Lista de obras - Nicholas R J Gascoigne - Dominio Público Uruguay

A THEMIS:SHP1 complex promotes T-cell survival

artículo científico publicado en 2015

A high content imaging flow cytometry approach to study mitochondria in T cells: MitoTracker Green FM dye concentration optimization

artículo científico publicado en 2017

A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness

artículo científico publicado en 2005

Allelic Exclusion of the TCR α-Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl ⬇️

artículo científico publicado el 1 de mayo de 2003

Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire

artículo científico publicado en 2014

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

artículo científico publicado en 2006

Autoimmune responses and inflammation in type 2 diabetes

artículo científico publicado en 2020

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

artículo científico publicado en 2002

CD8+ T cells have commitment issues

artículo científico publicado en 2018

CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.

artículo científico publicado en 2011

Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition

artículo científico publicado en 2016

Co-receptors and recognition of self at the immunological synapse

artículo científico publicado en 2010

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.

scientific article published on 12 August 2013

Correction: In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness

artículo científico publicado en 2014

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection

artículo científico publicado en 2014

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

artículo científico publicado en 2019

Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.

artículo científico publicado en 2018

Distinct footprints of TCR engagement with highly homologous ligands

artículo científico publicado en 2004

Do T cells need endogenous peptides for activation?

artículo científico publicado en 2008

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development

artículo científico publicado en 2013

In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness

artículo científico publicado en 2013

Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

artículo científico publicado en 2002

Initiation of TCR phosphorylation and signal transduction

artículo científico publicado en 2011

Lck bound to coreceptor is less active than free Lck

artículo científico publicado en 2020

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor

artículo científico publicado en 2014

Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma

artículo científico publicado en 2016

Molecular interactions at the T cell-antigen-presenting cell interface

artículo científico publicado en 2004

Monomeric TCRs drive T cell antigen recognition

scientific article published on 16 April 2018

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry

artículo científico publicado en 2009

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers

artículo científico publicado en 2012

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

artículo científico publicado en 2018

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

artículo científico publicado en 2005

Photobleaching-corrected FRET efficiency imaging of live cells

artículo científico publicado en 2004

Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation ⬇️

artículo científico publicado el 6 de diciembre de 2011

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function

artículo científico publicado en 2014

Protein kinase Cη, an emerging player in T-cell biology ⬇️

artículo científico publicado el 1 de marzo de 2012

SHP1-ing thymic selection

artículo científico publicado en 2016

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

artículo científico publicado en 2020

Signaling in thymic selection

artículo científico publicado en 2011

Spatiotemporal patterning during T cell activation is highly diverse

artículo científico publicado en 2009

Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells

artículo científico publicado en 2006

Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics

artículo científico publicado en 2003

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component ⬇️

artículo científico publicado el 28 de diciembre de 2010

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

artículo científico publicado en 2007

T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis

artículo científico publicado en 2020

T-cell differentiation: MHC class I's sweet tooth lost on maturity

artículo científico publicado en 2002

TCR Signal Strength and T Cell Development

artículo científico publicado en 2016

TCR affinity and negative regulation limit autoimmunity

article

TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants

artículo científico publicado en 2017

THEMIS: a critical TCR signal regulator for ligand discrimination

artículo científico publicado en 2015

Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities

artículo científico publicado en 2016

The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation

artículo científico publicado en 2008

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex

artículo científico publicado en 2002

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation

artículo científico publicado en 2008

The role of protein kinase cη in T cell biology

artículo científico publicado en 2012

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling

artículo científico publicado en 2009

Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation

artículo científico publicado en 2020

Themis sets the signal threshold for positive and negative selection in T-cell development

artículo científico publicado en 2013

Themis-associated phosphatase activity controls signaling in T cell development

article published in the Proceedings of the National Academy of Sciences of the United States of America

Thymic Origins of T Cell Receptor Alloreactivity

artículo científico publicado en 2017

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

artículo científico publicado en 2006

Thymocyte stimulation by anti-TCR-β, but not by anti-TCR-α, leads to induction of developmental transcription program

artículo científico publicado en 2005

Tolerance lies in the timing

artículo científico publicado en 2014

Too fast to die.

artículo científico publicado en 2013

Using live FRET imaging to reveal early protein-protein interactions during T cell activation

artículo científico publicado en 2004

Virus-specific T lymphocytes home to the skin during natural dengue infection

artículo científico publicado en 2015

Visualizing intermolecular interactions in T cells

artículo científico publicado en 2009

Vive la peptide différence!

artículo científico publicado en 2016

Lista de obras de Nicholas R J Gascoigne

A THEMIS:SHP1 complex promotes T-cell survival

A high content imaging flow cytometry approach to study mitochondria in T cells: MitoTracker Green FM dye concentration optimization

A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness

Allelic Exclusion of the TCR α-Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl ⬇️

Allelic exclusion of TCR α-chains upon severe restriction of Vα repertoire

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

Autoimmune responses and inflammation in type 2 diabetes

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

CD8+ T cells have commitment issues

CD8αα and -αβ isotypes are equally recruited to the immunological synapse through their ability to bind to MHC class I.

Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition

Co-receptors and recognition of self at the immunological synapse

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.

Correction: In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness

Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.

Distinct footprints of TCR engagement with highly homologous ligands

Do T cells need endogenous peptides for activation?

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development

In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness

Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse

Initiation of TCR phosphorylation and signal transduction

Lck bound to coreceptor is less active than free Lck

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor

Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma

Molecular interactions at the T cell-antigen-presenting cell interface

Monomeric TCRs drive T cell antigen recognition

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse

Photobleaching-corrected FRET efficiency imaging of live cells

Protein Kinase C η Is Required for T Cell Activation and Homeostatic Proliferation ⬇️

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function

Protein kinase Cη, an emerging player in T-cell biology ⬇️

SHP1-ing thymic selection

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

Signaling in thymic selection

Spatiotemporal patterning during T cell activation is highly diverse

Spectral shift of fluorescent dye FM4-64 reveals distinct microenvironment of nuclear envelope in living cells

Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics

T Cell Receptor (TCR)-induced Tyrosine Phosphorylation Dynamics Identifies THEMIS as a New TCR Signalosome Component ⬇️

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis

T-cell differentiation: MHC class I's sweet tooth lost on maturity

TCR Signal Strength and T Cell Development

TCR affinity and negative regulation limit autoimmunity

TCR-like antibodies mediate complement and antibody-dependent cellular cytotoxicity against Epstein-Barr virus-transformed B lymphoblastoid cells expressing different HLA-A*02 microvariants

THEMIS: a critical TCR signal regulator for ligand discrimination

Targeting Epstein-Barr virus-transformed B lymphoblastoid cells using antibodies with T-cell receptor-like specificities

The T cell receptor's alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation

The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation

The role of protein kinase cη in T cell biology

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling

Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation

Themis sets the signal threshold for positive and negative selection in T-cell development

Themis-associated phosphatase activity controls signaling in T cell development

Thymic Origins of T Cell Receptor Alloreactivity

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

Thymocyte stimulation by anti-TCR-β, but not by anti-TCR-α, leads to induction of developmental transcription program

Tolerance lies in the timing

Too fast to die.

Using live FRET imaging to reveal early protein-protein interactions during T cell activation

Virus-specific T lymphocytes home to the skin during natural dengue infection

Visualizing intermolecular interactions in T cells

Vive la peptide différence!