Filtros de búsqueda

Lista de obras de Ahmed Kamal

1,2,4-benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity

artículo científico publicado en 2007

2-Anilino-3-Aroylquinolines as Potent Tubulin Polymerization Inhibitors

artículo científico publicado en 2016

2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers

artículo científico publicado en 2011

2-Arylaminobenzothiazole-arylpropenone conjugates as tubulin polymerization inhibitors

scientific article published on 07 March 2017

2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway

artículo científico publicado en 2016

3‐Substituted 2‐Phenylimidazo[2,1‐b]benzothiazoles: Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization ⬇️

artículo científico publicado el 12 de enero de 2012

4β-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents.

artículo científico publicado en 2013

4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer.

artículo científico publicado en 2017

A carbohydrate approach for the formal total synthesis of (-)-aspergillide C.

artículo científico publicado en 2014

A comprehensive review on the therapeutic versatility of imidazo[2,1-b]- thiazoles

artículo científico publicado en 2019

A facile I2-catalyzed synthesis of imidazo[1,2-a]pyridines via sp3 C-H functionalization of azaarenes and evaluation of anticancer activity

scientific article published on 01 August 2017

A new facile chemoenzymatic synthesis of levamisole

artículo científico publicado en 2005

A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway.

artículo científico publicado en 2014

A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells

artículo científico publicado en 2015

A one-pot azido reductive tandem mono-N-alkylation employing dialkylboron triflates: online ESI-MS mechanistic investigation

artículo científico publicado en 2011

An Efficient Synthesis of 2-Substituted Benzimidazoles via Photocatalytic Condensation of o-Phenylenediamines and Aldehydes

artículo científico publicado en 2016

An efficient and facile nitration of phenols with nitric acid/zinc chloride under ultrasonic conditions

artículo científico publicado en 2004

An efficient one-pot approach for the regio- and diastereoselective synthesis of trans-dihydrofuran derivatives: cytotoxicity and DNA-binding studies

artículo científico publicado en 2017

An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity ⬇️

artículo científico publicado el 11 de noviembre de 2010

An efficient synthesis of bis(indolyl)methanes and evaluation of their antimicrobial activities

An evaluation of the CYP2D6 and CYP3A4 inhibition potential of metoprolol metabolites and their contribution to drug-drug and drug-herb interaction by LC-ESI/MS/MS.

artículo científico publicado en 2016

Anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates as p53 activators in cervical cancer cells.

artículo científico publicado en 2012

Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity

artículo científico publicado en 2005

Anti-tubercular agents. Part 5: synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners.

artículo científico publicado en 2010

Anti-tubercular agents. Part 6: Synthesis and antimycobacterial activity of novel arylsulfonamido conjugated oxazolidinones ⬇️

artículo científico publicado el 9 de enero de 2011

Anti-tubercular agents. Part 7: A new class of diarylpyrrole–oxazolidinone conjugates as antimycobacterial agents ⬇️

artículo científico publicado el 22 de marzo de 2013

Anti-tubercular agents. Part 8: synthesis, antibacterial and antitubercular activity of 5-nitrofuran based 1,2,3-triazoles

artículo científico publicado en 2013

Anti-tubercular agents. Part IV: Synthesis and antimycobacterial evaluation of nitroheterocyclic-based 1,2,4-benzothiadiazines

scientific article published on 21 July 2007

Antitubercular agents. Part 1: synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents

artículo científico publicado en 2005

Antitubercular agents. Part 2: new thiolactomycin analogues active against Mycobacterium tuberculosis

artículo científico publicado en 2005

Apoptosis inducing ability of silver decorated highly reduced graphene oxide nanocomposites in A549 lung cancer.

artículo científico publicado en 2016

Apoptosis-inducing agents: a patent review (2010 - 2013).

artículo científico

Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts

scientific article published on 01 October 2014

Base-mediated 1,3-dipolar cycloaddition of pyridinium bromides with bromoallyl sulfones: a facile access to indolizine scaffolds

artículo científico publicado en 2020

Benzo[b]furan derivatives induces apoptosis by targeting the PI3K/Akt/mTOR signaling pathway in human breast cancer cells.

artículo científico publicado en 2016

Bioconversion of Acrylonitrile to Acrylic Acid by Rhodococcus ruber Strain AKSH-84

artículo científico publicado el 1 de enero de 2011

Biotin-c10-AppCH2ppA is an effective new chemical proteomics probe for diadenosine polyphosphate binding proteins

artículo científico publicado en 2014

Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis.

