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Lista de obras de Jeffery W. Kelly

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

artículo científico publicado en 2017

A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity

artículo científico publicado en 2010

A biomimetic synthesis of thiazolines using hexaphenyloxodiphosphonium trifluoromethanesulfonate

artículo científico publicado en 2003

A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

article by Jeffery W. Kelly & Peter T. Lansbury published January 1994 in Amyloid

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin ⬇️

artículo científico publicado el 30 de diciembre de 2010

A cross-strand Trp Trp pair stabilizes the hPin1 WW domain at the expense of function

artículo científico publicado en 2007

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases

artículo científico publicado en 2016

A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence

artículo científico publicado en 2019

A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans

artículo científico publicado en 2015

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

artículo científico publicado en 2012

A general strategy for the bacterial expression of amyloidogenic peptides using BCL-XL-1/2 fusions

artículo científico publicado en 2009

A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion

artículo científico publicado en 2012

A kinetic aggregation assay allowing selective and sensitive amyloid-β quantification in cells and tissues

artículo científico publicado en 2011

A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis

artículo científico publicado en 2009

A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate

artículo científico publicado en 2010

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

artículo científico publicado en 2013

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization

artículo científico publicado en 2003

Adapting proteostasis for disease intervention

artículo científico publicado en 2008

Adsorption of beta-hairpin peptides on the surface of water: a neutron reflection study

artículo científico publicado en 2003

Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis

artículo científico publicado en 2017

Aggregating knowledge about prions and amyloid

artículo científico publicado en 2009

Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?

artículo científico publicado en 2007

Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies

artículo científico publicado en 2006

Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

artículo científico publicado en 2008

Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology.

artículo científico publicado en 2017

Amyloid as a natural product

artículo científico publicado en 2003

Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase

artículo científico publicado en 2012

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

artículo científico publicado en 2011

An Adaptable Standard for Protein Export from the Endoplasmic Reticulum

article

An experimental survey of the transition between two-state and downhill protein folding scenarios

artículo científico publicado en 2008

An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils.

artículo científico publicado en 2017

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

artículo científico publicado en 2003

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

artículo científico publicado en 2013

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

artículo científico publicado en 2016

Attacking amyloid

artículo científico publicado en 2005

Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.

artículo científico publicado en 2005

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

artículo científico publicado en 2003

Beta-sheet folding mechanisms from perturbation energetics

artículo científico publicado en 2006

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

artículo científico publicado en 2013

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

artículo científico publicado en 2011

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors

artículo científico publicado en 2008

Biochemical properties of highly neuroinvasive prion strains

artículo científico publicado en 2012

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

artículo científico publicado en 2005

Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma

artículo científico publicado en 2020

Broadly applicable methodology for the rapid and dosable small molecule-mediated regulation of transcription factors in human cells.

artículo científico publicado en 2013

Ca2+ binding protects against gelsolin amyloidosis

artículo científico publicado en 2004

Cell based screening of inhibitors of transthyretin aggregation

artículo científico publicado en 2006

Chaperonins resculpt folding free energy landscapes to avoid kinetic traps and accelerate protein folding

artículo científico publicado en 2014

Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis ⬇️

artículo científico publicado el 1 de diciembre de 2011

Chemical and biological approaches synergize to ameliorate protein-folding diseases.

artículo científico publicado en 2008

Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases

artículo científico publicado en 2010

Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants

artículo científico publicado en 2006

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

artículo científico publicado en 2002

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma

artículo científico publicado en 2010

Comparative Characterization of a Wild Type and Transmembrane Domain-Deleted Fatty Acid Amide Hydrolase: Identification of the Transmembrane Domain as a Site for Oligomerization ⬇️

artículo científico publicado el 27 de octubre de 1998

Comparison of Lethal and Nonlethal Transthyretin Variants and Their Relationship to Amyloid Disease ⬇️

artículo científico publicado el 17 de octubre de 1995

Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration

artículo científico publicado en 2011

Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding

artículo científico publicado en 2010

Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics

artículo científico publicado en 2004

Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.

artículo científico publicado en 2010

Controlling the morphology of cross beta-sheet assemblies by rational design

artículo científico publicado en 2005

Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics

artículo científico publicado en 2012

Correction to “Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin”

scientific article published on 07 January 2019

Cys-10 mixed disulfide modifications exacerbate transthyretin familial variant amyloidogenicity: a likely explanation for variable clinical expression of amyloidosis and the lack of pathology in C10S/V30M transgenic mice?

artículo científico publicado en 2005

Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions

artículo científico publicado en 2003

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

artículo científico publicado en 2003

De novo-designed enzymes as small-molecule-regulated fluorescence imaging tags and fluorescent reporters

artículo científico publicado en 2014

Deducing the presence of proteins and proteoforms in quantitative proteomics.

