Lista de obras - Paul J Lehner - Dominio Público Uruguay

A 58-year-old woman with abdominal symptoms and elevated C-reactive protein.

artículo científico publicado en 2008

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

artículo científico publicado en 2016

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

artículo científico

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

artículo científico publicado en 2015

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

artículo científico publicado en 2015

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

artículo científico publicado en 2020

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

artículo científico publicado en 2016

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

scientific article published on 01 January 2019

An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling

scientific article published on 01 November 2005

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

artículo científico publicado en 2009

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

scientific article published on 15 April 2020

Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification

artículo científico publicado en 2014

Antigen presentation: TAP dances with ATP

artículo científico publicado en 1999

Antigen presentation: coming out gracefully

artículo científico publicado en 1998

Antigen presentation: peptides and proteins scramble for the exit.

artículo científico publicado en 2000

CD8high(CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein‐Barr virus‐transformed B cell lines ⬇️

artículo científico publicado el 1 de noviembre de 1994

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

artículo científico publicado en 2017

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

artículo científico publicado en 2015

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

artículo científico publicado en 2014

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

artículo científico publicado en 2017

Cytomegalovirus: from evasion to suppression?

artículo científico publicado en 2001

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII

artículo científico publicado en 2006

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

artículo científico publicado en 2006

Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites

artículo científico publicado en 2019

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

artículo científico publicado en 2008

Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases.

artículo científico publicado en 2005

ESCRT proteins and the regulation of endocytic delivery to lysosomes

scientific article published on 01 February 2009

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

scientific article published on 19 June 2020

Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.

artículo científico publicado en 2009

Endosomal transport via ubiquitination ⬇️

artículo científico publicado el 28 de septiembre de 2011

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

artículo científico publicado en 2014

First report of Salmonella enterica serotype paratyphi A azithromycin resistance leading to treatment failure.

artículo científico publicado en 2010

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells

artículo científico publicado en 2012

Functional proteomic atlas of HIV infection in primary human CD4+ T cells

article

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

artículo científico publicado en 2015

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

artículo científico publicado en 2016

Genome surveillance by HUSH-mediated silencing of intronless mobile elements

artículo científico publicado en 2021

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

artículo científico publicado en 2014

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation

artículo científico publicado en 2011

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation

artículo científico

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

artículo científico publicado en 2016

Human cytomegalovirus: taking the strain

artículo científico

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

artículo científico publicado en 2021

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

artículo científico publicado en 2017

Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.

artículo científico publicado en 2010

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

artículo científico publicado en 2015

Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses

artículo científico publicado en 2000

Jenner's irony: cowpox taps into T cell evasion

scientific article published on 01 November 2009

Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins block distinct steps in transendothelial migration of effector memory CD4+ T cells by targeting different endothelial proteins.

artículo científico publicado en 2010

Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection

artículo científico publicado en 2013

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

scientific article published on 18 September 2005

MARCH-IX mediates ubiquitination and downregulation of ICAM-1.

artículo científico publicado en 2006

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

artículo científico publicado en 2018

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

artículo científico publicado en 2017

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

artículo científico publicado en 2013

Manipulation of immunometabolism by HIV-accessories to the crime?

artículo científico publicado en 2016

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

artículo científico publicado en 2016

Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells.

artículo científico publicado en 2001

Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.

artículo científico publicado en 2004

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

artículo científico publicado en 2017

NOTCH1 mediates a switch between two distinct secretomes during senescence.

artículo científico publicado en 2016

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

artículo científico publicado en 2018

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

scientific article published in Nature Communications

Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid-resistant tuberculosis

artículo científico publicado en 2007

Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses

artículo científico publicado en 2004

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141

artículo científico publicado en 2015

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

artículo científico publicado en 2016

Powering the peptide pump: TAP crosstalk with energetic nucleotides

artículo científico publicado en 2002

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

artículo científico publicado en 2014

RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation

artículo científico publicado en 2010

Recent developments in MHC-class-I-mediated antigen presentation.

artículo científico publicado en 2004

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

artículo científico publicado en 2018

Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin ⬇️

artículo científico publicado el 1 de enero de 1997

Role for the obesity-related FTO gene in the cellular sensing of amino acids

artículo científico publicado en 2013

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

scientific article published on 11 May 2020

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.