artículo científico publicado en 2015

Chalcone-imidazolone conjugates induce apoptosis through DNA damage pathway by affecting telomeres ⬇️

artículo científico publicado el 25 de abril de 2011

Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol

artículo científico publicado en 2004

Chemoselective aromatic azido reduction with concomitant aliphatic azide employing Al/Gd triflates/NaI and ESI-MS mechanistic studies

artículo científico publicado en 2009

Click chemistry-assisted synthesis of triazolo linked podophyllotoxin conjugates as tubulin polymerization inhibitors

artículo científico publicado en 2017

Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors.

artículo científico publicado en 2016

Combretastatin-based compounds with therapeutic characteristics: a patent review

scientific article published on 08 August 2019

Copper-catalyzed three-component synthesis of aminonaphthoquinone-sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity

artículo científico publicado en 2016

Correction: Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS.

artículo científico publicado en 2012

Correction: Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents

scientific article published on 18 July 2019

Corrigendum to "Synthesis of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates as microtubule targeting and apoptosis inducing agents" [Bioorg. Chem. 76 (2018) 1-12]

scientific article published on 12 February 2020

Cu(OAc)2-Et3N mediated oxidative coupling of α-azido ketones with pyridinium ylides: utilizing in situ generated imines for regioselective synthesis of imidazo[1,2-a]pyridines

artículo científico publicado en 2015

Curcumin inspired 2-chloro/phenoxy quinoline analogues: Synthesis and biological evaluation as potential anticancer agents

artículo científico publicado en 2018

DNA binding potential and cytotoxicity of newly designed pyrrolobenzodiazepine dimers linked through a piperazine side-armed-alkane spacer

artículo científico publicado en 2005

DNA-binding affinity and anticancer activity of β-carboline-chalcone conjugates as potential DNA intercalators: Molecular modelling and synthesis.

artículo científico publicado en 2015

Decolorization and biotransformation of triphenylmethane dye, methyl violet, by Aspergillus sp. isolated from Ladakh, India

artículo científico publicado el 1 de marzo de 2011

Design and synthesis of 1,2,3-triazolo linked benzo[d]imidazo[2,1-b]thiazole conjugates as tubulin polymerization inhibitors

artículo científico publicado en 2017

Design and synthesis of 4β-Acetamidobenzofuranone-podophyllotoxin hybrids and their anti-cancer evaluation

artículo científico publicado en 2019

Design and synthesis of C-8 linked pyrrolobenzodiazepine-naphthalimide hybrids as anti-tumour agents

scientific article published on 01 August 2002

Design and synthesis of C3-pyrazole/chalcone-linked beta-carboline hybrids: antitopoisomerase I, DNA-interactive, and apoptosis-inducing anticancer agents

artículo científico publicado en 2014

Design and synthesis of C3-tethered 1,2,3-triazolo-β-carboline derivatives: Anticancer activity, DNA-binding ability, viscosity and molecular modeling studies.

artículo científico publicado en 2015

Design and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIα inhibition

scientific article published on 08 November 2018

Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors

artículo científico publicado en 2014

Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agents

artículo científico publicado en 2011

Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability.

artículo científico publicado en 2016

Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability

artículo científico publicado en 2015

Design and synthesis of imidazo[2,1-b]thiazole linked triazole conjugates: Microtubule-destabilizing agents.

artículo científico publicado en 2016

Design and synthesis of imidazo[2,1-b]thiazole-chalcone conjugates: microtubule-destabilizing agents

artículo científico publicado en 2014

Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents

artículo científico publicado en 2003

Design and synthesis of pyrazole-oxindole conjugates targeting tubulin polymerization as new anticancer agents.

artículo científico publicado en 2013

Design and synthesis of pyrazole/isoxazole linked arylcinnamides as tubulin polymerization inhibitors and potential antiproliferative agents

artículo científico publicado en 2015

Design, Synthesis, and in vitro and in vivo Evaluations of (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides/sulfonates as Highly Potent Tubulin Polymerization Inhibitors

artículo científico publicado en 2017

Design, synthesis and anticancer evaluation of tetrahydro-β-carboline-hydantoin hybrids

artículo científico publicado en 2014

Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors

artículo científico publicado en 2015

Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis.