artículo científico publicado en 2018

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

artículo científico publicado en 2005

Determinants for Dephosphorylation of the RNA Polymerase II C-Terminal Domain by Scp1

artículo científico publicado en 2006

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

artículo científico publicado en 2004

Discovery and characterization of a mammalian amyloid disaggregation activity

artículo científico publicado en 2010

Dissecting the structure, thermodynamic stability, and aggregation properties of the A25T transthyretin (A25T-TTR) variant involved in leptomeningeal amyloidosis: identifying protein partners that co-aggregate during A25T-TTR fibrillogenesis in [...]

artículo científico publicado en 2011

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

artículo científico publicado en 2003

E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis.

artículo científico publicado en 2005

ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease.

artículo científico publicado en 2014

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

artículo científico publicado en 2006

Endoplasmic Reticulum Proteostasis Influences the Oligomeric State of an Amyloidogenic Protein Secreted from Mammalian Cells

artículo científico publicado en 2016

Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis.

artículo científico publicado en 2010

Energetic characteristics of the new transthyretin variant A25T may explain its atypical central nervous system pathology.

artículo científico publicado en 2003

Engineering a beta-sheet protein toward the folding speed limit

artículo científico publicado en 2005

Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity

artículo científico publicado en 2015

Erratum to “ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization” [J. Mol. Biol. 332 (2003) 601–615]

scholarly article published in Journal of Molecular Biology

Evaluating beta-turn mimics as beta-sheet folding nucleators

artículo científico publicado en 2009

Evolving protein stability through genetic selection.

artículo científico publicado en 2009

FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts.

artículo científico publicado en 2013

Finally, a transgenic light chain amyloidosis mouse model ⬇️

artículo científico publicado el 15 de diciembre de 2011

Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells.

artículo científico publicado en 2015

Formation of gelsolin amyloid fibrils in the rough endoplasmic reticulum of skeletal muscle in the gelsolin mouse model of inclusion body myositis: comparative analysis to human sporadic inclusion body myositis

artículo científico publicado en 2013

Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin

artículo científico publicado en 2006

Functional amyloid formation within mammalian tissue

artículo científico publicado en 2006

Functional amyloid--from bacteria to humans.

artículo científico publicado en 2007

Functional amyloidogenesis and cytotoxicity-insights into biology and pathology

artículo científico publicado en 2012

Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles

artículo científico publicado en 2005

Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention

artículo científico

Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type

artículo científico publicado en 2003

Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration

artículo científico publicado en 2014

Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis

artículo científico publicado en 2005

Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts

artículo científico publicado en 2011

Guanidine Hydrochloride-Induced Denaturation and Refolding of Transthyretin Exhibits a Marked Hysteresis: Equilibria with High Kinetic Barriers ⬇️

artículo científico publicado el 19 de agosto de 1997

Heat-shock response transcriptional program enables high-yield and high-quality recombinant protein production in Escherichia coli.

artículo científico publicado en 2014

Heparin accelerates gelsolin amyloidogenesis

artículo científico publicado en 2006

Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension

artículo científico publicado en 2011

High-Resolution Mapping of the Folding Transition State of a WW Domain

artículo científico publicado en 2016

Highly efficient biomimetic total synthesis and structural verification of bistratamides E and J from Lissoclinum bistratum

artículo científico publicado en 2004

Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate

artículo científico publicado en 2004

Hsp104 gives clients the individual attention they need

artículo científico publicado en 2012

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

artículo científico publicado en 2006

Human-murine transthyretin heterotetramers are kinetically stable and non-amyloidogenic. A lesson in the generation of transgenic models of diseases involving oligomeric proteins

artículo científico publicado en 2008

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease

artículo científico publicado en 2003

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

artículo científico publicado en 2004

Immunoprecipitation of amyloid fibrils by the use of an antibody that recognizes a generic epitope common to amyloid fibrils

artículo científico publicado en 2014

Improved Synthesis of the Boc and Fmoc Derivatives of 4-(2'-Aminoethyl)-6-dibenzofuranpropionic Acid: An Unnatural Amino Acid That Nucleates beta-Sheet Folding

artículo científico publicado en 1997

Improving mass spectrometric sequencing of arginine-containing peptides by derivatization with acetylacetone ⬇️

artículo científico publicado el 1 de diciembre de 1997

Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?

artículo científico publicado en 2017

Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli

artículo científico publicado en 2015

Influence of hPin1 WW N-terminal domain boundaries on function, protein stability, and folding

artículo científico publicado en 2007

Influence of the N-terminal domain on the aggregation properties of the prion protein

artículo científico publicado en 2005

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation ⬇️

artículo científico publicado el 27 de octubre de 1998

Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.

