Lista de obras - Graham Packham - Dominio Público Uruguay

A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells

artículo científico publicado en 2016

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

artículo científico publicado en 2013

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

artículo científico publicado en 2001

A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.

artículo científico publicado en 2016

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.

artículo científico publicado en 2013

Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target

artículo científico publicado en 2015

Anti-angiogenic effects of dietary isothiocyanates: Mechanisms of action and implications for human health ⬇️

artículo científico publicado el 16 de octubre de 2010

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

artículo científico publicado en 2022

B-cell receptor signaling in chronic lymphocytic leukemia.

artículo científico publicado en 2011

BAG-1 expression and function in human cancer

artículo científico publicado en 2002

BAG-1 immunostaining and survival in early breast cancer

artículo científico publicado en 2001

BAG-1 in carcinogenesis.

artículo científico publicado en 2004

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity

artículo científico

BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.

artículo científico

BAG-1: a multi-functional pro-survival molecule

artículo científico publicado en 2005

BAG-1: a multifunctional regulator of cell growth and survival

artículo científico publicado en 2003

BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.

artículo científico publicado en 2002

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

scientific article published on 28 August 2019

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

artículo científico publicado en 2015

BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells

Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

artículo científico publicado en 2005

British Journal of Pharmacology

article

Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro

scientific article published on 01 March 2001

CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM

article

Chronic lymphocytic leukaemia

article

Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

artículo científico publicado en 2021

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

scientific article published on 01 June 2020

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

artículo científico publicado en 2012

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

artículo científico publicado en 2002

Distinct promoters mediate constitutive and inducible Bcl-XL expression in malignant lymphocytes.

artículo científico

E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

artículo científico publicado en 2005

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

artículo científico publicado en 2011

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

artículo científico publicado en 2015

Epidermal Growth Factor Receptor Family Inhibition Identifies P38 Mitogen-activated Protein Kinase as a Potential Therapeutic Target in Bladder Cancer.

artículo científico publicado en 2017

Epigenetic modulators as therapeutic targets in prostate cancer

artículo científico publicado en 2016

FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.

artículo científico publicado en 2013

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

artículo científico publicado en 2017

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

artículo científico publicado en 2016

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

artículo científico publicado en 2010

High throughput imaging cytometer with acoustic focussing.

artículo científico publicado en 2015

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

artículo científico publicado en 2015

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

artículo científico publicado en 2016

IL-4 enhances expression and function of surface IgM in CLL cells.

artículo científico publicado en 2016

Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients

artículo científico publicado en 2018

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

artículo científico publicado en 2013

Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma

scientific article published on 01 March 2006

Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

artículo científico publicado en 2008

Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

artículo científico publicado en 2009

Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells.

artículo científico publicado en 2008

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior

Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies.

artículo científico

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

artículo científico publicado en 2018

Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells.

artículo científico publicado en 2015

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

artículo científico publicado en 2015

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

artículo científico publicado en 2008

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

artículo científico publicado en 2004

Mcl-1.

artículo científico publicado en 2005

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

artículo científico publicado en 2011

Mechanisms of cell death and disease: advances in therapeutic intervention

scientific article published on 01 June 2003

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation

artículo científico publicado en 2018

MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

scientific article published on 21 July 2008

Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts

artículo científico publicado en 2014

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2

scientific article published on 18 May 2012

Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells.

artículo científico publicado en 2005

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

scientific article published on 27 August 2016

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

artículo científico publicado en 2016

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

artículo científico publicado en 2006

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

artículo científico publicado en 2013

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

scientific article published on 12 December 2019

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

artículo científico publicado en 2013

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

artículo científico publicado en 2015

Regulation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Burkitt's lymphoma cell lines

scientific article published on 01 July 2003

Reply to 'Comment on 'BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses''

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

artículo científico publicado en 2007

S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.

artículo científico publicado en 2010

Shooting the messenger (RNA) in B-cell lymphoma

artículo científico publicado en 2016

Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth

artículo científico publicado en 2009

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis ⬇️

artículo científico publicado el 12 de enero de 2012

Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.

artículo científico publicado en 2014

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

artículo científico publicado en 2015

Structural and functional features of the B-cell receptor in IgG-positive chronic lymphocytic leukemia

artículo científico publicado en 2006

Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis

artículo científico publicado en 2007

Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL.

artículo científico publicado en 2016

Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

artículo científico publicado en 2010

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.

artículo científico publicado en 2011

T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice.

artículo científico publicado en 2015

TEL, a putative tumor suppressor, induces apoptosis and represses transcription of Bcl-XL.

artículo científico publicado en 2003

Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with Antitumor Activity

artículo científico publicado en 2018

Targeted inhibition of mRNA translation initiation factors as a novel therapeutic strategy for mature B-cell neoplasms

scientific article published on 01 February 2020

Targeting B-cell anergy in chronic lymphocytic leukemia.

artículo científico publicado en 2013

The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia

artículo científico publicado en 2016

The IGHV1-69/IGHJ3 recombinations of unmutated CLL are distinct from those of normal B cells.