artículo científico publicado en 1998

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.

artículo científico publicado en 2004

Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression.

artículo científico publicado en 2010

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

artículo científico publicado en 2013

Stromal cell protein kinase C-β inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance

artículo científico publicado en 2020

Structure and function: heat shock proteins and adaptive immunity.

artículo científico publicado en 2007

Studying ubiquitination of MHC class I molecules.

artículo científico publicado en 2013

Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.

artículo científico publicado en 2018

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

scientific article published on 02 October 2020

TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.

artículo científico publicado en 2015

Tapasin is a facilitator, not an editor, of class I MHC peptide binding.

artículo científico publicado en 2003

Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway

artículo científico publicado en 2013

Tartrate-resistant acid phosphatase (Acp 5): identification in diverse human tissues and dendritic cells.

artículo científico publicado en 2001

Temporal Proteomic Analysis of BK Polyomavirus Infection Reveals Virus-Induced G2 Arrest and Highly Effective Evasion of Innate Immune Sensing

artículo científico publicado en 2019

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants

artículo científico publicado en 2016

The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP

scientific journal article

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

artículo científico publicado en 2018

The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation

artículo científico publicado en 2012

The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes.

artículo científico publicado en 2011

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

artículo científico publicado en 1997

The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

artículo científico publicado en 2001

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1

artículo científico publicado en 2018

The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases.

artículo científico publicado en 2008

The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X

artículo científico publicado en 2008

The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex

scientific journal article

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

artículo científico publicado en 2020

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation

artículo científico publicado en 2014

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

artículo científico publicado en 2015

Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation

artículo científico publicado en 2002

Viral avoidance and exploitation of the ubiquitin system.

artículo científico publicado en 2009

What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation? ⬇️

artículo científico publicado el 28 de enero de 2011

Lista de obras de Paul J Lehner

A 58-year-old woman with abdominal symptoms and elevated C-reactive protein.

A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface.

A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I.

A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

Antibody-free magnetic cell sorting of genetically modified primary human CD4+ T cells by one-step streptavidin affinity purification

Antigen presentation: TAP dances with ATP

Antigen presentation: coming out gracefully

Antigen presentation: peptides and proteins scramble for the exit.

CD8high(CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein‐Barr virus‐transformed B cell lines ⬇️

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation

Cytomegalovirus: from evasion to suppression?

Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites

Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity

Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases.

ESCRT proteins and the regulation of endocytic delivery to lysosomes

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains.

Endosomal transport via ubiquitination ⬇️

Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm.

First report of Salmonella enterica serotype paratyphi A azithromycin resistance leading to treatment failure.

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells

Functional proteomic atlas of HIV infection in primary human CD4+ T cells

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

Genome surveillance by HUSH-mediated silencing of intronless mobile elements

HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells

HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation

Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries

Human cytomegalovirus: taking the strain

Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses

Jenner's irony: cowpox taps into T cell evasion

Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins block distinct steps in transendothelial migration of effector memory CD4+ T cells by targeting different endothelial proteins.

Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

MARCH-IX mediates ubiquitination and downregulation of ICAM-1.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation.

Manipulation of immunometabolism by HIV-accessories to the crime?

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells.

Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

NOTCH1 mediates a switch between two distinct secretomes during senescence.

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia

Orthotopic liver transplantation for subacute hepatic failure following partial treatment of isoniazid-resistant tuberculosis

Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses

Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Powering the peptide pump: TAP crosstalk with energetic nucleotides

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

RNA-binding E3 ubiquitin ligases: novel players in nucleic acid regulation

Recent developments in MHC-class-I-mediated antigen presentation.

Regulation of Human γδ T Cells by BTN3A1 Protein Stability and ATP-Binding Cassette Transporters.

Regulation of MHC class I heterodimer stability and interaction with TAP by tapasin ⬇️

Role for the obesity-related FTO gene in the cellular sensing of amino acids

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.

Solution structure of the Kaposi's sarcoma-associated herpesvirus K3 N-terminal domain reveals a Novel E2-binding C4HC3-type RING domain.

Stabilization of an E3 ligase-E2-ubiquitin complex increases cell surface MHC class I expression.