artículo científico publicado en 2017

Design, synthesis and biological evaluation of 1,3-diphenyl-1H-pyrazole derivatives containing benzimidazole skeleton as potential anticancer and apoptosis inducing agents

artículo científico publicado en 2015

Design, synthesis and biological evaluation of 3,5-diaryl-isoxazoline/isoxazole-pyrrolobenzodiazepine conjugates as potential anticancer agents.

artículo científico publicado en 2010

Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors

artículo científico publicado en 2016

Design, synthesis and biological evaluation of imidazopyridine-propenone conjugates as potent tubulin inhibitors

artículo científico publicado en 2017

Design, synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase I inhibitors

artículo científico publicado en 2017

Design, synthesis and biological evaluation of novel pyrazolochalcones as potential modulators of PI3K/Akt/mTOR pathway and inducers of apoptosis in breast cancer cells

artículo científico publicado en 2017

Design, synthesis of phenstatin/isocombretastatin-oxindole conjugates as antimitotic agents

artículo científico publicado en 2016

Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-c]pyrazole tethered carbohydrazide hybrids: exploring their in silico ADMET, ergosterol inhibition and ROS inducing potential

scientific article published on 26 April 2019

Design, synthesis, and evaluation of mixed imine-amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity

artículo científico publicado en 2004

Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity

artículo científico publicado en 2002

Design, synthesis, biological evaluation and QSAR studies of novel bisepipodophyllotoxins as cytotoxic agents

artículo científico publicado en 2004

Design, synthesis, in silico pharmacokinetics prediction and biological evaluation of 1,4-dihydroindeno[1,2-c]pyrazole chalcone as EGFR /Akt pathway inhibitors

artículo científico publicado en 2018

Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.

artículo científico publicado en 2008

Development of pyrrolo[2,1-c][1,4]benzodiazepine β-glucoside prodrugs for selective therapy of cancer

artículo científico publicado en 2017

Discovery of Novel Tankyrase Inhibitors through Molecular Docking-Based Virtual Screening and Molecular Dynamics Simulation Studies

scientific article published on 11 July 2020

Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

artículo científico publicado en 2017

Discovery of pyrrolospirooxindole derivatives as novel cyclin dependent kinase 4 (CDK4) inhibitors by catalyst-free, green approach

artículo científico publicado en 2015

Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: synthesis, DNA-binding affinity and cytotoxic activity

artículo científico publicado en 2015

Efficient chemoenzymatic synthesis of (S)- and (R)-5-(1-aminoethyl)-2-(cyclohexylmethoxy)benzamide: key intermediate for Src-SH2 inhibitor

artículo científico publicado en 2002

Efficient solid-phase synthesis of a library of imidazo[1,2-a]pyridine-8-carboxamides

artículo científico publicado en 2007

Efforts towards the development of new antitubercular agents: potential for thiolactomycin based compounds

artículo científico publicado en 2008

Embracing synthetic lethality of novel anticancer therapies

artículo científico

Evaluation of Anticancer and Anti-Mitotic Properties of Quinazoline and Quinazolino-Benzothiadiazine Derivatives

artículo científico publicado en 2019

Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions.

artículo científico publicado en 2017

H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation

artículo científico publicado en 2015

Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites

artículo científico publicado en 2021

Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line

scientific article published on 24 July 2018

In-silico driven design and development of spirobenzimidazo-quinazolines as potential DNA gyrase inhibitors

scientific article published on 24 December 2020

Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation ⬇️

artículo científico publicado el 26 de julio de 2012

Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.

artículo científico publicado en 2012

Investigation of the apoptotic pathway induced by benzimidazole-oxindole conjugates against human breast cancer cells MCF-7.

artículo científico publicado en 2016

Investigation of the mechanism and apoptotic pathway induced by 4β cinnamido linked podophyllotoxins against human lung cancer cells A549.

artículo científico publicado en 2015

Iodine mediated oxidative cross-coupling of unprotected anilines and heteroarylation of benzothiazoles with 2-methylquinoline

artículo científico publicado en 2018

Iodine promoted dual oxidative C(sp3)-H amination of 2-methyl-3-arylquinazolin-4(3H)-ones: a facile route to 1,4-diarylimidazo[1,5-a]quinazolin-5(4H)-ones

artículo científico publicado en 2018

Iodine-catalyzed Csp3-H functionalization of methylhetarenes: One-pot synthesis and cytotoxic evaluation of heteroarenyl-benzimidazoles and benzothiazole

artículo científico publicado en 2017

Iron-Mediated One-Pot Synthesis of 3,5-Diarylpyridines from β-Nitrostyrenes

artículo científico publicado en 2016

Isolation and identification of diadenosine 5',5'''-P1,P4-tetraphosphate binding proteins using magnetic bio-panning

artículo científico publicado el 29 de septiembre de 2011

Metabolic profiling and biological activities of bioactive compounds produced by Pseudomonas sp. strain ICTB-745 isolated from Ladakh, India.

