Lista de obras - Paul N. Barlow - Dominio Público Uruguay

1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.

artículo científico publicado en 2009

1H, 15N and 13C resonance assignments of complement control protein module pair 2-3 from the C4b-binding site of complement receptor type 1

artículo científico publicado en 2004

1H, 15N and 13C resonance assignments of the C345C domain of the complement component C5.

artículo científico publicado en 2004

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

artículo científico publicado en 2009

A new map of glycosaminoglycan and C3b binding sites on factor H

artículo científico publicado en 2008

A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy

artículo científico publicado en 2018

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

artículo científico publicado en 2004

An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

artículo científico publicado en 2008

Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells

artículo científico publicado en 2010

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

artículo científico publicado en 2010

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces

artículo científico publicado en 2004

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

artículo científico publicado en 2014

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis

artículo científico publicado en 2012

Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade

scientific article published on 12 November 2019

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation.

artículo científico publicado en 2015

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

artículo científico publicado en 2015

Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Complement factor H: using atomic resolution structure to illuminate disease mechanisms

artículo científico publicado en 2008

Complement factor h autoantibodies and age-related macular degeneration.

artículo científico publicado en 2010

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

scientific article published on 06 March 2020

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand ⬇️

artículo científico publicado en 2010

Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation

artículo científico publicado en 2015

Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces

artículo científico publicado en 2006

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

artículo científico publicado en 2011

Deciphering complement mechanisms: the contributions of structural biology

artículo científico publicado en 2007

Decoding the components of dynamics in three-domain proteins.

artículo científico publicado en 2013

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

artículo científico publicado en 2011

Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure

artículo científico publicado en 2006

Disease-associated sequence variations in factor H: a structural biology approach

artículo científico publicado en 2006

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation

artículo científico publicado en 2017

Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

artículo científico publicado en 2000

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

artículo científico publicado en 2020

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings

artículo científico publicado en 2011

Factor H autoantibodies in membranoproliferative glomerulonephritis.

artículo científico publicado en 2012

Functional anatomy of complement factor H.

artículo científico

Functional insights from the structure of the multifunctional C345C domain of C5 of complement

artículo científico publicado en 2004

Genome-Wide Association Studies Identify Disease Mechanisms in Age-Related Macular Degeneration

artículo científico publicado en 2018

Grasping the nettle: A bacterial invasin that targets immunoglobulin variable domains.

artículo científico publicado en 2018

Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor

artículo científico publicado en 2006

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

scholarly article by Kate Smith-Jackson et al published 4 February 2019 in Journal of Clinical Investigation

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

artículo científico publicado en 2012

Large-scale modelling as a route to multiple surface comparisons of the CCP module family

article

Last of the..

artículo científico publicado en 1996

Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor

artículo científico publicado en 2002

Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.

artículo científico

MDM4 binds ligands via a mechanism in which disordered regions become structured

artículo científico publicado en 2010

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.

artículo científico publicado en 2008

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

artículo científico publicado en 2007

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes ⬇️

artículo científico publicado en 2019

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

artículo científico publicado en 2012

New approaches to the treatment of dense deposit disease

artículo científico publicado en 2007

Opportunities for new therapies based on the natural regulators of complement activation

artículo científico publicado en 2005

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes ⬇️

artículo científico publicado en 2011

Polychromatic selective population inversion for TROSY experiments with large proteins

artículo científico publicado en 2005

Production of biologically active complement factor H in therapeutically useful quantities ⬇️

artículo científico publicado el 10 de diciembre de 2010

Quantitative cross-linking/mass spectrometry reveals subtle protein conformational changes

artículo científico publicado en 2016

Rational engineering of a minimized immune inhibitor with unique triple-targeting properties

artículo científico publicado en 2013

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

artículo científico publicado en 2016

Resonance assignments of the central complement control protein module pair of human decay accelerating factor

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes ⬇️

artículo científico publicado en 2015

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

artículo científico publicado en 2012

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement

artículo científico publicado en 2009

Solution structure of a functionally active fragment of decay-accelerating factor

artículo científico publicado en 2003

Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin

artículo científico publicado en 2002

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

artículo científico publicado en 2012

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

scientific journal article

Structural and functional characterization of the product of disease-related factor H gene conversion

artículo científico publicado en 2012

Structural basis and functional effects of the interaction between complement inhibitor C4b-binding protein and DNA

scientific article published on 19 August 2008

Structural basis for complement factor H linked age-related macular degeneration

artículo científico publicado en 2007

Structural basis for engagement by complement factor H of C3b on a self surface

artículo científico publicado en 2011

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

artículo científico publicado en 2009

Structure and flexibility of the multiple domain proteins that regulate complement activation

artículo científico publicado en 2001

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

artículo científico publicado en 2016

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

artículo científico publicado en 2005

Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor

artículo científico publicado en 2002

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

artículo científico publicado en 2008

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism

artículo científico publicado en 2007

Structure-based Mapping of DAF Active Site Residues That Accelerate the Decay of C3 Convertases

scientific article published in Journal of Biological Chemistry

Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core

artículo científico publicado en 2003

The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

artículo científico publicado en 2009

The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module

artículo científico publicado en 2010

The interaction of Jagged-1 cytoplasmic tail with afadin PDZ domain is local, folding-independent, and tuned by phosphorylation.

