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Lista de obras de Godefridus J Peters

"One marker does not fit all": additional translational and validation studies are needed to identify faithful predictors of pemetrexed activity in mesothelioma

artículo científico publicado en 2013

"Open Sesame?": Biomarker Status of the Human Equilibrative Nucleoside Transporter-1 and Molecular Mechanisms Influencing its Expression and Activity in the Uptake and Cytotoxicity of Gemcitabine in Pancreatic Cancer

artículo científico publicado en 2020

"The only thing I know is that I know nothing": 5-fluorouracil in human milk

artículo científico publicado en 2012

11C-sorafenib and 15O-H2O PET for early evaluation of sorafenib therapy

artículo científico publicado en 2020

2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

artículo científico publicado en 1993

3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells

artículo científico publicado en 2002

3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma

scientific article published on 14 January 2020

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer.

artículo científico publicado en 2018

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

artículo científico publicado en 2004

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients

artículo científico publicado en 2001

5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil

artículo científico publicado en 1999

5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man

artículo científico publicado en 1997

A bug in the resistance to EGFR inhibitors: is there a role for Mycoplasma and cytidine deaminase in reducing the activity of osimertinib in lung cancer patients?

artículo científico publicado en 2021

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa ⬇️

artículo científico publicado el 1 de noviembre de 1991

A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer.

artículo científico publicado en 2017

A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer

artículo científico publicado en 2010

A novel cytidine analog, RX-3117, shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.

artículo científico publicado en 2014

A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors

artículo científico publicado en 2007

A phase I and pharmacokinetic study of gemcitabine given by 24-h hepatic arterial infusion

artículo científico publicado en 2009

A polymorphism in the promoter is associated with EZH2 expression but not with outcome in advanced pancreatic cancer patients

artículo científico publicado en 2014

A sensitive non-radioactive assay for pyrimidine nucleoside phosphorylase using reversed-phase high performance liquid chromatography

artículo científico publicado en 1988

A sensitive, nonradiometric assay for dihydroorotic acid dehydrogenase using anion-exchange high-performance liquid chromatography

scientific article published on 01 February 1987

A single nucleotide polymorphism in EZH2 predicts overall survival rate in patients with cholangiocarcinoma

artículo científico publicado en 2013

A specific inhibitor of lactate dehydrogenase overcame the resistance toward gemcitabine in hypoxic mesothelioma cells, and modulated the expression of the human equilibrative transporter-1.

artículo científico publicado en 2016

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates

artículo científico publicado en 2005

AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients

artículo científico publicado en 2014

Abstract 1267: Unusual mechanism of resistance to the novel cytidine analog fluorocyclopentenylcytosine (RX-3117)

scholarly article

Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells

artículo científico publicado en 2010

Acquired tumor cell resistance to sunitinib causes resistance in a HT-29 human colon cancer xenograft mouse model without affecting sunitinib biodistribution or the tumor microvasculature

artículo científico publicado en 2014

Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies.

artículo científico publicado en 2017

Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines

artículo científico publicado en 2006

Addition of leucovorin in modulation of 5-fluorouracil with methotrexate: potentiating or reversing effect?

artículo científico publicado en 1995

Adenosine and deoxyadenosine metabolism in mammalian lymphocytes ⬇️

artículo científico publicado el 1 de enero de 1981

Adenosine deaminase and purine nucleoside phosphorylase in childhood lymphoblastic leukemia: relation with differentiation stage, in vitro drug resistance and clinical prognosis

artículo científico publicado el 1 de mayo de 1992

Adherence and Patients' Experiences with the Use of Capecitabine in Daily Practice

artículo científico publicado en 2016

Advances in purine and pyrimidine metabolism in health and diseases

artículo científico publicado en 2016

Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series

artículo científico publicado en 2011

Alternative scheduling of pulsatile, high dose sunitinib efficiently suppresses tumor growth

artículo científico publicado en 2016

Aminopeptidase antibodies in mesothelioma: new wine deserves new sacks

artículo científico publicado en 2018

An Expedient Assay for Determination of Gemcitabine and Its Metabolite in Human Plasma Using Isocratic Ion-Pair Reversed-Phase High-Performance Liquid Chromatography ⬇️

artículo científico publicado el 1 de octubre de 2003

Analysis of Drug Interactions

artículo científico publicado en 2011

Analysis of deoxycytidine accumulation in gemcitabine treated patients

artículo científico publicado en 2006

Anaplastic lymphoma kinase inhibition in metastatic non-small cell lung cancer: clinical impact of alectinib

artículo científico publicado en 2017

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

artículo científico publicado en 1999

Antiproliferative activity and mechanism of action of fatty acid derivatives of arabinosylcytosine (ara-C) in leukemia and solid tumor cell lines

artículo científico publicado en 2004

Antiproliferative activity and mechanism of action of fatty acid derivatives of gemcitabine in leukemia and solid tumor cell lines and in human xenografts.

artículo científico publicado en 2004

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models.

artículo científico publicado en 2010

Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines.

artículo científico publicado en 2011

Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines

artículo científico publicado en 2018

Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts

artículo científico publicado en 2008

Antitumor activity of brequinar sodium (Dup-785) against human head and neck squamous cell carcinoma xenografts

artículo científico publicado en 1990

Antitumor activity of prolonged as compared with bolus administration of 2',2'-difluorodeoxycytidine in vivo against murine colon tumors

artículo científico publicado en 1996

Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.

artículo científico publicado en 1995

Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia ⬇️

artículo científico publicado el 1 de noviembre de 2003

Assessment of mercaptopurine (6MP) metabolites and 6MP metabolic key-enzymes in childhood acute lymphoblastic leukemia

artículo científico publicado en 2014

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.

artículo científico publicado en 2011

Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.

artículo científico publicado en 2010

Basis for effective combination cancer chemotherapy with antimetabolites

artículo científico publicado en 2000

Better to be alone than in bad company: The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer.

artículo científico publicado en 2016

Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells

Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice

artículo científico publicado el 1 de enero de 1992

Biological Evaluation of the Antiproliferative and Anti-migratory Activity of a Series of 3-(6-Phenylimidazo[2,1-b][1,3,4]thiadiazol-2-yl)-1H-indole Derivatives Against Pancreatic Cancer Cells

artículo científico publicado en 2019

Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase?