artículo científico publicado en 2012

Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India ⬇️

artículo científico publicado el 21 de marzo de 2013

Microwave-assisted one-pot synthesis of new phenanthrene fused-tetrahydrodibenzo-acridinones as potential cytotoxic and apoptosis inducing agents.

artículo científico publicado en 2018

Mild and efficient reduction of azides to amines: synthesis of fused [2,1-b]quinazolinones

article

NMR structural studies on the covalent DNA binding of a pyrrolobenzodiazepine-naphthalimide conjugate

artículo científico publicado en 2010

Naphthalimide derivatives with therapeutic characteristics: a patent review ⬇️

artículo científico publicado el 1 de febrero de 2013

New (3-(1H-benzo[d]imidazol-2-yl))/(3-(3H-imidazo[4,5-b]pyridin-2-yl))-(1H-indol-5-yl)(3,4,5-trimethoxyphenyl)methanone conjugates as tubulin polymerization inhibitors

scientific article published on 12 December 2017

Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer.

artículo científico publicado en 2015

Novel anthranilamide-pyrazolo[1,5-a]pyrimidine conjugates modulate the expression of p53-MYCN associated micro RNAs in neuroblastoma cells and cause cell cycle arrest and apoptosis

artículo científico publicado en 2013

One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents

artículo científico publicado en 2015

One-pot, three-component approach to the synthesis of 3,4,5-trisubstituted pyrazoles

artículo científico publicado en 2015

Optimization of nitrilase production from Alcaligenes faecalis MTCC 10757 (IICT-A3): effect of inducers on substrate specificity ⬇️

artículo científico publicado el 25 de diciembre de 2010

Peptides as Potential Anticancer Agents

scientific article published on 01 January 2019

PhI(OAc)2-mediated one-pot oxidative decarboxylation and aromatization of tetrahydro-β-carbolines: synthesis of norharmane, harmane, eudistomin U and eudistomin I

artículo científico publicado en 2015

Phenacyl azides as efficient intermediates: one-pot synthesis of pyrrolidines and imidazoles

artículo científico publicado en 2017

Phosphonate-linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: synthesis, DNA-binding affinity and cytotoxicity

artículo científico publicado en 2008

Podophyllotoxin derivatives: a patent review (2012 - 2014).

artículo científico

Purification and biochemical characterization of feruloyl esterases from Aspergillus terreus MTCC 11096.

artículo científico publicado en 2013

Pyrazole-oxadiazole conjugates: synthesis, antiproliferative activity and inhibition of tubulin polymerization

artículo científico publicado en 2014

Pyrazolo-benzothiazole hybrids: Synthesis, anticancer properties and evaluation of antiangiogenic activity using in vitro VEGFR-2 kinase and in vivo transgenic zebrafish model

artículo científico publicado en 2019

Pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity

artículo científico publicado en 2004

Pyrrolo[2,1-c][1,4]benzodiazepine-beta-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies.

artículo científico publicado en 2008

Quinazolino linked 4β-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation.

artículo científico publicado en 2013

Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents.

artículo científico publicado en 2009

Rapid access to novel 1,2,3-triazolo-heterocyclic scaffolds via tandem Knoevenagel condensation/azide-alkyne 1,3-dipolar cycloaddition reaction in one pot

artículo científico publicado en 2014

Rational design and synthesis of 2-anilinopyridinyl-benzothiazole Schiff bases as antimitotic agents.

artículo científico publicado en 2017

Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents.

