Lista de obras - John H Bushweller - Dominio Público Uruguay

1H, 13C and 15N NMR resonance assignments of vaccinia glutaredoxin-1 in the fully reduced form

artículo científico publicado en 1998

3D 13C-15N-heteronuclear two-spin coherence spectroscopy for polypeptide backbone assignments in 13C-15N-double-labeled proteins.

artículo científico publicado en 1993

A PCR-based method for uniform 13C/15N labeling of long DNA oligomers

artículo científico publicado en 1998

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

artículo científico publicado en 2017

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

artículo científico publicado en 2007

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

artículo científico publicado en 2005

An optimized PCR-based procedure for production of 13C/15N-labeled DNA.

artículo científico publicado en 2001

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB

artículo científico publicado en 2010

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

artículo científico publicado en 2003

Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex.

artículo científico publicado en 2017

Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction

artículo científico publicado en 1999

Biosynthetic 15N and 13C isotope labelling of glutathione in the mixed disulfide with Escherichia coli glutaredoxin documented by sequence-specific NMR assignments

scientific article published on 01 December 1993

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

artículo científico publicado en 2018

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

artículo científico publicado en 2018

Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.

artículo científico publicado en 2004

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

artículo científico publicado en 2015

Complete heteronuclear NMR resonance assignments and secondary structure of core binding factor beta (1-141).

artículo científico publicado en 1998

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

artículo científico publicado en 2017

Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

artículo científico publicado en 2015

Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.

artículo científico publicado en 2007

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

artículo científico publicado en 2003

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

artículo científico publicado en 2013

Hepatoma derived growth factor is a nuclear targeted mitogen

artículo científico publicado en 2003

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.

artículo científico publicado en 2005

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4

artículo científico publicado en 2014

Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A.

artículo científico publicado en 2006

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

artículo científico publicado en 2022

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

artículo científico publicado en 2012

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.

artículo científico publicado en 2016

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

artículo científico publicado en 2008

MQ-hCN-based pulse sequences for the measurement of 13C1'-1H1', 13C1'-15N, 1H1'-15N, 13C1'-13C2', 1H1'-13C2',13C6/8-1H6/8, 13C6/8-15N, 1H6/8-15N, 13C6-13C5, 1H6-13C5 dipolar couplings in 13C, 15N-labeled DNA (and RNA).

artículo científico publicado en 2002

Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion

artículo científico publicado en 2005

Mitotic gene bookmarking by RUNX1 contributes to stabilization of the normal mammary epithelial phenotype

article

Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia

artículo científico publicado en 2017

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit

scientific journal article

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

artículo científico publicado en 2009

Optimal mutation sites for PRE data collection and membrane protein structure prediction.

artículo científico publicado en 2011

Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit ⬇️

artículo científico publicado el 23 de enero de 1998

Preparation, characterization, and complete heteronuclear NMR resonance assignments of the glutaredoxin (C14S)-ribonucleotide reductase B1 737-761 (C754S) mixed disulfide

scientific article published on 01 April 1998

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

scientific article published on 13 February 2019

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

artículo científico publicado en 2017

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

scientific article published on 25 April 2019

Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy.

artículo científico publicado en 2006

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

artículo científico publicado en 2016

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

artículo científico publicado en 2018

Solution structure and elevator mechanism of the membrane electron transporter CcdA.

artículo científico publicado en 2018

Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.

artículo científico publicado en 2003

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione

artículo científico publicado el 29 de septiembre de 1992

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

artículo científico publicado en 2007

Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.

artículo científico publicado en 2017

Structure of outer membrane protein A transmembrane domain by NMR spectroscopy

artículo científico publicado en 2001

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

artículo científico publicado en 2009

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

artículo científico publicado en 2009

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.

artículo científico publicado en 2004

Targeting transcription factors in cancer - from undruggable to reality

scientific article published on 11 September 2019

The NMR solution structure of human glutaredoxin in the fully reduced form

artículo científico publicado en 1998

The NOESY jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data.

artículo científico publicado en 2000

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression, ⬇️

artículo científico publicado el 10 de agosto de 2010

The binding of the PDZ tandem of syntenin to target proteins.