artículo científico publicado en 1999

Biotransformation of 6‐thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6‐thioguanine ⬇️

artículo científico publicado el 1 de junio de 2011

Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?

artículo científico

Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells

artículo científico publicado en 2009

Breastfeeding during R-CHOP chemotherapy: please abstain!

scientific article published on 19 August 2019

CX-5461 Inhibits Pancreatic Ductal Adenocarcinoma Cell Growth, Migration and Induces DNA Damage

scientific article published on 04 December 2019

Calcium/Magnesium Infusion for Oxaliplatin-Induced Neuropathy: Protective or Not?

artículo científico publicado en 2014

Can cytidine deaminase be used as predictive biomarker for gemcitabine toxicity and response?

article

Cancer of the esophagus and gastric cardia: recent advances

artículo científico publicado en 2004

Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines.

artículo científico publicado en 1999

Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines

artículo científico publicado en 2009

Cell cycle effects of fatty acid derivatives of cytarabine, CP-4055, and of gemcitabine, CP-4126, as basis for the interaction with oxaliplatin and docetaxel.

artículo científico publicado en 2010

Cell specific cytotoxicity and structure-activity relationship of lipophilic 1-B-D-arabinofuranosylcytosine (ara-C) derivatives.

artículo científico publicado en 1999

Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins

artículo científico publicado en 2009

Cellular pharmacology of multi- and duplex drugs consisting of ethynylcytidine and 5-fluoro-2'-deoxyuridine

artículo científico publicado en 2009

Cellular pharmacology studies of anticancer agents: recommendations from the EORTC-PAMM group

artículo científico publicado en 2017

Cellular resistance against troxacitabine in human cell lines and pediatric patient acute myeloid leukemia blast cells

artículo científico publicado en 2006

Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil

artículo científico publicado en 2004

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels

artículo científico publicado en 2007

Characterization of and protection from neurotoxicity induced by oxaliplatin, bortezomib and epothilone-B.

artículo científico publicado en 2014

Chemosensitizing acridones: in vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies.

artículo científico publicado en 2013

Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460.

artículo científico publicado en 2000

Clinical and pharmacologic study of orally administered uridine

artículo científico publicado en 1991

Clinical phase I and pharmacology study of gemcitabine (2', 2'-difluorodeoxycytidine) administered in a two-weekly schedule

artículo científico publicado en 2007

Clinical relevance of biochemical modulation of 5-fluorouracil

artículo científico publicado en 1991

Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines

scientific article published on 24 July 2019

Collateral sensitivity to gemcitabine (2',2'-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines

artículo científico publicado en 2001

Combination Therapies of Artemisinin and its Derivatives as a Viable Approach for Future Cancer Treatment

artículo científico publicado en 2019

Combination chemotherapy studies with gemcitabine

artículo científico publicado en 1997

Combination chemotherapy studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines

artículo científico publicado en 1999

Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors

artículo científico publicado en 2004

Combinations of 5-fluorouracil with UCN-01 or staurosporine

artículo científico publicado en 2004

Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients

artículo científico publicado en 2008

Comment on: Targeting the HGF/c-MET pathway in advanced pancreatic cancer: a key element of treatment that limits primary tumour growth and eliminates metastasis

artículo científico publicado en 2020

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.

artículo científico publicado en 1999

Comparison of 5-Fluoro-2’-Deoxyuridine and 5-Fluorouracil in the Treatment of Murine Colon Cancer; Effects on Thymidylate Synthase ⬇️

artículo científico publicado el 1 de enero de 1994

Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase

scientific article published on 01 January 1993

Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing ⬇️

artículo científico publicado el 1 de enero de 1991

Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (gemcitabine).

artículo científico publicado en 1991

Concentration, synthesis and utilization of phosphoribosylpyrophosphate in lymphocytes of five mammalian species ⬇️

artículo científico publicado el 1 de enero de 1979

Contemporary reviews on cancer treatment

artículo científico publicado en 2016

Correlation between cytidine deaminase genotype and gemcitabine deamination in blood samples

artículo científico publicado en 2008

Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients.

artículo científico publicado en 2008

Correlation of cytidine deaminase polymorphisms and activity with clinical outcome in gemcitabine-/platinum-treated advanced non-small-cell lung cancer patients.

artículo científico publicado en 2011

Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma

artículo científico publicado en 2013

Crizotinib sensitizes the erlotinib resistant HCC827GR5 cell line by influencing lysosomal function

scientific article published on 20 January 2020

Cross-Resistance to Thymidylate Synthase Inhibitors in P-Glycoprotein and Non-P-Glycoprotein Cell Lines ⬇️

artículo científico publicado el 1 de enero de 1994

Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs

artículo científico publicado en 2000

Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.

artículo científico publicado en 1998

Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression ⬇️

artículo científico publicado el 15 de junio de 1997

Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib.

artículo científico publicado en 2015

Cytidine deaminase enzymatic activity is a prognostic biomarker in gemcitabine/platinum-treated advanced non-small-cell lung cancer: a prospective validation study

artículo científico publicado en 2018

Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures

scientific article published on 01 January 1993

Cytotoxicity of sphingoid marine compound analogs in mono- and multilayered solid tumor cell cultures

artículo científico publicado en 2006

Cytotoxicity studies of some novel fluoro acridone derivatives against sensitive and resistant cancer cell lines and their mechanistic studies

artículo científico publicado en 2011

DNA copy number profiles correlate with outcome in colorectal cancer patients treated with fluoropyrimidine/antifolate-based regimens

artículo científico publicado en 2011

DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer

artículo científico publicado en 2009

DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors

artículo científico publicado en 2018

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells

artículo científico publicado en 2013

DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects

artículo científico publicado en 1988

Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line

scientific article published on 10 May 2019

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

artículo científico publicado en 1999

Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts

scientific article published on 01 January 1993

Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro

artículo científico publicado en 2011

Design and synthesis of quinazolinone tagged acridones as cytotoxic agents and their effects on EGFR tyrosine kinase

artículo científico publicado en 2014

Design of new drug molecules to be used in reversing multidrug resistance in cancer cells

artículo científico publicado en 2009

Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000.

artículo científico publicado en 2004

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

artículo científico publicado en 2002

Determinants of the therapeutic efficacy of thymidylate synthase inhibitors

artículo científico publicado en 1998

Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells

artículo científico publicado en 2005

Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy

artículo científico publicado en 1993

Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.