artículo científico publicado en 2017

Recent advances in the solid-phase combinatorial synthetic strategies for the benzodiazepine based privileged structures

artículo científico publicado en 2006

Recent advances in the solid-phase combinatorial synthetic strategies for the quinoxaline, quinazoline and benzimidazole based privileged structures

artículo científico publicado en 2006

Recent developments in the design, synthesis and structure-activity relationship studies of pyrrolo[2,1-c][1,4]benzodiazepines as DNA-interactive antitumour antibiotics

artículo científico publicado en 2002

Recent developments towards podophyllotoxin congeners as potential apoptosis inducers

artículo científico publicado en 2015

Regioselective Ring Expansion of Isatins with In Situ Generated α-Aryldiazomethanes: Direct Access to Viridicatin Alkaloids

artículo científico publicado en 2018

Regioselective oxidative cross-coupling of benzo[d]imidazo[2,1-b]thiazoles with styrenes: a novel route to C3-dicarbonylation

artículo científico publicado en 2017

Regioselective synthesis, antimicrobial evaluation and theoretical studies of 2-styryl quinolines

artículo científico publicado en 2015

Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers

artículo científico publicado en 2008

Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential

artículo científico publicado en 2009

Search for new and novel chemotherapeutics for the treatment of human malignancies

scientific article published on May 2010

Silver catalyzed domino aza-annulation/Diels-Alder cyclization of 2-ene-yne anilines: a facile one-pot access to carbazole, dihydrocarbazole and tetrahydrocarbazole frameworks

artículo científico publicado en 2016

Solid-phase synthesis of a library of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones with potential antitubercular activity

artículo científico publicado en 2007

Solid-phase synthesis of new pyrrolobenzodiazepine-chalcone conjugates: DNA-binding affinity and anticancer activity

artículo científico publicado en 2008

Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex

artículo científico publicado en 2009

Spectroscopic and calorimetric studies on the DNA recognition of pyrrolo[2,1-c][1,4]benzodiazepine hybrids

artículo científico publicado en 2008

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies

artículo científico publicado en 2015

Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain

artículo científico publicado en 2016

Statistical optimization of production conditions of β-glucosidase from Bacillus stratosphericus strain SG9.

artículo científico publicado en 2017

Styryl Quinazolinones as Potential Inducers of Myeloid Differentiation via Upregulation of C/EBPα

artículo científico publicado en 2018

Styryl quinazolinones and its ethynyl derivatives induce myeloid differentiation

scientific article published on 20 June 2019

Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies.

artículo científico publicado en 2018

Sulfamic acid promoted one-pot three-component synthesis and cytotoxic evaluation of spirooxindoles

artículo científico publicado en 2015

Syntheses of stable, synthetic diadenosine polyphosphate analogues using recombinant histidine-tagged lysyl tRNA synthetase (LysU).

artículo científico publicado en 2014

Synthesis and Anticancer Activities of New Benzothiadiazinyl Hydrazinecarboxamides and Anilino[1,2,4]triazolo[1,5-b][1,2,4]thiadiazine 5,5-diones ⬇️

artículo científico publicado el 1 de mayo de 2011

Synthesis and Biological Evaluation of 1,2,3-triazole tethered Pyrazoline and Chalcone Derivatives

artículo científico publicado en 2016

Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

artículo científico publicado en 2004

Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers

artículo científico publicado en 2006

Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates

artículo científico publicado en 2005

Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers ⬇️

artículo científico publicado el 17 de noviembre de 2003

Synthesis and anti-cancer activity of chalcone linked imidazolones.

artículo científico publicado en 2010

Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents ⬇️

artículo científico publicado el 20 de noviembre de 2011

Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers ⬇️

artículo científico publicado el 30 de mayo de 2011

Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents

artículo científico publicado en 2012

Synthesis and anticancer activity of oxindole derived imidazo[1,5-a]pyrazines

artículo científico publicado en 2011

Synthesis and anticancer potential of benzothiazole linked phenylpyridopyrimidinones and their diones as mitochondrial apoptotic inducers

artículo científico publicado en 2013

Synthesis and antimicrobial potential of nitrofuran-triazole congeners

artículo científico publicado en 2015

Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c]benzodiazepine hybrids

artículo científico publicado en 2004

Synthesis and apoptosis inducing ability of new anilino substituted pyrimidine sulfonamides as potential anticancer agents

artículo científico publicado en 2011

Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.

artículo científico publicado en 2005

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers

artículo científico publicado en 2014

Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents

artículo científico publicado en 2018

Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents ⬇️

artículo científico publicado el 14 de diciembre de 2010

Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors

artículo científico publicado en 2014

Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents ⬇️

artículo científico publicado el 16 de junio de 2011

Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.

artículo científico publicado en 2012

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents.

