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Lista de obras de Steven A Porcelli

"Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes".

artículo científico publicado en 2015

"The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report

artículo científico publicado en 2017

A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity

artículo científico publicado en 2010

A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells

artículo científico publicado en 2011

A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-γ Production

artículo científico publicado en 2015

A critical role for CD8 T cells in a nonhuman primate model of tuberculosis

artículo científico publicado en 2009

A glycan shield for bacterial sphingolipids

artículo científico publicado en 2008

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids

artículo científico publicado en 2011

A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis

artículo científico publicado en 2011

A review of the PD-1/PD-L1 checkpoint in bladder cancer: From mediator of immune escape to target for treatment

artículo científico publicado en 2016

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

artículo científico publicado en 2011

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens

artículo científico publicado en 2014

A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan

artículo científico publicado en 2004

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

artículo científico publicado en 2009

Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands

artículo científico publicado en 2009

Alteration of the relative levels of iNKT cell subsets is associated with chronic mycobacterial infections

artículo científico publicado en 2008

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

artículo científico publicado en 2016

AnN-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and β2-Microglobulin

scientific article published in Journal of Biological Chemistry

Anthrax lethal toxin kills macrophages in a strain-specific manner by apoptosis or caspase-1-mediated necrosis.

artículo científico publicado en 2007

Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response

artículo científico publicado en 2005

Autoimmune response to transthyretin in juvenile idiopathic arthritis

artículo científico publicado en 2016

B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response

artículo científico publicado en 2013

Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance

artículo científico publicado en 2013

Balancing safety and immunogenicity in live-attenuated mycobacterial vaccines for use in humans at risk for HIV: response to misleading comments in Ranganathan et al. "recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell respon

artículo científico publicado en 2010

Bird genes give new insights into the origins of lipid antigen presentation

artículo científico publicado en 2005

CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver.

artículo científico publicado en 2006

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

artículo científico publicado en 2009

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids

CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens

artículo científico publicado en 2013

CD1d and natural killer T cells in immunity to Mycobacterium tuberculosis

artículo científico

CD1d-Restricted Natural Killer T Cells: Roles in Tumor Immunosurveillance and Tolerance

CD1d-restricted T cell activation by nonlipidic small molecules

scholarly article

Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation

artículo científico publicado en 2008

Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect

artículo científico publicado en 2017

Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect

artículo científico publicado en 2015

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity.

artículo científico publicado en 2009

Combined natural killer T-cell based immunotherapy eradicates established tumors in mice

artículo científico publicado en 2007

Control of NKT cell differentiation by tissue-specific microenvironments

artículo científico publicado en 2003

Correction: Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies

artículo científico publicado en 2015

Current efforts and future prospects in the development of live mycobacteria as vaccines

artículo científico publicado en 2015

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice

scientific journal article

Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia

artículo científico publicado en 2010

Direct measurement of antigen binding properties of CD1 proteins using fluorescent lipid probes

artículo científico publicado en 2003

Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells

artículo científico publicado en 2011

Diverse CD1d-restricted reactivity patterns of human T cells bearing “invariant” AV24BV11 TCR

artículo científico publicado en 1998

Dual Modifications of α-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.

artículo científico publicado en 2018

Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against Mycobacterium tuberculosis determined by PCR array

artículo científico publicado en 2008

Efficient activation of Valpha14 invariant NKT cells by foreign lipid antigen is associated with concurrent dendritic cell-specific self recognition

artículo científico publicado en 2007

Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes

artículo científico publicado en 2015

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis

artículo científico publicado en 2007

Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors

artículo científico publicado en 2009

Erratum: Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

artículo científico publicado en 1999

Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis

artículo científico

Exacting Edward Jenner's revenge: The quest for a new tuberculosis vaccine

artículo científico publicado en 2019

Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black x New Zealand White)F1 mice

artículo científico publicado en 2005

Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies

artículo científico publicado en 2015

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex

artículo científico publicado en 2002

Fine tuning by human CD1e of lipid-specific immune responses

artículo científico publicado en 2011

Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses

artículo científico publicado en 2014

Generation of IL-3-Secreting CD4+ T Cells by Microbial Challenge at Skin and Mucosal Barriers

artículo científico publicado en 2019

Glycolipid activators of invariant NKT cells as vaccine adjuvants

artículo científico publicado en 2016

Glycolipids that Elicit IFN-γ-Biased Responses from Natural Killer T Cells

artículo científico publicado en 2011

Human CD1-restricted T cell recognition of lipids from pollens

artículo científico publicado en 2005

Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells

artículo científico publicado en 2013

Human NKT cells express granulysin and exhibit antimycobacterial activity

artículo científico publicado en 2003

Human and Mouse Type I Natural Killer T Cell Antigen Receptors Exhibit Different Fine Specificities for CD1d-Antigen Complex

artículo científico publicado en 2012

Identification of Mycobacterial Ribosomal Proteins as Targets for CD4 T Cells That Enhance Protective Immunity in Tuberculosis

scholarly article published by Alessandro Sette in 2018

Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells

artículo científico publicado en 2017

Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis

artículo científico publicado en 2003

Improving Mycobacterium bovis bacillus Calmette-Guèrin as a vaccine delivery vector for viral antigens by incorporation of glycolipid activators of NKT cells

artículo científico publicado en 2014

In vitro culture medium influences the vaccine efficacy of Mycobacterium bovis BCG

artículo científico publicado en 2012

In vitro derivation of macrophage from guinea pig bone marrow with human M-CSF.