artículo científico publicado en 2011

Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.

artículo científico publicado en 1994

Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines.

artículo científico publicado en 1993

Development of new molecular agents targeting key signalling pathways activated by growth factors in human cancer

scientific article published on 01 January 2013

Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.

artículo científico publicado en 1996

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates

artículo científico publicado en 2000

Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome

artículo científico publicado en 2002

Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.

artículo científico publicado en 2010

Differential effects of gemcitabine on nucleotide pools of 19 solid tumor cell lines

artículo científico publicado en 1998

Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukaemia cell lines.

artículo científico publicado en 2000

Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases

artículo científico publicado en 2002

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia

artículo científico publicado en 2002

Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay

artículo científico publicado en 1999

Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluorouracil

scientific article published on 01 January 1998

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

artículo científico publicado en 2011

Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.

artículo científico publicado en 2004

Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors

artículo científico publicado en 2002

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC.

artículo científico publicado en 2017

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.

artículo científico publicado en 2000

Drug transport and metabolism of novel anticancer drugs

artículo científico publicado en 2015

Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

artículo científico publicado en 2008

Drug-induced apoptosis in lung cnacer cells is not mediated by the Fas/FasL (CD95/APO1) signaling pathway.

artículo científico publicado en 2000

Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo

artículo científico publicado en 2008

EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity

artículo científico publicado en 2012

EO9 (Apaziquone): from the clinic to the laboratory and back again

artículo científico publicado en 2013

Effect of Leucovorin on 5-Fluorouracil Induced Inhibition of Thymidylate Synthase in Patients with Colon Cancer ⬇️

artículo científico publicado el 1 de enero de 1991

Effect of WR-2721 on the toxicity and antitumor activity of the combination of carboplatin and 5-fluorouracil

artículo científico publicado en 1992

Effect of dexamethasone on the antileukemic effect of cytarabine: role of deoxycytidine kinase

artículo científico publicado en 2020

Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase

artículo científico publicado en 1993

Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase

artículo científico publicado el 1 de abril de 1992

Effect of gemcitabine and cis-platinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines

artículo científico publicado en 2003

Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia

artículo científico publicado en 2005

Effects of adenosine and deoxyadenosine on pha-stimulation of lymphocytes of man, horse and pig ⬇️

artículo científico publicado el 1 de enero de 1982

Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase

artículo científico publicado en 2002

Effects of gemcitabine on cis-platinum-DNA adduct formation and repair in a panel of gemcitabine and cisplatin-sensitive or -resistant human ovarian cancer cell lines.

artículo científico publicado en 2006

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

scientific article published on 01 January 1994

Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review.

artículo científico publicado en 2016

Efficacy, pharmacokinetic and pharmacodynamic evaluation of apaziquone in the treatment of non-muscle invasive bladder cancer

artículo científico

Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors ⬇️

artículo científico publicado el 15 de septiembre de 1992

Elucidation of chemosensitization effect of acridones in cancer cell lines: Combined pharmacophore modeling, 3D QSAR, and molecular dynamics studies.

artículo científico publicado en 2018

End-joining deficiency and radiosensitization induced by gemcitabine

artículo científico publicado en 2001

Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.

artículo científico publicado en 2006

Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN

artículo científico publicado en 2017

Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation.

artículo científico publicado en 2002

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes

artículo científico publicado en 1989

Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer

artículo científico publicado en 2013

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and Chemotherapy: A Glimmer of Hope?

artículo científico publicado en 2016

Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer

artículo científico

Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines.

artículo científico publicado en 2009

Epithelial Transfer of the Tyrosine Kinase Inhibitors Erlotinib, Gefitinib, Afatinib, Crizotinib, Sorafenib, Sunitinib, and Dasatinib: Implications for Clinical Resistance

artículo científico publicado en 2020

Erratum to: Glutamate and α-ketoglutarate: key players in glioma metabolism.

artículo científico publicado en 2017

Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines

artículo científico publicado en 1993

Ex vivo resistance in childhood acute lymphoblastic leukemia: Correlations between BCRP, MRP1, MRP4 and MRP5 ABC transporter expression and intracellular methotrexate polyglutamate accumulation

artículo científico publicado en 2019

Experimental drugs and drug combinations in pancreatic cancer

artículo científico publicado en 1999

Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations

artículo científico publicado en 2005

Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver

artículo científico publicado en 2003

Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia

scientific article published on 20 April 2020

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer

artículo científico publicado en 2016

Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines ⬇️

artículo científico publicado el 21 de mayo de 1984

Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors

Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor

artículo científico publicado en 2001

Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).

artículo científico publicado en 2004

Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.

artículo científico publicado en 2000

Folate deprivation induces BCRP (ABCG2) expression and mitoxantrone resistance in Caco-2 cells.

artículo científico publicado en 2008

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases

artículo científico publicado en 2019

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action

artículo científico publicado en 2016

Folates provoke cellular efflux and drug resistance of substrates of the multidrug resistance protein 1 (MRP1).

artículo científico publicado en 2014

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance

artículo científico publicado en 2015

From 'Targeted Therapy' to Targeted Therapy

scientific article published on 01 July 2019

Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein ⬇️

artículo científico publicado el 1 de septiembre de 1995

Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells

artículo científico publicado en 2008

Galectin-4 expression is associated with reduced lymph node metastasis and modulation of Wnt/β-catenin signalling in pancreatic adenocarcinoma

artículo científico publicado en 2014

Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer

scientific article published on 01 July 1999

Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions

artículo científico publicado en 2009

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer

artículo científico publicado en 2008

Gemcitabine-cisplatin: a schedule finding study.

artículo científico publicado en 1999

Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer.

artículo científico publicado en 2002

Gender, Cytidine Deaminase, and 5-Aza/Decitabine--Letter

artículo científico publicado en 2013

Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis

artículo científico publicado en 2009

Glutamate and α-ketoglutarate: key players in glioma metabolism

artículo científico publicado en 2017

Gout and hyperuricemia in Japan: perspectives for international research on purines and pyrimidines in man.

artículo científico publicado en 2011

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

High inter-individual variability of serum xanthine oxidoreductase activity in IBD patients

artículo científico publicado en 2018

High-dose 5-Fluorouracil with uridine-diphosphoglucose rescue increases thymidylate synthase inhibition but not 5-Fluorouracil incorporation into RNA in murine tumors.