artículo científico publicado en 2012

The Nrf2 transcription factor contributes to resistance to cisplatin in bladder cancer.

artículo científico

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

artículo científico publicado en 2015

The anti-CD20 antibody rituximab augments the immunospecific therapeutic effectiveness of an anti-CD19 immunotoxin directed against human B-cell lymphoma.

artículo científico publicado en 2006

The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

artículo científico publicado en 2015

The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation.

artículo científico publicado en 2008

The effect of 2-methoxyoestrone-3-O-sulphamate on the growth of breast cancer cells and induced mammary tumours

artículo científico publicado en 2000

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

artículo científico publicado en 2007

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.

artículo científico publicado en 2017

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

artículo científico publicado en 2011

The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia.

artículo científico publicado en 2014

The normal IGHV1-69-derived B-cell repertoire contains stereotypic patterns characteristic of unmutated CLL.

artículo científico publicado en 2009

The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription.

artículo científico publicado en 2003

The outcome of B-cell receptor signaling in chronic lymphocytic leukemia: proliferation or anergy

artículo científico publicado en 2014

The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines

artículo científico publicado en 2003

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

artículo científico publicado en 2009

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

artículo científico publicado en 2011

Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor

scientific article published on 01 February 2004

Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

artículo científico publicado en 2004

Variable induction of PRDM1 and differentiation in chronic lymphocytic leukemia is associated with anergy.

artículo científico publicado en 2014

Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

artículo científico publicado en 2008

miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance

artículo científico publicado en 2013

p53 pathway gene single nucleotide polymorphisms and chronic lymphocytic leukemia.

artículo científico publicado en 2007

Lista de obras de Graham Packham

A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53

A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.

Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target

Anti-angiogenic effects of dietary isothiocyanates: Mechanisms of action and implications for human health ⬇️

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

B-cell receptor signaling in chronic lymphocytic leukemia.

BAG-1 expression and function in human cancer

BAG-1 immunostaining and survival in early breast cancer

BAG-1 in carcinogenesis.

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity

BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome.

BAG-1: a multi-functional pro-survival molecule

BAG-1: a multifunctional regulator of cell growth and survival

BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

BCR-signaling-induced cell death demonstrates dependency on multiple BH3-only proteins in a murine model of B-cell lymphoma.

BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells

Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

British Journal of Pharmacology

Brn-3a activates the expression of Bcl-x(L) and promotes neuronal survival in vivo as well as in vitro

CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM

Chronic lymphocytic leukaemia

Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

DC-SIGN binding to mannosylated B-cell receptors in follicular lymphoma down-modulates receptor signaling capacity

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.

Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia

Distinct promoters mediate constitutive and inducible Bcl-XL expression in malignant lymphocytes.

E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Epidermal Growth Factor Receptor Family Inhibition Identifies P38 Mitogen-activated Protein Kinase as a Potential Therapeutic Target in Bladder Cancer.

Epigenetic modulators as therapeutic targets in prostate cancer

FOXO3 expression during colorectal cancer progression: biomarker potential reflects a tumour suppressor role.

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

Glycosylation of surface Ig creates a functional bridge between human follicular lymphoma and microenvironmental lectins

High throughput imaging cytometer with acoustic focussing.

Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.

IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus

IL-4 enhances expression and function of surface IgM in CLL cells.

Ibrutinib therapy releases leukemic surface IgM from antigen drive in chronic lymphocytic leukemia patients

Identification in CLL of circulating intraclonal subgroups with varying B-cell receptor expression and function

Immunohistochemical analysis of the antiapoptotic Mcl-1 and Bcl-2 proteins in follicular lymphoma

Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling.

Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

Inhibition of proteasomal degradation of Mcl-1 by cobalt chloride suppresses cobalt chloride-induced apoptosis in HCT116 colorectal cancer cells.

Insertion of atypical glycans into the tumor antigen-binding site identifies DLBCLs with distinct origin and behavior

Investigational epigenetically targeted drugs in early phase trials for the treatment of haematological malignancies.

LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models.

Lectin binding to surface Ig variable regions provides a universal persistent activating signal for follicular lymphoma cells.

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

Mcl-1.

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

Mechanisms of cell death and disease: advances in therapeutic intervention

Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation

MicroRNAs: key players in carcinogenesis and novel therapeutic targets.

Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts

Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2

Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells.

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.

PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

Pharmacological inhibitors of NF-κB accelerate apoptosis in chronic lymphocytic leukaemia cells

Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

Preclinical Evaluation of a Novel SHIP1 Phosphatase Activator for Inhibition of PI3K Signaling in Malignant B Cells

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.

Regulation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Burkitt's lymphoma cell lines

Reply to 'Comment on 'BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses''

Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

S-adenosylhomocysteine hydrolase inhibition by 3-deazaneplanocin A analogues induces anti-cancer effects in breast cancer cell lines and synergy with both histone deacetylase and HER2 inhibition.

Shooting the messenger (RNA) in B-cell lymphoma

Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis ⬇️