artículo científico publicado en 2010

Synthesis and biological evaluation of arylcinnamide linked combretastatin-A4 hybrids as tubulin polymerization inhibitors and apoptosis inducing agents.

artículo científico publicado en 2016

Synthesis and biological evaluation of benzimidazole-oxindole conjugates as microtubule-targeting agents

artículo científico publicado en 2015

Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis

artículo científico publicado en 2013

Synthesis and biological evaluation of benzo[d][1,3]dioxol-5-yl chalcones as antiproliferating agents

artículo científico publicado en 2015

Synthesis and biological evaluation of chalcone-linked pyrazolo[1,5-a]pyrimidines as potential anticancer agents.

artículo científico publicado en 2017

Synthesis and biological evaluation of cinnamido linked benzophenone hybrids as tubulin polymerization inhibitors and apoptosis inducing agents

artículo científico publicado en 2014

Synthesis and biological evaluation of cinnamido linked pyrrolo[2,1-c][1,4]benzodiazepines as antimitotic agents

artículo científico publicado en 2010

Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers.

artículo científico publicado en 2016

Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents ⬇️

artículo científico publicado el 23 de agosto de 2012

Synthesis and biological evaluation of conformationally flexible as well as restricted dimers of monastrol and related dihydropyrimidones

artículo científico publicado en 2011

Synthesis and biological evaluation of curcumin inspired imidazo[1,2-a]pyridine analogues as tubulin polymerization inhibitors.

artículo científico publicado en 2017

Synthesis and biological evaluation of curcumin inspired indole analogues as tubulin polymerization inhibitors

artículo científico publicado en 2016

Synthesis and biological evaluation of diaryl ether linked DC-81 conjugates as potential antitumor agents.

artículo científico publicado en 2013

Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents ⬇️

artículo científico publicado el 12 de marzo de 2011

Synthesis and biological evaluation of imidazo[1,5-a]pyridine-benzimidazole hybrids as inhibitors of both tubulin polymerization and PI3K/Akt pathway.

artículo científico publicado en 2014

Synthesis and biological evaluation of imidazo[2,1-b][1,3,4]thiadiazole-linked oxindoles as potent tubulin polymerization inhibitors

artículo científico publicado en 2014

Synthesis and biological evaluation of imidazo[2,1-b]thiazole-benzimidazole conjugates as microtubule-targeting agents

artículo científico publicado en 2018

Synthesis and biological evaluation of imidazopyridine-oxindole conjugates as microtubule-targeting agents

artículo científico publicado en 2013

Synthesis and biological evaluation of imidazopyridinyl-1,3,4-oxadiazole conjugates as apoptosis inducers and topoisomerase IIα inhibitors

artículo científico publicado en 2016

Synthesis and biological evaluation of mercapto triazolo-benzothiadiazine linked aminobenzothiazoles as potential anticancer agents.

artículo científico publicado en 2009

Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners

artículo científico publicado en 2005

Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers

artículo científico publicado en 2019

Synthesis and biological evaluation of phaitanthrin congeners as anti-mycobacterial agents

artículo científico publicado en 2015

Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors

artículo científico publicado en 2014

Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability

scientific article published on 16 January 2019

Synthesis and biological evaluation of pyrazolo-triazole hybrids as cytotoxic and apoptosis inducing agents.

artículo científico publicado en 2015

Synthesis and biological evaluation of spiro[cyclopropane-1,3'-indolin]-2'-ones as potential anticancer agents

artículo científico publicado en 2015

Synthesis and biological evaluation of substituted N-(2-(1H-benzo[d]imidazol-2-yl)phenyl)cinnamides as tubulin polymerization inhibitors

artículo científico publicado en 2020

Synthesis and cytotoxic activity of 2-anilinopyridine-3-acrylamides as tubulin polymerization inhibitors

artículo científico publicado en 2014

Synthesis and evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)nicotinamides as potential anticancer agents that inhibit tubulin polymerization

artículo científico publicado en 2014

Synthesis and in vitro Cytotoxicity Evaluation of Phenanthrene Linked 2,4-Thiazolidinediones as Potential Anticancer Agents

artículo científico publicado en 2020

Synthesis and in vitro cytotoxicity evaluation of β-carboline-combretastatin carboxamides as apoptosis inducing agents: DNA intercalation and topoisomerase-II inhibition

artículo científico publicado en 2019

Synthesis and mechanistic aspects of 2-anilinonicotinyl-pyrazolo[1,5-a]pyrimidine conjugates that regulate cell proliferation in MCF-7 cells via estrogen signaling.