artículo científico publicado en 2002

High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer

artículo científico publicado en 2012

Highly sensitive determination of 5-fluorouracil in human plasma by capillary gas chromatography and negative ion chemical ionization mass spectrometry

scholarly article published 1 September 1985

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?

artículo científico publicado en 2018

Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis

artículo científico publicado el 8 de mayo de 1992

Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer

artículo científico publicado en 2010

Imidazo[2,1-b] [1,3,4]thiadiazoles with antiproliferative activity against primary and gemcitabine-resistant pancreatic cancer cells

scientific article published on 25 January 2020

Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity

artículo científico publicado en 2004

Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples

artículo científico publicado en 2008

Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib.

artículo científico publicado en 2009

Impact of cytidine deaminase polymorphisms on toxicity after gemcitabine: the question is still ongoing.

artículo científico publicado en 2010

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds

scientific article published on 04 June 2020

Impact ofABCG2polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients

article

Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma

scientific article published on 01 December 1993

In vitro activity and mechanism of action of a duplex and multidrug of ethynylcytidine and 5-fluorodeoxyuridine

artículo científico publicado en 2008

In vitro and in vivo antitumor activity of methotrexate conjugated to human serum albumin in human cancer cells ⬇️

artículo científico publicado el 1 de mayo de 2003

In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil.

artículo científico publicado en 1989

In vitro antiproliferative effects, toxicity profiles in vivo in mice and antitumour activity in tumour-bearing mice of five organotin compounds

artículo científico publicado el 1 de enero de 1995

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil ⬇️

artículo científico publicado el 1 de marzo de 1988

In vitro chemosensitivity testing of multilayered microcultures

artículo científico publicado el 1 de julio de 1992

In vitro optimization of non-small cell lung cancer activity with troxacitabine, L-1,3-dioxolane-cytidine, prodrugs

artículo científico publicado en 2007

In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia

artículo científico publicado en 2006

In vitro sequence-dependent synergistic effect of suramin and camptothecin.

artículo científico publicado en 1994

In vivo and in vitro activity and mechanism of action of the multidrug cytarabine-L-glycerylyl-fluorodeoxyuridine

artículo científico publicado en 2007

In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant

artículo científico publicado en 2005

Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients

artículo científico publicado en 2012

Increased migration by stimulation of thymidine phosphorylase in endothelial cells of different origin

artículo científico publicado en 2010

Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines

scientific article published on 01 January 1998

Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines

artículo científico publicado en 2003

Induction of in vivo resistance against gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine).

artículo científico publicado en 1998

Induction of resistance to 2',2'-difluorodeoxycytidine in the human ovarian cancer cell line A2780.

artículo científico publicado en 1995

Induction of resistance to the lipophilic cytarabine prodrug elacytarabine (CP-4055) in CEM leukemic cells

artículo científico publicado en 2010

Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression

artículo científico publicado en 2003

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

artículo científico publicado en 2002

Influence of different types of diuresis on renal excretion of urea studied in the rat by means of renal micropunctures ⬇️

artículo científico

Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer

artículo científico publicado en 2011

Inherited germline T790M mutation and somatic epidermal growth factor receptor mutations in non-small cell lung cancer patients.

artículo científico publicado en 2011

Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390)

artículo científico publicado en 1987

Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine

artículo científico publicado en 2015

Integrating Collection of Biospecimens in Clinical Trials: The Approach of the European Organization for Research and Treatment of Cancer

scientific article published on 01 June 2011

Interaction between celecoxib and docetaxel or cisplatin in human cell lines of ovarian cancer and colon cancer is independent of COX-2 expression levels

artículo científico publicado en 2007

Interaction between cisplatin and gemcitabine in vitro and in vivo.

artículo científico publicado en 1995

Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay.

artículo científico publicado en 2001

Intermittent continuous infusion of 5-fluorouracil and low dose oral leucovorin in patients with gastrointestinal cancer: relationship between plasma concentrations and clinical parameters

artículo científico publicado en 1995

Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma

publication published on 30 May 2021

Intracellular thymidylate synthase inhibition by trifluorothymidine in FM3A cells

artículo científico publicado en 2004

Intracellular trafficking of MDR transporters and relevance of SNPs.

artículo científico publicado en 2009

Intrarenal distribution of urea in rat water diuresis

artículo científico

Intrarenal urea and electrolyte concentrations as influenced by water diuresis and by hydrochlorothiazide ⬇️

artículo científico

Intravesical administration of gemcitabine in superficial bladder cancer: a phase I study with pharmacodynamic evaluation.

artículo científico publicado en 2004

Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer

artículo científico publicado en 2001

Irinotecan-induced cytotoxicity to colon cancer cells in vitro is stimulated by pre-incubation with trifluorothymidine

artículo científico publicado en 2006

Is there a role for dacomitinib, a second-generation irreversible inhibitor of the epidermal-growth factor receptor tyrosine kinase, in advanced non-small cell lung cancer?

scientific article published on 15 April 2020

Isolated Liver Perfusion Versus Hepatic Artery Infusion with 5-Fluorouracil in a Rat Model; Effects on Thymidylate Synthase ⬇️

artículo científico publicado el 1 de enero de 1991

Issues of normal tissue toxicity in patient and animal studies--effect of carbogen breathing in rats after 5-fluorouracil treatment.

artículo científico publicado en 2001

Kinase Inhibitor Treatment of Patients with Advanced Cancer Results in High Tumor Drug Concentrations and in Specific Alterations of the Tumor Phosphoproteome

artículo científico publicado en 2020

Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells

artículo científico publicado en 2012

Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate

artículo científico publicado en 1994

Limited intra-individual variability in hypoxanthine-Guanine phosphoribosyl transferase, thiopurine S-methyl transferase, and xanthine oxidase activity in inflammatory bowel disease patients during 6-thioguanine therapy

artículo científico publicado en 2010

Lipophilic prodrugs and formulations of conventional (deoxy)nucleoside and fluoropyrimidine analogs in cancer

artículo científico

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

artículo científico publicado en 2002

Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells

artículo científico publicado en 2005

Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance.

artículo científico publicado en 2011

MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1.