artículo científico publicado en 2007

Kinetic stabilization of an oligomeric protein by a single ligand binding event

artículo científico publicado en 2005

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

artículo científico publicado en 2005

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis

artículo científico publicado en 2005

Localized structural fluctuations promote amyloidogenic conformations in transthyretin

artículo científico publicado en 2013

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins

scientific article published on 14 June 2009

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

artículo científico publicado en 2013

Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies

artículo científico publicado en 2009

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

artículo científico publicado en 2016

Mechanism of Action of the Cytotoxic Asmarine Alkaloids.

artículo científico publicado en 2018

Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs

artículo científico publicado en 2011

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

artículo científico publicado en 2013

Medicine. The yin-yang of sirtuins

artículo científico publicado en 2007

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

scholarly article

Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

artículo científico publicado en 2005

Mispacking of the Phe87 Side Chain Reduces the Kinetic Stability of Human Transthyretin

scientific article published on 14 December 2018

N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation

artículo científico publicado en 2011

N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability

artículo científico publicado en 2012

N-terminal domains elicit formation of functional Pmel17 amyloid fibrils

artículo científico publicado en 2009

NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations

artículo científico publicado en 2018

NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the x-ray crystal structures of Pin1

artículo científico publicado en 2002

Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin

scientific article published on 01 July 2002

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

artículo científico publicado en 2005

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

artículo científico publicado en 2004

Opposing activities protect against age-onset proteotoxicity

artículo científico publicado en 2006

Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis

artículo científico publicado en 2006

Ordered Langmuir-Blodgett Films of Amphiphilic β-Hairpin Peptides Imaged by Atomic Force Microscopy

artículo científico publicado en 2002

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

artículo científico publicado en 2005

Oxidized cholesterol metabolites found in human atherosclerotic lesions promote apolipoprotein C-II amyloid fibril formation

artículo científico publicado en 2007

Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis

artículo científico publicado en 2008

Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.

artículo científico publicado en 2005

Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation.

artículo científico publicado en 2017

Pathological and functional amyloid formation orchestrated by the secretory pathway

artículo científico publicado en 2003

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

artículo científico publicado en 2017

Peripheral Blood Cell Gene Expression Diagnostic for Identifying Symptomatic Transthyretin Amyloidosis Patients: Male and Female Specific Signatures.

artículo científico publicado en 2016

Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy).

artículo científico publicado en 2015

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

artículo científico publicado en 2018

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

artículo científico publicado en 2019

Pharmacologic chaperoning as a strategy to treat Gaucher disease

artículo científico publicado en 2007

Phosphatase Inhibition Delays Translational Recovery ⬇️

artículo científico publicado el 1 de abril de 2011

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

artículo científico publicado en 2011

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

artículo científico publicado en 2005

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

artículo científico publicado en 2003

Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis.

artículo científico publicado en 2009

Protein energetics in maturation of the early secretory pathway.

artículo científico publicado en 2007

Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns

artículo científico publicado en 2011

Proteins downhill all the way

artículo científico publicado en 2006

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

scientific article published on 07 June 2008

Quantification of transthyretin kinetic stability in human plasma using subunit exchange.

artículo científico publicado en 2014

Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein

R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression

Recombinant Human Retinol-Binding Protein Refolding, Native Disulfide Formation, and Characterization ⬇️

artículo científico publicado el 1 de octubre de 1998

Recombinant expression, purification, and comparative characterization of torsinA and its torsion dystonia-associated variant Delta E-torsinA.

artículo científico publicado en 2003

Reduced IGF-1 signaling delays age-associated proteotoxicity in mice

artículo científico publicado en 2009

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

artículo científico publicado en 2010

Regioselective phosphoranylation and cyclodehydration of triols with diethoxytriphenylphosphorane ⬇️

artículo científico publicado el 1 de noviembre de 1986

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

artículo científico publicado en 2017

Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-glycosylation Efficiency.

artículo científico publicado en 2017

Response

artículo científico publicado en 2020

Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis

artículo científico publicado en 2005

Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry

artículo científico publicado en 2002

Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

artículo científico publicado en 2009

Semen-derived amyloid fibrils drastically enhance HIV infection

artículo científico publicado en 2007

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors

artículo científico publicado en 2017

Sequence determinants of thermodynamic stability in a WW domain--an all-beta-sheet protein

artículo científico publicado en 2009

Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

artículo científico publicado en 2002

Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity

scholarly article

Small molecule oxidation products trigger disease-associated protein misfolding.

artículo científico publicado en 2006

Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts

artículo científico publicado en 2014

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

artículo científico

Solid-State NMR Studies Reveal Native-like β-Sheet Structures in Transthyretin Amyloid.