artículo científico publicado en 2013

Incorporation of NKT cell-activating glycolipids enhances immunogenicity and vaccine efficacy of Mycobacterium bovis bacillus Calmette-Guerin

artículo científico publicado en 2009

Induction of CD1-restricted immune responses in guinea pigs by immunization with mycobacterial lipid antigens

artículo científico publicado en 2002

Infection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pH.

artículo científico publicado en 2018

Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani

artículo científico publicado en 2004

Intracellular pathways of CD1 antigen presentation

artículo científico publicado en 2003

Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.

artículo científico publicado en 2007

Invariant natural killer T cell-natural killer cell interactions dictate transplantation outcome after alpha-galactosylceramide administration

artículo científico publicado en 2009

Isolation and In vivo Transfer of Antigen Presenting Cells.

artículo científico publicado en 2014

Isolation of intact RNA from murine CD4+ T cells after intracellular cytokine staining and fluorescence-activated cell sorting

artículo científico publicado en 2018

Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation

artículo científico publicado en 2009

Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

artículo científico publicado en 2004

Lipid and glycolipid antigens of CD1d-restricted natural killer T cells

artículo científico publicado en 2009

Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation

artículo científico publicado en 2002

Lysine Auxotrophy Combined with Deletion of the SecA2 Gene Results in a Safe and Highly Immunogenic Candidate Live Attenuated Vaccine for Tuberculosis ⬇️

artículo científico publicado el 10 de enero de 2011

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer

scholarly article

Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by V 14i NKT Cells

artículo científico publicado en 2010

Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of alpha-galactosylceramides

artículo científico publicado en 2005

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase

artículo científico publicado en 2008

Mouse and human iNKT cell agonist β-mannosylceramide reveals a distinct mechanism of tumor immunity

artículo científico publicado en 2011

Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae

artículo científico publicado en 2018

Multiple immuno-regulatory defects in type-1 diabetes

artículo científico publicado en 2002

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

scientific journal article

Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response

artículo científico publicado en 2004

Mycobacterial membrane vesicles administered systemically in mice induce a protective immune response to surface compartments of Mycobacterium tuberculosis

artículo científico publicado en 2014

Mycobacterium tuberculosis DeltaRD1 DeltapanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis.

artículo científico publicado en 2006

Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule

scientific journal article

Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells

artículo científico publicado en 2007

Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells

artículo científico publicado en 2004

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production

artículo científico publicado en 2008

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

artículo científico publicado en 2003

New CD1d agonists: synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

artículo científico publicado en 2012

Optimizing NKT cell ligands as vaccine adjuvants

artículo científico

Pillars article: analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain. J. Exp. Med. 1993. 178: 1-16.

artículo científico publicado en 2014

Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d

artículo científico publicado en 2007

Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis

artículo científico publicado en 2004

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

artículo científico publicado en 2010

Rapid identification of immunostimulatory alpha-galactosylceramides using synthetic combinatorial libraries

artículo científico publicado en 2007

Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.

artículo científico publicado en 2010

Recognition of lipids from pollens by CD1-restricted T cells

artículo científico publicado en 2007

Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors

artículo científico publicado en 2011

Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques

artículo científico publicado en 2014

Recombinant pro-apoptotic Mycobacterium tuberculosis generates CD8+ T cell responses against human immunodeficiency virus type 1 Env and M. tuberculosis in neonatal mice

artículo científico publicado en 2009

Role of lipid trimming and CD1 groove size in cellular antigen presentation

artículo científico

Saposin C is required for lipid presentation by human CD1b

article

Similarities and differences between selective and nonselective BAFF blockade in murine SLE

artículo científico publicado en 2006

Species Specific Differences of CD1d Oligomer Loading In Vitro

artículo científico publicado en 2015

Structural Basis for the Recognition of C20:2-αGalCer by the Invariant Natural Killer T Cell Receptor-like Antibody L363

artículo científico publicado en 2012

Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

artículo científico publicado en 2011

Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes

scientific article published on 19 November 2018

Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47.

artículo científico publicado en 2016

Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry

artículo científico publicado en 2010

Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000.

artículo científico publicado en 2010

Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides

artículo científico publicado en 2010

Synthesis and evaluation of an acyl-chain unsaturated analog of the Th2 biasing, immunostimulatory glycolipid, OCH.

artículo científico publicado en 2009

Synthesis and evaluation of sphinganine analogues of KRN7000 and OCH.

artículo científico publicado en 2005

Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand

artículo científico publicado en 2008

Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents

artículo científico publicado en 2016

T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection

artículo científico publicado en 2003

Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines

artículo científico publicado en 2016

The CD1b structure: antigen presentation adapts to a high-fat diet

artículo científico publicado en 2002

The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques

artículo científico publicado en 2003

The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition

scholarly article

The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis

artículo científico publicado en 2016

The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d

artículo científico publicado en 2006

The diverse functions of CD1d-restricted NKT cells and their potential for immunotherapy

artículo científico publicado en 2005

The human CD1-restricted T cell repertoire is limited to cross-reactive antigens: implications for host responses against immunologically related pathogens.

artículo científico publicado en 2005

Tuberculosis: unsealing the apoptotic envelope

artículo científico publicado en 2008

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages

artículo científico publicado en 2007

V 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen

artículo científico publicado en 2011

Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation

artículo científico publicado en 2004

pH-dependent interdomain tethers of CD1b regulate its antigen capture

scientific article published on June 2008

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents

artículo científico publicado en 2010

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