artículo científico publicado en 2013

MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedside

artículo científico

MRP3, an organic anion transporter able to transport anti-cancer drugs

artículo científico publicado en 1999

Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside

artículo científico publicado en 2002

Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system

artículo científico publicado en 1991

Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells

artículo científico publicado en 2007

Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition

artículo científico publicado en 2007

Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines

artículo científico publicado en 1999

Mechanisms of synergism between gemcitabine and cisplatin

artículo científico publicado en 1998

Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126

artículo científico publicado en 2011

Metabolism of phosphoribosylpyrophosphate in peripheral and phytohemagglutin-stimulated mammalian lymphocytes ⬇️

artículo científico publicado el 1 de enero de 1981

Metabolism of purine nucleosides and phosphoribosylpyrophosphate in thymocytes and splenocytes of various mammalian species ⬇️

artículo científico publicado el 1 de enero de 1982

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360).

artículo científico publicado en 2013

Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia

artículo científico publicado en 2000

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

artículo científico publicado en 2015

Methylation specific PCR to characterize methylation of the promoter of deoxycytidine kinase

artículo científico publicado en 2010

Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia

artículo científico publicado en 2007

MiRNAs and Their Interference with the Main Molecular Mechanisms Responsible for Drug Resistance in Pancreatic Cancer

Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits

artículo científico publicado en 2006

MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

artículo científico publicado en 2010

Micropuncture Techniques as a Tool in Renal Pharmacology ⬇️

artículo científico publicado el 1 de enero de 1979

Modulation of cytarabine induced cytotoxicity using novel deoxynucleoside analogs in the HL60 cell line

artículo científico publicado en 2004

Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines

artículo científico publicado en 1986

Modulation of fluorouracil toxicity with uridine

artículo científico publicado el 1 de abril de 1992

Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds

scientific article published on 21 August 2007

Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines

artículo científico publicado en 1996

Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.

artículo científico publicado en 1998

Modulation of signaling enhances the efficacy of the combination of satraplatin and erlotinib

artículo científico publicado en 2014

Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl-l-aspartate in murine colon carcinoma no. 26 ⬇️

artículo científico publicado el 1 de junio de 1995

Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein

artículo científico publicado en 2008

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed

scientific article published on 01 May 2000

Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells

artículo científico publicado en 2017

Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell lines.

artículo científico publicado en 2009

Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells.

artículo científico publicado en 2013

Molecular mechanisms involved in the synergistic interaction of the EZH2 inhibitor 3-deazaneplanocin A with gemcitabine in pancreatic cancer cells

artículo científico publicado en 2012

Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer.

artículo científico publicado en 2013

Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice.

artículo científico publicado en 2011

Molecular mechanisms underlying the role of microRNAs in resistance to epidermal growth factor receptor-targeted agents and novel therapeutic strategies for treatment of non-small-cell lung cancer

artículo científico publicado en 2013

Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells.

artículo científico publicado en 2008

Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

artículo científico publicado en 2008

Molecular targets of gemcitabine action: rationale for development of novel drugs and drug combinations

artículo científico publicado en 2012

Multicentre EORTC study 16997: feasibility and phase II trial of farnesyl transferase inhibitor & gemcitabine combination in salvage treatment of advanced urothelial tract cancers

artículo científico publicado en 2005

Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment

artículo científico publicado en 2005

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

artículo científico publicado en 2015

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.

artículo científico publicado en 2002

N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation

artículo científico publicado en 2011

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

artículo científico

NUC-1031 in biliary tract cancer: from bench to bedside and back?

artículo científico publicado en 2020

Never let it go: Stopping key mechanisms underlying metastasis to fight pancreatic cancer.

artículo científico publicado en 2017

New Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives Inhibit FAK Phosphorylation and Potentiate the Antiproliferative Effects of Gemcitabine Through Modulation of the Human Equilibrative Nucleoside Transporter-1 in Peritoneal Mesothelioma

artículo científico publicado en 2020

New developments in the management of non-small-cell lung cancer, focus on rociletinib: what went wrong?

artículo científico publicado en 2016

New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted therapies

artículo científico

New targets for pyrimidine antimetabolites for the treatment of solid tumours. 2: Deoxycytidine kinase

artículo científico publicado en 1994

New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase

artículo científico publicado en 1994

New tricks for old biomarkers: thymidylate synthase expression as a predictor of pemetrexed activity in malignant mesothelioma

artículo científico publicado en 2010

Nitric oxide releasing acridone carboxamide derivatives as reverters of doxorubicin resistance in MCF7/Dx cancer cells

artículo científico publicado en 2015

No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil

artículo científico publicado en 1998

No evidence of gemcitabine accumulation during weekly administration.

artículo científico publicado en 2005

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

artículo científico

Novel approaches to selective treatments of human solid tumors: Laboratory and clinical correlation ⬇️

artículo científico publicado el 1 de abril de 1993

Novel cell death mechanisms of trifluorothymidine.

artículo científico publicado en 2008

Novel developments in metabolic disorders of purine and pyrimidine metabolism and therapeutic applications of their analogs

artículo científico publicado en 2014

Novel developments in the use of antimetabolites

artículo científico publicado en 2014

Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine

artículo científico publicado en 2019

Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.

artículo científico publicado en 2012

O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells

artículo científico publicado en 2007

Obituary to Lynette Fairbanks, PhD

scholarly article

On the pharmacogenetics of non-small cell lung cancer treatment

artículo científico publicado en 2016

On the use of pharmacogenetics in cancer treatment and clinical trials

artículo científico publicado en 2014

On therapeutic drug monitoring of thiopurines in inflammatory bowel disease; pharmacology, pharmacogenomics, drug intolerance and clinical relevance

artículo científico publicado en 2009

Online fluorescent method to assess BCRP/ABCG2 activity in suspension cells

artículo científico publicado en 2004

Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors

artículo científico publicado en 2013

Overcoming crizotinib resistance in ALK-rearranged NSCLC with the second-generation ALK-inhibitor ceritinib.

artículo científico publicado en 2015

Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine

artículo científico publicado en 2014

Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines

artículo científico publicado en 2008

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models

artículo científico publicado en 2020

Pegylated nanoliposomal cisplatin ameliorates chemotherapy-induced peripheral neuropathy

artículo científico publicado en 2024

Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography

artículo científico publicado en 2013

Personalized medicine in rheumatoid arthritis: methotrexate polyglutamylation revisited

scholarly article

Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin.

artículo científico publicado en 2012

Pharmacogenetics of conventional chemotherapy in non-small-cell lung cancer: a changing landscape?