artículo científico publicado en 2016

Solid-phase synthesis and stereochemical assignments of tenuecyclamides A-D employing heterocyclic amino acids derived from commercially available Fmoc alpha-amino acids

artículo científico publicado en 2004

Stilbene Vinyl Sulfonamides as Fluorogenic Sensors of and Traceless Covalent Kinetic Stabilizers of Transthyretin That Prevent Amyloidogenesis

artículo científico publicado en 2013

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments

artículo científico publicado en 2013

Structural and Energetic Basis of Carbohydrate–Aromatic Packing Interactions in Proteins

artículo científico publicado en 2013

Structural biology: form and function instructions

artículo científico publicado en 2005

Structural insight into pH-induced conformational changes within the native human transthyretin tetramer

artículo científico publicado en 2008

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

artículo científico publicado en 2010

Structure-function-folding relationship in a WW domain

artículo científico publicado en 2006

Sulfated glycosaminoglycans accelerate transthyretin amyloidogenesis by quaternary structural conversion

artículo científico publicado en 2011

Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes

artículo científico publicado en 2013

Synthesis and Conformational Preferences of a Potential beta-Sheet Nucleator Based on the 9,9-Dimethylxanthene Skeleton

scientific article published on 01 October 1996

Synthesis and Hydrogen Bonding Capabilities of Biphenyl-Based Amino Acids Designed To Nucleate beta-Sheet Structure

artículo científico publicado en 1996

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization

artículo científico publicado en 2003

Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy.

artículo científico publicado en 2015

Synthesis of a negatively charged dibenzofuran-based beta-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability

artículo científico publicado en 2002

Synthesis of all nineteen appropriately protected chiral alpha-hydroxy acid equivalents of the alpha-amino acids for Boc solid-phase depsi-peptide synthesis

artículo científico publicado en 2004

Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors

artículo científico publicado en 2002

Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial

artículo científico publicado en 2012

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

artículo científico publicado en 2012

Targeting protein aggregation for the treatment of degenerative diseases

artículo científico publicado en 2015

Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases

artículo científico

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

artículo científico publicado en 2009

The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic

artículo científico publicado en 2009

The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate

artículo científico publicado en 2016

The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains

artículo científico publicado en 2016

The Role of Protein Thermodynamics and Primary Structure in Fibrillogenesis of Variable Domains from Immunoglobulin Light Chains

scientific article published on 14 August 2019

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways ⬇️

artículo científico publicado el 1 de febrero de 1998

The biological and chemical basis for tissue-selective amyloid disease

artículo científico publicado en 2005

The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability

artículo científico publicado en 2009

The effect of backbone cyclization on the thermodynamics of beta-sheet unfolding: stability optimization of the PIN WW domain

artículo científico publicado en 2002

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

artículo científico publicado en 2017

The environmental dependency of protein folding best explains prion and amyloid diseases ⬇️

artículo científico publicado el 3 de febrero de 1998

The integration of cell and chemical biology in protein folding

artículo científico publicado en 2006

The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis

artículo científico publicado en 2014

The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation

artículo científico publicado en 2007

The pathway by which the tetrameric protein transthyretin dissociates.

artículo científico publicado en 2005

The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug

artículo científico publicado en 2012

The two shapes of the Tau protein

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

artículo científico publicado en 2018

Therapeutic strategies for human amyloid diseases

artículo científico publicado en 2002

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

artículo científico publicado en 2004

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

artículo científico publicado en 2008

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies †

artículo científico publicado en 2009

Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations

scientific article published on 01 December 2004

Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein

artículo científico

Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils

artículo científico publicado en 2013

Translation efficiency is maintained at elevated temperature in E. coli

artículo científico publicado en 2017

Translational attenuation differentially alters the fate of disease-associated fibulin proteins

artículo científico publicado en 2012

Transthyretin Quaternary and Tertiary Structural Changes Facilitate Misassembly into Amyloid ⬇️

artículo científico publicado el 1 de enero de 1997

Transthyretin aggregation under partially denaturing conditions is a downhill polymerization

artículo científico publicado en 2004

Treating the Periphery to Ameliorate Neurodegenerative Diseases ⬇️

artículo científico publicado el 10 de junio de 2011

Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation

artículo científico publicado en 2003

Understanding and Ameliorating the TTR Amyloidoses

Understanding the mechanism of beta-sheet folding from a chemical and biological perspective

artículo científico publicado en 2008

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

artículo científico publicado en 2014

Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis.

artículo científico publicado en 2014

Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities

artículo científico publicado en 2017

Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery

scientific article published on 31 August 2020

X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease

artículo científico publicado en 2005

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