artículo científico publicado en 2011

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution.

artículo científico publicado en 2012

The pluripotency rheostat Nanog functions as a dimer

artículo científico publicado en 2008

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

scientific journal article

Towards a structural basis for complement factor H linked age-related macular degeneration

Use of time‐resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus) ⬇️

artículo científico publicado el 1 de diciembre de 2011

Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor

artículo científico publicado en 2013

Utilising ion mobility-mass spectrometry to interrogate macromolecules: Factor H complement control protein modules 10–15 and 19–20 and the DNA-binding core domain of tumour suppressor p53

article

Vaccinia virus complement control protein is monomeric, and retains structural and functional integrity after exposure to adverse conditions

artículo científico publicado en 2002

¹H, ¹³C and ¹⁵N resonance assignments of the complement control protein modules of the complement component C7.

artículo científico publicado el 28 de septiembre de 2012

Lista de obras de Paul N. Barlow

1H, 15N and 13C resonance assignment of the pair of Factor-I like modules of the complement protein C7.

1H, 15N and 13C resonance assignments of complement control protein module pair 2-3 from the C4b-binding site of complement receptor type 1

1H, 15N and 13C resonance assignments of the C345C domain of the complement component C5.

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family

A new map of glycosaminoglycan and C3b binding sites on factor H

A novel combination of chemical cross-linking, mass spectrometry and NMR reveals the architecture of complement component C7

An Engineered Complement Factor H Construct for Treatment of C3 Glomerulopathy

An atomic resolution model for assembly, architecture, and function of the Dr adhesins.

An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin

Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis

Combining SPR with atomic-force microscopy enables single-molecule insights into activation and suppression of the complement cascade

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation.

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

Complement factor H: using atomic resolution structure to illuminate disease mechanisms

Complement factor h autoantibodies and age-related macular degeneration.

Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand ⬇️

Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation

Critical role of the C-terminal domains of factor H in regulating complement activation at cell surfaces

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

Deciphering complement mechanisms: the contributions of structural biology

Decoding the components of dynamics in three-domain proteins.

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

Disease-associated sequence variations congregate in a polyanion recognition patch on human factor H revealed in three-dimensional structure

Disease-associated sequence variations in factor H: a structural biology approach

Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation

Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A

Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings

Factor H autoantibodies in membranoproliferative glomerulonephritis.

Functional anatomy of complement factor H.

Functional insights from the structure of the multifunctional C345C domain of C5 of complement

Genome-Wide Association Studies Identify Disease Mechanisms in Age-Related Macular Degeneration

Grasping the nettle: A bacterial invasin that targets immunoglobulin variable domains.

Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

Large-scale modelling as a route to multiple surface comparisons of the CCP module family

Last of the..

Letter to the Editor: Resonance assignments of the central complement control protein module pair of human decay accelerating factor

Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.

MDM4 binds ligands via a mechanism in which disordered regions become structured

Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes ⬇️

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

New approaches to the treatment of dense deposit disease

Opportunities for new therapies based on the natural regulators of complement activation

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes ⬇️

Polychromatic selective population inversion for TROSY experiments with large proteins

Production of biologically active complement factor H in therapeutically useful quantities ⬇️

Quantitative cross-linking/mass spectrometry reveals subtle protein conformational changes

Rational engineering of a minimized immune inhibitor with unique triple-targeting properties

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection

Resonance assignments of the central complement control protein module pair of human decay accelerating factor

Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes ⬇️

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

Solution Structure of Factor I-like Modules from Complement C7 Reveals a Pair of Follistatin Domains in Compact Pseudosymmetric Arrangement

Solution structure of a functionally active fragment of decay-accelerating factor

Solution structure of the calponin CH domain and fitting to the 3D-helical reconstruction of F-actin:calponin

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded

Structural and functional characterization of the product of disease-related factor H gene conversion

Structural basis and functional effects of the interaction between complement inhibitor C4b-binding protein and DNA

Structural basis for complement factor H linked age-related macular degeneration

Structural basis for engagement by complement factor H of C3b on a self surface

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation

Structure and flexibility of the multiple domain proteins that regulate complement activation

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.

Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism