Lista de obras - Judith Frydman - Dominio Público Uruguay

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement

artículo científico publicado en 2010

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability

artículo científico publicado en 2018

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

artículo científico publicado en 2014

A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle

artículo científico publicado en 2012

A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis

artículo científico publicado en 2010

Aberrant protein folding as the molecular basis of cancer

artículo científico publicado en 2003

Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation

artículo científico publicado en 2005

Action of the chaperonin GroEL/ES on a non-native substrate observed with single-molecule FRET.

artículo científico publicado en 2010

An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex ⬇️

artículo científico publicado el 1 de junio de 1992

An information theoretic framework reveals a tunable allosteric network in group II chaperonins

artículo científico publicado en 2017

Broad action of Hsp90 as a host chaperone required for viral replication

artículo científico

Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species

artículo científico publicado en 2012

Cellular strategies of protein quality control

artículo científico publicado en 2011

Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro

artículo científico publicado en 2005

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

artículo científico publicado en 2014

Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis

artículo científico publicado en 2003

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

artículo científico publicado en 2016

Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis

artículo científico publicado en 2021

Cotranslational signal-independent SRP preloading during membrane targeting

artículo científico publicado en 2016

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure

artículo científico publicado en 2011

CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin

artículo científico publicado en 2021

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

scholarly article

Crystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding Cycle

artículo científico publicado en 2010

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

artículo científico publicado en 2015

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

artículo científico publicado en 2008

Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes

artículo científico publicado en 2011

Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation

artículo científico publicado en 2015

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

artículo científico publicado en 2020

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

artículo científico publicado en 2018

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

artículo científico publicado en 2007

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy

artículo científico publicado en 2019

Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

artículo científico publicado en 2011

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

scientific article published on 11 April 2019

Dynamics and clustering of IRE1α during ER stress

scientific article published on 04 February 2020

Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins

artículo científico publicado en 2007

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

artículo científico publicado en 2012

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

artículo científico publicado en 2007

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

artículo científico publicado en 2013

Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways

scientific article published on 01 June 2005

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

artículo científico publicado en 1994

Hardware-based anti-Brownian electrokinetic trap (ABEL trap) for single molecules: Control loop simulations and application to ATP binding stoichiometry in multi-subunit enzymes

artículo científico publicado en 2008

Heterozygous yeast deletion collection screens reveal essential targets of Hsp90

artículo científico publicado en 2011

Hsp110 cooperates with different cytosolic HSP70 systems in a pathway for de novo folding

artículo científico publicado en 2005

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

article published in 2017

Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus

artículo científico publicado en 2013

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

artículo científico publicado en 2018

Huntingtin’s N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective

artículo científico publicado en 2018

Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins

artículo científico publicado en 2006

Interplay between chaperones and protein disorder promotes the evolution of protein networks

artículo científico publicado en 2014

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

artículo científico publicado en 2014

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

artículo científico publicado en 2018

Mechanism of folding chamber closure in a group II chaperonin

artículo científico publicado en 2010

Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT

artículo científico publicado en 2008

Mechanism of nucleotide sensing in group II chaperonins

artículo científico publicado en 2012

Mechanism of nucleotide sensing in group II chaperonins

artículo científico publicado en 2012

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

artículo científico publicado en 2004

Mechanisms and Functions of Spatial Protein Quality Control

artículo científico publicado en 2017

Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae

artículo científico publicado en 2019

Misfolded proteins partition between two distinct quality control compartments

artículo científico publicado en 2008

Modeling of possible subunit arrangements in the eukaryotic chaperonin TRiC.

artículo científico publicado en 2006

Modulation of STAT3 folding and function by TRiC/CCT chaperonin

artículo científico publicado en 2014

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

artículo científico publicado en 2016

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

scientific article published on 07 August 2019

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein

scientific journal article

Principles of cotranslational ubiquitination and quality control at the ribosome

artículo científico publicado en 2013

Probing the sequence of conformationally induced polarity changes in the molecular chaperonin GroEL with fluorescence spectroscopy

artículo científico publicado en 2005

Protein misfolding in neurodegenerative diseases: implications and strategies

artículo científico publicado en 2017

Protein quality control: chaperones culling corrupt conformations

artículo científico publicado en 2005

Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay

artículo científico publicado en 2020

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

artículo científico publicado en 2014

REP-X: An Evolution-guided Strategy for the Rational Design of Cysteine-less Protein Variants

scientific article published on 10 February 2020

Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution

artículo científico publicado en 2011

Sorting out the trash: the spatial nature of eukaryotic protein quality control

artículo científico publicado en 2014

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

artículo científico publicado en 2013

State of the science: an update on renal cell carcinoma

artículo científico publicado en 2012

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective

artículo científico publicado en 2017

Sub-diffraction imaging of huntingtin protein aggregates by fluorescence blink-microscopy and atomic force microscopy