artículo científico publicado en 2006

The nuclear magnetic resonance solution structure of the mixed disulfide between Escherichia coli glutaredoxin(C14S) and glutathione.

artículo científico publicado en 1994

The role of CBFbeta in AML1-ETO's activity

artículo científico publicado en 2009

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

artículo científico publicado en 2009

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

artículo científico publicado en 2006

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism

artículo científico publicado en 2015

Lista de obras de John H Bushweller

1H, 13C and 15N NMR resonance assignments of vaccinia glutaredoxin-1 in the fully reduced form

3D 13C-15N-heteronuclear two-spin coherence spectroscopy for polypeptide backbone assignments in 13C-15N-double-labeled proteins.

A PCR-based method for uniform 13C/15N labeling of long DNA oligomers

A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

An optimized PCR-based procedure for production of 13C/15N-labeled DNA.

Application of fragment-based drug discovery to membrane proteins: identification of ligands of the integral membrane enzyme DsbB

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

Bacillus anthracis Peptidoglycan Integrity Is Disrupted by the Chemokine CXCL10 through the FtsE/X Complex.

Binding specificity and mechanistic insight into glutaredoxin-catalyzed protein disulfide reduction

Biosynthetic 15N and 13C isotope labelling of glutathione in the mixed disulfide with Escherichia coli glutaredoxin documented by sequence-specific NMR assignments

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia

Charged gels as orienting media for measurement of residual dipolar couplings in soluble and integral membrane proteins.

Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Complete heteronuclear NMR resonance assignments and secondary structure of core binding factor beta (1-141).

Corrigendum to: "Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers" [EBioMedicine 8 (2016) 117-131].

Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential.

Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.

Energetic contribution of residues in the Runx1 Runt domain to DNA binding.

Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.

Hepatoma derived growth factor is a nuclear targeted mitogen

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.

Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4

Increasing the accuracy of solution NMR structures of membrane proteins by application of residual dipolar couplings. High-resolution structure of outer membrane protein A.

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

MQ-hCN-based pulse sequences for the measurement of 13C1'-1H1', 13C1'-15N, 1H1'-15N, 13C1'-13C2', 1H1'-13C2',13C6/8-1H6/8, 13C6/8-15N, 1H6/8-15N, 13C6-13C5, 1H6-13C5 dipolar couplings in 13C, 15N-labeled DNA (and RNA).

Membrane structures of the hemifusion-inducing fusion peptide mutant G1S and the fusion-blocking mutant G1V of influenza virus hemagglutinin suggest a mechanism for pore opening in membrane fusion

Mitotic gene bookmarking by RUNX1 contributes to stabilization of the normal mammary epithelial phenotype

Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia

Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Optimal mutation sites for PRE data collection and membrane protein structure prediction.

Overexpression, Purification, and Biophysical Characterization of the Heterodimerization Domain of the Core-binding Factor β Subunit ⬇️

Preparation, characterization, and complete heteronuclear NMR resonance assignments of the glutaredoxin (C14S)-ribonucleotide reductase B1 737-761 (C754S) mixed disulfide

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1

Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy.

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

Solution structure and elevator mechanism of the membrane electron transporter CcdA.

Structural and functional characterization of Runx1, CBF beta, and CBF beta-SMMHC.

Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14----S) and its mixed disulfide with glutathione

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.

Structure of outer membrane protein A transmembrane domain by NMR spectroscopy

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.

Targeting transcription factors in cancer - from undruggable to reality

The NMR solution structure of human glutaredoxin in the fully reduced form

The NOESY jigsaw: automated protein secondary structure and main-chain assignment from sparse, unassigned NMR data.

The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression, ⬇️

The binding of the PDZ tandem of syntenin to target proteins.

The nuclear magnetic resonance solution structure of the mixed disulfide between Escherichia coli glutaredoxin(C14S) and glutathione.

The role of CBFbeta in AML1-ETO's activity

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA.

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

Tom1 Modulates Binding of Tollip to Phosphatidylinositol 3-Phosphate via a Coupled Folding and Binding Mechanism