artículo científico

Pharmacogenetics of non-small cell lung cancer (NSCLC): time to "work it out"?

artículo científico

Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors

scientific article published on 01 April 1999

Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective

artículo científico publicado en 2016

Pharmacologic modifications of renal tubular transport

artículo científico publicado el 1 de diciembre de 1976

Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).

artículo científico publicado en 2010

Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate.

artículo científico

Pharmacologically directed strategies in academic anticancer drug discovery based on the European NCI compounds initiative

artículo científico

Pharmacology of the paclitaxel-cisplatin, gemcitabine-cisplatin, and paclitaxel-gemcitabine combinations in patients with advanced non-small cell lung cancer.

artículo científico publicado en 2006

Phase I Dose-Escalation Study of Once Weekly or Once Every Two Weeks Administration of High-Dose Sunitinib in Patients With Refractory Solid Tumors

Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors

artículo científico publicado en 2000

Phase I study of aerosolized SLIT cisplatin in the treatment of patients with carcinoma of the lung

scientific article published on 01 April 2007

Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer

artículo científico publicado en 2004

Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase

artículo científico publicado en 2005

Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer.

artículo científico publicado en 2004

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

artículo científico publicado en 2017

Physicochemical properties of novel protein kinase inhibitors in relation to their substrate specificity for drug transporters.

artículo científico publicado en 2015

Platinum-induced neurotoxicity and preventive strategies: past, present, and future

artículo científico publicado en 2015

Polymorphisms correlated with the clinical outcome of locally advanced or metastatic colorectal cancer patients treated with ALIRI vs. FOLFIRI

Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia

artículo científico publicado en 2008

Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.

artículo científico publicado en 2009

Polymorphisms to predict outcome to the tyrosine kinase inhibitors gefitinib, erlotinib, sorafenib and sunitinib

artículo científico

Positioning of aminopeptidase inhibitors in next generation cancer therapy

artículo científico

Positron emission tomography using 2-deoxy-2-[18F]-fluoro-D-glucose for response monitoring in locally advanced gastroesophageal cancer; a comparison of different analytical methods

artículo científico publicado en 2003

Postconfluent multilayered cell line cultures for selective screening of gemcitabine

artículo científico publicado en 1998

Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent

scientific article published on 01 January 1993

Potentiation of in vitro ara-C cytotoxicity by ribonucleotide reductase inhibitors, cyclin-dependent kinase modulators and the DNA repair inhibitor aphidicolin in paediatric acute myeloid leukaemia

artículo científico publicado en 2005

Preclinical combination therapy with gemcitabine and mechanisms of resistance

artículo científico publicado en 1996

Preclinical emergence of vandetanib as a potent antitumour agent in mesothelioma: molecular mechanisms underlying its synergistic interaction with pemetrexed and carboplatin

artículo científico publicado en 2011

Predictive role of repair enzymes in the efficacy of Cisplatin combinations in pancreatic and lung cancer

artículo científico

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients

artículo científico publicado en 2005

Preface

Preface to a supplement to Pharmacy World on the 5TH Symposium of the European Society for the Study of Purine & Pyrimidtne Metabolism in Man (ESSPPMM 1995)

Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.

artículo científico publicado en 2002

Prognostic and Predictive Roles of Thymidylate Synthase Expression in Lung Cancer: The Debate Is Still Open

artículo científico publicado en 2015

Prognostic factors in gemcitabine-cisplatin polychemotherapy regimens in pancreatic cancer: XPD-Lys751Gln polymorphism strikes back

artículo científico publicado en 2013

Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma

scientific article published on 01 January 1993

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.

artículo científico publicado en 2018

Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer.

artículo científico publicado en 2011

Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil

artículo científico publicado el 1 de enero de 1992

Protection of Normal Tissues from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine (WR-2721): Preclinical Aspects ⬇️

artículo científico publicado el 1 de enero de 1995

Protective autophagy by thymidine causes resistance to rapamycin in colorectal cancer cells <i>in vitro</i>

artículo científico publicado en 2021

Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma

artículo científico publicado en 2018

Purine Metabolism in Splenocytes and Thymocytes of Various Mammalian Species ⬇️

artículo científico publicado el 1 de enero de 1984

Purine Nucleotide Interconversion Enzymes in Childhood Leukemia: Relation with Cell Cycle and Clinical Outcome ⬇️

artículo científico publicado el 1 de enero de 1994

Purine and pyrimidine metabolism in peripheral blood lymphocytes ⬇️

artículo científico publicado el 1 de enero de 1983

Purine and pyrimidine metabolism in the fist decade of the 21st century--highlights and perspectives

artículo científico publicado en 2010

Purine and pyrimidine metabolism: still a black box?

scientific article published on 01 April 1994

Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity

artículo científico publicado en 1987

Pyrimidine metabolism in lymphocytes and erythrocytes of man, horse and cattle ⬇️

artículo científico publicado el 1 de enero de 1979

Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay

scientific article published on 01 October 1995

Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.

artículo científico publicado en 2004

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier

artículo científico publicado en 2020

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

artículo científico publicado en 2019

Radiosensitization by thymidine phosphorylase inhibitor in thymidine phosphorylase negative and overexpressing bladder cancer cell lines

artículo científico publicado en 2014

Randomized phase 2 study of gemcitabine and cisplatin with or without vitamin supplementation in patients with advanced esophagogastric cancer.

artículo científico publicado en 2018

Rapid Homogeneous Immunoassay to Quantify Gemcitabine in Plasma for Therapeutic Drug Monitoring.

artículo científico publicado en 2017

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer

artículo científico publicado en 2001

Re-evaluation of Brequinar sodium, a dihydroorotate dehydrogenase inhibitor

artículo científico publicado en 2018

Recent updates on purine and pyrimidine metabolism in physiological and pathological settings

artículo científico publicado en 2020

Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and-resistant leukemia cells

scientific article published on 01 January 1997

Regulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells.