artículo científico publicado en 2016

Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines.

artículo científico publicado en 2010

Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells

artículo científico publicado en 2013

Synthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers

artículo científico publicado en 2015

Synthesis of (Z)-1-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(phenylamino)prop-2-en-1-one derivatives as potential anticancer and apoptosis inducing agents.

artículo científico publicado en 2016

Synthesis of (Z)-3-(arylamino)-1-(3-phenylimidazo[1,5-a]pyridin-1-yl)prop-2-en-1-ones as potential cytotoxic agents

artículo científico publicado en 2020

Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing 'click' chemistry: DNA-binding affinity and anticancer activity

artículo científico publicado en 2007

Synthesis of 2,3,6,7-tetramethoxyphenanthren-9-amine: An efficient precursor to access new 4-aza-2,3-dihydropyridophenanthrenes as apoptosis inducing agents

artículo científico publicado en 2017

Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents

artículo científico publicado en 2014

Synthesis of 2-anilinopyridyl-triazole conjugates as antimitotic agents

artículo científico publicado en 2015

Synthesis of 2-aryl-1,2,4-oxadiazolo-benzimidazoles: Tubulin polymerization inhibitors and apoptosis inducing agents

artículo científico publicado en 2015

Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity ⬇️

artículo científico publicado el 29 de julio de 2010

Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities ⬇️

artículo científico publicado el 10 de noviembre de 2010

Synthesis of 4β-amido and 4β-sulphonamido analogues of podophyllotoxin as potential antitumour agents ⬇️

artículo científico publicado el 17 de noviembre de 2003

Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents ⬇️

artículo científico publicado el 21 de marzo de 2011

Synthesis of Benzo[d]imidazo[2,1-b]thiazole-Propenone Conjugates as Cytotoxic and Apoptotic Inducing Agents

artículo científico publicado en 2019

Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents ⬇️

artículo científico publicado el 1 de marzo de 2013

Synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-cancer agents

artículo científico publicado en 2002

Synthesis of C-8 methanesulphonate substituted pyrrolobenzodiazepines as potential antitumour agents

artículo científico publicado en 2003

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

artículo científico publicado en 2004

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity

artículo científico publicado en 2004

Synthesis of Combretastatin-A4 Carboxamidest that Mimic Sulfonyl Piperazines by a Molecular Hybridization Approach: in vitro Cytotoxicity Evaluation and Inhibition of Tubulin Polymerization

artículo científico publicado en 2019

Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors

artículo científico publicado en 2018

Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents ⬇️

artículo científico publicado el 24 de febrero de 2011

Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents

artículo científico publicado en 2006

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.

artículo científico publicado en 2014

Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability.

artículo científico publicado en 2011

Synthesis of arylpyrazole linked benzimidazole conjugates as potential microtubule disruptors

artículo científico publicado en 2015

Synthesis of benzo[d]imidazo[2,1-b]thiazole-chalcone conjugates as microtubule targeting and apoptosis inducing agents

artículo científico publicado en 2017

Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents ⬇️

artículo científico publicado el 10 de abril de 2012

Synthesis of enamino-2-oxindoles via conjugate addition between α-azido ketones and 3-alkenyl oxindoles: Cytotoxicity evaluation and apoptosis inducing studies

article

Synthesis of fluorinated analogues of SJG-136 and their DNA-binding potential

artículo científico publicado en 2004

Synthesis of imidazo-thiadiazole linked indolinone conjugates and evaluated their microtubule network disrupting and apoptosis inducing ability

artículo científico publicado en 2017

Synthesis of imidazothiazole-chalcone derivatives as anticancer and apoptosis inducing agents.

artículo científico publicado en 2010

Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity

artículo científico publicado en 2008

Synthesis of new bis-pyrazole linked hydrazides and their in vitro evaluation as antimicrobial and anti-biofilm agents: A mechanistic role on ergosterol biosynthesis inhibition in Candida albicans

scientific article published on 22 April 2019

Synthesis of new triazole fused imidazo[2,1-b]thiazole hybrids with emphasis on Staphylococcus aureus virulence factors

scientific article published on 12 August 2019

Synthesis of novel C2 and C2–C8 linked pyrrolo[2,1- c ][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents ⬇️

artículo científico publicado el 20 de octubre de 2003

Synthesis of phenstatin/isocombretastatin-chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers

artículo científico publicado en 2015

Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors

artículo científico publicado en 2017

Synthesis of pyrazolo[1,5-a]pyrimidine linked aminobenzothiazole conjugates as potential anticancer agents.