artículo científico publicado en 2011

Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies

Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates

artículo científico publicado en 2014

Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle

artículo científico publicado en 2011

Systematic functional prioritization of protein posttranslational modifications

artículo científico publicado en 2012

Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells

artículo científico publicado en 2006

TRiC's tricks inhibit huntingtin aggregation

artículo científico publicado en 2013

The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story

scientific article published on 09 April 2019

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

scientific article published on 04 April 2019

The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex

artículo científico publicado en 2003

The Hsp90 mosaic: a picture emerges

artículo científico publicado en 2009

The Mechanism and Function of Group II Chaperonins

artículo científico

The TRiC chaperonin controls reovirus replication through outer-capsid folding

artículo científico publicado en 2018

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

artículo científico publicado en 2009

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

artículo científico publicado en 2006

The cotranslational contacts between ribosome-bound nascent polypeptides and the subunits of the hetero-oligomeric chaperonin TRiC probed by photocross-linking

artículo científico publicado en 2005

The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis

artículo científico publicado en 2013

The dynamic conformational cycle of the group I chaperonin C-termini revealed via molecular dynamics simulation

artículo científico publicado en 2015

The molecular architecture of the eukaryotic chaperonin TRiC/CCT

artículo científico publicado en 2012

The predicted structure of the headpiece of the Huntingtin protein and its implications on Huntingtin aggregation

artículo científico publicado en 2009

The ribosome as a hub for protein quality control

artículo científico publicado en 2013

The role of mutational robustness in RNA virus evolution

artículo científico publicado en 2013

The stop-and-go traffic regulating protein biogenesis: How translation kinetics controls proteostasis

scientific article published on 30 November 2018

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT

scientific journal article

Time-Resolved Measurement of the ATP-Dependent Motion of the Group II Chaperonin by Diffracted Electron Tracking.

artículo científico publicado en 2018

Tracheostomy and mechanical ventilation weaning in children affected by respiratory virus according to a weaning protocol in a pediatric intensive care unit in Argentina: an observational restrospective trial ⬇️

artículo científico publicado el 19 de enero de 2011

Trivalent arsenic inhibits the functions of chaperonin complex

artículo científico publicado en 2010

Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin binding

artículo científico publicado en 2003

Where chaperones and nascent polypeptides meet

artículo científico publicado en 2002

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

artículo científico publicado en 2019

xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry

artículo científico publicado en 2015

Lista de obras de Judith Frydman

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement

A Viral Protein Restricts Drosophila RNAi Immunity by Regulating Argonaute Activity and Stability

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle

A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis

Aberrant protein folding as the molecular basis of cancer

Actin mutations in hypertrophic and dilated cardiomyopathy cause inefficient protein folding and perturbed filament formation

Action of the chaperonin GroEL/ES on a non-native substrate observed with single-molecule FRET.

An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex ⬇️

An information theoretic framework reveals a tunable allosteric network in group II chaperonins

Broad action of Hsp90 as a host chaperone required for viral replication

Cellular inclusion bodies of mutant huntingtin exon 1 obscure small fibrillar aggregate species

Cellular strategies of protein quality control

Chaperonin GroEL and its mutant D87K protect from ischemia in vivo and in vitro

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis

Cotranslational signal-independent SRP preloading during membrane targeting

Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure

CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin

CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

Crystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding Cycle

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes

Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation

Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network

Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches.

Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy

Dual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin Chamber

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

Dynamics and clustering of IRE1α during ER stress

Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes

Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

Hardware-based anti-Brownian electrokinetic trap (ABEL trap) for single molecules: Control loop simulations and application to ATP binding stoichiometry in multi-subunit enzymes

Heterozygous yeast deletion collection screens reveal essential targets of Hsp90

Hsp110 cooperates with different cytosolic HSP70 systems in a pathway for de novo folding

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus

Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation.

Huntingtin’s N-Terminus Rearrangements in the Presence of Membranes: A Joint Spectroscopic and Computational Perspective

Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins

Interplay between chaperones and protein disorder promotes the evolution of protein networks

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging.

Mechanism of folding chamber closure in a group II chaperonin

Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT

Mechanism of nucleotide sensing in group II chaperonins

Mechanism of nucleotide sensing in group II chaperonins

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

Mechanisms and Functions of Spatial Protein Quality Control

Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae

Misfolded proteins partition between two distinct quality control compartments

Modeling of possible subunit arrangements in the eukaryotic chaperonin TRiC.

Modulation of STAT3 folding and function by TRiC/CCT chaperonin

Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction

Nascent Polypeptide Domain Topology and Elongation Rate Direct the Cotranslational Hierarchy of Hsp70 and TRiC/CCT

Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein

Principles of cotranslational ubiquitination and quality control at the ribosome

Probing the sequence of conformationally induced polarity changes in the molecular chaperonin GroEL with fluorescence spectroscopy

Protein misfolding in neurodegenerative diseases: implications and strategies

Protein quality control: chaperones culling corrupt conformations

Proteostasis in Viral Infection: Unfolding the Complex Virus-Chaperone Interplay

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1

REP-X: An Evolution-guided Strategy for the Rational Design of Cysteine-less Protein Variants

Sensing cooperativity in ATP hydrolysis for single multisubunit enzymes in solution

Sorting out the trash: the spatial nature of eukaryotic protein quality control

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

State of the science: an update on renal cell carcinoma

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective

Sub-diffraction imaging of huntingtin protein aggregates by fluorescence blink-microscopy and atomic force microscopy

Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies

Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates