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A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62.

artículo científico publicado en 2003

Acanthocheilonema viteae: phosphorylcholine is attached to the major excretory-secretory product via an N-linked glycan

scientific article published on 01 December 1993

Allergy and parasites

artículo científico publicado en 2013

An oligonucleotide probe specific for Onchocerca volvulus

artículo científico publicado en 1989

Antigen receptor signaling is subverted by an immunomodulatory product secreted by a filarial nematode

artículo científico publicado en 2001

Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells

artículo científico publicado en 2017

Avoiding detection: parasites and the immune system

artículo científico publicado en 2002

Biosynthetic radiolabelling of excretions-secretions of adult male Onchocerca gibsoni

artículo científico publicado en 1994

Brugia malayi Antigen (BmA) Inhibits HIV-1 Trans-Infection but Neither BmA nor ES-62 Alter HIV-1 Infectivity of DC Induced CD4+ Th-Cells

artículo científico publicado en 2016

Characterization of the surface polypeptides of Strongyloides ratti: a comparison of homogonic and heterogonic strains

scientific article published on 01 March 1994

Cloning of a species-specific DNA probe from Onchocerca gibsoni

artículo científico publicado en 1990

Cloning of specific diagnostic antigens of Onchocerca volvulus

artículo científico publicado en 1990

DNA-based detection of onchocerca volvulus.

artículo científico publicado en 2002

Designing anti-inflammatory drugs from parasitic worms: a synthetic small molecule analogue of the Acanthocheilonema viteae product ES-62 prevents development of collagen-induced arthritis.

artículo científico publicado en 2013

Development of Acanthocheilonema viteae in Meriones shawi: absence of microfilariae and production of active ES-62

artículo científico publicado en 2020

Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline?

artículo científico publicado en 2007

ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology

article

Evaluation of the potential of excretions-secretions (E-S) of Litomosoides carinii to substitute for human filarial E-S

artículo científico publicado en 1989

Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific.

artículo científico publicado en 2002

Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens.

artículo científico publicado en 2008

From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis.

artículo científico publicado en 2015

Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis.

artículo científico publicado en 2007

Immunomodulatory properties of ES-62, a phosphorylcholine-containing glycoprotein secreted by Acanthocheilonema viteae

artículo científico publicado en 2012

Impact of worms and their products on eosinophils and neutrophils in experimental asthma.

artículo científico

Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro

scientific article published on 01 October 1986

Investigation of strategies with potential for producing a phosphorylcholine-free version of the filarial nematode immunomodulator, ES-62

artículo científico publicado en 2006

Modulation of the host immune system by phosphorylcholine-containing glycoproteins secreted by parasitic filarial nematodes

artículo científico publicado en 2001

Onchocerca antigens in protection, diagnosis and pathology.

artículo científico publicado en 1987

Onchocerca ochengi acquisition in zebu Gudali cattle exposed to natural transmission: parasite population dynamics and IgG antibody subclass responses to Ov10/Ov11 recombinant antigens.

artículo científico publicado en 2004

Origin, kinetics of circulation and fate in vivo of the major excretory-secretory product of Acanthocheilonema viteae

artículo científico publicado en 1989

Parasite excretory-secretory products and their effects on metabolic syndrome

artículo científico publicado en 2017

Parasite modulation of the immune response

artículo científico publicado en 2005

Prevention of attachment of phosphorylcholine to a major excretory-secretory product of Acanthocheilonema viteae using tunicamycin

scientific article published on 01 April 1996

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

artículo científico publicado en 2015

Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms

scientific article published on 01 July 1993

Schistosoma mansoni: exposure in vitro of adult male surface antigens

artículo científico publicado en 1986

Secretory products of helminth parasites as immunomodulators.

artículo científico publicado en 2014

Site-specific glycoproteomic characterization of ES-62: The major secreted product of the parasitic worm Acanthocheilonema viteae

artículo científico publicado en 2019

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

artículo científico publicado en 2014

Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62.

artículo científico publicado en 2004

Structural/functional aspects of ES-62--a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein

artículo científico publicado en 2003

Structure and synthesis of nematode phosphorylcholine-containing glycoconjugates.

artículo científico publicado en 2004

Studies on a 14-kilodalton surface protein of Onchocerca microfilariae.

artículo científico publicado en 1991

Successful vaccination against Onchocerca ochengi infestation in cattle using live Onchocerca volvulus infective larvae.

artículo científico publicado en 2007

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

artículo científico publicado en 2021

Surface antigens of male worms and microfilariae of Onchocerca gibsoni

artículo científico publicado en 1991

The Carbohydrate-linked Phosphorylcholine of the Parasitic Nematode Product ES-62 Modulates Complement Activation.

artículo científico publicado en 2016

The Interaction of Membrane-active Compounds with the Surfaces of Schistosomula and Adult Schistosoma mansoni.

artículo científico publicado en 1982

The anthelmintic action of praziquantel

artículo científico publicado en 1988

The effects of retinol (vitamin A alcohol) and various non-ionic detergents on he surfaces of schistosomula and adult Schistosoma mansoni

artículo científico publicado en 1982

The helminth product ES-62 protects against septic shock via Toll-like receptor 4–dependent autophagosomal degradation of the adaptor MyD88

artículo científico publicado el 27 de febrero de 2011

The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model

artículo científico publicado en 2015

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing

scientific article published on 12 March 2020

The parasitic worm product ES-62 targets myeloid differentiation factor 88-dependent effector mechanisms to suppress antinuclear antibody production and proteinuria in MRL/lpr mice

artículo científico publicado en 2015

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

artículo científico publicado en 2016

The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62.

artículo científico publicado en 2007

The use of membrane-active compounds to examine the structure of the surface membrane of Schistosoma mansoni

artículo científico publicado en 1981

Variation in class-specific humoral immune responses of different mouse strains to microfilariae of Dipetalonema viteae.

artículo científico publicado en 1987