Lista de obras - Laura C Greaves - Dominio Público Uruguay

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices

scientific article published on 28 May 2019

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

artículo científico publicado en 2016

A methodological approach to tracing cell lineage in human epithelial tissues

artículo científico publicado en 2009

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

artículo científico publicado en 2018

Aberrant mitochondrial function in ageing and cancer

scientific article published on 04 December 2019

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis

artículo científico publicado en 2020

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

artículo científico publicado en 2010

Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy

artículo científico publicado en 2014

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

artículo científico publicado en 2014

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.

artículo científico publicado en 2006

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

artículo científico publicado en 2014

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations

artículo científico publicado en 2012

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

artículo científico publicado en 2010

Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up

scientific article published on 02 August 2019

Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells

artículo científico publicado en 2009

Differences in the accumulation of mitochondrial defects with age in mice and humans

scientific article published on 12 October 2011

Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk

scientific article published on 22 March 2019

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

artículo científico publicado en 2014

Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition

artículo científico publicado en 2018

In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells.

artículo científico publicado en 2011

Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

scientific article published on 05 November 2018

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

artículo científico publicado en 2019

Locating the stem cell niche and tracing hepatocyte lineages in human liver

artículo científico publicado en 2009

Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells

artículo científico publicado en 2007

Mitochondria are required for pro-ageing features of the senescent phenotype.

artículo científico publicado en 2016

Mitochondrial DNA and disease

scientific article published on 21 November 2011

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease.

artículo científico publicado en 2017

Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

artículo científico publicado en 2010

Mitochondrial DNA mutations and aging.

artículo científico publicado en 2007

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

artículo científico publicado en 2006

Mitochondrial DNA mutations in human colonic crypt stem cells

artículo científico publicado en 2003

Mitochondrial DNA mutations in human disease

artículo científico publicado en 2006

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

artículo científico publicado en 2020

Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: link to colon cancer?

artículo científico publicado en 2009

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

artículo científico publicado en 2017

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

artículo científico publicado en 2015

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

artículo científico publicado en 2018

Quantification of mitochondrial DNA mutation load

artículo científico publicado en 2009

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.

artículo científico publicado en 2018

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

artículo científico publicado en 2014

Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles

artículo científico publicado en 2010

The ageing mitochondrial genome

artículo científico publicado en 2007

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.

artículo científico publicado en 2015

The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential.

artículo científico publicado en 2013

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(-/-) mice

artículo científico publicado en 2016

Lista de obras de Laura C Greaves

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision-Cut Liver Slices

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

A methodological approach to tracing cell lineage in human epithelial tissues

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

Aberrant mitochondrial function in ageing and cancer

Age-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

Clonal expansion in the human gut: mitochondrial DNA mutations show us the way.

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations

Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up

Detection of cytochrome c oxidase activity and mitochondrial proteins in single cells

Differences in the accumulation of mitochondrial defects with age in mice and humans

Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk

Human stem cell aging: do mitochondrial DNA mutations have a causal role?

Impact of age-related mitochondrial dysfunction and exercise on intestinal microbiota composition

In situ lineage tracking of human prostatic epithelial stem cell fate reveals a common clonal origin for basal and luminal cells.

Inherited pathogenic mitochondrial DNA mutations and gastrointestinal stem cell populations

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Locating the stem cell niche and tracing hepatocyte lineages in human liver

Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells

Mitochondria are required for pro-ageing features of the senescent phenotype.

Mitochondrial DNA and disease

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease.

Mitochondrial DNA defects and selective extraocular muscle involvement in CPEO.

Mitochondrial DNA mutations and aging.

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

Mitochondrial DNA mutations in human colonic crypt stem cells

Mitochondrial DNA mutations in human disease

Mitochondrial dysfunction impairs osteogenesis, increases osteoclast activity, and accelerates age related bone loss

Modelling mitochondrial DNA mutations in bacterial cytochrome c oxidase: link to colon cancer?

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression.

Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

Quantification of mitochondrial DNA mutation load

Roles of Mitochondrial DNA Mutations in Stem Cell Ageing.

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles

The ageing mitochondrial genome

The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease.

The role of the mitochondrial ribosome in human disease: searching for mutations in 12S mitochondrial rRNA with high disruptive potential.

Unique quadruple immunofluorescence assay demonstrates mitochondrial respiratory chain dysfunction in osteoblasts of aged and PolgA(-/-) mice