artículo científico publicado en 2011

Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia

artículo científico publicado el 1 de septiembre de 1992

Research Highlights: Highlights from the latest articles in pharmacogenomics of irinotecan/cisplatin toxicity

article

Resistance Mechanisms to AZD9291 and Rociletinib-Letter

artículo científico publicado en 2017

Resistance to differentiation affects ribo- and deoxyribonucleotide pools and sensitivity to pyrimidine metabolism antagonists in HL60 cells

artículo científico publicado en 2020

Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine

artículo científico publicado en 1993

Role of Akt signaling in resistance to DNA-targeted therapy

artículo científico publicado en 2016

Role of CYB5A in pancreatic cancer prognosis and autophagy modulation

artículo científico publicado en 2013

Role of E3 ubiquitin ligases in lung cancer

artículo científico publicado en 2013

Role of c-MET Inhibitors in Overcoming Drug Resistance in Spheroid Models of Primary Human Pancreatic Cancer and Stellate Cells.

artículo científico publicado en 2019

Role of deoxycytidine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytidine deaminase (dCDA) in the antitumor activity of gemcitabine (dFdC)

artículo científico publicado en 1998

Role of genomic factors beyond thymidylate synthase in the prediction of response to 5-fluorouracil

artículo científico publicado en 2016

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

artículo científico publicado en 2003

Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools ⬇️

artículo científico publicado en 2017

Schedule dependence of sensitivity to 2',2'-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumour cell lines and solid tumours

artículo científico publicado en 1994

Schedule-Dependent Synergy Between the Histone Deacetylase Inhibitor Belinostat and the Dihydrofolate Reductase Inhibitor Pralatrexate in T-and B-cell Lymphoma Cells in vitro

artículo científico publicado en 2020

Schedule-dependent antitumor effect of gemcitabine in in vivo model system

scientific article published on 01 August 1995

Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours

scientific article published on 01 December 2000

Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts

artículo científico publicado en 1995

Scheduling of gemcitabine and cisplatin in Lewis lung tumour bearing mice

artículo científico publicado en 1999

Selection of the best blood compartment to measure cytidine deaminase activity to stratify for optimal gemcitabine or cytarabine treatment.

artículo científico publicado en 2014

Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures.

artículo científico publicado en 1999

Selective protection by uridine of growth inhibition by 5-fluorouracil (5FU) mediated by 5FU incorporation into RNA, but not the thymidylate synthase mediated growth inhibition by 5FU-leucovorin.

artículo científico publicado en 2008

Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA.

artículo científico publicado en 2016

Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.

artículo científico publicado en 2002

Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing

artículo científico publicado en 1984

Separation of several 5-fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5-fluorouracil-nucleotide sugars

scientific article published on 01 November 1984

Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines.

artículo científico publicado en 2000

Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines

artículo científico publicado en 1999

Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin

artículo científico publicado en 2010

Should alectinib or ceritinib be given as first line therapy for ALK positive non-small cell lung cancer patients instead of crizotinib?

Similar changes were induced by Cladribine and by gemcitabine, in the deoxypyrimidine salvage, during short-term treatments

artículo científico publicado en 1998

Simple and selective method for the determination of various tyrosine kinase inhibitors used in the clinical setting by liquid chromatography tandem mass spectrometry

artículo científico publicado en 2010

Single-nucleotide polymorphisms in the genes of CES2, CDA and enzymatic activity of CDA for prediction of the efficacy of capecitabine-containing chemotherapy in patients with metastatic breast cancer.

artículo científico publicado en 2017

Sorafenib administered using a high-dose, pulsatile regimen in patients with advanced solid malignancies: a phase I exposure escalation study

artículo científico publicado en 2020

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma

artículo científico publicado en 2018

Statins Potentiate Aminopeptidase Inhibitor (pro)Drug Activity in Acute Myeloid Leukemia Cells ⬇️

artículo científico publicado en 2018

Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase

artículo científico publicado en 2010

Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells

artículo científico publicado en 2001

Study by micropuncture of urea excretion by rats overloaded with saline solutions

artículo científico

Study of apoptosis induction and deoxycytidine kinase/cytidine deaminase modulation in the synergistic interaction of a novel ceramide analog and gemcitabine in pancreatic cancer cells.

artículo científico publicado en 2010

Successful treatment of renal cell carcinoma with sorafenib after effective but hepatotoxic sunitinib exposure

artículo científico publicado en 2012

Sulfasalazine down-regulates the expression of the angiogenic factors platelet-derived endothelial cell growth factor/thymidine phosphorylase and interleukin-8 in human monocytic-macrophage THP1 and U937 cells

artículo científico publicado en 2004

Synergistic Interaction between Cisplatin and Gemcitabine in Ovarian and Colon Cancer Cell Lines ⬇️

artículo científico publicado el 1 de enero de 1994

Synergistic interaction between cisplatin and gemcitabine in vitro.

artículo científico publicado en 1996

Synergistic interaction between trifluorothymidine and docetaxel is sequence dependent.

artículo científico publicado en 2008

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

artículo científico publicado en 2013

Synthesis and biological activity of a gemcitabine phosphoramidate prodrug

artículo científico publicado en 2007

Synthesis of 2-fluoro N(10)-substituted acridones and their cytotoxicity studies in sensitive and resistant cancer cell lines and their DNA intercalation studies

artículo científico publicado en 2009

Synthesis, in vitro cytotoxicity and in vivo anti-inflammatory activity of long chain 3-amino-1,2-diols

artículo científico publicado en 1999

TAS-102: more than an antimetabolite.

artículo científico publicado en 2012

TFAP2E-DKK4and Chemoresistance in Colorectal Cancer

artículo científico publicado en 2012

Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival

artículo científico publicado en 2015

Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance

artículo científico publicado en 2019

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.

artículo científico publicado en 2016

The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib

artículo científico publicado en 2014

The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells

artículo científico publicado en 2006

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter.

artículo científico publicado en 2016

The Role of MicroRNAs in Resistance to Current Pancreatic Cancer Treatment: Translational Studies and Basic Protocols for Extraction and PCR Analysis

artículo científico publicado en 2016

The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies

scientific article published on 04 December 2019

The Role of the Microbiome in Cancer and Therapy Efficacy: Focus on Lung Cancer

artículo científico publicado en 2020

The activity of the lipophilic nucleoside derivatives elacytarabine and CP-4126 in a panel of tumor cell lines resistant to nucleoside analogues

artículo científico publicado en 2010

The allosteric AKT inhibitor MK2206 shows a synergistic interaction with chemotherapy and radiotherapy in glioblastoma spheroid cultures

artículo científico publicado en 2017

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

artículo científico publicado en 2016

The concentration of 5-phosphoribosyl 1-pyrophosphate in monolayer tumor cells and the effect of various pyrimidine antimetabolites

artículo científico publicado en 1985

The continuous rediscovery and the benefit-risk ratio of thioguanine, a comprehensive review

artículo científico publicado en 2020

The determination of gemcitabine and 2'-deoxycytidine in human plasma and tissue by APCI tandem mass spectrometry

artículo científico publicado en 2006

The dichotomous role of the glycolytic metabolism pathway in cancer metastasis: Interplay with the complex tumor microenvironment and novel therapeutic strategies

scientific article published on 21 August 2019

The effect of G-CSF on the in vitro cytotoxicity of cytarabine and fludarabine in the FLAG combination in pediatric acute myeloid leukemia.