artículo científico publicado en 2013

Synthesis of pyrrolo[2,1-c][1,4]benzodiazepines and their conjugates by azido reductive cyclization strategy as potential DNA-binding agents

artículo científico publicado en 2005

Synthesis of substituted biphenyl methylene indolinones as apoptosis inducers and tubulin polymerization inhibitors

artículo científico publicado en 2019

Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies.

artículo científico publicado en 2017

Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors ⬇️

artículo científico publicado el 12 de enero de 2012

Synthesis of β-carboline-benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation.

artículo científico publicado en 2014

Synthesis, DNA Binding Ability and Anticancer Activity of 2-heteroaryl Substituted Benzimidazoles Linked Pyrrolo[2,1-c][1,4]benzodiazepine Conjugates ⬇️

artículo científico publicado el 1 de agosto de 2013

Synthesis, DNA binding affinity and anticancer activity of novel 4H-benzo[g][1,2,3]triazolo[5,1-c][1,4]oxazocines

artículo científico publicado en 2016

Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

artículo científico publicado en 2007

Synthesis, DNA-binding ability and anticancer activity of benzothiazole/benzoxazole-pyrrolo[2,1-c][1,4]benzodiazepine conjugates.

artículo científico publicado en 2010

Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates

artículo científico publicado en 2008

Synthesis, anticancer activity and apoptosis inducing ability of anthranilamide-PBD conjugates

artículo científico publicado en 2010

Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates

artículo científico publicado en 2011

Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates.

artículo científico publicado en 2010

Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4′,7-dihydroxyflavone and their analogues ⬇️

artículo científico publicado el 23 de mayo de 2012

Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents ⬇️

artículo científico publicado el 5 de febrero de 2013

Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors

scientific article published on 01 November 2020

Synthesis, structural characterization and biological evaluation of novel [1,2,4]triazolo [1,5-b][1,2,4]benzothiadiazine-benzothiazole conjugates as potential anticancer agents

artículo científico publicado en 2007

Synthesis, structure analysis, and antibacterial activity of some novel 10-substituted 2-(4-piperidyl/phenyl)-5,5-dioxo[1,2,4]triazolo[1,5-b][1,2,4]benzothiadiazine derivatives

scientific article published on 06 August 2007

Synthetic lethality on drug discovery: an update on cancer therapy

scientific article published on 31 March 2020

Tankyrase inhibitors as therapeutic targets for cancer

artículo científico

Telomerase Inhibition and Human Telomeric G-Quadruplex DNA Stabilization by a β-Carboline-Benzimidazole Derivative at Low Concentrations.

artículo científico publicado en 2017

The design and development of imidazothiazole–chalcone derivatives as potential anticancer drugs ⬇️

artículo científico publicado el 15 de enero de 2013

The effect of C2-fluoro group on the biological activity of DC-81 and its dimers

artículo científico publicado en 2004

The first total synthesis of nhatrangin A

artículo científico publicado en 2013

The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism

artículo científico publicado en 2016

Therapeutic potential of benzothiazoles: a patent review (2010 - 2014).

artículo científico publicado en 2015

Time-Domain Analysis of Molecular Dynamics Trajectories Using Deep Neural Networks: Application to Activity Ranking of Tankyrase Inhibitors

artículo científico publicado en 2019

Transition-Metal-Free One-Pot Tandem Synthesis of 3-Ketoisoquinolines from Aldehydes and Phenacyl Azides

artículo científico publicado en 2019

Tubulin inhibitors as novel anticancer agents: an overview on patents (2013-2018)

artículo científico publicado en 2019

Ultrasonic activated efficient method for the cleavage of epoxides with aromatic amines

artículo científico publicado en 2005

Vanadium-Catalyzed Oxidative C(CO)-C(CO) Bond Cleavage for C-N Bond Formation: One-Pot Domino Transformation of 1,2-Diketones and Amidines into Imides and Amides.

artículo científico publicado en 2017

Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update

artículo científico publicado en 2019

p53–Mdm2 inhibitors: patent review (2009 – 2010) ⬇️

artículo científico publicado el 9 de febrero de 2012

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda