian tissues

scientific journal article

The importance of acidic amino acid residues in the binding of ligands to the V1a vasopressin receptor

scientific article published on 01 February 1995

The role of putative glycosylation sites in the extracellular loops of the vasopressin V1a receptor ⬇️

artículo científico publicado el 1 de agosto de 1997

The role of the extracellular loops of the CGRP receptor, a family B GPCR.

artículo científico publicado en 2012

The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

artículo científico publicado en 2005

The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain

artículo científico publicado en 1987

The study of neurohypophyseal hormone receptors by ligand binding.

artículo científico publicado en 1994

The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.

artículo científico publicado en 2004

The use of site-directed mutagenesis to study GPCRs

artículo científico publicado en 2011

Visualization of oxytocin receptors using selective biotinylated probes

artículo científico publicado en 1997

Lista de obras de Mark Wheatley

A Gly/Ala switch contributes to high affinity binding of benzoxazinone-based non-peptide oxytocin receptor antagonists.

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis

A selective biotinylated probe for V1a vasopressin receptors

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor ⬇️

An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.

An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist

Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate

Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs.

Calcium-mobilizing actions of chimeric hormone-mastoparan peptides.

Characterisation of brain D2 dopamine receptors solubilised by lysophosphatidylcholine

Characterization of G protein-coupled receptors expressed by ECV304 human endothelial cells.

Characterization of an epitope-tagged vasopressin V1a receptor: a probe for receptor structure and function

Characterization of the human oxytocin receptor ligand binding site

Characterization of the structure of RAMP1 by mutagenesis and molecular modeling

Chimeric analogues of vasopressin and bradykinin

Chimeric hormones and neuropeptides

Chimeric strategies for the rational design of bioactive analogs of small peptide hormones ⬇️

Critical role of a subdomain of the N-terminus of the V1a vasopressin receptor for binding agonists but not antagonists; functional rescue by the oxytocin receptor N-terminus.

Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor.

Defining the ligand-binding site for vasopressin receptors: a peptide mimetic approach.

Design and synthesis of heterofunctional V1a-selective vasopressin receptor ligands with lysine at position 9

Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†

Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors

Family resemblances? Ligand binding and activation of family A and B G-protein-coupled receptors

Fluorescent and biotinylated linear peptides as selective bifunctional ligands for the V1a vasopressin receptor.

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

G Protein-Coupled Receptors

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

G-protein-coupled receptor phosphorylation and palmitoylation.

G-protein-coupled receptors: from structural insights to functional mechanisms

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.

Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role.

Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity--absence of VPRs in sheep liver

Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin

Homology between neurohypophyseal hormone receptors.

Human liver vasopressin receptors

Identification of an extracellular segment of the oxytocin receptor providing agonist-specific binding epitopes.

Interaction of calcitonin-gene-related peptide with its receptors

Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context

Intramedullary blood vessels of the spinal cord express V1a vasopressin receptors: visualization by a biotinylated ligand

Lifting the lid on GPCRs: the role of extracellular loops

Ligand Binding and Activation of the CGRP Receptor

Ligand binding and activation of the CGRP receptor.

Ligand-induced conformational changes in a SMALP-encapsulated GPCR

Localisation of arginine vasopressin V1a receptors on sympatho-adrenal preganglionic neurones.

Molecular pharmacology of V1a vasopressin receptors.

Muscarinic receptor subtypes and the selectivity of agonists and antagonists

Novel strategies for the design of receptor-selective vasopressin analogues: Aib-substitution and retro-inverso transformation.

Novel vasopressin receptor ligands ⬇️

Palmitoylation of the vasopressin V1a receptor reveals different conformational requirements for signaling, agonist-induced receptor phosphorylation, and sequestration.

Pharmacological characterization of linear analogues of vasopressin generated by the systematic substitution of positions 1 and 6 by L-amino acids

Preparation of a membrane fraction for receptor studies and solubilization of receptor proteins with retention of biological activity

Probing the V1a vasopressin receptor binding site with pyroglutamate-substituted linear antagonists

Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor

Reconstitution of solubilised brain D2 dopamine receptors into phospholipid vesicles

Renal bradykinin and vasopressin receptors: ligand selectivity and classification

Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles

Soluble and membrane-bound muscarinic acetylcholine receptors

Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins

Structure and function of neurohypophysial hormone receptors.

Structure-function analysis of RAMP1 by alanine mutagenesis

Structure-function analysis of RAMP1-RAMP3 chimeras.

Structure/function studies on receptors for vasopressin and oxytocin

Surfactant-free purification of membrane proteins with intact native membrane environment

Synthesis and characterization of tagged human oxytocin receptors (hOTRs) ⬇️

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies.

The Effect on CGRP-Binding of Mutations to the Hydrophilic Residues within the First Transmembrane Region of Human Calcitonin Receptor-Like Receptor (CRLR)

The activation of the CGRP receptor

The expression, activity and localisation of the secretory pathway Ca2+ -ATPase (SPCA1) in different mammalian tissues

The importance of acidic amino acid residues in the binding of ligands to the V1a vasopressin receptor

The role of putative glycosylation sites in the extracellular loops of the vasopressin V1a receptor ⬇️

The role of the extracellular loops of the CGRP receptor, a family B GPCR.

The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain

The study of neurohypophyseal hormone receptors by ligand binding.

The third extracellular loop of G-protein-coupled receptors: more than just a linker between two important transmembrane helices.