artículo científico publicado en 2004

The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study

artículo científico publicado en 2013

The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat ⬇️

artículo científico publicado el 1 de enero de 1995

The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor on the expression of thymidine phosphorylase

artículo científico publicado en 2004

The effect of food on the pharmacokinetics of S-1 after single oral administration to patients with solid tumors

artículo científico publicado en 2004

The effect of schedule, protein binding and growth factors on the activity of suramin

artículo científico publicado en 1992

The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms

artículo científico publicado en 2012

The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia

artículo científico publicado en 2005

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

artículo científico publicado en 2005

The impact of folate status on the efficacy of colorectal cancer treatment.

artículo científico publicado en 2011

The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.

artículo científico publicado en 1993

The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells.

artículo científico publicado en 2014

The potential of multi-compound nanoparticles to bypass drug resistance in cancer.

artículo científico publicado en 2017

The radiosensitizing effect of fluorocyclopentenyl-cytosine (RX-3117) in ovarian and lung cancer cell lines

artículo científico publicado en 2016

The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines

artículo científico publicado en 2006

The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium

artículo científico publicado en 1989

The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of brequinar sodium (DUP-785; NSC 368390).

artículo científico publicado en 1989

The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells

artículo científico publicado en 2000

The role of Eph receptors in cancer and how to target them: novel approaches in cancer treatment

artículo científico publicado en 2020

The role of deoxycytidine kinase in gemcitabine cytotoxicity

artículo científico publicado en 2000

The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis

artículo científico publicado en 2003

The role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in tumor behavior

scientific article published on June 2008

The role of the microbiome in drug resistance in gastrointestinal cancers

artículo científico publicado en 2020

The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil

artículo científico publicado en 1998

The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells

artículo científico publicado en 2006

The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB.

artículo científico publicado en 2011

The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent

artículo científico publicado en 2007

The use of capecitabine in daily practice: a study on adherence and patients' experiences

artículo científico publicado en 2012

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients

artículo científico publicado en 2003

Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies

artículo científico publicado en 2015

Therapeutic potential of the dual-targeted TAS-102 formulation in the treatment of gastrointestinal malignancies

artículo científico publicado en 2007

Therapy Related Disturbances in Nucleotides in Cancer Cells ⬇️

artículo científico publicado el 1 de enero de 1994

Thiopurines with low-dose allopurinol (ThiLDA)-a prospective clinical one-way crossover trial

artículo científico publicado en 2019

Thymidine phoshorylase as a target for antiangiogenesis treatment

artículo científico publicado en 2008

Thymidine phosphorylase in angiogenesis and drug resistance. Homology with platelet-derived endothelial cell growth factor

artículo científico publicado en 2000

Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors.

artículo científico publicado en 2011

Thymidine phosphorylase: its role in sensitivity and resistance to anticancer drugs.

artículo científico publicado en 1999

Thymidylate Synthase and Excision Repair Cross-Complementing Group-1 as Predictors of Responsiveness in Mesothelioma Patients Treated with Pemetrexed/Carboplatin

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer

artículo científico publicado en 2007

Thymidylate synthase and drug resistance ⬇️

artículo científico publicado el 1 de julio de 1995

Thymidylate synthase as a target in cancer chemotherapy

artículo científico publicado en 1995

Thymidylate synthase expression in patients with colorectal carcinoma using a polyclonal thymidylate synthase antibody in comparison to the TS 106 monoclonal antibody

scientific article published on 01 June 2000

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate ⬇️

artículo científico publicado el 1 de enero de 1991

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil

scientific article published on 01 October 1994

Thymidylate synthase inhibition induces p53 dependent and independent cell death

artículo científico publicado en 2000

Thymidylate synthase inhibitors

scientific article published on 01 January 2002

Thymidylate synthase inhibitors

artículo científico publicado en 2003

Thymidylate synthase inhibitors for non-small cell lung cancer

artículo científico

Thymidylate synthase inhibitors for thoracic tumors

Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin

scientific article published on 01 April 1992

Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities

artículo científico publicado en 1986

To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology

scientific article published on 01 July 2019

Tolerability and Safety of Conventional Thiopurines Concomitantly With Allopurinol in IBD-Patients With a Skewed Thiopurine Metabolism

artículo científico publicado en 2011

Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine

artículo científico publicado en 1986

Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism

artículo científico publicado en 1993

Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance

Trifluorothymidine induces cell death independently of p53.

artículo científico publicado en 2008

Trifluorothymidine resistance is associated with decreased thymidine kinase and equilibrative nucleoside transporter expression or increased secretory phospholipase A2.

artículo científico publicado en 2010

Tyrosine kinase inhibitors: Multi-targeted or single-targeted?

artículo científico publicado en 2011

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.

artículo científico

Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma

artículo científico

Urea excretion during compensatory adaptation of renal functions

artículo científico

Uridine Cytidine Kinase 2 as a Potential Biomarker for Treatment with RX-3117 in Pancreatic Cancer

artículo científico publicado en 2019

Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites

artículo científico publicado en 1987

Variable pharmacodynamics of antifolates in squamous cell carcinoma of the head and neck.

artículo científico publicado en 1993

XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center

artículo científico publicado en 2009

[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study.

artículo científico publicado en 2008

c-Met as a Target for Personalized Therapy

artículo científico publicado en 2015

cMET Exon 14 Skipping: From the Structure to the Clinic.

artículo científico publicado en 2016

hENT-1 Expression and Localization Predict Outcome After Adjuvant Gemcitabine in Resected Cholangiocarcinoma Patients

artículo científico publicado en 2016

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

artículo científico publicado en 2000

miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells

artículo científico publicado en 2014

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

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